المؤلفون: Ironside, Maria, Duda, Jessica M., Moser, Amelia D., Holsen, Laura M., Zuo, Chun S., Du, Fei, Perlo, Sarah, Richards, Christine E., Chen, Xi, Nickerson, Lisa D., Null, Kaylee E., Esfand, Shiba M., Alexander, Madeline M., Crowley, David J., Lauze, Meghan, Misra, Madhusmita, Goldstein, Jill M., Pizzagalli, Diego A.

المصدر: American Journal of Psychiatry; Jul2024, Vol. 181 Issue 7, p639-650, 12p

مصطلحات موضوعية: YOUNG adults, CINGULATE cortex, FUNCTIONAL connectivity, NUCLEAR magnetic resonance spectroscopy, FRONTOPARIETAL network, DYSTHYMIC disorder

مستخلص: Objective: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and GABA in current or remitted major depressive disorder (MDD). Methods: Multimodal imaging data were collected from 130 young adults (ages 18–25), of whom 44 had current MDD, 42 had remitted MDD, and 44 were healthy comparison subjects. GABA+ (γ-aminobutyric acid and macromolecules) was assessed using magnetic resonance spectroscopy, and task-related functional MRI data were collected under acute stress and analyzed using data-driven network modeling. Results: Across modalities, trait-related abnormalities emerged. Relative to healthy comparison subjects, both clinical groups were characterized by lower rostral anterior cingulate cortex (rACC) GABA+ and frontoparietal network amplitude but higher amplitude in salience and stress-related networks. For the remitted MDD group, differences from the healthy comparison group emerged in the context of elevated cortisol levels, whereas the MDD group had lower cortisol levels than the healthy comparison group. In the comparison group, frontoparietal and stress-related network connectivity was positively associated with cortisol level (highlighting putative top-down regulation of stress), but the opposite relationship emerged in the MDD and remitted MDD groups. Finally, rACC GABA+ was associated with stress-induced changes in connectivity between overlapping default mode and salience networks. Conclusions: Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD. [ABSTRACT FROM AUTHOR]

: Copyright of American Journal of Psychiatry is the property of American Psychiatric Publishing, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Volkert, Michael R., Crowley, David J.

المساهمون: Department of Microbiology and Physiological Systems

المصدر: Frontiers in neuroscience ; 14 ; 611904

مصطلحات موضوعية: OXR1, gene therapy, neurodegeneration, oxidative stress resistance, reactive oxygen species, retinal degeneration, Biochemical Phenomena, Metabolism, and Nutrition, Cellular and Molecular Physiology, Molecular and Cellular Neuroscience, Nervous System Diseases, Neurology

الوصف: Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage resulting from ischemia are among the notable neurodegenerative diseases in which oxidative stress occurs shortly before the onset of neurodegeneration. A shared feature of these diseases is the depletion of OXR1 (oxidation resistance 1) gene products shortly before the onset of neurodegeneration. In animal models of these diseases, restoration of OXR1 has been shown to reduce or eliminate the deleterious effects of oxidative stress induced cell death, delay the onset of symptoms, and reduce overall severity. Moreover, increasing OXR1 expression in cells further increases oxidative stress resistance and delays onset of disease while showing no detectable side effects. Thus, restoring or increasing OXR1 function shows promise as a therapeutic for multiple neurodegenerative diseases. This review examines the role of OXR1 in oxidative stress resistance and its impact on neurodegenerative diseases. We describe the potential of OXR1 as a therapeutic in light of our current understanding of its function at the cellular and molecular level and propose a possible cascade of molecular events linked to OXR1's regulatory functions.

العلاقة: Link to Article in PubMed; Volkert MR, Crowley DJ. Preventing Neurodegeneration by Controlling Oxidative Stress: The Role of OXR1. Front Neurosci. 2020 Dec 15;14:611904. doi:10.3389/fnins.2020.611904. PMID: 33384581; PMCID: PMC7770112. Link to article on publisher's site; 1662-453X (Linking); http://hdl.handle.net/20.500.14038/41710Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5530&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4500Test; oapubs/4500

الإتاحة: https://doi.org/10.3389/fnins.2020.611904Test
https://doi.org/20.500.14038/41710Test
https://hdl.handle.net/20.500.14038/41710Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5530&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/4500Test

المؤلفون: Volkert, Michael R., Crowley, David J.

