المؤلفون: Daisuke Nishikawa, 西川 大輔

المصدر: 喉頭 / Koutou (THE LARYNX JAPAN). 2023, 35(2):108

المؤلفون: Hiromasa Ishihara, Daisuke Nishikawa, Daisuke Muraoka, Katsuhiro Masago, Shintaro Beppu, Hoshino Terada, Hirokazu Matsushita, Nobuhiro Hanai

المصدر: Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: cytokine/chemokine, head and neck cancer, immunogenic cell death, near‐infrared photoimmunotherapy, neutrophil‐to‐lymphocyte ratio, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Near‐infrared photoimmunotherapy (NIR‐PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR‐PIT in real clinical settings. Methods Seven NIR‐PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage‐associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR‐PIT. Results The serum concentration of HMGB1 increased after NIR‐PIT (p = 0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP‐1α (CCL3) and MIP‐1β (CCL4) increased significantly 1–3 days after treatment (CCL3, p = 0.0036; CCL4, p = 0.0016, Wilcoxon test). A low pre‐treatment neutrophil‐to‐lymphocyte ratio (NLR) was associated with a better response to therapy and survival. Conclusions The release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR‐PIT.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/5fcaefc2ede440ddaa7ecbe4507e02d2Test

المؤلفون: Takashi Matsuzuka, Kiyoaki Tsukahara, Seiichi Yoshimoto, Kazuaki Chikamatsu, Akihiro Shiotani, Isao Oze, Yoshiko Murakami, Takeshi Shinozaki, Yuichiro Enoki, Shinichi Ohba, Daisuke Kawakita, Nobuhiro Hanai, Yusuke Koide, Michi Sawabe, Yusuke Nakata, Yujiro Fukuda, Daisuke Nishikawa, Gaku Takano, Takahiro Kimura, Keisuke Oguri, Hitoshi Hirakawa, Yasuhisa Hasegawa

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract This sentinel node (SN) biopsy trial aimed to assess its effectiveness in identifying predictive factors of micrometastases and to determine whether elective neck dissection is necessary in oral squamous cell carcinoma. This retrospective study included 55 patients from three previous trials, with positive SNs. The relationship between the sizes of the metastatic focus and metastasis in non-sentinel node (NSN) was investigated. Four of the 55 largest metastatic focus were isolated tumor cells, and the remaining 51 were ranged from 0.2 to 15 mm, with a median of 2.6 mm. The difference of prevalence between 46 negative- and 9 positive-NSN was statistically significant with regard to age, long diameter of primary site and number of cases with regional recurrence. In comparing the size of largest metastatic focus dividing the number of positive SN, with metastaic focus range of

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/b214fa17c81b46239647ba5b2177ae8cTest

المؤلفون: Daisuke Nishikawa, Hidenori Suzuki, Hoshino Terada, Koichi Yoshizawa, Nobuhiro Hanai, Shintaro Beppu, 別府 慎太郎, 吉澤 宏一, 寺田 星乃, 花井 信広, 西川 大輔, 鈴木 秀典

المصدر: 頭頸部癌 / Toukeibu Gan. 2023, 49(4):288

المؤلفون: Daisuke Nishikawa, Mitsuo Goto, Nobuhiro Hanai, Toru Nagao, Yasuhisa Hasegawa

المصدر: Journal of Hard Tissue Biology. 2023, 32(1):77

المؤلفون: Daisuke Nishikawa, Ichiro Ota, Masayuki Shugyo, Tadashi Kitahara, Taeko Ito, Tomoyuki Shiozaki, Yoshiro Wada, 伊藤 妙子, 北原 糺, 和田 佳郎, 執行 雅之, 塩崎 智之, 太田 一郎, 西川 大祐

المصدر: 日本耳鼻咽喉科頭頸部外科学会会報 / Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo). 2022, 125(11):1626

المؤلفون: Daisuke Nishikawa, Hirokazu Uemura, Katsunari Yane, Shiori Adachi, Tadashi Kitahara, Takashi Masui, 上村 裕和, 北原 糺, 家根 旦有, 桝井 貴史, 西川 大祐, 足立 詩織

المصدر: 耳鼻咽喉科臨床 / Practica Oto-Rhino-Laryngologica. 2023, 116(3):241

المؤلفون: Hidenori Suzuki, Eiichi Sasaki, Gaku Takano, Seiya Goto, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe, Nobuhiro Hanai

المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: Lymph node ratio, Log odds of positive lymph nodes, Overall survival, Minor salivary gland carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck. Methods Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. Log-rank test and Cox’s proportional hazards model were used for uni−/multi-variate survival analyses adjusting for pathological stage, respectively. Results Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = − 2.73 predicted the carcinoma-specific death. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54–57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48–11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05–24.8) survival in the multivariate analysis. Conclusion A higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2407Test

الوصول الحر: https://doaj.org/article/e32daa7d41b7412c9c411fbb9d1e68b6Test

المؤلفون: Sumitaka Hagiwara, Eiichi Sasaki, Yasuhisa Hasegawa, Hidenori Suzuki, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe, Masahide Takahashi, Nobuhiro Hanai

المصدر: Cancer Medicine, Vol 10, Iss 4, Pp 1335-1346 (2021)

مصطلحات موضوعية: cancer biomarker, enzyme‐linked immunosorbent assay, head and neck squamous cell carcinoma, node metastasis, SCC antigen, serum CD109, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Various biomarkers are being developed for the early diagnosis of cancer and for predicting its prognosis. The aim of this study is to evaluate the diagnostic significance of serum CD109 in head and neck squamous cell carcinoma (HNSCC). Methods The serum CD109 levels in a total of 112 serum samples collected before and after surgery from 56 HNSCC patients were analyzed with an enzyme‐linked immunosorbent assay (ELISA). The clinical factor that showed a statistically significant association with both the preoperative serum CD109 level, and the CD109 index: which was defined as the ratio of the preoperative serum CD109 level to the postoperative serum CD109 level, were assessed. The correlations between the serum CD109 levels and lymph node density (LND), pathological features such as lymphatic invasion, and serum SCC antigen levels were also assessed. Results The ELISA measurement revealed that preoperative serum CD109 levels were elevated in patients with node metastasis‐positive and stage IV disease, in comparison to those with node metastasis‐negative and Stage I+II+III disease, respectively. A multiple regression analysis indicated that serum CD109 level was significantly associated with the node metastasis status. A Spearman's rank correlation analysis also revealed a positive correlation between the preoperative serum CD109 level and LND. Furthermore, the probabilities of the overall and relapse‐free survival were significantly lower in patients with a preoperative serum CD109 level of ≥38.0 ng/ml and a CD109 index of ≥1.6, respectively, than in others. There was no significant correlation between the serum CD109 and SCC antigen levels. Conclusions The serum CD109 levels were elevated in patients with advanced stage disease, reflecting the node metastasis status. CD109 in sera could be a novel prognostic marker for HNSCC involving lymph node metastasis.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/e9872661f570443a83cb2cd62405ea5dTest

المؤلفون: Hidenori Suzuki, Shintaro Beppu, Daisuke Nishikawa, Hoshino Terada, Michi Sawabe, Nobuhiro Hanai

المصدر: Biomedicines, Vol 10, Iss 11, p 2923 (2022)

مصطلحات موضوعية: lymph node ratio, squamous cell carcinoma, head and neck, submental artery flap, survival, Biology (General), QH301-705.5

الوصف: This study aimed to investigate the relationship between the lymph node ratio (LNR) and survival results of patients with head and neck squamous cell carcinoma (HNSCC) reconstructed by a submental artery flap (SMAF) to limit tumor size. This study retrospectively recruited 49 patients with HNSCC who underwent both primary resection and neck dissection with SMAF reconstruction. The LNR was the ratio of the number of metastatic lymph nodes to the sum number of examined lymph nodes. A LNR of 0.04 was the best cut-off value for HNSCC-specific death on receiver operating curve analysis. Patients with LNRs > 0.04 were univariately related to cancer-specific, disease-free, distant metastasis-free, and locoregional recurrence-free survival than those with LNRs ≤ 0.04 by log-rank test. In a Cox’s proportional hazards model with hazard ratio (HR) and 95% confidence interval (CI) adjusting for pathological stage, extranodal extension and or surgical margins, the LNR (>0.04/≤0.04) predicted multivariate shorter cancer-specific (HR = 9.24, 95% CI = 1.49–176), disease-free (HR = 3.44, 95% CI = 1.23–10.3), and distant metastasis-free (HR = 9.76, 95% CI = 1.57–187) survival. In conclusion, LNR for patients of HNSCC with SMAF reconstruction for limited tumor size was a prognostic factor for survival outcomes.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2227-9059/10/11/2923Test; https://doaj.org/toc/2227-9059Test

الوصول الحر: https://doaj.org/article/dab8bb3102b545b3a0e29f5cbf772f9bTest