المؤلفون: Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea

المساهمون: Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea

مصطلحات موضوعية: Coronary artery abnormalitie, Hypotension, Kawasaki disease, Multisystem inflammatory syndrome associated with coronavirus disease, Myocarditi, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, SARS-CoV-2, Age Distribution, Antirheumatic Agent, Aspirin, C-Reactive Protein, COVID-19, Child, Preschool, Coronary Artery Disease, Cough, Diarrhea, Dyspnea, Female, Glucocorticoid, Heart Failure, Human, Hyperferritinemia, Immunoglobulins, Intravenou, Immunologic Factor, Infant, Intensive Care Units, Pediatric, Interleukin 1 Receptor Antagonist Protein

الوصف: There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33726806; info:eu-repo/semantics/altIdentifier/wos/WOS:000629587400001; volume:19; issue:1; firstpage:-; lastpage:-; numberofpages:11; journal:PEDIATRIC RHEUMATOLOGY ONLINE JOURNAL; http://hdl.handle.net/11368/2990427Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102710196; https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-021-00511-7Test

الإتاحة: https://doi.org/10.1186/s12969-021-00511-7Test
http://hdl.handle.net/11368/2990427Test

المؤلفون: Marchesi A., Rigante D., Cimaz R., Ravelli A., Tarissi de Jacobis I., Rimini A., Cardinale F., Cattalini M., De Zorzi A., Dellepiane R. M., Salice P., Secinaro A., Taddio A., Palma P., El Hachem M., Cortis E., Maggio M. C., Corsello G., Villani A.

المساهمون: Marchesi, A., Rigante, D., Cimaz, R., Ravelli, A., Tarissi de Jacobis, I., Rimini, A., Cardinale, F., Cattalini, M., De Zorzi, A., Dellepiane, R. M., Salice, P., Secinaro, A., Taddio, A., Palma, P., El Hachem, M., Cortis, E., Maggio, M. C., Corsello, G., Villani, A.

مصطلحات موضوعية: Aspirin, Children, Coronary artery abnormalitie, Intravenous immunoglobulin, Kawasaki disease

الوصف: Aim of these revised recommendations for the general management of Kawasaki disease is to encourage its prompter recognition and warrant the most appropriate therapy, based on ascertained scientific data, raising awareness of the complications related to misdiagnosis or delayed treatment. A set of 20 synthetic operative statements is herein provided, including the definition of Kawasaki disease, its protean presentations, clinical course and seminal treatment modalities of all disease phases. The application of these recommendations should improve prognosis of Kawasaki disease and prevent the progression to permanent vascular abnormalities, thereby diminishing morbidity and mortality.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33494789; info:eu-repo/semantics/altIdentifier/wos/WOS:000613077000002; volume:47; issue:1; firstpage:"-"; lastpage:"-"; numberofpages:12; journal:THE ITALIAN JOURNAL OF PEDIATRICS; http://hdl.handle.net/11368/2990431Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099736636; https://ijponline.biomedcentral.com/articles/10.1186/s13052-021-00962-4Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830049Test/

الإتاحة: https://doi.org/10.1186/s13052-021-00962-4Test
http://hdl.handle.net/11368/2990431Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830049Test/

المؤلفون: Marchesi, Alessandra, Tarissi De Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto

المساهمون: Marchesi, Alessandra, Tarissi De Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto

مصطلحات موضوعية: aspirin, children, coronary artery abnormalitie, intravenous immunoglobulin, Kawasaki disease, pediatrics, perinatology and child health

الوصف: The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists' contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations. Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should not be considered a norm that limits treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient's condition, and disease severity or complications.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30157897; info:eu-repo/semantics/altIdentifier/wos/WOS:000443134700001; volume:44; issue:1; numberofpages:18; journal:THE ITALIAN JOURNAL OF PEDIATRICS; http://hdl.handle.net/11573/1151877Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85052723417

الإتاحة: https://doi.org/10.1186/s13052-018-0536-3Test
http://hdl.handle.net/11573/1151877Test

المؤلفون: Marchesi, Alessandra, Tarissi De Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto

المساهمون: Marchesi, Alessandra, Tarissi De Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto

مصطلحات موضوعية: aspirin, child, coronary artery abnormalitie, innovative biotechnologie, intravenous immunoglobulin, Kawasaki disease, personalized medicine, pediatrics, perinatology and child health