المصدر: Biological and Physical Sciences Department Faculty Works

مصطلحات موضوعية: Gene therapy, OXR1, Oxidative stress resistance, Reactive oxygen species, Neurodegeneration, Retinal degeneration, Neuroscience and Neurobiology

الوصف: Parkinson’s disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage resulting from ischemia are among the notable neurodegenerative diseases in which oxidative stress occurs shortly before the onset of neurodegeneration. A shared feature of these diseases is the depletion of OXR1 (oxidation resistance 1) gene products shortly before the onset of neurodegeneration. In animal models of these diseases, restoration of OXR1 has been shown to reduce or eliminate the deleterious effects of oxidative stress induced cell death, delay the onset of symptoms, and reduce overall severity. Moreover, increasing OXR1 expression in cells further increases oxidative stress resistance and delays onset of disease while showing no detectable side effects. Thus, restoring or increasing OXR1 function shows promise as a therapeutic for multiple neurodegenerative diseases. This review examines the role of OXR1 in oxidative stress resistance and its impact on neurodegenerative diseases. We describe the potential of OXR1 as a therapeutic in light of our current understanding of its function at the cellular and molecular level and propose a possible cascade of molecular events linked to OXR1’s regulatory functions.

وصف الملف: application/pdf

العلاقة: https://digitalcommons.assumption.edu/sciences-faculty/26Test; https://digitalcommons.assumption.edu/context/sciences-faculty/article/1025/viewcontent/Crowley_2020_01.pdfTest

الإتاحة: https://doi.org/10.3389/fnins.2020.611904Test
https://digitalcommons.assumption.edu/sciences-faculty/26Test
https://digitalcommons.assumption.edu/context/sciences-faculty/article/1025/viewcontent/Crowley_2020_01.pdfTest

المؤلفون: Nag, Sagorika, DasSarma, Priya, Crowley, David J., Hamawi, Rafael, Tepper, Samantha, Anton, Brian P., Guzmán, Daniel, DasSarma, Shiladitya

المصدر: Microorganisms; Mar2023, Vol. 11 Issue 3, p607, 17p

مصطلحات موضوعية: GENOMICS, ULTRAVIOLET radiation, GENETIC variation, HALOBACTERIUM, SALT

مستخلص: Ultraviolet (UV) radiation responses of extremophilic and archaeal microorganisms are of interest from evolutionary, physiological, and astrobiological perspectives. Previous studies determined that the halophilic archaeon, Halobacterium sp. NRC-1, which survives in multiple extremes, is highly tolerant of UV radiation. Here, Halobacterium sp. NRC-1 UV tolerance was compared to taxonomically diverse Haloarchaea isolated from high-elevation salt flats, surface warm and cold hypersaline lakes, and subsurface Permian halite deposits. Haloterrigena/Natrinema spp. from subsurface halite deposits were the least tolerant after exposure to photoreactivating light. This finding was attributed to deviation of amino acid residues in key positions in the DNA photolyase enzyme or to the complete absence of the photolyase gene. Several Halobacterium, Halorubrum and Salarchaeum species from surface environments exposed to high solar irradiance were found to be the most UV tolerant, and Halorubrum lacusprofundi from lake sediment was of intermediate character. These results indicate that high UV tolerance is not a uniform character trait of Haloarchaea and is likely reflective of UV exposure experienced in their environment. This is the first report correlating natural UV tolerance to photolyase gene functionality among Haloarchaea and provides insights into their survival in ancient halite deposits and potentially on the surface of Mars. [ABSTRACT FROM AUTHOR]

: Copyright of Microorganisms is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Rosso, Isabelle M, Crowley, David J, Silveri, Marisa M, Rauch, Scott L, Jensen, J Eric

المصدر: Neuropsychopharmacology ; volume 42, issue 8, page 1698-1705 ; ISSN 0893-133X 1740-634X

مصطلحات موضوعية: Psychiatry and Mental health, Pharmacology

الإتاحة: https://doi.org/10.1038/npp.2017.32Test
http://www.nature.com/articles/npp201732.pdfTest
http://www.nature.com/articles/npp201732Test

المؤلفون: Gonenc, Atilla, Frazier, Jean A., Crowley, David J.

المصدر: Journal of the American Academy of Child & Adolescent Psychiatry. Dec 2010 49(12):1260-1268.

تمت مراجعته من قبل الزملاء: Y

Page Count: 9

الواصفات: Mental Disorders, Diagnostic Tests, Cytology, Brain Hemisphere Functions, Children, Adolescents, Control Groups, Measurement, Physiology

مستخلص: Objective: Transverse relaxation time (T2) imaging provides the opportunity to examine membrane fluidity, which can affect a number of cellular functions. The objective of the present work was to examine T2 abnormalities in children with unmodified DSM-IV-TR bipolar disorder (BD) in bilateral cingulate-paracingulate (CPC) white matter. Method: A total of 21 children and adolescents with BD and 16 healthy control subjects underwent magnetic resonance imaging at 1.5 Tesla and were compared using a region-of-interest analysis. A post hoc diffusion tensor imaging (DTI) analysis was also performed on selected subjects. Results: The T2 values were significantly decreased on the right-side of the subjects with BD compared with that of the control subjects. Hemispheric difference was also observed in the BD group, with decreased T2 on the right side compared with the left side. No significant difference was observed between left and right CPC T2 in control subjects. For participants who had both T2 and DTI measurements, significant DTI differences were observed: On the left side, fractional anisotropy was reduced and trace and radial diffusivity were increased, whereas on the right side, trace was increased and T2 was decreased in subjects with BD compared with control subjects. Conclusions: Our findings suggest that the observed T2 difference is a reflection of cerebral blood flow rather than an alteration of the fluidity of cell membranes. It is possible that myelin damage occurs on the left side in early-onset BD, in addition to changes in the blood flow. Prospective studies with larger numbers of subjects are warranted to further explore the relevance of the presented results. (Contains 3 figures and 3 tables.)

