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1دورية أكاديمية
المؤلفون: Holmes Iv, James Hill, Molnar, Joseph A, Carter, Jeffrey E, Hwang, James, Cairns, Bruce A, King, Booker T, Smith, David J, Cruse, C Wayne, Foster, Kevin N, Peck, Michael D, Sood, Rajiv, Feldman, Michael J, Jordan, Marion H, Mozingo, David W, Greenhalgh, David G, Palmieri, Tina L, Griswold, John A, Dissanaike, Sharmila, Hickerson, William L
المصدر: Journal of burn care & research : official publication of the American Burn Association. 39(5)
مصطلحات موضوعية: Humans, Burns, Tissue and Organ Harvesting, Treatment Outcome, Skin Transplantation, Transplantation, Autologous, Prospective Studies, Surgical Mesh, Wound Healing, Adolescent, Adult, Middle Aged, Female, Male, Young Adult, Transplantation, Autologous, Clinical Sciences, Emergency & Critical Care Medicine
الوصف: Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a noncultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration using minimal donor skin. A prospective study was conducted to evaluate the clinical performance of ReCell vs meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain. At 4 weeks, 98% of the ASCS-treated sites were healed compared with 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (P < .0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (P = .04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (P ≤ .05 at each time point). Long-term patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. This study provides evidence that the treatment of deep partial-thickness burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/9vh3j6x3Test
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2دورية أكاديمية
المؤلفون: Doepker, Matthew P, Yamamoto, Maki, Applebaum, Matthew A, Patel, Nupur U, Jaime Montilla-Soler, M, Sarnaik, Amod A, Wayne Cruse, C, Sondak, Vernon K, Zager, Jonathan S
المصدر: Annals of Surgical Oncology. 24(2)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Biomedical Imaging, Cancer, Clinical Research, Rare Diseases, Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Merkel Cell, Carcinoma, Squamous Cell, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Lymph Node Excision, Lymphoscintigraphy, Male, Melanoma, Middle Aged, Prognosis, Radiopharmaceuticals, Retrospective Studies, Sarcoma, Sentinel Lymph Node, Sentinel Lymph Node Biopsy, Skin Neoplasms, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed, Young Adult, Oncology & Carcinogenesis, Oncology and carcinogenesis
الوصف: BackgroundAccurate preoperative lymphoscintigraphy is vital to performing sentinel lymph node biopsy (SLNB) for cutaneous malignancies. Potential advantages of single-photon emission computed tomography with integrated computed tomography (SPECT/CT) include the ability to readily identify aberrant drainage patterns as well as provide the surgeon with three-dimensional anatomic landmarks not seen on conventional planar lymphoscintigraphy (PLS).MethodsPatients with cutaneous malignancies who underwent SLNB with preoperative imaging using both SPECT/CT and PLS from 2011 to 2014 were identified.ResultsBoth SPECT/CT and PLS were obtained in 351 patients (median age, 69 years; range, 5-94 years) with cutaneous malignancies (melanoma = 300, Merkel cell carcinoma = 33, squamous cell carcinoma = 8, other = 10) after intradermal injection of 99mtechnetium sulfur colloid (median dose 300 µCi). A mean of 4.3 hot spots were identified on SPECT/CT compared to 3.0 on PLS (p
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/7dg007kfTest
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3تقرير
المؤلفون: Husemann, U., Adams, M., Bocker, M., Bruggemann, M., Buchholz, P., Cruse, C., Kolotaev, Y.
