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1دورية أكاديمية
المؤلفون: Damon Asher, Daisy Dai, Alexa C. Klimchak, Lauren E. Sedita, Katherine L. Gooch, Louise Rodino-Klapac
المصدر: Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 474-483 (2023)
مصطلحات موضوعية: delandistrogene moxeparvovec, Duchenne muscular dystrophy, gene therapy, rare disease, scientific spillover, SRP-9001, Genetics, QH426-470, Cytology, QH573-671
الوصف: Gene therapies have potential to improve outcomes of severe diseases after only a single administration. Novel therapies are continually being developed using knowledge gained from prior successes, a concept known as scientific spillover. Gene therapy advancement requires extensive development at each stage: preclinical work to create and evaluate vehicles for delivery of the therapy, design of clinical development programs, and establishment of a large-scale manufacturing process. Pioneering gene therapies are generating spillover as investigators confront myriad issues specific to this treatment modality. These include frameworks for construct engineering, dose evaluation, patient selection, outcome assessment, and safety monitoring. Consequently, the benefits of these therapies extend beyond offering knowledge for treating any one disease to establishing new platforms and paradigms that will accelerate advancement of future gene therapies. This impact is even more profound in rare diseases, where developing therapies in isolation may not be possible. This review describes some instances of scientific spillover in healthcare, and specifically gene therapy, using delandistrogene moxeparvovec (SRP-9001), a gene therapy recently approved by the US Food and Drug Administration for the treatment of ambulatory pediatric patients aged 4–5 years with Duchenne muscular dystrophy with a confirmed mutation in the DMD gene, as a case study.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S232905012300116XTest; https://doaj.org/toc/2329-0501Test
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2دورية أكاديمية
المؤلفون: Louis Fok, Berhanu Erko, David Brett-Major, Abebe Animut, M. Jana Broadhurst, Daisy Dai, John Linville, Bruno Levecke, Yohannes Negash, Abraham Degarege
المصدر: Diagnostics, Vol 14, Iss 10, p 1037 (2024)
مصطلحات موضوعية: urogenital schistosomiasis, FlukeCatcher, FlukeFinder, microscopy, Schistosoma haematobium, diagnosis, Medicine (General), R5-920
الوصف: Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium eggs in human urine samples. Urine samples were collected from 572 school-age children in Afar, Ethiopia in July 2023 and examined using UFM and FCM approaches. Using the combined UFM and FCM results as a reference, the sensitivity, negative predictive value, and agreement levels for the two testing methods in detecting S. haematobium eggs in urine samples were calculated. The sensitivity and negative predictive value of detecting S. haematobium eggs in urine samples for FCM was 84% and 97%, respectively, compared to 65% and 93% for UFM. The FCM test results had an agreement of 61% with the UFM results, compared to 90% with the combined results of FCM and UFM. However, the average egg count estimates were lower when using FCM (6.6 eggs per 10 mL) compared to UFM (14.7 eggs per 10 mL) (p < 0.0001). Incorporating FCM into specimen processing could improve the diagnosis of S. haematobium infection but may underperform in characterizing the intensity of infection.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Carlos K H Wong, William C W Wong, Cindy L K Lam, Y F Wan, Winnie H T Wong, K L Chung, Daisy Dai, Eva L H Tsui, Daniel Y T Fong
المصدر: PLoS ONE, Vol 9, Iss 5, p e95328 (2014)
الوصف: To evaluate the effects of a large population-based patient empowerment programme (PEP) on clinical outcomes and health service utilization rates in type 2 diabetes mellitus (T2DM) patients in the primary care setting.A stratified random sample of 1,141 patients with T2DM enrolled to PEP between March and September 2010 were selected from general outpatient clinics (GOPC) across Hong Kong and compared with an equal number of T2DM patients who had not participated in the PEP (non-PEP group) matched by age, sex and HbA1C level group.Clinical outcomes of HbA1c, SBP, DBP and LDL-C levels, and health service utilization rates including numbers of visits to GOPC, specialist outpatient clinics (SOPC), emergency department (ED) and inpatient admissions, were measured at baseline and at 12-month post-recruitment. The effects of PEP on clinical outcomes and health service utilization rates were assessed by the difference-in-difference estimation, using the generalized estimating equation models.Compared with non-PEP group, PEP group achieved additional improvements in clinical outcomes over the 12-month period. A significantly greater percentage of patients in the PEP group attained HbA1C≤7% or LDL-C≤2.6 mmol/L at 12-month follow-up compared with the non-PEP group. PEP group had a mean 0.813 fewer GOPC visits in comparison with the non-PEP group.PEP was effective in improving the clinical outcomes and reduced the general outpatient clinic utilization rate over a 12-month period. Empowering T2DM patients on self-management of their disease can enhance the quality of diabetes care in primary care.ClinicalTrials.gov NCT01935349.
