المؤلفون: El-Seedi, Hesham, Salama, Suzy, El-Wahed, Aida A. Abd, Guo, Zhiming, Di Minno, Alessandro, Daglia, Maria, Li, Chuan, Guan, Xiao, Buccato, Daniele Giuseppe, Khalifa, Shaden A. M., Wang, Kai

المصدر: Nutrients. 16(3)

مصطلحات موضوعية: royal jelly, diabetes mellitus, gastrointestinal diseases, cardiovascular diseases, bioactive compounds

الوصف: Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review's focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the "Queen bee acid," show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ's role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ's therapeutic effects.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524044Test
https://doi.org/10.3390/nu16030393Test
https://uu.diva-portal.org/smash/get/diva2:1841432/FULLTEXT01.pdfTest

المؤلفون: Buccato, Daniele Giuseppe, Ullah, Hammad, De Lellis, Lorenza Francesca, Piccinocchi, Roberto, Baldi, Alessandra, Xiao, Xiang, Arciola, Carla Renata, Di Minno, Alessandro, Daglia, Maria

المساهمون: Buccato, Daniele Giuseppe, Ullah, Hammad, De Lellis, Lorenza Francesca, Piccinocchi, Roberto, Baldi, Alessandra, Xiao, Xiang, Arciola, Carla Renata, Di Minno, Alessandro, Daglia, Maria

مصطلحات موضوعية: Scutellaria lateriflora L, bioaccessibility, bioavailability, cortisol, osteoporosi, stress

الوصف: Excess cortisol release is associated with numerous health concerns, including psychiatric issues (i.e., anxiety, insomnia, and depression) and nonpsychiatric issues (i.e., osteoporosis). The aim of this study was to assess the in vitro inhibition of cortisol release, bioaccessibility, and bioavailability exerted by a chemically characterized Scutellaria lateriflora L. extract (SLE). The treatment of H295R cells with SLE at increasing, noncytotoxic, concentrations (5-30 ng/mL) showed significant inhibition of cortisol release ranging from 58 to 91%. The in vitro simulated gastric, duodenal, and gastroduodenal digestions, induced statistically significant reductions (p < 0.0001) in the bioactive polyphenolic compounds that most represented SLE. Bioavailability studies on duodenal digested SLE, using Caco-2 cells grown on transwell inserts and a parallel artificial membrane permeability assay, indicated oroxylin A glucuronide and oroxylin A were the only bioactive compounds able to cross the Caco-2 cell membrane and the artificial lipid membrane, respectively. The results suggest possible applications of SLE as a food supplement ingredient against cortisol-mediated stress response and the use of gastroresistant oral dosage forms to partially prevent the degradation of SLE bioactive compounds. In vivo studies and clinical trials remain necessary to draw a conclusion on the efficacy and tolerability of this plant extract.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38338331; info:eu-repo/semantics/altIdentifier/wos/WOS:001161107400001; volume:29; issue:3; firstpage:1; lastpage:19; numberofpages:19; journal:MOLECULES; https://hdl.handle.net/11585/962426Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85184480495; https://www.mdpi.com/1420-3049/29/3/586Test

الإتاحة: https://doi.org/10.3390/molecules29030586Test
https://hdl.handle.net/11585/962426Test
https://www.mdpi.com/1420-3049/29/3/586Test

المؤلفون: Hammad Ullah, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Alessandra Baldi, Hesham R. El-Seedi, Shaden A.M. Khalifa, Gaetano Piccinocchi, Xiang Xiao, Roberto Sacchi, Maria Daglia

المصدر: Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115858- (2023)

مصطلحات موضوعية: Functional dyspepsia, Digestive enzymes, Food supplements, Nepean dyspepsia index, Quality of life, Randomized clinical trial, Therapeutics. Pharmacology, RM1-950

