المؤلفون: Ajibade, Adeola, Pandian, Haridha, Jain, Nibha, Gupta, Latika, Laxminarayan, Ramasharan, Moorthy, Arumugam, Amarasena, Roshan, Cox, Natasha, Sapkota, Hem, Kakade, Girish, Elamanchi, Srinivasa, Prabu, Athiveeraramapandian, Al-Samaraaie, Elaf, Barkham, Nick

المصدر: Ajibade , A , Pandian , H , Jain , N , Gupta , L , Laxminarayan , R , Moorthy , A , Amarasena , R , Cox , N , Sapkota , H , Kakade , G , Elamanchi , S , Prabu , A , Al-Samaraaie , E & Barkham , N 2023 , ' Effectiveness and safety of secukinumab in ankylosing spondylitis : real-life data from Midlands Ankylosing Spondylitis Collaboration (MASC) ' , Rheumatology Advances in Practice , vol. 7 , no. 1 , rkad029 . https://doi.org/10.1093/rap/rkad029Test

العلاقة: https://research.manchester.ac.uk/en/publications/7588429e-b18d-4001-9081-862902d5658dTest

الإتاحة: https://doi.org/10.1093/rap/rkad029Test
https://research.manchester.ac.uk/en/publications/7588429e-b18d-4001-9081-862902d5658dTest
http://www.scopus.com/inward/record.url?scp=85160435270&partnerID=8YFLogxKTest

المؤلفون: Cox, Natasha, Hawarden, Ashley, Bajpai, Ram, Farooq, Saeed, Twohig, Helen, Muller, Sara, Scott, Ian C.

المساهمون: Keele Haywood Academic Rheumatology Group and The Haywood Foundation, National Institute for Health and Care Research, Versus Arthritis

المصدر: Rheumatology International ; ISSN 1437-160X

مصطلحات موضوعية: Immunology, Immunology and Allergy, Rheumatology

الوصف: Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly considering cross-sectional studies, (b) focusing on the relationship between pain and mental health in the context of disease activity/quality of life, and (c) not specifically considering the impact of treating depression/anxiety on pain. This PROSPERO-registered (CRD42023411823) systematic review will address this knowledge-gap by synthesizing evidence to summarise the associations (and potential mediators) between pain and depression/anxiety and evaluate the impact of treating co-morbid depression/anxiety on pain in IA. Relevant databases will be searched, articles screened and their quality appraised (using Joanna Briggs Institute critical appraisal tools) by two reviewers. Eligible studies will include adults with rheumatoid arthritis or spondyloarthritis, be a clinical trial or observational study, and either (a) report the relationship between pain and depression/anxiety (observational studies/baseline trials), or (b) randomise participants to a pharmacological or psychological treatment to manage depression/anxiety with a pain outcome as an endpoint (trials). To synthesise data on the association between pain and depression/anxiety, where available adjusted coefficients from regression models will be pooled in a random-effects meta-analysis. A synthesis without meta-analysis will summarise mediators. To evaluate the impact of treating depression/anxiety on pain, endpoint mean differences between treatment arms will be combined in a random-effects meta-analysis. Through understanding how depression/anxiety contribute to pain in IA, our review has the potential to help optimise approaches to IA pain.

الإتاحة: https://doi.org/10.1007/s00296-023-05450-yTest

المؤلفون: Cox, Natasha, Kettle, Chelsea, Wang, Haboo, Dutta, Shouma, Packham, Jon, Galloway, James, Hill, Jonathan, Muller, Sara, Hider, Samantha, Paskins, Zoe, Bullock, Laurna, Scott, Ian C