الوصف: This second part of practical Guidelines related to Kawasaki disease (KD) has the goal of contributing to prompt diagnosis and most appropriate treatment of KD resistant forms and cardiovascular complications, including non-pharmacologic treatments, follow-up, lifestyle and prevention of cardiovascular risks in the long-term through a set of 17 recommendations. Guidelines, however, should not be considered a norm that limits the treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient's condition, and disease severity or individual complications.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30157893; info:eu-repo/semantics/altIdentifier/wos/WOS:000443134700002; volume:44; numberofpages:18; journal:THE ITALIAN JOURNAL OF PEDIATRICS; http://hdl.handle.net/11573/1183965Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85052725593

الإتاحة: https://doi.org/10.1186/s13052-018-0529-2Test
http://hdl.handle.net/11573/1183965Test

المؤلفون: D. Rigante, L. Andreozzi, M. Fastiggi, B. Bracci, M. F. Natale, S. Esposito

المساهمون: D. Rigante, L. Andreozzi, M. Fastiggi, B. Bracci, M.F. Natale, S. Esposito

مصطلحات موضوعية: Kawasaki syndrome, coronary artery abnormalitie, intravenous immunoglobulin, Settore MED/38 - Pediatria Generale e Specialistica

الوصف: Kawasaki syndrome (KS) is the most relevant cause of heart disease in children living in developed countries. Intravenous immunoglobulin (IVIG) has a preventive function in the formation of coronary artery abnormalities and a poor strictly-curative action in established coronary damage. More than two decades ago, the Harada score was set to assess which children with KS should be subject to administration of IVIG, evaluating retrospectively a large cohort of patients with regard to age, sex and laboratory data. Nowadays, high dose IVIG is administered to all children with a confirmed diagnosis of KS, but a tool for predicting non-responsiveness to the initial infusion of IVIG has not been found. The prediction of IVIG resistance is a crucial issue, as recognising these high-risk patients should consent the administration of an intensified initial treatment in combination with IVIG in order to prevent coronary injuries. Few reports have focused on factors, referring to both clinical parameters and laboratory data at the onset of KS, in order to predict which patients might be IVIG non-responsive. We have analysed three different risk scores which were formulated to predict IVIG resistance in Japanese children with typical KS, but their application in non-Japanese patients or in those with incomplete and atypical patterns of the disease has been studied in a fragmentary way. Overall, our analysis showed that early and definite ascertainment of likely IVIG non-responders who require additional therapies reducing the development of coronary artery involvement in children with KS is still a challenge.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26927060; info:eu-repo/semantics/altIdentifier/wos/WOS:000373712800132; volume:17; issue:3; firstpage:1; lastpage:10; numberofpages:10; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/2434/369849Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84959189418

الإتاحة: https://doi.org/10.3390/ijms17030278Test
http://hdl.handle.net/2434/369849Test

المؤلفون: Patrizia Salice, Marco Cattalini, Fabio Cardinale, Paolo Palma, Isabella Tarissi de Jacobis, Andrea Zorzi, Rolando Cimaz, Angelo Ravelli, Maria Cristina Maggio, Giovanni Corsello, Elisabetta Cortis, Maya El Hachem, Alessandro Rimini, Alberto Villani, Aurelio Secinaro, Donato Rigante, Andrea Taddio, Alessandra Marchesi, Rosa Maria Dellepiane

المساهمون: Marchesi, A., Rigante, D., Cimaz, R., Ravelli, A., Tarissi de Jacobis, I., Rimini, A., Cardinale, F., Cattalini, M., De Zorzi, A., Dellepiane, R. M., Salice, P., Secinaro, A., Taddio, A., Palma, P., El Hachem, M., Cortis, E., Maggio, M. C., Corsello, G., Villani, A., Marchesi A., Rigante D., Cimaz R., Ravelli A., Tarissi de Jacobis I., Rimini A., Cardinale F., Cattalini M., De Zorzi A., Dellepiane R.M., Salice P., Secinaro A., Taddio A., Palma P., El Hachem M., Cortis E., Maggio M.C., Corsello G., Villani A.

