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1دورية أكاديمية
المؤلفون: Virginia Zamponi, Rossella Mazzilli, Olimpia Bitterman, Soraya Olana, Cristina Iorio, Camilla Festa, Chiara Giuliani, Fernando Mazzilli, Angela Napoli
المصدر: BMC Women's Health, Vol 20, Iss 1, Pp 1-7 (2020)
مصطلحات موضوعية: Female sexual dysfunction, FSFI, Diabetes mellitus, CSII, Diabetes complications, BMI, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
الوصف: Abstract Background This study aims to evaluate: 1) the prevalence of Female Sexual Dysfunction (FSD) in women affected by type 1 Diabetes Mellitus (DM) and the control group; 2) the correlation between duration of DM, HbA1C levels and sexual life quality; 3) the relationship between different methods of insulin administration and sexual life quality; 4) the correlation between FSD and diabetes complications. Methods We selected 33 women with type 1 DM and 39 healthy women as controls. Each participant underwent a detailed medical history and physical examination and completed the 6-item Female Sexual Function Index questionnaire (FSFI-6). In patients affected by type 1 DM, the different methods of insulin administration (Multi Drug Injection - MDI or Continuous Subcutaneous Insulin Infusion - CSII) and the presence of DM complications were also investigated. Results The prevalence of FSD (total score ≤ 19) was significantly higher in the type 1 DM group than in the control group (12/33, 36.4% and 2/39, 5.2%, respectively; p = 0.010). No statistically significant differences were found regarding FSD according to the presence of complications, method of insulin administration or previous pregnancies. Conclusions This study underlined that FSD is higher in women affected by type 1 DM than in healthy controls. This could be due to the diabetic neuropathy/angiopathy and the type of insulin administration. Therefore, it is important to investigate FSD in diabetic women, as well as erectile dysfunction in diabetic men.
وصف الملف: electronic resource
العلاقة: http://link.springer.com/article/10.1186/s12905-020-00939-1Test; https://doaj.org/toc/1472-6874Test
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2دورية أكاديمية
المؤلفون: Soraya Olana, Rossella Mazzilli, Michele Delfino, Virginia Zamponi, Cristina Iorio, Fernando Mazzilli
المصدر: Archivio Italiano di Urologia e Andrologia, Vol 90, Iss 3, Pp 208-211 (2018)
مصطلحات موضوعية: adolescent, andrological examination, prevention, sexual dysfunctions, varicocele, Diseases of the genitourinary system. Urology, RC870-923
الوصف: Objective: The aims of this research were to study: a) the prevalence of male adolescents, aged between 10 and 19 years of age, referred to our Unit for an andrological assessment; b) the reasons (stated and subsequently modified) for referral; c) the prevalence of clinically diagnosed diseases. Materials and methods: A total of 2.855 subjects, referred to the Andrology Unit for a first examination, were retrospectively studied. For each adolescent, a medical history was taken and an andrological physical examination was carried out. Results: Prevalence was found to be 6.9% (197/2855). Subjects were divided into two groups according to age (A: ≤ 14 and B: ≥ 15 years). The original reason stated for their consultation was corrected by 11.7% of the subjects (23/197); this correction concerned almost all the Group B subjects (21/23 (91.3%) vs 2/23 (8.7%) of Group A; p < 0.01). Regarding sexual dysfunctions, a simple explanation of certain conditions reassured the subject in about 15% of the cases. Furthermore, the physical examination proved extremely useful, revealing clinical alterations in more than 60% of subjects. Conclusions: In conclusion, to date in Italy, the prevalence of adolescents among males referred to an Andrology Unit for assessment is very low. It is important to encourage adolescents to undergo andrological examination to enable identification of reproductive function and psycho-sexual disorders.