وصف الملف: electronic resource
العلاقة: http://europepmc.org/articles/PMC4006782?pdf=renderTest; https://doaj.org/toc/1932-6203Test
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4دورية أكاديمية
المؤلفون: Troy Puga, Yadi Liu, Peng Xiao, Ran Dai, Hongying Daisy Dai
مصطلحات موضوعية: Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Developmental Biology, Mental Health, Infectious Diseases,
+sex%22">xlink "> sex, variance component models, children &# 8211, certain populations may, approximately equal male, >= 63 %<, >= 55 %<, >= 53 %<, >= 48 %<, >= 34 %<, >= 28 %<, mz ), dz ), significant health disparities, sex twin pairs, >< sup ><, initiating alcohol use, alcohol use due, effects across sex, >= 4 %< الوقت: 65, 39
الوصف: Introduction Alcohol intent (the susceptibility to initiating alcohol use) and alcohol sips (the initiation of alcohol) in youth are a multifactorial puzzle with many components. This research aims to examine the connection between genetic and environmental factors across sex, race and ethnicity. Methods Data was obtained from the twin hub of the Adolescent Brain Cognitive Development (ABCD) study at baseline (2016–2018). Variance component models were conducted to dissect the additive genetic (A), common (C) and unique environmental (E) effects on alcohol traits. The proportion of the total alcohol phenotypic variation attributable to additive genetic factors is reported as heritability ( h 2 ). Results The sample (n = 1,772) included an approximately equal male-female distribution. The 886 same-sex twin pairs were 60.4% dizygotic (DZ), 39.6% monozygotic (MZ), 65.4% non-Hispanic Whites, 13.9% non-Hispanic Blacks, 10.8% of Hispanics with a mean age of 121.2 months. Overall, genetic predisposition was moderate for alcohol intent ( h 2 = 28% , p = . 006 ) and low for alcohol initiation ( h 2 = 4% , p = 0 . 83 ). Hispanics ( h 2 = 53% , p < . 0001) and Blacks ( h 2 = 48% , p < . 0001 ) demonstrated higher alcohol intent due to additive genetic factors than Whites ( h 2 = 34% , p < . 0001) . Common environmental factors explained more variation in alcohol sips in females ( c 2 = 63% , p = . 001) than in males ( c 2 = 55% , p = . 003) . Unique environmental factors largely attributed to alcohol intent, while common environmental factors explained the substantial variation in alcohol initiation. Conclusion Sex and racial/ethnic disparities in genetic and environmental risk factors for susceptibility to alcohol initiation can lead to significant health disparities. Certain populations may be at greater risk for alcohol use due to their genetic and ecological factors at an early age.
الإتاحة: https://doi.org/10.1371/journal.pone.0298456.s001Test
https://figshare.com/articles/journal_contribution/S1_Appendix_-/25227558Test -
5دورية أكاديمية
المصدر: Metabolites; Volume 13; Issue 6; Pages: 682
مصطلحات موضوعية: ichthyosis, spasticity, intellectual disability, fatty aldehyde, fatty alcohol, lipid metabolism, pathogenesis
الوصف: Sjögren–Larsson syndrome (SLS) is a rare inherited neurocutaneous disease characterized by ichthyosis, spastic diplegia or tetraplegia, intellectual disability and a distinctive retinopathy. SLS is caused by bi-allelic mutations in ALDH3A2, which codes for fatty aldehyde dehydrogenase (FALDH) and results in abnormal lipid metabolism. The biochemical abnormalities in SLS are not completely known, and the pathogenic mechanisms leading to symptoms are still unclear. To search for pathways that are perturbed in SLS, we performed untargeted metabolomic screening in 20 SLS subjects along with age- and sex-matched controls. Of 823 identified metabolites in plasma, 121 (14.7%) quantitatively differed in the overall SLS cohort from controls; 77 metabolites were decreased and 44 increased. Pathway analysis pointed to disrupted metabolism of sphingolipids, sterols, bile acids, glycogen, purines and certain amino acids such as tryptophan, aspartate and phenylalanine. Random forest analysis identified a unique metabolomic profile that had a predictive accuracy of 100% for discriminating SLS from controls. These results provide new insight into the abnormal biochemical pathways that likely contribute to disease in SLS and may constitute a biomarker panel for diagnosis and future therapeutic studies.
