المؤلفون: Liffert Vogt, Taisiya Bezhaeva, Ellen K. Hoogeveen, Daniel Eefting, Laurens Huisman, Roos C. van Nieuwenhuizen, Irene M. van der Meer, Randolph G. Statius van Eps, Joris I. Rotmans, Johannes O. Groeneveld, Marcel C. Weijmer, K.E.A. van der Bogt, Henk Boom, Jan van Schaik, Bas A. Th.F. Gabreëls, Josbert M. Metselaar, Bram M. Voorzaat, Diederik Boon, Cornelis A Verburgh, Karien van der Putten

المساهمون: ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Nephrology

المصدر: Kidney International Reports
Kidney International Reports, 5(8), 1327-1332. Elsevier Inc.
Kidney international / Reports 5(8), 1327-1332 (2020). doi:10.1016/j.ekir.2020.05.030
Kidney International Reports, 5(8), 1327-1332. Elsevier

مصطلحات موضوعية: medicine.medical_specialty, Randomized controlled trial, Nephrology, law, business.industry, Radiocephalic fistula, Prednisolone, Research Letter, Medicine, business, law.invention, Surgery, medicine.drug

الوصف: Kidney international / Reports 5(8), 1327-1332 (2020). doi:10.1016/j.ekir.2020.05.030
Published by Elsevier, Amsterdam

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d13f6ee9dcb7822b463fff0154c6b46Test
https://hdl.handle.net/1887/3181297Test

المؤلفون: J.M. van Laar, A E L Hak, Darius Soonawala, Hilde H F Remmelts, Abraham Rutgers, Y K O Teng, Cornelis A Verburgh, Peter M J Verhoeven, Ebru Dirikgil, Willem Jan W Bos, Gozewijn D. Laverman, Sander W. Tas, H.J. Bernelot Moens, Daphne H. T. IJpelaar

المصدر: Annals of the Rheumatic Diseases. 79:380-381

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Immunology, ANCA-Associated Vasculitis, Disease, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Clinical Practice, Rheumatology, Median follow-up, Induction therapy, Internal medicine, medicine, Immunology and Allergy, Rituximab, Microscopic polyangiitis, business, Granulomatosis with polyangiitis, medicine.drug

الوصف: Background:ANCA associated vasculitis (AAV) is a complex, rare systemic autoimmune disease with an estimated prevalence of 5-18 patients per 100.000 individuals worldwide. Managing a low prevalent disease can be challenging which is reflected in clinical practice variation.Objectives:This study investigated clinical practice variation of the care for AAV patients in the Netherlands.Methods:In a nationwide online survey, AAV patients were selected from academic and non-academic centers. Within centers, patients were eligible when they had a confirmed diagnosis of microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) or eosinophilic granulomatosis with polyangiitis (eGPA) according to the treating physician. There were no exclusion criteria. In each center a comparable number of patients was included. Data capture encompassed a wide set of variables on diagnosis, management and outcomes.Results:From December 2018 to November 2019, 230 AAV patients were recruited in 6 non-academic and 3 academic hospitals (120 vs 110 patients respectively). Differences in clinical diagnoses (GPA, MPA and eGPA) were observed between non-academic and academic centers (p=0.05), which was mainly caused by a higher number of MPA patients in non-academic centers. The year of diagnosis was comparable (median 2013 [2009-2016], p=0.150). The median follow up since diagnosis was 4.8 years [1.8-9.6] with a median in-hospital time-to-diagnosis of 13 days [2-50]. Patients were diagnosed at a mean age of 63 years (±11.18) in non-academic centers and 53 years (±16.92) in academic centers (pConclusion:The present study highlights important practice variation in the management of AAV between academic and non-academic hospitals in the Netherlands. A high proportion of patients is treated with oral cyclophosphamide as induction therapy while rituximab is increasingly used in academic centers. Rates of mortality, infections and malignancies were not different. Altogether, this study raises awareness into the variation of management for AAV patients and allows the identification of areas for improvement of clinical care for Dutch AAV patients.Disclosure of Interests:Ebru Dirikgil: None declared, Abraham Rutgers: None declared, Sander Tas: None declared, Cornelis A. Verburgh: None declared, Darius Soonawala: None declared, A. Elisabeth Hak: None declared, Hilde H.F. Remmelts: None declared, Daphne IJpelaar: None declared, Gozewijn D. Laverman: None declared, Jacob M. van Laar Grant/research support from: MSD, Genentech, Consultant of: MSD, Roche, Pfizer, Eli Lilly, BMS, H.J. Bernelot Moens: None declared, Peter Verhoeven: None declared, Willem Jan W. Bos: None declared, Y.K. Onno Teng Grant/research support from: GSK, Consultant of: GSK, Aurinia Pharmaceuticals, Novartis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fcc35600a7abf97686dc1ec2548b8e23Test
https://doi.org/10.1136/annrheumdis-2020-eular.1297Test