المصدر: Rheumatology ; volume 63, issue Supplement_1 ; ISSN 1462-0324 1462-0332

الوصف: Background/Aims Electronic patient-reported outcome measures (ePROMs) assessing disease activity, function, pain, and quality of life can facilitate innovative inflammatory arthritis (IA) care, such as automating patient-initiated follow-up. This mixed-methods study evaluated whether their use is feasible and acceptable in routine care of people with inflammatory arthritis in an NHS setting. Methods The Haywood Arthritis Portal (HAP) is an NHS co-designed online patient platform, enabling people with IA under the Midlands Partnership University NHS Foundation Trust (MPFT) to enter ePROMs using any internet-enabled device. People with IA attending recruiting clinics from January-October 2023 received text message/letter invitations to complete HAP pre-appointment. Non-completers could complete HAP on tablets at the clinic. Consenters also completed a survey assessing ePROMs acceptability and HAP usability. Responses were summarised as proportions, stratified by age, gender, IA type, and home/clinic-completion status. Purposively sampled survey-completers participated in semi-structured interviews, providing deeper understanding of ePROMs/HAP feasibility/acceptability. This abstract presents data from an interim analysis of consenting patients with available survey and case report form data. Results Survey Population: 210 patients were included: 107 (51%) home-completers; 98 (47%) clinic-completers; 5 (2%) HAP non-completers; 70% female; mean age 60 years. Most had RA (70%), followed by Axial SpA (15%), undifferentiated IA (8%), and PsA/other SpA (7%). ePROMs Acceptability: 86% rated ePROMs acceptable/completely acceptable; 82% felt their completion required little/no effort; 87% agreed/strongly agreed their answers were likely to help their care. Fewer people aged >70 years rated ePROMs acceptable/completely acceptable (70%) compared with younger age groups (ranging 82%-100%); the same was the case for clinic-completers (79%) vs. home-completers (93%). Perceived ePROMs Use by Clinicians: 58% ...

الإتاحة: https://doi.org/10.1093/rheumatology/keae163.269Test
https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.269/57304414/keae163.269.pdfTest

المؤلفون: Cox, Natasha, Bateman, James

المصدر: Rheumatology ; volume 63, issue Supplement_1 ; ISSN 1462-0324 1462-0332

الوصف: Background/Aims In the United Kingdom (UK), to combat the coronavirus disease 2019 (COVID-19) pandemic, social distancing measures were implemented to varying degrees between March-2020 and December-2021. UK policy deemed patients with rheumatic disease (RD) at higher risk from COVID-19 and many were categorised as ‘clinically extremely vulnerable’ (CEV), these patients were required to follow more stringent social distancing measures. Social isolation and loneliness are implicated as predictors of mortality; the impact of these strict social distancing measures in patients with RD on mortality is unknown. In addition, Health related quality of life (HRQoL) measures provide useful insights into a patients physical and mental wellbeing. HRQoL is recognised as an important measure of health outcomes and there is limited evidence suggesting HRQoL measures such as the Health Assessment Questionnaire (HAQ) and the Short Form-36 questionnaire (SF-36) are associated with mortality in patients with rheumatoid arthritis. The predictive value of the SF-12 (a validated, shortened version of the SF-36) in RD patient’s mortality is unknown. In this UK-based, observational cohort study we evaluated the impact of stricter social distancing measures during the pandemic on 3-year mortality and assessed the utility of the SF-12 in predicting mortality in patients with RD. Methods We distributed a web-based survey via a linked mobile-phone SMS message, to all rheumatology patients, with a validated mobile number, under follow-up at the Royal Wolverhampton Trust, April-2020. We collected demographics, CEV status, and Short Form-12 mental (MCS) and physical health component scores (PCS) for health-related quality of life. Mortality was audited July-2023. Data were analysed using SPSS version 26 and R. Results There were 7,911 active follow up patients with linked mobile numbers. Survey responses were received from 1605 (20%); responders were female (69%), white (94%), CEV (47%), had a mean age of 61years, and most had ...

الإتاحة: https://doi.org/10.1093/rheumatology/keae163.089Test
https://academic.oup.com/rheumatology/article-pdf/63/Supplement_1/keae163.089/57304333/keae163.089.pdfTest

المؤلفون: Cox, Natasha^1,2 (AUTHOR) n.cox1@keele.ac.uk, Hawarden, Ashley^1,2 (AUTHOR), Bajpai, Ram¹ (AUTHOR), Farooq, Saeed^1,3 (AUTHOR), Twohig, Helen¹ (AUTHOR), Muller, Sara¹ (AUTHOR), Scott, Ian C.^1,2 (AUTHOR)

المصدر: Rheumatology International. Mar2024, Vol. 44 Issue 3, p435-440. 6p.