المصدر: Italian Journal of Pediatrics
Italian Journal of Pediatrics, Vol 47, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, 2019-20 coronavirus outbreak, Aspirin, Children, Coronary artery abnormalities, Intravenous immunoglobulin, Kawasaki disease, Review, 030204 cardiovascular system & hematology, Mucocutaneous Lymph Node Syndrome, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, hemic and lymphatic diseases, medicine, Humans, Child, Coronary artery abnormalitie, business.industry, Clinical course, lcsh:RJ1-570, Immunoglobulins, Intravenous, lcsh:Pediatrics, General Medicine, Delayed treatment, medicine.disease, Prognosis, Settore MED/38, Disease phases, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, El Niño, Italy, Treatment modality, Disease Progression, Aspirin, Children, Coronary artery abnormalities, Intravenous immunoglobulin, Kawasaki disease, business, medicine.drug

الوصف: Aim of these revised recommendations for the general management of Kawasaki disease is to encourage its prompter recognition and warrant the most appropriate therapy, based on ascertained scientific data, raising awareness of the complications related to misdiagnosis or delayed treatment. A set of 20 synthetic operative statements is herein provided, including the definition of Kawasaki disease, its protean presentations, clinical course and seminal treatment modalities of all disease phases. The application of these recommendations should improve prognosis of Kawasaki disease and prevent the progression to permanent vascular abnormalities, thereby diminishing morbidity and mortality.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1961512fac2acf77543bc7695cca9b03Test
http://hdl.handle.net/11379/540196Test

المؤلفون: Cattalini M, Della Paolera S, Zunica F, Bracaglia C, Giangreco M, Verdoni L, Meini A, Sottile R, Caorsi R, Zuccotti G, Fabi M, Montin D, Meneghel A, Consolaro A, Dellepiane RM, Maggio MC, La Torre F, Marchesi A, Simonini G, Villani A, Cimaz R, Ravelli A, Taddio A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities 'G. D’Alessandro', University of Palermo, Palermo Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan Italy, Veronica Bennato: U. O. Pediatria, Ospedale A, Manzoni Lecco, Francesca Biscaro: UOC Pediatria, Ospedale Ca’ Foncello, Treviso, Grazia Bossi: UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, Pavia Italy, Andrea Campana: Bambino Gesù Children’s Hospital, Rome Italy, Maurizio Carone: UO Malattie Infettive, Ospedale Pediatrico ‘Giovanni XXIII’, Bari Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of Trieste, Trieste Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological Sciences, Sapeinza University of Rome, Polo Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O. Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s Hospital, Piazza S. Onofrio n. 4, 00165 Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biago e C. Arrigo, Alessandria Italy, Giovanni Filocamo: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ilenia Floretta: Pediatria, Ospedale Santa Chiara, Trento Italy, Maria Loreta Foschini: SC Pediatria, PO SAN MICHELE AOBrotzu, Cagliari Italy, Marcello Lanari: Department of Pediatrics, University of Bologna, IRCCS S. Orsola-Malpighi Hospital, Bologna Italy, Bianca Lattanzi: SOD Pediatria, Ospedali Riuniti, Ancona Italy, Alessandra Lazzerotti: Clinica Pediatrica, Università Milano Bicocca, Fondazione MBBM - onlus c/o Ospedale San Gerardo, Monza Italy, Francesco Licciardi: Department of Pediatrics and Public Health, University of Turin, Turin Italy, Alessandra Manerba: Child Cardiology, ASST Spedali Civili di Brescia and University of Brescia, Brescia Italy, Savina Mannarino: Division of Cardiology, Children’s Hospital V Buzzi, ASST FBF Sacco, Achille Marino: Department of Pediatrics, Desio Hospital, ASST Monza, Desio Italy, Agostina Marolda: Pediatrics and Neonatology Dipartment, ASST Ovest Milanese, 'G. Fornaroli' Hospital, Magenta Milan, Laura Martelli: Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo Italy, Giorgia Martini, Department of Woman’s and Child’s Health, University of Padova, Padua Italy, Angela Mauro: Department of Paediatrics, Emergency Department, Santobono-Pausilipon Children’s Hospital, Naples, Italy. Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy. Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di Bologna, Francesca Minoia: Fondazione IRCCS Cà Granda, Alma Olivieri: Dipartimento della donna, del bambino e di chirurgia generale e specialistica, Università della Campania, 'L Vanvitelli, Napoli, Guido Pennoni: Dipartimento Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria e Neonatologia, ASST Lodi, Lodi, Francesca Ricci, Clinica Pediatrica, ASST Spedali Civili di Brescia e Università degli Studi di Brescia, Donato Rigante: Department of Pediatrics, Univarsità Cattolica Sacro Cuore, Matilde Rossi: UOC di Pediatrai e Neonatologia, Ospedale di Macerata, Macerata, Claudia Santagati: Dipartimento di Pediatria, Ospedale di Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child Health, Division of Paediatrics, ASST Grande Ospedale Metropolitano Niguarda, Milano Italy, Barbara Teruzzi: Maternal and Child Health, Elpidio Tierno: UOC di Pediatria, Dipartimento della Salute della Donna e del Bambin, AORN 'Sant’Anna e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento Materno-Infantile, Pediatria, ASST Bergamo-EST, Seriate Bergamo, Piero Valentini, Department of Pediatrics, Gianluca Vergine, UOC Pediatria Rimini, Ospedale Infermi, ASL Romagna, Rimini Italy.