الوصف: Functional dyspepsia is a form of dyspepsia lacking in clear causes following clinical assessment. Dyspepsia is characterized by episodic or persistent abdominal pain or discomfort of the upper gastrointestinal (GI) tract. Its onset has been linked with a deficiency or dysfunction of digestive enzymes. Thus, consumption of digestive multi-enzymatic preparations may be effectively used for the reduction of symptoms. The aim of this study is to assess the effectiveness and tolerability of the supplementation of a normal diet with a multi-enzyme blend obtained from fungal fermentation, in a randomized, placebo-controlled, double-blind, clinical trial. Enrolled subjects (n = 120, male: 63, female: 57), aged 18–59 years, were randomized (allocation ratio 1:1) to receive either 2 capsules per day of the food supplement (containing 200 mg of the multi-enzyme blend/capsule) or placebo, for 2 months. The primary outcome of the study (i.e., improvements in quality of life) was evaluated by the Nepean Dyspepsia Index-SF (NDI-SF) questionnaire, while the secondary outcomes (i.e., severity of pain and the quality of sleep) were assessed through the Visual Analogue Scale (VAS) and Pittsburgh Sleep Quality Index (PSQI) questionnaire. The results showed an improvement in NDI-SF1, NDI-SF2–5, VAS, and PSQI scores in subjects treated with the multi-enzyme blend, indicating an improvement in quality of life and of sleep, and a decreased severity of pain, following the supplementation with digestive enzymes, without side effects. In conclusion, treatment with digestive enzymes was found to be effective in the reduction of functional dyspepsia symptoms and in the improvement of sleep quality, and is well-tolerated.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0753332223016566Test; https://doaj.org/toc/0753-3322Test

الوصول الحر: https://doaj.org/article/42f4c026c7a44b348a203dc2ed97ab6cTest

المؤلفون: Alessandro Di Minno, Hammad Ullah, Lorenza Francesca De Lellis, Daniele Giuseppe Buccato, Alessandra Baldi, Paola Cuomo, Hesham R. El-Seedi, Shaden A. M. Khalifa, Xiang Xiao, Roberto Piccinocchi, Gaetano Piccinocchi, Roberto Sacchi, Maria Daglia

المصدر: Nutrients, Vol 16, Iss 6, p 862 (2024)

مصطلحات موضوعية: Scutellaria lateriflora L., Cistus × incanus L., gingivitis, chewing gum, randomized clinical trial, Nutrition. Foods and food supply, TX341-641

الوصف: Preclinical studies have shown that the combination of Cistus × incanus L. and Scutellaria lateriflora L. extracts exerts beneficial effects on oral health against gingivitis. Thus, this study aimed to assess the tolerability of a chewing gum and its efficacy on gingivitis in a double-blind, placebo-controlled clinical trial. Enrolled subjects (n = 60, 18–70 years) were randomized to receive two chewing gums or a placebo daily for 3 months. At baseline (t0) and monthly (t1, t2, and t3) timepoints, the Quantitative Gingival Bleeding Index (QGBI), the Modified Gingival Index (MGI), and the Oral Health 15 items (OH-15)] were employed to assess potential improvements in gingivitis. Pain was self-quantified via the Visual Analogue Scale (VAS), and the Clinical Global Impression Scale for Severity of illness (CGI-S) helped in evaluating the oral general conditions. This study is listed on the ISRCTN registry. At t3, the QGBI, MGI, OH-15, VAS, and CGI-S values decreased in the treated but not in the placebo group (β = 0.6 ± 0.1, t176 = 3.680, p < 0.001; β = 0.87 ± 0.21, t115 = 4.263, p < 0.001; β = 5.3 ± 2.5, t172 = 2.086, p = 0.038; β = 3.16 ± 0.51, t88 = 6.253, p < 0.001; and β = 1.09 ± 0.32, t83 = 3.419, p < 0.001, respectively). A significant improvement in gingival health occurred after a 3-month intervention with the chewing gums containing S. lateriflora and C. incanus extracts.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/16/6/862Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/04512775d8e54cd198b32aea19a8de4eTest

