يعرض 1 - 10 نتائج من 123 نتيجة بحث عن '"Dalla Costa, M."', وقت الاستعلام: 1.30s تنقيح النتائج
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    دورية أكاديمية

    الوصف: This work was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES/PROEX) - Finance Code 001, PRPG/UFSM, INCT-GD, CAPES proc 23038.000776/2017-54, CNPQ proc 465640/2014-1 and FAPERGS proc 17/2551-0000517-1 and in part by the Spanish government under grants PID2019-105568RB-I00 and TED2021-129372B-I00.

    العلاقة: IEEE Transactions on Industry Applications; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105568RB-I00/ES/OPTIMIZACION ADAPTATIVA DEL CONSUMO DE ENERGIA Y LA REPRODUCCION DE COLOR EN SISTEMAS DE ILUMINACION ELECTRONICA MEDIANTE LED/; TED2021-129372B-I00; http://dx.doi.org/10.1109/TIA.2023.3280469Test; IEEE Transactions on Industry Applications p. 1-11 (2023); doi:10.1109/TIA.2023.3280469; https://hdl.handle.net/10651/69906Test

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    دورية أكاديمية
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    دورية أكاديمية

    المساهمون: Garelli S., Dalla Costa M., Sabbadin C., Barollo S., Rubin B., Scarpa R., Masiero S., Fierabracci A., Bizzarri C., Crino A., Cappa M., Valenzise M., Meloni A., De Bellis A.M., Giordano C., Presotto F., Perniola R., Capalbo D., Salerno M.C., Stigliano A., Radetti G., Camozzi V., Greggio N.A., Bogazzi F., Chiodini I., Pagotto U., Black S.K., Chen S., Rees Smith B., Furmaniak J., Weber G., Pigliaru F., De Sanctis L., Scaroni C., Betterle C.

    الوصف: Background: Autoimmune Polyglandular Syndrome type 1 (APS-1) is a rare recessive inherited disease, caused by AutoImmune Regulator (AIRE) gene mutations and characterized by three major manifestations: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism (CH) and Addison’s disease (AD). Methods: Autoimmune conditions and associated autoantibodies (Abs) were analyzed in 158 Italian patients (103 females and 55 males; F/M 1.9/1) at the onset and during a follow-up of 23.7 ± 15.1 years. AIRE mutations were determined. Results: The prevalence of APS-1 was 2.6 cases/million (range 0.5–17 in different regions). At the onset 93% of patients presented with one or more components of the classical triad and 7% with other components. At the end of follow-up, 86.1% had CH, 77.2% AD, 74.7% CMC, 49.5% premature menopause, 29.7% autoimmune intestinal dysfunction, 27.8% autoimmune thyroid diseases, 25.9% autoimmune gastritis/pernicious anemia, 25.3% ectodermal dystrophy, 24% alopecia, 21.5% autoimmune hepatitis, 17% vitiligo, 13.3% cholelithiasis, 5.7% connective diseases, 4.4% asplenia, 2.5% celiac disease and 13.9% cancer. Overall, 991 diseases (6.3 diseases/patient) were found. Interferon-ω Abs (IFNωAbs) were positive in 91.1% of patients. Overall mortality was 14.6%. The AIRE mutation R139X was found in 21.3% of tested alleles, R257X in 11.8%, W78R in 11.4%, C322fsX372 in 8.8%, T16M in 6.2%, R203X in 4%, and A21V in 2.9%. Less frequent mutations were present in 12.9%, very rare in 9.6% while no mutations in 11% of the cases. Conclusions: In Italy, APS-1 is a rare disorder presenting with the three major manifestations and associated with different AIRE gene mutations. IFNωAbs are markers of APS-1 and other organ-specific autoantibodies are markers of clinical, subclinical or potential autoimmune conditions.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34003463; info:eu-repo/semantics/altIdentifier/wos/WOS:000651689200002; firstpage:1; lastpage:18; numberofpages:18; journal:JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION; http://hdl.handle.net/2318/1798169Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85106226694