المؤلفون: Lonneke, Bahler, Caroline E, Douma, Gerald M, Peterson, Wim T, van Dorp, Cornelis A, Verburgh

المصدر: Nederlands tijdschrift voor geneeskunde. 162

مصطلحات موضوعية: Uterine Prolapse, Humans, Female, Acute Kidney Injury, Middle Aged, Aged, Nephrostomy, Percutaneous

الوصف: Kidney failure due to uterine prolapse is rare, nonetheless, early recognition and treatment of this form of postrenal kidney failure are essential in order to prevent serious complications.In this article we describe a 73-year-old woman and a 63-year-old-woman with severe kidney failure due to a uterine prolapse. Both patients were initially treated with a nephrostomy catheter to ensure the passage of urine from the kidneys, after which the uterus was repositioned using a vaginal ring.Renal failure due to uterine prolapse can be easily diagnosed by physical examination. If uterine prolapse is diagnosed in a patient with renal failure, it is essential to quickly ensure the passage of urine in order to secure the function of the kidney.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::1889b264cfcd768140c522f4eac6047bTest
https://pubmed.ncbi.nlm.nih.gov/30040279Test

المؤلفون: Nynke Halbesma, Gjalt J. Westland, Diana C. Grootendorst, Friedo W. Dekker, Cornelis A. Verburgh

المصدر: Journal of Renal Nutrition, 25(3), 265-270

مصطلحات موضوعية: Male, Pediatrics, medicine.medical_specialty, Cross-sectional study, Nutritional Status, Medicine (miscellaneous), Renal function, Protein-Energy Malnutrition, Sex Factors, Renal Dialysis, Risk Factors, Odds Ratio, medicine, Humans, Outpatient clinic, Renal Insufficiency, Chronic, Wasting, Aged, Netherlands, Nutrition and Dietetics, Wasting Syndrome, business.industry, Age Factors, Odds ratio, medicine.disease, Malnutrition, Cross-Sectional Studies, Nephrology, Female, medicine.symptom, business, Body mass index, Glomerular Filtration Rate, Kidney disease

الوصف: Objective To examine the prevalence of and risk factors for malnutrition at the start of specialized predialysis care. Design The present analysis was performed on cross-sectional data collected at inclusion in the study. The study included 25 outpatient clinics delivering specialized predialysis care in the Netherlands. Subjects Three hundred seventy-six incident patients with advanced chronic kidney disease attending one of the participating outpatient clinics. Main Outcome Measure Subjective global assessment (SGA) of nutritional status. Results At the start of specialized predialysis care, 11% of patients suffer from moderate protein–energy wasting as measured by SGA. Independent risk factors are age >75 years (Odds ratio [OR], 3.88 [1.74-8.66]), female gender (OR, 2.95 [1.37-6.32]), and having a body mass index 2 (OR, 2.56 [1.19-5.49]). Estimated glomerular filtration rate was not significantly associated with SGA (OR, 1.63 [0.76-3.48]). Conclusions Eleven percent of patients started on specialized predialysis care suffer from moderate protein–energy wasting; risk factors are age >75 years, female gender, and BMI 2 .