المؤلفون: Giuseppe Leone, Massimo Muto, Flavio Giordano, Gianluigi Guarnieri, Antonio Di Donna, Camilla Russo, Daniele Giuseppe Romano, Paolo Candelaresi, Giovanna Servillo, Emanuele Spina, Antonio De Mase, Vincenzo Andreone, Mario Muto

المصدر: Neurointervention, Vol 18, Iss 1, Pp 30-37 (2023)

مصطلحات موضوعية: acute ischemic stroke, intervention, stroke, thrombectomy, aspiration, Medicine (General), R5-920, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Purpose A direct aspiration, first pass technique (ADAPT) has been introduced as a rapid and safe thrombectomy strategy in patients with intracranial large vessel occlusion (LVO). The aim of the study is to determine the technical feasibility, safety, and functional outcome of ADAPT using the newly released large bore pHLO 0.072-inch aspiration catheter (AC; Phenox). Materials and Methods We performed a retrospective analysis of data collected prospectively (October 2019–November 2021) from 2 comprehensive stroke centers. Accessibility of the thrombus, vascular recanalization, time to recanalization, and procedure-related complications were evaluated. National Institutes of Health stroke scale scores at presentation and discharge and the modified Rankin scale (mRS) score at 90 days post-procedure were recorded. Results Twenty-five patients (14 female, 11 male) with occlusions of the anterior circulation were treated. In 84% of cases, ADAPT led to successful recanalization with a median procedure time of 28 minutes. In the remaining cases, successful recanalization required (to a total of 96%; modified thrombolysis in cerebral infarction score 2b/3) the use of stent retrievers. No AC-related complications were reported. Other complications included distal migration of the thrombus, requiring a stent-retriever, and symptomatic PH2 hemorrhage in 16% and 4%, respectively. After 3 months, 52% of the patients had mRS scores of 0–2 with an overall mortality rate of 20%. Conclusion Results from our retrospective case series revealed that thrombectomy of LVOs with pHLO AC is safe and effective in cases of large-vessel ischemic stroke. Rates of complete or near-complete recanalization after the first pass with this method might be used as a new benchmark in future trials.

وصف الملف: electronic resource

العلاقة: http://neurointervention.org/upload/pdf/neuroint-2022-00479.pdfTest; https://doaj.org/toc/2093-9043Test; https://doaj.org/toc/2233-6273Test

الوصول الحر: https://doaj.org/article/7ae530ccc4094549928a6de9483ef875Test

المؤلفون: Ullah, Hammad, Di Minno, Alessandro, Di Filippis, Anna, Sommella, Eduardo, Buccato, Daniele Giuseppe, De Lellis, Lorenza Francesca, El-Seedi, Hesham R., Khalifa, Shaden A. M., 1974, Piccinocchi, Roberto, Galdiero, Massimiliano, Campiglia, Pietro, Daglia, Maria

المصدر: Foods. 12(9)

مصطلحات موضوعية: Cistus x incanus L., Scutellaria lateriflora L., oral health, gingivitis, Porphyromonas gingivalis

الوصف: Periodontal diseases are oral inflammatory diseases ranging from gingivitis to chronic periodontitis. Porphyromonas gingivalis is one of the major pathogens responsible for severe and chronic periodontitis. Plant extracts with antimicrobial activity could be considered possible alternatives to chlorhexidine, an antiseptic substance used in oral hygiene thatcan cause bacteria resistance. Here, two commercial extracts obtained from Cistus × incanus L. and Scutellaria lateriflora L. were chemically characterized usingUltra-High-Performance Liquid Chromatography (UHPLC) coupled with a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer. The extracts were studied for their bioaccessibility after simulated in vitro oral digestion, their antimicrobial activity against P. gingivalis, their protective effects against cellular invasion by P. gingivalis, and their antibiofilm activity. The extracts were found to contain very complex mixtures of polyphenols, which were quite stable after in vitro simulated oral digestion and demonstrated mild, dose-dependent inhibitory activity against P. gingivalis growth. This activity increased with the combination of the two extracts. Moreover, the combination of the extracts induced a reduction in P. gingivalis HaCaT invasiveness, and the reduction in biofilm came to around 80%. In conclusion, a combination of C. incanus and S. lateriflora showed promising effects useful in the treatment of gingivitis.