وصف الملف: application/pdf
العلاقة: Endocrinology and Clinical Metabolic Research; https://dx.doi.org/10.3390/metabo13060682Test
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6دورية أكاديمية
المؤلفون: Roberta Freitas-Lemos, Devin C. Tomlinson, Yu-Hua Yeh, Candice L. Dwyer, Hongying Daisy Dai, Adam Leventhal, Allison N. Tegge, Warren K. Bickel
المصدر: Preventive Medicine Reports, Vol 35, Iss , Pp 102280- (2023)
مصطلحات موضوعية: COVID-19, Vaccine hesitancy, Delay discounting, Decision-making, Medicine
الوصف: Despite being a major threat to health, vaccine hesitancy (i.e., refusal or reluctance to vaccinate despite vaccine availability) is on the rise. Using a longitudinal cohort of young adults (N = 1260) from Los Angeles County, California we investigated the neurobehavioral mechanisms underlying COVID-19 vaccine hesitancy. Data were collected at two time points: during adolescence (12th grade; fall 2016; average age = 16.96 (±0.42)) and during young adulthood (spring 2021; average age = 21.33 (±0.49)). Main outcomes and measures were delay discounting (DD; fall 2016) and tendency to act rashly when experiencing positive and negative emotions (UPPS-P; fall 2016); self-reported vaccine hesitancy and vaccine beliefs/knowledge (spring 2021). A principal components analysis determined four COVID-19 vaccine beliefs/knowledge themes: Collective Responsibility, Confidence and Risk Calculation, Complacency, and Convenience. Significant relationships were found between themes, COVID-19 vaccine hesitancy, and DD. Collective Responsibility (β = -1.158[-1.213,-1.102]) and Convenience (β = -0.132[-0.185,-0.078]) scores were negatively associated, while Confidence and Risk Calculation (β = 0.283[0.230,0.337]) and Complacency (β = 0.412[0.358,0.466]) scores were positively associated with COVID-19 vaccine hesitancy. Additionally, Collective Responsibility (β = -0.060[-0.101,-0.018]) was negatively associated, and Complacency (β = -0.063[0.021,0.105]) was positively associated with DD from fall 2016. Mediation analysis revealed immediacy bias during adolescence, measured by DD, predicted vaccine hesitancy 4 years later while being mediated by two types of vaccine beliefs/knowledge: Collective Responsibility (β = 0.069[0.022,0.116]) and Complacency (β = 0.026[0.008,0.044]). These findings provide a further understanding of individual vaccine-related decision-making among young adults and inform public health messaging to increase vaccination acceptance.
العلاقة: http://www.sciencedirect.com/science/article/pii/S2211335523001717Test; https://doaj.org/toc/2211-3355Test; https://doaj.org/article/ee21b352d3264629a4bb285aa98dae17Test
الإتاحة: https://doi.org/10.1016/j.pmedr.2023.102280Test
https://doaj.org/article/ee21b352d3264629a4bb285aa98dae17Test -
7دورية أكاديمية
المؤلفون: Guenzel, Nicholas, Daisy Dai, Hongying, Dean, Lyndsay
المصدر: PeerJ ; volume 11, page e16482 ; ISSN 2167-8359
الوصف: Background Addiction is a significant problem among many Native American groups but has rarely been examined in urban populations. In particular, little is known about the context in which urban Native Americans first use substances. This study compares cases (people with a history of addiction) to controls (people without a history of addiction) on demographics, substance use history, context of first substance use, and polysubstance use. In addition, this appears to be the first study to overcome the lack of Native American professionals by employing and training lay community members to identify criteria of substance use disorders in survey participants. Employing community members helped foster trust that enabled the revelation of sensitive and often illegal activity. As a result, the investigators were able to recruit participants who likely would not have engaged with traditional researchers. Methods The trained Native American lay research assistants recruited community members and administered surveys. They first asked questions regarding the criteria for substance use disorders. Individuals who were determined to have met criteria for a substance use disorder in the past were classified as cases ( n = 38) and those who never met such criteria were classified as controls ( n = 42). They then asked demographic, substance use, and polysubstance use questions. Lastly, eight cases and eight controls were randomly selected for a second interview by a licensed drug and alcohol counselor (LDAC) who conducted a blinded assessment regarding the presence or absence of a history of a substance use disorder. Results Both groups reported a relatively young age of first substance use (age 16 years for cases and age 15 years for controls). Alcohol was the first substance most commonly used in both groups. Controls reported first benzodiazepine use at a younger age than cases but no other significant differences were found. Both groups reported first obtaining their first drug from family, friends, or at home (rather ...