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65af238dba4780f7ed51ca3a3144c012Test
https://doi.org/10.1053/j.jrn.2014.10.004Test

المؤلفون: Herbert A. Hauer, Fokko J. van der Woude, Cornelis A. Verburgh, Renato Alberto Sinico, Laure-Hélène Noël, Hans C. van Houwelingen, Ingeborg M. Bajema, Emile de Heer, Rüdiger Waldherr, Jan A. Bruijn, Gill Gaskin, Franco Ferrario, Philippe Lesavre, E. Christiaan Hagen

المساهمون: Hauer, H, Bajema, I, Hagen, E, Noël, L, Ferrario, F, Waldherr, R, van Houwelingen, H, Lesavre, P, Sinico, R, van der Woude, F, Gaskin, G, Verburgh, C, de Heer, E, Bruijn, J

المصدر: Nephrology Dialysis Transplantation. 17:587-596

مصطلحات موضوعية: Adult, Male, Vasculitis, Pathology, medicine.medical_specialty, Biopsy, Kidney, urologic and male genital diseases, Follow-Up Studie, Antibodies, Antineutrophil Cytoplasmic, Necrosis, chemistry.chemical_compound, Retrospective Studie, medicine, Humans, Aged, Retrospective Studies, Anti-neutrophil cytoplasmic antibody, Transplantation, Creatinine, medicine.diagnostic_test, urogenital system, business.industry, Glomerulosclerosis, Middle Aged, Necrosi, medicine.disease, medicine.anatomical_structure, chemistry, Nephrology, Female, Renal biopsy, business, Cell Division, Human, Follow-Up Studies, Kidney disease

الوصف: Background. We reported previously that in renal disease in relation to antineutrophil cytoplasm auto-antibodies (ANCA)-associated vasculitis, renal outcome correlates better with the percentage of normal glomeruli than with separate active lesions. This may imply that glomeruli, once affected by necrotizing and crescentic lesions, are irreversibly damaged. We quantified and evaluated the course of renal lesions in the present study. Methods. We retrospectively analysed 31 patients with renal disease in relation to ANCA-associated vasculitis, all treated with immunosuppressive drugs. In all patients, a renal biopsy was performed at diagnosis. A follow-up biopsy was performed in all patients on the indication of a suspected renal relapse, after a mean interval of 31 months. Results. The mean percentage of normal glomeruli in the renal biopsy did not change over time (29% in the initial and 30% in the follow-up biopsy). The mean percentage of glomeruli with crescents, however, significantly decreased from 57 to 30% (P < 0.001). The percentage of glomerulosclerosis significantly increased from 12 to 39% (P < 0.001). The data were independent of diagnosis, gender, age, time interval between the biopsies, and treatment. Conclusions. This is the first study to quantify glomerular changes between two time points in patients with renal vasculitis. Our results suggest that, on average, no new glomeruli are recruited into the active disease process. The sum of the percentage of crescentic and sclerotic glomeruli in the initial biopsies is larger than the percentage of sclerotic glomeruli in the follow-up biopsies. Thus, therapy seems not only to prevent normal glomeruli from being recruited into the active disease process for a certain time, but seems also to allow part of the active lesions to revert into a normal phenotype, although another part of the active lesions will be transformed to a chronic phenotype

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32102672d0413acb058c2b524d7df86aTest
https://doi.org/10.1093/ndt/17.4.587Test