المصدر: IEEE Trans.Nucl.Sci. 50 (2003) 1059-1066
مصطلحات موضوعية: High Energy Physics - Experiment
الوصف: We present the design and commissioning of a new multiplicity veto for the HERA-B detector, a fixed-target spectrometer originally designed to study the physics of B mesons in proton-nucleus interactions. The HERA-B trigger is a message-driven multi-level track trigger. The first level trigger (FLT) consists of custom-made electronics, and the higher trigger levels are implemented as PC farms. The multiplicity veto has been designed to reject high-multiplicity events before they enter the trigger chain. A veto signal is generated based on the comparison of the number of photons in part of the HERA-B ring-imaging Cherenkov counter (RICH) with a programmable threshold. The RICH Multiplicity Veto is a modular system. First the hits in 256 detector channels are summed by Base Sum Cards (BSC), then FED Sum Cards (FSC) sum the subtotals of up to eight BSCs. Finally the Veto Board (VB) takes the veto decision based on the sum of up to 14 FSCs. The RICH Multiplicity Veto has been successfully installed and commissioned in HERA-B. The measured veto efficiency is (99.9991+/-0.0001)%, and the system is used in the routine data-taking of the HERA-B experiment.
Comment: 16 pages, 17 figures. to be published in IEEE Transactions on Nuclear Scienceالوصول الحر: http://arxiv.org/abs/hep-ex/0304033Test
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4دورية أكاديمية
المؤلفون: Yacoub, Abraham, Soni, Kiran K., Mojica, Lysenia, Mai, Jane, Morano, Jamie, Cruse, C. Wayne, Sandin, Ramon L., Nanjappa, Sowmya, Bohra, Chandrashekar, Gajanan, Ganesh, Greene, John N.
المصدر: Cancer Control ; volume 23, issue 3, page 265-271 ; ISSN 1073-2748 1073-2748
مصطلحات موضوعية: Oncology, Hematology, General Medicine
الوصف: Background Opportunistic fungal infections caused by Aspergillus and Candida followed by infections with Fusarium, Rhizopus, Mucor, and Alternaria species are an important cause of morbidity and mortality in patients with hematological malignancies. Cutaneous mucormycosis infections are rare, and the incidence, outcomes, and factors associated with survival in the setting of hematological malignancies are not clear. Methods A literature search was conducted for all cases of primary cutaneous mold infections in patients with hematological malignancy, of which 50 cases were found. Our case of a patient with a hematological malignancy who sustained a cat bite that in turn caused a primary cutaneous mold infection is also included. Results In the 51 cases identified, 66.7% were neutropenic upon presentation, and 54.9% were male with an average age of 32 years. Aspergillus species (33.3%) was the most cited followed by Rhizopus species (19.6%). Overall mortality rate was 29.4% and was observed more frequently in patients with neutropenia (60.0%) and without surgical intervention (73.3%). Survival rate was higher (35.3%) for cases utilizing both antifungal and surgical intervention. The antifungal agent with the highest survival rate was amphotericin B and its formulations (58.8%). Conclusions Neutropenia within hematological malignancies demonstrate a risk for developing severe cutaneous fungal infections, of which primary cutaneous mucormycosis can carry significant mortality. Combination antifungal therapy and surgical debridement appears to be associated with higher survival outcomes and warrants further investigation.
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7دورية أكاديمية
المؤلفون: Smith, Franz O., Yue, Binglin, Marzban, Suroosh S., Walls, Brooke L., Carr, Michael, Jackson, Ryan S., Puleo, Christopher A., Padhya, Tapan, Cruse, C. Wayne, Gonzalez, Ricardo J., Sarnaik, Amod A., Schell, Michael J., DeConti, Ronald C., Messina, Jane L., Sondak, Vernon K., Zager, Jonathan S.