مصطلحات موضوعية: *MENTAL depression, *PSYCHOTHERAPY, *ARTHRITIS, *RHEUMATOID arthritis, *SPONDYLOARTHROPATHIES, *PAIN, *PAIN catastrophizing, *INFECTIOUS arthritis

مستخلص: Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly considering cross-sectional studies, (b) focusing on the relationship between pain and mental health in the context of disease activity/quality of life, and (c) not specifically considering the impact of treating depression/anxiety on pain. This PROSPERO-registered (CRD42023411823) systematic review will address this knowledge-gap by synthesizing evidence to summarise the associations (and potential mediators) between pain and depression/anxiety and evaluate the impact of treating co-morbid depression/anxiety on pain in IA. Relevant databases will be searched, articles screened and their quality appraised (using Joanna Briggs Institute critical appraisal tools) by two reviewers. Eligible studies will include adults with rheumatoid arthritis or spondyloarthritis, be a clinical trial or observational study, and either (a) report the relationship between pain and depression/anxiety (observational studies/baseline trials), or (b) randomise participants to a pharmacological or psychological treatment to manage depression/anxiety with a pain outcome as an endpoint (trials). To synthesise data on the association between pain and depression/anxiety, where available adjusted coefficients from regression models will be pooled in a random-effects meta-analysis. A synthesis without meta-analysis will summarise mediators. To evaluate the impact of treating depression/anxiety on pain, endpoint mean differences between treatment arms will be combined in a random-effects meta-analysis. Through understanding how depression/anxiety contribute to pain in IA, our review has the potential to help optimise approaches to IA pain. [ABSTRACT FROM AUTHOR]

المؤلفون: Ajibade, Adeola, Pandian, Haridha, Jain, Nibha, Gupta, Latika, Laxminarayan, Ramasharan, Moorthy, Arumugam, Amarasena, Roshan, Cox, Natasha, Sapkota, Hem, Kakade, Girish, Elamanchi, Srinivasa, Prabu, Athiveeraramapandian, Al-Samaraaie, Elaf, Barkham, Nick

المصدر: Rheumatology Advances in Practice ; volume 7, issue 1 ; ISSN 2514-1775

مصطلحات موضوعية: Rheumatology

الإتاحة: https://doi.org/10.1093/rap/rkad029Test
https://academic.oup.com/rheumap/article-pdf/7/1/rkad029/49555885/rkad029.pdfTest

المؤلفون: Cox, Natasha, Raizada, Sabrina R, Barkham, Nick, Venkatachalam, Srinivasan, Sheeran, Tom P, Adizie, Tochukwu, Sapkota, Hem, Scott, Ian C, Muller, Sara, Bateman, James

المساهمون: National Institute for Health and Care Researc

المصدر: Rheumatology Advances in Practice ; volume 7, issue 1 ; ISSN 2514-1775

مصطلحات موضوعية: Rheumatology

الوصف: Objective The aim was to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic and stringent social isolation measures on patients with rheumatic disease (RD) from the beginning of the pandemic (April 2020). Methods In this UK-based single-centre, prospective, observational cohort study, all RD follow-up patients at our centre were invited by SMS text message in April 2020 to participate in the study. Participants completed questionnaires at four time points between April 2020 and December 2021. We collected demographics, clinically extremely vulnerable (CEV) status, short form 12 mental (MCS) and physical health component scores (PCS) for health-related quality of life, vaccination status, COVID-19 infection rates and incidence of long COVID. Results We enrolled 1605 patients (female, 69.0%; CEV, 46.5%); 906 of 1605 (56.4%) completed linked responses to our final questionnaire. MCS improved (+0.6, P < 0.05), whereas PCS scores deteriorated (−1.4, P < 0.001) between April 2020 and December 2021. CEV patients had worse mental and physical health scores than non-CEV patients at entry (PCS, 36.7 and 39.3, respectively, P < 0.001; MCS, 40.9 and 43.0, respectively, P < 0.001) and at each time point throughout the study; both mental and physical health outcomes were worse in CEV compared with non-CEV patients (P < 0.001 and P = 0.004, respectively). At study close, 148 of 906 (16.3%) reported COVID infection, with no difference in infection, vaccination or long COVID rates between CEV and non-CEV patients. Conclusions Mental and physical health in RD patients has changed throughout the pandemic; outcomes for both metrics of health were worse in CEV patients, although there were no differences in infection rates between the groups. These data might assist the understanding and planning of future health-care policy and social restrictions in RD patients. Trial registration ClinicalTrials.gov, www.clinicaltrials.gov, NCT04542031.