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    مؤتمر

    الوصف: Desde ya hace algunos años se percibe en el mundo una marcada tendencia a la eficiencia energética y esto involucra, desde luego, a las distintas fuentes de luz eléctrica. La Argentina no ha sido ajena a estos cambios habiéndose prohibido en el país la fabricación y venta de lámparas incandescentes de potencias superiores a 25 W, incentivando de esta manera el uso de lámparas más eficientes como las fluorescentes compactas, mientras el mercado, recientemente, ha incorporado lámparas LED para uso general. Las diferentes tecnologías no sólo tienen un impacto en el rendimiento energético sino que existe, entre otras cosas, una interacción desde el punto de vista de la Compatibilidad Electromagnética (CE) entre estos dispositivos y la red eléctrica de la que son alimentadas. Específicamente, en lo que ocupa a este trabajo, se hará referencia a distintos tipos de lámparas (principalmente incandescentes, fluorescentes y LEDs) en donde las mismas serán pasibles de aceptar perturbaciones provenientes de la red o de generarlas de acuerdo a sus características y principio de funcionamiento. De estas perturbaciones se analizarán las armónicas y las fluctuaciones de tensión (flicker). En el artículo se presenta una breve descripción de los distintos sistemas de iluminación, las topologías requeridas para alimentar a las lámparas modernas y el encuadramiento de los distintos sistemas dentro de la Compatibilidad Electromagnética; particularmente la emisión de armónicas por parte de éstas y la susceptibilidad que las mismas poseen a las fluctuaciones de tensión. Adicionalmente, se profundizará sobre la normativa internacional que vincula la CE con la iluminación y finalmente se presentarán resultados de ensayos de laboratorio caracterizando a las lámparas como cargas perturbadoras o susceptibles en las redes eléctricas. ; Comité de estudio C4: Desempeño técnico del sistema. ; Instituto de Investigaciones Tecnológicas para Redes y Equipos Eléctricos (IITREE)

    وصف الملف: application/pdf

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    دورية أكاديمية

    المساهمون: European Union 7th Framework Programme, EurAdrenal, University of Padova

    المصدر: Clinical and Experimental Immunology ; volume 176, issue 3, page 373-379 ; ISSN 1365-2249 0009-9104

    مصطلحات موضوعية: Immunology, Immunology and Allergy

    الوصف: Summary Steroidogenic enzyme autoantibodies (SEAbs) are frequently present and are markers of autoimmune premature ovarian failure (POF) in females with autoimmune Addison's disease (AAD). The prevalence and significance of SEAbs in males with AAD have not yet been defined. We studied the prevalence of SEAbs in a large cohort of males with AAD and assessed the relationship between SEAbs positivity and testicular function. A total of 154 males with AAD (mean age 34 years) were studied. SEAbs included autoantibodies to steroid-producing cells (StCA), detected by immunofluorescence, and steroid 17α-hydroxylase (17α-OHAbs) and side chain cleavage enzyme (SCCAbs) measured by immunoprecipitation assays. Gonadal function was evaluated by measuring follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), sex hormone-binding globulin (SHGB), anti-müllerian hormone (AMH) and inhibin-B (I-B). Twenty-six males, 10 SEAbs(+) and 16 SEAbs(–), were followed-up for a mean period of 7·6 years to assess the behaviour of SEAbs and testicular function. SEAbs were found in 24·7% of males with AAD, with the highest frequency in patients with autoimmune polyendocrine syndrome type 1 (APS-1). The levels of reproductive hormones in 30 SEAbs(+) males were in the normal range according to age and were not significantly different compared to 55 SEAbs(–) males (P > 0·05). During follow-up, both SEAbs(+) and SEAbs(–) patients maintained normal testicular function. SEAbs were found with high frequency in males with AAD; however, they were not associated with testicular failure. This study suggests that the diagnostic value of SEAbs in males with AAD differs compared to females, and this may be related to the immunoprivileged status of the testis.

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    دورية أكاديمية
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    المصدر: Endocrine Connections
    Endocrine Connections, Vol 7, Iss 9, Pp 965-974 (2018)

    الوصف: Introduction and Aim The purpose of replacement therapy in adrenal insufficiency (AI) is mimicking endogenous cortisol levels as closely as possible: dual release hydrocortisone (DR-HC) has been introduced to replicate the circadian cortisol rhythm. Multiple daily saliva collections could be used to assess the cortisol rhythm during real life: our aim was to study the salivary cortisol profile in AI. Materials and Methods We prospectively evaluated, in an observational study, 18 adult outpatients with AI (11 primary and 7 secondary AI), switched from conventional treatment (conv-HC, 25 mg/day) to the same dose of DR-HC. We collected six samples of saliva in a day, measuring cortisol (F) and cortisone (E) with LC-MS/MS. Forty-three matched healthy subjects served as controls. Results F levels were similar in the morning (and higher than controls) in patients treated with conv-HC or DR-HC; otherwise F levels and exposure were lower in the afternoon and evening in patients with DR-HC, achieving a cortisol profile closer to healthy controls. Daily cortisol exposure, measured with area under the curve, was lower with DR-HC. Morning F and E presented sensitivity and specificity >90% to diagnose AI (respectively threshold of 3 and 9.45 nmol/L). Total cholesterol and HbA1c levels reduced with DR-HC. Conclusions Salivary cortisol daily curve could be used as a new tool to assess the cortisol profiles in patients treated with conv-HC and DR-HC. A lower daily cortisol exposure was achieved with DR-HC (despite the same HC dose), especially in the afternoon-evening.

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    دورية أكاديمية
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    مؤتمر