المصدر: Cancer ; volume 121, issue 18, page 3252-3260 ; ISSN 0008-543X 1097-0142
الوصف: BACKGROUND The purposes of this study were 1) to determine the impact of primary tumor‐related factors on the prediction of the sentinel lymph node (SLN) status and 2) to identify clinical and pathologic factors associated with survival in Merkel cell carcinoma (MCC). METHODS An institutional review board–approved, retrospective review of patients with MCC treated between 1988 and 2011 at a single center was performed. Patients were categorized into 5 groups: 1) negative SLN, 2) positive SLN, 3) clinically node‐negative but SLN biopsy not performed, 4) regional nodal disease without a known primary tumor, and 5) primary MCC with synchronous clinically evident regional nodal disease. Factors predictive of the SLN status were analyzed with logistic regressions, and overall survival (OS) and disease‐specific survival (DSS) were analyzed with Cox models and competing risk models assuming proportional hazards, respectively. RESULTS Three hundred seventy‐five patients were analyzed, and 70% were male; the median age was 75 years. The median tumor diameter was 1.5 cm (range, 0.2‐12.5 cm), and the median tumor depth was 4.8 mm (range, 0.3‐45.0 mm). One hundred ninety‐one patients underwent SLN biopsy, and 59 (31%) were SLN‐positive. Increasing primary tumor diameter and increasing tumor depth were associated with SLN positivity ( P = .007 and P = .017, respectively). Age and sex were not associated with the SLN status. Immunosuppression, increasing tumor diameter, and increasing tumor depth were associated with worse OS ( P = .007, P = .003, and P = .025, respectively). DSS differed significantly by group and was best for patients with a negative SLN and worst for those with primary MCC and synchronous clinically evident nodal disease ( P = .018). CONCLUSION For patients with MCC, increasing primary tumor diameter and increasing tumor depth are independently predictive of a positive SLN, worse OS, and worse DSS. Tumor depth should be routinely reported when primary MCC specimens are being evaluated histopathologically. ...
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8دورية أكاديمية
المؤلفون: Han, Dale, Han, Gang, Zhao, Xiuhua, Rao, Nikhil G., Messina, Jane L., Marzban, Suroosh S., Sarnaik, Amod A., Cruse, C. Wayne, Sondak, Vernon K., Zager, Jonathan S.
المساهمون: Slominski, Andrzej T
المصدر: PLOS ONE ; volume 10, issue 3, page e0119716 ; ISSN 1932-6203
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9دورية أكاديمية
المؤلفون: Strom, Tobin, Caudell, Jimmy J., Han, Dale, Zager, Jonathan S., Yu, Daohai, Cruse, C. Wayne, Marzban, Suroosh S., Messina, Jane L., Trotti, Andy M., Sondak, Vernon K., Rao, Nikhil G.
المصدر: Cancer ; volume 120, issue 9, page 1369-1378 ; ISSN 0008-543X 1097-0142
الوصف: BACKGROUND Desmoplastic melanoma may have a high risk of local recurrence after wide excision. The authors hypothesized that adjuvant radiotherapy (RT) would improve local control in patients with desmoplastic melanoma, resulting in at least a 10% absolute decrease in local recurrence rate. METHODS A total of 277 patients from 1989 through 2010 who were treated for nonmetastatic desmoplastic melanoma by surgery with or without adjuvant RT were reviewed. Clinicopathologic and treatment variables were assessed with regard to their role in local control. RESULTS A total of 113 patients (40.8%) received adjuvant RT. After a median follow‐up of 43.1 months, adjuvant RT was found to be independently associated with improved local control on multivariable analysis (hazards ratio, 0.15; 95% confidence interval, 0.06‐0.39 [ P < .001]). Among 35 patients with positive resection margins, 14% who received RT developed a local recurrence versus 54% who did not ( P = .004). In patients with negative resection margins, there was a trend ( P = .09) toward improved local control with RT. In patients with negative resection margins and traditionally high‐risk features, including a head and neck tumor location, a Breslow depth > 4 mm, or a Clark level V tumor, RT was found to significantly improve local control ( P < .05). The data from the current study would suggest that patients who would be good candidates for omitting RT included those with negative resection margins, a Breslow depth ≤ 4 mm, and either no perineural invasion present or a non‐head and neck tumor location. CONCLUSIONS RT for desmoplastic melanoma was independently associated with improved local control. Patients with positive resection margins or deeper tumors appeared to benefit the most from RT, whereas selected low‐risk patients can safely omit RT. Cancer 2014;120:1369–1378 . © 2013 American Cancer Society .
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10دورية أكاديمية
المؤلفون: Smith, David J., Karlnoski, Rachel A., Patel, Ami, Cruse, C. Wayne, Brown, Kimberly S., Robson, Martin C.
المصدر: Surgical Science ; volume 04, issue 05, page 268-272 ; ISSN 2157-9407 2157-9415