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-220584Test
https://doi.org/10.3390/foods12091826Test

المؤلفون: Daniele Giuseppe Buccato, Hammad Ullah, Lorenza Francesca De Lellis, Roberto Piccinocchi, Alessandra Baldi, Xiang Xiao, Carla Renata Arciola, Alessandro Di Minno, Maria Daglia

المصدر: Molecules, Vol 29, Iss 3, p 586 (2024)

مصطلحات موضوعية: Scutellaria lateriflora L., cortisol, stress, bioaccessibility, bioavailability, osteoporosis, Organic chemistry, QD241-441

الوصف: Excess cortisol release is associated with numerous health concerns, including psychiatric issues (i.e., anxiety, insomnia, and depression) and nonpsychiatric issues (i.e., osteoporosis). The aim of this study was to assess the in vitro inhibition of cortisol release, bioaccessibility, and bioavailability exerted by a chemically characterized Scutellaria lateriflora L. extract (SLE). The treatment of H295R cells with SLE at increasing, noncytotoxic, concentrations (5–30 ng/mL) showed significant inhibition of cortisol release ranging from 58 to 91%. The in vitro simulated gastric, duodenal, and gastroduodenal digestions, induced statistically significant reductions (p < 0.0001) in the bioactive polyphenolic compounds that most represented SLE. Bioavailability studies on duodenal digested SLE, using Caco-2 cells grown on transwell inserts and a parallel artificial membrane permeability assay, indicated oroxylin A glucuronide and oroxylin A were the only bioactive compounds able to cross the Caco-2 cell membrane and the artificial lipid membrane, respectively. The results suggest possible applications of SLE as a food supplement ingredient against cortisol-mediated stress response and the use of gastroresistant oral dosage forms to partially prevent the degradation of SLE bioactive compounds. In vivo studies and clinical trials remain necessary to draw a conclusion on the efficacy and tolerability of this plant extract.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1420-3049/29/3/586Test; https://doaj.org/toc/1420-3049Test

الوصول الحر: https://doaj.org/article/2c0b0048ab584894b84a3432c125b43dTest

المؤلفون: Hesham R. El-Seedi, Suzy Salama, Aida A. Abd El-Wahed, Zhiming Guo, Alessandro Di Minno, Maria Daglia, Chuan Li, Xiao Guan, Daniele Giuseppe Buccato, Shaden A. M. Khalifa, Kai Wang

المصدر: Nutrients, Vol 16, Iss 3, p 393 (2024)

مصطلحات موضوعية: royal jelly, diabetes mellitus, gastrointestinal diseases, cardiovascular diseases, bioactive compounds, Nutrition. Foods and food supply, TX341-641

الوصف: Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review’s focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the “Queen bee acid,” show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ’s role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ’s therapeutic effects.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/16/3/393Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/7c5d0090766b4e3a8d94c68ce83b6cd8Test

المؤلفون: Lopez, Chiara, Bima, Chiara, Bollati, Martina, Bioletto, Fabio, Procopio, Matteo, Arata, Stefano, Candela, Daniele Giuseppe, Beccuti, Guglielmo, Ghigo, Ezio, Maccario, Mauro, Parasiliti-Caprino, Mirko

المساهمون: Lopez, Chiara, Bima, Chiara, Bollati, Martina, Bioletto, Fabio, Procopio, Matteo, Arata, Stefano, Candela, Daniele Giuseppe, Beccuti, Guglielmo, Ghigo, Ezio, Maccario, Mauro, Parasiliti-Caprino, Mirko

مصطلحات موضوعية: catecholamine, glucose intolerance, hypoglycemia, paraganglioma, pheochromocytoma, secondary diabetes mellitus