الإتاحة: https://doi.org/10.7717/peerj.16482Test
https://peerj.com/articles/16482.pdfTest
https://peerj.com/articles/16482.xmlTest
https://peerj.com/articles/16482.htmlTest -
8دورية أكاديمية
المؤلفون: Lili Li, Cody Abbey, Huan Wang, Annli Zhu, Terry Shao, Daisy Dai, Songqing Jin, Scott Rozelle
المصدر: International Journal of Environmental Research and Public Health; Volume 19; Issue 22; Pages: 14815
مصطلحات موضوعية: adolescent health, video game time, mental health, rural China, developing countries
جغرافية الموضوع: agris
الوصف: As digital devices like computers become more widely available in developing countries, there is a growing need to understand how the time that adolescents spend using these devices for recreational purposes such as playing video games is linked with their mental health outcomes. We measured the amount of time that adolescents in rural China spent playing video games and the association of video game time with their mental health. We collected data from primary and junior high schools in a poor, rural province in northwest China (n = 1603 students) and used the Depression, Anxiety, and Stress Scales (DASS-21) to measure mental health symptoms. The results indicated that the average video game time was about 0.69 h per week. There was a significant association between adolescent video game time and poorer mental health. Each additional hour of playing video games also increased the chance of having moderate or above symptoms. Moreover, boys and non-left-behind children had worse mental health if they played more video games. Our study contributes to literature on the links between recreational screen time and mental health, and it sheds light on an issue addressed by recent government legislation to limit the video game time of minors in China.
وصف الملف: application/pdf
العلاقة: Children's Health; https://dx.doi.org/10.3390/ijerph192214815Test
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9دورية أكاديمية
المؤلفون: Hongying Daisy Dai, Adam Leventhal
المصدر: Preventive Medicine Reports, Vol 30, Iss , Pp 102048- (2022)
مصطلحات موضوعية: E-cigarette, Trend, Racial disparity, Cigarette smoking, Subjective depression, Medicine
الوصف: E-cigarette use increased from 2017 to 2019 and then declined in 2020 among U.S. adults. It is important to understand whether the decline differed by smoking status and sociodemographic groups and whether daily e-cigarette use has subsequently changed. This study estimated e-cigarette use prevalence in 2019 and 2020 by analyzing the pooled National Health Interview Survey (n = 63,565) in 2022. Multivariable logistics regressions were performed to examine biannual change in current and daily e-cigarette use, overall and stratified by cigarette smoking status, sociodemographic factors, and subjective depression frequency. Among US adults, change in current e-cigarette use during 2019–2020 differed by smoking status (cigarette smoking status × year, p =.01) and race/ethnicity (race/ethnicity × year, p =.03). Current e-cigarette use prevalence decreased among current cigarette smokers (11.7 % to 8.0 %, p = 0.0001) but not among former or never smokers, and among Non-Hispanic White adults (5.1 % to 4.2 %, p = 0.04) and Non-Hispanic Black adults (3.4 % to 1.6 %, p = 0.0003) but not among other racial and ethnic groups. Current e-cigarette use also declined among those 25–64 years old but not among young adults 18–24 years old. Daily e-cigarette use did not significantly change during 2019–2020 in the overall sample (2.3 % to 2.0 %, p = 0.10), but declined among adults who were Non-Hispanic Black (2.4 % to 0.9 %, p = 0.0007), aged 35–44 years, and lived below the federal poverty level. Adults with monthly depressive episodes (vs without) continued to have a higher prevalence of current (7.0 % vs 3.0 %) and daily e-cigarette use (3.6 % vs 1.6 %) in 2020. Continuous monitoring of cross-population differences in adult e-cigarette use is warranted.
العلاقة: http://www.sciencedirect.com/science/article/pii/S2211335522003552Test; https://doaj.org/toc/2211-3355Test; https://doaj.org/article/74758327e02245b2a983b29b9aacd850Test
الإتاحة: https://doi.org/10.1016/j.pmedr.2022.102048Test
https://doaj.org/article/74758327e02245b2a983b29b9aacd850Test -
10
المؤلفون: Troy Puga, Yadi Liu, Peng Xiao, Ran Dai, Hongying Daisy Dai
مصطلحات موضوعية: Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Developmental Biology, Mental Health, Infectious Diseases,
+sex%22">xlink "> sex, variance component models, children &# 8211, certain populations may, approximately equal male, >= 63 %<, >= 55 %<, >= 53 %<, >= 48 %<, >= 34 %<, >= 28 %<, mz ), dz ), significant health disparities, sex twin pairs, >< sup ><, initiating alcohol use, alcohol use due, effects across sex, >= 4 %< الوقت: 65, 39
الوصف: Variance component analysis of genetic heritability for alcohol-related traits.
الإتاحة: https://doi.org/10.1371/journal.pone.0298456.t002Test
https://figshare.com/articles/dataset/Variance_component_analysis_of_genetic_heritability_for_alcohol-related_traits_/25227567Test
النص الكامل