المؤلفون: Jan A. Bruijn, Cornelis A. Verburgh, Tom W J Huizinga

المصدر: American Journal of Kidney Diseases. 37:653-657

مصطلحات موضوعية: Systemic disease, medicine.medical_specialty, Lupus erythematosus, business.industry, Lupus nephritis, Glomerulonephritis, medicine.disease, Connective tissue disease, Dermatology, Nephritic syndrome, Nephrology, Immunology, medicine, business, Nephrotic syndrome, Anti-SSA/Ro autoantibodies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b845334ef40cc1b49340268ba5f7bcf6Test
https://doi.org/10.1053/ajkd.2001.22097Test

المؤلفون: Jan A. Bruijn, Cornelis A. Verburgh, Leendert A. van Es, Mohamed R. Daha

المصدر: American Journal of Kidney Diseases. 34:344-348

مصطلحات موضوعية: Adult, Male, Hemoptysis, Pathology, medicine.medical_specialty, Anti-Glomerular Basement Membrane Disease, urologic and male genital diseases, Antibodies, Antineutrophil Cytoplasmic, Glomerulonephritis, Pulmonary-renal syndrome, medicine, Goodpasture's syndrome, Humans, Goodpasture syndrome, Anti-neutrophil cytoplasmic antibody, urogenital system, business.industry, medicine.disease, Nephrology, Immunoglobulin G, Pauci-immune, Immunology, medicine.symptom, Vasculitis, business, Nephritis

الوصف: The medical history is presented of a 23-year-old man experiencing three episodes of pulmonary-renal syndrome. On the first occasion, a diagnosis of anti-glomerular basement membrane (GBM) disease (with linear deposition of immunoglobulin G [IgG] along the GBM) was made, whereas anti-neutrophil cytoplasmic autoantibodies were also present in serum. On the third occasion, 5 years later, p-ANCA-associated vasculitis (with pauci-immune crescentic glomerulonephritis) was diagnosed, whereas anti-GBM antibodies were absent. The current literature on ANCA-positive anti-GBM disease is briefly reviewed. A substantial proportion (20% to 30%) of patients with histologically and serologically proven anti-GBM nephritis display the presence of ANCA as well. In this group of patients with dual antibodies, clinical and histological findings suggest that ANCA are not merely epiphenomena, but are of pathogenetic importance and might be responsible for an initial vasculitic insult to the kidney with resultant secondary anti-GBM nephritis. The clinical course in our patient lends further support to this concept. Histological demonstration of anti-GBM nephritis followed by ANCA-associated pauci-immune glomerulonephritis in a single patient has not been reported before.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6965ed2805ff4d7b67e63d10c07cefc5Test
https://doi.org/10.1016/s0272-6386Test(99)70366-5

المؤلفون: Cornelis A. Verburgh, S. Van Veen, C. G. Vermeij, J. M. J. M. Zijlmans, L. A. Van Es

المصدر: Nephrology Dialysis Transplantation. 11:1332-1337

مصطلحات موضوعية: Hemolytic anemia, Transplantation, medicine.medical_specialty, Thrombotic microangiopathy, business.industry, medicine.medical_treatment, Total body irradiation, medicine.disease, Gastroenterology, Surgery, Sepsis, surgical procedures, operative, medicine.anatomical_structure, immune system diseases, Nephrology, hemic and lymphatic diseases, Cyclosporin a, Internal medicine, medicine, Hemodialysis, Bone marrow, Complication, business

الوصف: Thrombotic microangiopathy (TMA) can be a late complication of bone marrow transplantation (BMT). A patient is described in whom the haemolytic uraemic syndrome developed 10 months after BMT and who died of E. coli sepsis while on maintenance haemodialysis. The literature is reviewed, regarding clinical presentation, incidence, pathogenesis and therapy. TMA can be observed, after an interval of 3-12 months, in about 6-26% of patients following BMT. Reported cases vary considerably in clinical severity, from mild presentations to severe TMA with high mortality rates despite intensive therapy. Important pathogenetic roles are ascribed to the conditioning total body irradiation and the use of cyclosporin A, but other factors may be involved as well. Next to supportive therapy, plasma exchange and the use of ACE inhibitors may be of value in treating BMT-associated TMA.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1460648dd4568c23162995d3e0b8b403Test
https://doi.org/10.1093/ndt/11.7.1332Test