المساهمون: Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea, Cattalini, M, Della Paolera, S, Zunica, F, Bracaglia, C, Giangreco, M, Verdoni, L, Meini, A, Sottile, R, Caorsi, R, Zuccotti, G, Fabi, M, Montin, D, Meneghel, A, Consolaro, A, Dellepiane, Rm, Maggio, Mc, La Torre, F, Marchesi, A, Simonini, G, Villani, A, Cimaz, R, Ravelli, A, Taddio, A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile, Care, Internal Medicine and Medical Specialities 'G., D’Alessandro', University of, Palermo, Palermo, Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico, - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care, Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore, Policlinico, Milan, Italy, Veronica Bennato: U. O., Pediatria, Ospedale, A, Manzoni, Lecco, Francesca Biscaro: UOC, Pediatria, Ospedale Ca’, Foncello, Treviso, Grazia Bossi: UOC, Pediatria, Fondazione IRCCS Policlinico San, Matteo, Pavia, Italy, Andrea Campana: Bambino Gesù Children’s, Hospital, Rome, Italy, Maurizio Carone: UO Malattie, Infettive, Ospedale Pediatrico ‘Giovanni, Xxiii’, Bari, Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of, Trieste, Trieste, Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological, Science, Sapeinza University of, Rome, Polo, Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O., Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s, Hospital, Piazza, S. Onofrio n. 4., 00165, Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency, Unit, The Children, Hospital, AO SS Antonio e Biago e C., Arrigo, Alessandria, Italy, Giovanni Filocamo: Fondazione IRCCS Cà, Granda, Ospedale Maggiore, Policlinico, Milano, Ilenia Floretta:, Pediatria, Ospedale Santa, Chiara, Trento, Italy, Maria Loreta Foschini: SC, Pediatria, PO SAN MICHELE, Aobrotzu, Cagliari, Italy, Marcello Lanari: Department of, Pediatric, University of, Bologna, IRCCS S., Orsola-Malpighi Hospital, Bologna, Italy, Bianca Lattanzi: SOD, Pediatria, Ospedali, Riuniti, Ancona, Italy, Alessandra Lazzerotti: Clinica, Pediatrica, Università Milano, Bicocca, Fondazione MBBM, - onlus c/o Ospedale San Gerardo, Monza, Italy, Francesco Licciardi: Department of Pediatrics and Public, Health, University of, Turin, Turin, Italy, Alessandra Manerba: Child, Cardiology, ASST Spedali Civili di Brescia and University of, Brescia, Brescia, Italy, Savina Mannarino: Division of, Cardiology, Children’s Hospital, V Buzzi, ASST FBF, Sacco, Achille Marino: Department of, Pediatric, Desio, Hospital, Asst, Monza, Desio, Italy, Agostina Marolda: Pediatrics and Neonatology, Dipartment, ASST Ovest, Milanese, 'G., Fornaroli' Hospital, Magenta, Milan, Laura Martelli: Paediatric, Department, Hospital Papa Giovanni, Xxiii, Bergamo, Italy, Giorgia, Martini, Department of Woman’s and Child’s, Health, University of, Padova, Padua, Italy, Angela Mauro: Department of, Paediatric, Emergency, Department, Santobono-Pausilipon Children’s, Hospital, Naples, Italy., Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, Aou, Meyer, University of, Florence, Florence, Italy., Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica, Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di, Bologna, Francesca Minoia: Fondazione IRCCS Cà, Granda, Alma Olivieri: Dipartimento della, Donna, del bambino e di chirurgia generale, e specialistica, Università della, Campania, 'L, Vanvitelli, Napoli, Claudio, Guido Pennoni: Dipartimento, Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria, e Neonatologia, Asst, Lodi, Lodi, Francesca, Ricci, Clinica, Pediatrica, ASST Spedali Civili di Brescia, e Università degli Studi di Brescia, Donato Rigante: Department of, Pediatric, Univarsità Cattolica Sacro, Cuore, Matilde Rossi: UOC di Pediatrai, e Neonatologia, Ospedale di, Macerata, Macerata, Claudia Santagati: Dipartimento di, Pediatria, Ospedale di, Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of, Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child, Health, Division of, Paediatric, ASST Grande Ospedale Metropolitano, Niguarda, Milano, Italy, Barbara Teruzzi: Maternal and Child, Health, Elpidio Tierno: UOC di, Pediatria, Dipartimento della Salute della Donna, e del Bambin, AORN 'Sant’Anna, e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento, Materno-Infantile, Pediatria, Asst, Bergamo-EST, Seriate, Bergamo, Piero, Valentini, Department of, Pediatric, Gianluca, Vergine, UOC Pediatria, Rimini, Ospedale, Infermi, Asl, Romagna, Rimini, Italy., Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini A., Sottile R., Caorsi R., Zuccotti G., Fabi M., Montin D., Meneghel A., Consolaro A., Dellepiane R.M., Maggio M.C., La Torre F., Marchesi A., Simonini G., Villani A., Cimaz R., Ravelli A., Taddio A., Adamoli P., Alberelli M.C., Alizzi C., Barone P., Bennato V., Biscaro F., Bossi G., Campana A., Carone M., Civino A., Conti G., Rossi E.D., Del Giudice E., Dell'Anna A., De Luca M., Felici E., Filocamo G., Floretta I., Foschini M.L., Lanari M., Lattanzi B., Lazzerotti A., Licciardi F., Manerba A., Mannarino S., Marino A., Marolda A., Martelli L., Martini G., Mauro A., Mastrolia M.V., Mazza A., Miniaci A., Minoia F., Olivieri A., Pennoni G., Pignataro R., Ricci F., Rigante D., Rossi M., Santagati C., Soliani M., Sonego S., Sperli D., Stucchi S., Teruzzi B., Tierno E., Utytatnikova T., Valentini P., Vergine G.