وصف الملف: electronic resource
العلاقة: https://www.pagepressjournals.org/index.php/aiua/article/view/7615Test; https://doaj.org/toc/1124-3562Test; https://doaj.org/toc/2282-4197Test
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3دورية أكاديمية
المؤلفون: Maurizio Poggi, Irene Samperi, Lorenza Mattia, Arianna Di Rocco, Cristina Iorio, Salvatore Monti, Giuseppe Pugliese, Vincenzo Toscano
المصدر: Frontiers in Molecular Biosciences, Vol 6 (2020)
مصطلحات موضوعية: Thalassemia Major, adrenal insufficiency, synachten, endocrine comorbidities, cortisol peak, Biology (General), QH301-705.5
الوصف: Background: Thalassemia Major (TM) is a complex pathology that needs a highly skilled approach. Endocrine comorbidities are nowadays the most important complications, including hypogonadism, hypothyroidism, diabetes mellitus, and bone diseases. Recent works stated that there could be a relevant prevalence of adrenal insufficiency (AI) present in TM, and this fact may become crucial, especially in case of major stressful events.Aim: Test the reliability of the standard test to diagnose AI in a group of TM and correlate it with clinical, hematological, and radiological data.Methods: We evaluated endocrine damages and the efficacy of iron chelation therapy in 102 patients affected by TM. AI was assessed by tetracosactide (Synacthen) 1 mcg iv (low-dose test, LDT) stimulation test. Patients with a subnormal response (peak cortisol < 500 nmol/L) were followed up to 5 years to check the symptoms and signs of AI.Results: We found AI in 13.7% of the population studied. We did not find any correlation between AI and all data evaluated. Only female gender seems to be a protective factor. A follow up of the patients affected by AI showed no signs of adrenal crisis, in spite of no replacement therapy.Conclusions: Our study shows a relevant prevalence of AI in TM, especially in males. The absence of an adrenal crisis, in spite of no replacement therapy, during the long-term follow up, seems to underline that current methods to evaluate AI, in TM, should consider a different and specific diagnostic test or different cut off for diagnosis.
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/article/10.3389/fmolb.2019.00162/fullTest; https://doaj.org/toc/2296-889XTest
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4دورية أكاديمية
المؤلفون: Rossella Mazzilli, Antonio Stigliano, Michele Delfino, Soraya Olana, Virginia Zamponi, Cristina Iorio, Giuseppe Defeudis, Danilo Cimadomo, Vincenzo Toscano, Fernando Mazzilli
المصدر: Frontiers in Endocrinology, Vol 10 (2019)
مصطلحات موضوعية: congenital adrenal hyperplasia, testicular lesion, semen analysis, male infertility, testicular adrenal rest tumor, azoospermia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
الوصف: Introduction: The aims of this study were to determine the prevalence of testicular-adrenal rest tumors (T-ARTs) in patients with congenital adrenal hyperplasia (CAH) and to evaluate the related ultrasound (US) features, hormonal profiles, and semen parameters. Therefore, we attempted to understand the potential impact of adrenocorticotropic hormone (ACTH) on the persistence or disappearance of T-ART.Methods: We conducted a longitudinal cohort study including patients with CAH who were undergoing treatment with cortisone and, when indicated, fludrocortisone replacement therapy. We performed andrological examinations, US of the testis, hormone profiling, and semen analysis.Results: Of the 25 patients (mean ± SD age, 32.2 ± 7.5 years), T-ARTs were detected by US in 14 (56.0%) patients. The mean ± SD diameter of the lesions was 13.2 ± 6.8 mm. Among 3 (21.4%) patients, the lesions were observed in one testis, whereas both testes were affected in the remaining 11 (78.6%) patients. The lesions were hypoechoic in 12 (85.7%) patients and hyperechoic in 2 (14.3%). Plasma ACTH and 17-hydroxyprogesterone (17-OHP) levels were significantly higher in patients with T-ART than in patients without lesions (319.4 ± 307.0 pg/ml and 12.4 ± 2.7 ng/ml vs. 33.5 ± 10.7 pg/ml and 8.2 ± 1.8 ng/ml, respectively; p < 0.01). The mean values of sperm concentration and motility were significantly lower in patients with T-ART than in patients without lesions (12.1 ± 12.4 × 106 cells/ml and 18.4 ± 11.1% vs. 41.5 ± 23.2 × 106 cells/ml and 30.8 ± 15.4%, respectively; p < 0.05). Logistic regression analysis showed ACTH level as a significant predictor of T-ART (p < 0.05). In patients with T-ART, the dose of hydrocortisone was increased by ~25–30%, while the fludrocortisone treatment remained unchanged. After 6 months of steroid treatment, patients underwent US and hormonal evaluation. Disappearance and a reduction in T-ART were observed in 6 (42.9%) and 5 (35.7%) patients, respectively; a reduction in ACTH levels (from 319.4 ± 307.0 to 48.1 ± 5.1 pg/ml; p < 0.01) was reported. A significant correlation between ACTH level reduction and T-ART diameter reduction was observed (p < 0.5; r = 0.55).Conclusions: T-ARTs were detected in 56% of patients with CAH and were associated with impaired semen parameters. However, these lesions are potentially reversible, as demonstrated by the disappearance/reduction after adjustment of cortisone therapy and by the reduction in plasma ACTH level. Our study supports the importance of periodic US evaluation and maintenance of plasma ACTH levels within the normal range in men with CAH.
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/article/10.3389/fendo.2019.00335/fullTest; https://doaj.org/toc/1664-2392Test
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