المؤلفون: Marleen S, van Brussel, Cornelis T, Grutters, Cornelis A, Verburgh

المصدر: Nederlands tijdschrift voor geneeskunde. 155(48)

مصطلحات موضوعية: Abdomen, Acute, Diagnosis, Differential, Male, L-Lactate Dehydrogenase, Infarction, Creatinine, Humans, Middle Aged, Kidney, Aged

الوصف: Renal infarction is a condition not known to every physician, with often non-specific symptoms. The diagnosis is therefore often not considered initially in patients with acute abdominal pain.In a 77-year-old man a renal infarction was found by chance on a CT-scan performed performed for the evaluation of dyspnoea. Previously he had visited the emergency unit with abdominal pain, in retrospect attributable to renal infarction. A 61-year-old man initially labelled as suffering from gastro-enteritis was diagnosed correctly with renal infarction after his renal function deteriorated and the lactate dehydrogenase (LDH) activity increased.A raised serum creatinine level and LDH activity are classic indicators of renal infarction. In addition, most patients have haematuria. Typical wedge-shaped perfusion defects are visible on a CT-scan with intravenous contrast. Timely diagnosis of renal infarction is important both for the prevention of recurrence of thromboembolic complications and for potential revascularisation. The diagnosis of renal infarction should be included in the differential diagnosis in patients with acute abdominal pain.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::3d2cbed9a2b2bb9a81ebc8b37284246fTest
https://pubmed.ncbi.nlm.nih.gov/22152410Test

المؤلفون: Rene C. Bakker, Cornelis A. Verburgh, Mark A. van Buchem, Leendert C. Paul

المصدر: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 18(11)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Hypertensive encephalopathy, Pediatrics, Encephalopathy, Brain Edema, Cerebral edema, Central nervous system disease, Hypertensive Encephalopathy, Medicine, Humans, Transplantation, business.industry, Brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Uremia, Surgery, Ophthalmoscopy, Blood pressure, Nephrology, Female, business, Complication, Kidney disease

الوصف: In 1914, the German physicians Volhard and Fahrintroduced the name ‘maligne Form der Hypertonie’for a syndrome consisting of a severe elevation in bloodpressure (BP) accompanied by signs of acute end-organdamage [1]. They noted that neurological signs andsymptoms were often part of the clinical picture andemphasized the serious prognostic importance ofcertain fundoscopic changes. By analogy the term‘malignant hypertension’ was applied by Keith andWagener in 1921 when they observed papilloedemain patients with severe hypertension [2]. In 1928,Oppenheimer and Fishberg described a 19-year-oldcollege student who suffered from severe hypertensioncoinciding with repeated bouts of headache, neurolog-ical deficits and convulsions and first used the term‘hypertensive encephalopathy’ (HE) [3]. Although thecharacteristic retinal signs of malignant hypertensionwere not present at presentation but developed later inthe course of the illness, fundoscopy became a veryuseful tool in the diagnosis of HE. Nowadays bilateralretinal haemorrhages and/or exudates are also includedin the definition of malignant hypertension becausefurther research has indicated that survival rates ofpatients with haemorrhages and/or exudates with orwithout additional papilloedema were equal [4,5].The presence of severe acute end-organ damage decideswhether a patient needs a carefully controlledimmediate reduction of BP [6]. In this report wedescribe three patients who suffered from HE, yet inwhom the classical retinal signs of malignant hyper-tensionwerelacking.ThediagnosisHEcould,however,be confirmed quickly by the use of recently developedtechniques in cerebral imaging.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db4c8e10e1005e4aec6447ede26db9cTest
https://pubmed.ncbi.nlm.nih.gov/14551378Test