المصدر: Pediatric Rheumatology Online Journal
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: Coronary artery abnormalities, Hypotension, Kawasaki disease, Multisystem inflammatory syndrome associated with coronavirus disease, Myocarditis, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, SARS-CoV-2, Age Distribution, Antirheumatic Agents, Aspirin, C-Reactive Protein, COVID-19, Child, Child, Preschool, Coronary Artery Disease, Cough, Diarrhea, Dyspnea, Female, Glucocorticoids, Heart Failure, Humans, Hyperferritinemia, Immunoglobulins, Intravenous, Immunologic Factors, Infant, Intensive Care Units, Pediatric, Interleukin 1 Receptor Antagonist Protein, Italy, Lymphopenia, Male, Mucocutaneous Lymph Node Syndrome, Platelet Aggregation Inhibitors, Shock, Systemic Inflammatory Response Syndrome, Tachypnea, Troponin T, Vomiting, lcsh:Diseases of the musculoskeletal system, coronary artery abnormalities, hypotension, kawasaki disease, multisystem inflammatory syndrome associated with coronavirus disease, myocarditis, pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, age distribution, antirheumatic agents, aspirin, C-reactive protein, child, preschool, coronary artery disease, cough, diarrhea, yspnea, female, glucocorticoids, heart failure, humans, hyperferritinemia, immunoglobulins, intravenous, immunologic factors, infant, intensive care units, pediatric, interleukin 1 receptor antagonist protein, italy, lymphopenia, male, mucocutaneous lymph node syndrome, platelet aggregation inhibitors, shock, systemic inflammatory response syndrome, tachypnea, troponin T, vomiting, Myocarditi, 030204 cardiovascular system & hematology, SARS-CoV-2, Kawasaki disease, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, Myocarditis, Hypotension, Multisystem inflammatory syndrome associated with coronavirus disease, Coronary artery abnormalities, Coronary artery disease, Settore MED/38 - Pediatria Generale E Specialistica, 0302 clinical medicine, Glucocorticoid, Immunologic Factor, Immunology and Allergy, Coronary artery abnormalitie, Fisher's exact test, Pediatric, biology, lcsh:RJ1-570, Antirheumatic Agent, Settore MED/38, Intensive Care Units, Cohort, symbols, Platelet aggregation inhibitor, Intravenous, Human, Research Article, medicine.medical_specialty, Immunoglobulins, 03 medical and health sciences, symbols.namesake, Rheumatology, Internal medicine, medicine, Preschool, 030203 arthritis & rheumatology, business.industry, Platelet Aggregation Inhibitor, lcsh:Pediatrics, medicine.disease, Systemic inflammatory response syndrome, Immunoglobulins, Intravenou, Pediatrics, Perinatology and Child Health, biology.protein, lcsh:RC925-935, business