الإتاحة: https://doi.org/10.1093/rap/rkad009Test
https://academic.oup.com/rheumap/article-pdf/7/1/rkad009/49086833/rkad009.pdfTest

المؤلفون: Bateman, James, Cox, Natasha, Rajagopala, Lavanya, Ford, Mark, Jasim, Muhamad, Mulherin, Diarmuid, Venkatachalam, Srinivasan, Douglas, Barbara, Hirsch, George, Sheeran, Tom

المصدر: The Lancet Rheumatology ; volume 3, issue 6, page e399-e401 ; ISSN 2665-9913

مصطلحات موضوعية: Immunology, Immunology and Allergy, Rheumatology

الإتاحة: https://doi.org/10.1016/s2665-9913Test(21)00148-x
https://api.elsevier.com/content/article/PII:S266599132100148X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S266599132100148X?httpAccept=text/plainTest

المؤلفون: Cox, Natasha, Bateman, James

المصدر: Rheumatology ; volume 62, issue Supplement_2 ; ISSN 1462-0324 1462-0332

مصطلحات موضوعية: Pharmacology (medical), Rheumatology

الوصف: Background/Aims It is recognised that immunosuppressive medications, often relied upon in the management of autoimmune rheumatic disease, inhibit vaccine-induced immunity against the SARS-CoV-2 virus. A key challenge for rheumatologists is maximising immunity provided by the vaccine in their patients. Recent data has implicated methotrexate (MXT), a commonly used disease modifying anti-rheumatic drug (DMARD), in reducing patients’ vaccine-induced immunity against the virus and studies have demonstrated the effectiveness of pausing MXT medication for 2-weeks after receiving the vaccine in boosting patients’ immunity. There is a lack of data exploring the impact of concurrent biologic-DMARD (b-DMARD) use with MXT on COVID-19 infection rates in vaccinated individuals. This analysis forms part of a larger programme of research (clinicaltrials.gov NCT04542031) exploring COVID-19 in patients with rheumatic disease. Here we provide a comparative analysis of COVID-19 infection rates between patients taking MXT either with or without b-DMARD therapy and those on no immunosuppression. Methods We distributed two web-based questionnaires via SMS-messaging in April 2020 and December 2021 and two interim monitoring questionnaires in December 2020 and June 2021. All rheumatology patients with a valid mobile telephone number under follow up at the Royal Wolverhampton Trust were invited to participate in the study; those that consented received follow up questionnaires. We collected information on demographics, rheumatology diagnosis and treatment, vaccination status, and COVID-19 infection rates. Data were collected 7-days following questionnaire distribution. Results Initial questionnaires were sent to 7911 active follow up patients, 1636/7911 (21%) responded and consented to further follow up; 906/1636 (55.4%) provided a complete response to the final survey which was subsequently linked to survey one enabling analysis. Responders were female (622/906, 68.7%), white (865, 95.5%), 60 years or above (519, 57.3%), and ...

الإتاحة: https://doi.org/10.1093/rheumatology/kead104.098Test
https://academic.oup.com/rheumatology/article-pdf/62/Supplement_2/kead104.098/50065065/kead104.098.pdfTest

المؤلفون: Ryan, Maxwell, Robles, Anthony, Brinker, Grant, Shockley, Daelon, Cox, Natasha

المساهمون: Kosbar, Kurt, Department of Electrical and Computer Engineering, Missouri University of Science and Technology

المصدر: International Telemetering Conference Proceedings

الوصف: This paper details a science system designed for a prototype Mars rover for the purpose of competing in the 2022 University Rover Challenge. The science system was designed to analyze an environment and determine its ability to support life. Data from a sensor array, heater, and absolute encoders are gathered by individual microcontrollers connected in a local, rover-side network. Various communication standards are used to interface with these devices. This data is transmitted over a 5.8 GHz radio link to a basestation where the data is interpreted by the rover operators. Embedded control is also critical to rover operations as feedback loops are used to ensure safe operation of the system. ; International Foundation for Telemetering ; Proceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit https://telemetry.org/contact-usTest/ if you have questions about items in this collection.

العلاقة: http://www.telemetry.orgTest/; Ryan, M., Robles, A., Brinker, G., Shockley, D., & Cox, N. (2022). Science System for a Prototype Mars Rover. International Telemetering Conference Proceedings, 57.; http://hdl.handle.net/10150/666952Test; International Telemetering Conference Proceedings

الإتاحة: http://hdl.handle.net/10150/666952Test