Abstractor: As Provided

المؤلفون: Gonenc, Atilla, Frazier, Jean A., Crowley, David J., Moore, Constance M.

المساهمون: Department of Psychiatry

المصدر: Journal of the American Academy of Child and Adolescent Psychiatry ; 49 ; 12 ; 1260-8

مصطلحات موضوعية: Bipolar Disorder, Diffusion Tensor Imaging, Membrane Fluidity, Psychiatry

الوصف: OBJECTIVE: Transverse relaxation time (T2) imaging provides the opportunity to examine membrane fluidity, which can affect a number of cellular functions. The objective of the present work was to examine T2 abnormalities in children with unmodified DSM-IV-TR bipolar disorder (BD) in bilateral cingulate-paracingulate (CPC) white matter. METHOD: A total of 21 children and adolescents with BD and 16 healthy control subjects underwent magnetic resonance imaging at 1.5 Tesla and were compared using a region-of-interest analysis. A post hoc diffusion tensor imaging (DTI) analysis was also performed on selected subjects. RESULTS: The T2 values were significantly decreased on the right-side of the subjects with BD compared with that of the control subjects. Hemispheric difference was also observed in the BD group, with decreased T2 on the right side compared with the left side. No significant difference was observed between left and right CPC T2 in control subjects. For participants who had both T2 and DTI measurements, significant DTI differences were observed: On the left side, fractional anisotropy was reduced and trace and radial diffusivity were increased, whereas on the right side, trace was increased and T2 was decreased in subjects with BD compared with control subjects. CONCLUSIONS: Our findings suggest that the observed T2 difference is a reflection of cerebral blood flow rather than an alteration of the fluidity of cell membranes. It is possible that myelin damage occurs on the left side in early-onset BD, in addition to changes in the blood flow. Prospective studies with larger numbers of subjects are warranted to further explore the relevance of the presented results. Published by Elsevier Inc. All rights reserved.

العلاقة: Link to Article in PubMed; http://dx.doi.org/10.1016Test/j.jaac.2010.08.015; J Am Acad Child Adolesc Psychiatry. 2010 Dec;49(12):1260-8. Epub 2010 Oct 29. Link to article on publisher's site; 0890-8567 (Linking); http://hdl.handle.net/20.500.14038/45900Test; https://escholarship.umassmed.edu/psych_pp/426Test; 1775367; psych_pp/426

الإتاحة: https://doi.org/10.1016Test/j.jaac.2010.08.015
https://doi.org/20.500.14038/45900Test
https://hdl.handle.net/20.500.14038/45900Test
https://escholarship.umassmed.edu/psych_pp/426Test

المؤلفون: Kinney, Dennis K., Miller, Andrea M., Crowley, David J., Huang, Emerald, Gerber, Erika

المصدر: Journal of Autism and Developmental Disorders. Mar 2008 38(3):481-488.

تمت مراجعته من قبل الزملاء: Y

Page Count: 8

الواصفات: Incidence, Autism, Pregnancy, Children, Natural Disasters, Stress Variables, Computation, Census Figures, Prenatal Influences

مصطلحات جغرافية: Louisiana

مستخلص: Hurricanes and tropical storms served as natural experiments for investigating whether autism is associated with exposure to stressful events during sensitive periods of gestation. Weather service data identified severe storms in Louisiana from 1980 to 1995 and parishes hit by storm centers during this period. Autism prevalences in different cohorts were calculated using anonymous data on birth dates and parishes of children diagnosed with autism in the state mental health system, together with corresponding census data on all live births in Louisiana. Prevalence increased in dose-response fashion with severity of prenatal storm exposure, especially for cohorts exposed near the middle or end of gestation (p less than 0.001). Results complement other evidence that factors disrupting development during sensitive gestational periods may contribute to autism.

Abstractor: Author

المؤلفون: Stantial, Nicole, Dumpe, Jarrod, Pietrosimone, Kathryn, Baltazar, Felicia, Crowley, David J.

المساهمون: National Science Foundation, American Society for Microbiology, NSF

المصدر: DNA Repair ; volume 41, page 63-68 ; ISSN 1568-7864

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1016Test/j.dnarep.2016.03.007
https://api.elsevier.com/content/article/PII:S1568786415301154?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1568786415301154?httpAccept=text/plainTest

المؤلفون: Crowley, David J.

مصطلحات موضوعية: Information theory.

العلاقة: Pid: 69177; Proquest: AAINK29753

الإتاحة: https://escholarship.mcgill.ca/concern/theses/0z708x41vTest