الوصف: Background There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p Conclusion Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1edde4e3ad084013d31cd2737af2d82Test
https://pubmed.ncbi.nlm.nih.gov/33726806Test

المؤلفون: Domenico Del Principe, Elisabetta Cortis, Gian Luigi Marseglia, Alberto Villani, Elisabetta Straface, Ugo Giordano, Maya El Hachem, Silvana Martino, Isabella Tarissi de Jacobis, Alessandro Rimini, Savina Mannarino, Aurelio Secinaro, Donato Rigante, Rosa Maria Dellepiane, Marzia Duse, Donatella Pietraforte, Rossella Massaro, Grazia Bossi, Alessandra Marchesi, Walter Malorni, Christian Pescosolido, Fabio Cardinale, Susanna Esposito, Patrizia Salice, Fabrizio De Benedetti, Giovanni Corsello, Giulia Marucci, Sabrina Buonuomo, Fernanda Falcini, Maria Cristina Maggio, Andrea Zorzi, Livio D’Isanto, Maria Cristina Pietrogrande

المساهمون: Marchesi, Alessandra, Tarissi De Jacobis, Isabella, Rigante, Donato, Rimini, Alessandro, Malorni, Walter, Corsello, Giovanni, Bossi, Grazia, Buonuomo, Sabrina, Cardinale, Fabio, Cortis, Elisabetta, De Benedetti, Fabrizio, De Zorzi, Andrea, Duse, Marzia, Del Principe, Domenico, Dellepiane, Rosa Maria, D'Isanto, Livio, El Hachem, Maya, Esposito, Susanna, Falcini, Fernanda, Giordano, Ugo, Maggio, Maria Cristina, Mannarino, Savina, Marseglia, Gianluigi, Martino, Silvana, Marucci, Giulia, Massaro, Rossella, Pescosolido, Christian, Pietraforte, Donatella, Pietrogrande, Maria Cristina, Salice, Patrizia, Secinaro, Aurelio, Straface, Elisabetta, Villani, Alberto

المصدر: Italian Journal of Pediatrics
Italian Journal of Pediatrics, Vol 44, Iss 1, Pp 1-18 (2018)

مصطلحات موضوعية: Male, Pediatrics, Review, Severity of Illness Index, 0302 clinical medicine, Retrospective Studie, Epidemiology, 030212 general & internal medicine, Disease management (health), Coronary artery abnormalitie, Children, Societies, Medical, Randomized Controlled Trials as Topic, Pediatric, lcsh:RJ1-570, Disease Management, Immunoglobulins, Intravenous, General Medicine, Prognosis, Settore MED/38, Treatment Outcome, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Meta-analysis, Acute Disease, Practice Guidelines as Topic, Disease Progression, Female, Coronary artery abnormalities, Aspirin, Intravenous immunoglobulin, Kawasaki disease, Human, medicine.medical_specialty, Prognosi, Mucocutaneous Lymph Node Syndrome, Risk Assessment, 03 medical and health sciences, 030225 pediatrics, Severity of illness, medicine, Humans, Risk factor, Retrospective Studies, aspirin, children, coronary artery abnormalities, intravenous immunoglobulin, pediatrics, perinatology and child health, business.industry, lcsh:Pediatrics, Retrospective cohort study, medicine.disease, Immunoglobulins, Intravenou, Pediatrics, Perinatology and Child Health, perinatology and child health, Differential diagnosis, business

الوصف: The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists’ contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations. Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should not be considered a norm that limits treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient’s condition, and disease severity or complications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f97a3cdbff0505798cf78c50acfd5bTest
https://hdl.handle.net/2108/317154Test

المؤلفون: ISIDORI, CHIARA, Sebastiani, Lisa, CARDELLINI, MARIA CHIARA, DI CARA, GIUSEPPE, Rigante, Donato, Esposito, Susanna Maria Roberta