الوصف: Glycemic alterations are frequent in patients with pheochromocytoma and paraganglioma (PPGL), but the real incidence of secondary diabetes mellitus (DM) is uncertain, because prospective multicenter studies on this topic are lacking in the literature. The main pathophysiological mechanisms of glucose homeostasis alterations in PPGL, related to catecholamine hypersecretion, are impaired insulin and glucagon-like peptide type 1 (GLP-1) secretion and increased insulin resistance. Moreover, it has been reported that different pathways leading to glucose intolerance may be related to the secretory phenotype of the chromaffin tumor. Predictive factors for the development of glucose intolerance in PPGL patients are a higher age at diagnosis, the need for a higher number of anti-hypertensive drugs, and the presence of secreting neoplasms. Tumor resection is strongly related to the resolution of DM in PPGL patients, with a significant improvement of glycemic control in most cases. We can hypothesize a different personalized therapeutic approach based on the secretory phenotype. The adrenergic phenotype is more closely related to reduced insulin secretion, so insulin therapy may be required. On the other hand, the noradrenergic phenotype mainly acts by increasing insulin resistance and, therefore, insulin-sensitizing antidiabetic agents can find a greater application. Regarding GLP-1 receptor agonists, the data suggest a possible promising therapeutic effect, based on the assumption that GLP-1 secretion is impaired in patients with PPGL. The principal predictors of remission of glycemic alterations after surgery for PPGL are a lower preoperative body mass index (BMI), a larger tumor, higher preoperative catecholamine levels, and a shorter duration of the disease (under three years). Otherwise, after resection of PPGL, hypoglycemia can occur as the result of an excessive rebound of preoperative hyperinsulinemia. It is a rare, but potentially severe complication reported in a lot of case reports and a few small ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36982228; info:eu-repo/semantics/altIdentifier/wos/WOS:000955385500001; volume:24; issue:6; firstpage:1; lastpage:11; numberofpages:11; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/2318/1901294Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85151111853

الإتاحة: https://doi.org/10.3390/ijms24065153Test
https://hdl.handle.net/2318/1901294Test

المؤلفون: Daniele Giuseppe Romano, Giulia Frauenfelder, Francesco Diana, Renato Saponiero

المصدر: BMC Neurology, Vol 22, Iss 1, Pp 1-5 (2022)

مصطلحات موضوعية: Stroke, Thrombectomy, Angiography, Technique, Catheter, Neurology. Diseases of the nervous system, RC346-429

الوصف: Abstract Background To describe technical features and initial results of a novel large-bore reperfusion catheter as first thromboaspiration approach for endovascular stroke treatment in terminal internal carotid artery (T-ICA) occlusions. Methods All patients treated with A Direct Aspiration first-Pass Technique (ADAPT) using JET 7 “Standard Tip” Penumbra Reperfusion catheter for acute T-ICA occlusion were retrospectively included in the study. Baseline data, puncture to recanalization time, number of attempts, switch to second device/technique rate and successful recanalization rate were assessed. Successful recanalization was defined by a thrombolysis in cerebral infarction (TICI) score ≥ 2b and favorable functional outcome was defined according to modified Rankin scale (score, 0–2). Catheter specifics and thromboaspiration reperfusion technique with JET 7 were reported. Results A total of 21 patients who underwent ADAPT with JET 7 Reperfusion catheter were enrolled for the final analysis. ADAPT was performed as first approach in all cases (100%). First attempt successful recanalization (eTICI ≥2b) was obtained in 90,5% of cases. Mean puncture to recanalization time was 16 minutes. Final successful recanalization was reached in 96.5%. Functional independence at 90 was achieved in 57,1% cases. Symptomatic intracranial hemorrhage occurred in one patient within 24 h. Conclusion The large-bore JET 7 reperfusion catheter could be considered as first-line in patients with acute T-ICA occlusion, allowing rapid recanalization and low rate of rescue therapy with stent retriver. Further series and/or trial evaluation are required to confirm our results.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2377Test

الوصول الحر: https://doaj.org/article/c25e17a3a2b04facbca55041abe3646eTest