المساهمون: Isidori, Chiara, Sebastiani, Lisa, Cardellini, MARIA CHIARA, DI CARA, Giuseppe, Rigante, Donato, Esposito, Susanna Maria Roberta

مصطلحات موضوعية: Atypical Kawasaki disease, Coronary artery abnormalitie, Echocardiography, Erythematous perineal rash, Kawasaki disease

الوصف: Background: The occurrence of a distinctive perineal eruption that appears early in infants with Kawasaki disease (KD), the most relevant type of febrile vasculitis of childhood, has received little attention in pediatric reports. KD diagnosis is based on clinical criteria, which can be supported by laboratory abnormalities or positive echocardiography findings: difficulty in diagnosis can be increased by incomplete or atypical presentations, but a timely diagnostic process is essential in the youngest patients who are more prone to the risk of cardiac sequelae resulting from KD. Case Presentation: In this report, we present the case of a 2-month-old infant with an unusual presentation of KD, in whom diagnosis was made despite fever remission on the fourth day of hospitalization following intravenous corticosteroid therapy to treat concomitant bronchoconstriction. The presence of early desquamating perineal erythema led to the consideration of KD diagnosis, confirmed by the echocardiographic assessment of right and left coronary artery dilatations with pericardial effusion on the fifth day of hospital stay. Conclusions: Diagnosis of KD represents a demanding challenge, mainly when the illness starts with an incomplete or nuanced presentation. An erythematous desquamating perineal rash is a valuable early clinical clue, which might facilitate a prompt diagnosis of KD. This case emphasizes that an accurate assessment of all clinical features, including perineal erythema with early tendency to desquamation, and an eventual echocardiography, are necessary in an infant displaying fever to corroborate the suspicion of KD.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28665334; info:eu-repo/semantics/altIdentifier/wos/WOS:000407370700042; volume:14; issue:7; firstpage:710; lastpage:716; numberofpages:7; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; http://hdl.handle.net/11391/1415557Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85021669191; http://www.mdpi.com/1660-4601/14/7/710/pdfTest

الإتاحة: https://doi.org/10.3390/ijerph14070710Test
http://hdl.handle.net/11391/1415557Test
http://www.mdpi.com/1660-4601/14/7/710/pdfTest

المؤلفون: Rigante D., Andreozzi L., Fastiggi M., Bracci B., Natale M. F., Esposito S.

المساهمون: Rigante, D., Andreozzi, L., Fastiggi, M., Bracci, B., Natale, M. F., Esposito, S.

مصطلحات موضوعية: Coronary artery abnormalitie, Intravenous immunoglobulin, Kawasaki syndrome, Biomarker, Child, Coronary Artery Disease, Human, Immunoglobulin, Injections, Intravenou, Japan, Mucocutaneous Lymph Node Syndrome

الوصف: Kawasaki syndrome (KS) is the most relevant cause of heart disease in children living in developed countries. Intravenous immunoglobulin (IVIG) has a preventive function in the formation of coronary artery abnormalities and a poor strictly-curative action in established coronary damage. More than two decades ago, the Harada score was set to assess which children with KS should be subject to administration of IVIG, evaluating retrospectively a large cohort of patients with regard to age, sex and laboratory data. Nowadays, high dose IVIG is administered to all children with a confirmed diagnosis of KS, but a tool for predicting non-responsiveness to the initial infusion of IVIG has not been found. The prediction of IVIG resistance is a crucial issue, as recognising these high-risk patients should consent the administration of an intensified initial treatment in combination with IVIG in order to prevent coronary injuries. Few reports have focused on factors, referring to both clinical parameters and laboratory data at the onset of KS, in order to predict which patients might be IVIG non-responsive. We have analysed three different risk scores which were formulated to predict IVIG resistance in Japanese children with typical KS, but their application in non-Japanese patients or in those with incomplete and atypical patterns of the disease has been studied in a fragmentary way. Overall, our analysis showed that early and definite ascertainment of likely IVIG non-responders who require additional therapies reducing the development of coronary artery involvement in children with KS is still a challenge.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26927060; info:eu-repo/semantics/altIdentifier/wos/WOS:000373712800132; volume:17; issue:3; firstpage:278; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11573/1284325Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84959189418

الإتاحة: https://doi.org/10.3390/ijms17030278Test
http://hdl.handle.net/11573/1284325Test