المؤلفون: Diray-Arce, Joann, Fourati, Slim, Jayavelu, Naresh Doni, Patel, Ravi, Maguire, Cole, Chang, Ana C, Dandekar, Ravi, Qi, Jingjing, Lee, Brian H, van Zalm, Patrick, Schroeder, Andrew, Chen, Ernie, Konstorum, Anna, Brito, Anderson, Gygi, Jeremy P, Kho, Alvin, Chen, Jing, Pawar, Shrikant, Gonzalez-Reiche, Ana Silvia, Hoch, Annmarie, Milliren, Carly E, Overton, James A, Westendorf, Kerstin, Network, IMPACC, Abraham, James, Adkisson, Michael, Albert, Marisa, Torres, Luz Altamirano, Alvarenga, Bonny, Anderson, Matthew L, Anderson, Evan J, Arnett, Azlann, Asashima, Hiromitsu, Atkinson, Mark A, Baden, Lindsey R, Barton, Brenda, Beach, Katherine, Beagle, Elizabeth, Becker, Patrice M, Bell, Matthew R, Bernui, Mariana, Bime, Chris, Kumar, Arun Boddapati, Booth, Leland J, Borresen, Brittney, Brakenridge, Scott C, Bristow, Laurel, Bryant, Robert, Calfee, Carolyn S, Manuel, Juan Carreño, Carrillo, Sidney, Chak, Suzanna, Chang, Iris, Connors, Jennifer, Conway, Michelle, Corry, David B, Cowan, David, Croen, Brett, Dela Cruz, Charles S, Cusimano, Gina, Eaker, Lily, Edwards, Carolyn, Ehrlich, Lauren IR, Elashoff, David, Erickson, Heidi, Erle, David J, Farhadian, Shelli, Farrugia, Keith, Fatou, Benoit, Fernandes, Andrea, Fernandez-Sesma, Ana, Fragiadakis, Gabriela K, Furukawa, Sara, Geltman, Janelle N, Ghale, Rajani, Bermúdez, Maria González Carolina, Goonewardene, Michael I, Sanchez, Estella Guerrero, Guirgis, Faheem W, Hafler, David A, Hamilton, Sydney, Harris, Paul, Nemati, Arash Hayati, Hendrickson, Carolyn M, Agudelo, Nelson I Higuita, Hodder, Thomas, Holland, Steven M, Hough, Catherine L, Huerta, Christopher, Hurley, Kerin C, Hutton, Scott R, Iwasaki, Akiko, Jauregui, Alejandra, Jha, Meenakshi, Johnson, Brandi, Joyner, David, Kangelaris, Kirsten N, Kelly, Geoffrey, Khalil, Zain, Khan, Zenab

المصدر: Cell Reports Medicine. 4(6)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Prevention, Rare Diseases, Clinical Research, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Humans, COVID-19, SARS-CoV-2, Longitudinal Studies, Multiomics, Disease Progression, IMPACC Network, immunophenotyping, longitudinal modeling, multi-omics, systems immunology, Biomedical and clinical sciences

الوصف: The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 longitudinal blood and nasal samples from 540 participants of the IMPACC cohort, using 14 distinct assays. These unbiased analyses identify cellular and molecular signatures present within 72 h of hospital admission that distinguish moderate from severe and fatal COVID-19 disease. Importantly, cellular and molecular states also distinguish participants with more severe disease that recover or stabilize within 28 days from those that progress to fatal outcomes (TG4 vs. TG5). Furthermore, our longitudinal design reveals that these biologic states display distinct temporal patterns associated with clinical outcomes. Characterizing host immune responses in relation to heterogeneity in disease course may inform clinical prognosis and opportunities for intervention.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6m67c638Test

المؤلفون: Georas, Steve N, Wright, Rosalind J, Ivanova, Anastasia, Israel, Elliot, LaVange, Lisa M, Akuthota, Praveen, Carr, Tara F, Denlinger, Loren C, Fajt, Merritt L, Kumar, Rajesh, O’Neal, Wanda K, Phipatanakul, Wanda, Szefler, Stanley J, Aronica, Mark A, Bacharier, Leonard B, Burbank, Allison J, Castro, Mario, Alexander, Laura Crotty, Bamdad, Julie, Cardet, Juan Carlos, Comhair, Suzy AA, Covar, Ronina A, DiMango, Emily A, Erwin, Kim, Erzurum, Serpil C, Fahy, John V, Gaffin, Jonathan M, Gaston, Benjamin, Gerald, Lynn B, Hoffman, Eric A, Holguin, Fernando, Jackson, Daniel J, James, John, Jarjour, Nizar N, Kenyon, Nicholas J, Khatri, Sumita, Kirwan, John P, Kraft, Monica, Krishnan, Jerry A, Liu, Andrew H, Liu, Mark C, Marquis, M Alison, Martinez, Fernando, Mey, Jacob, Moore, Wendy C, Moy, James N, Ortega, Victor E, Peden, David B, Pennington, Emily, Peters, Michael C, Ross, Kristie, Sanchez, Maria, Smith, Lewis J, Sorkness, Ronald L, Wechsler, Michael E, Wenzel, Sally E, White, Steven R, Zein, Joe, Zeki, Amir A, Noel, Patricia, Billheimer, Dean, Bleecker, Eugene R, Branch, Emily, Conway, Michelle, Daines, Cori, Deaton, Isaac, Evans, Alexandria, Field, Paige, Francisco, Dave, Hastie, Annette T, Hmieleski, Bob, Krings, Jeffrey O, Liu, Yanqin, Merchen, Janell L, Meyers, Deborah A, Narendran, Nirushan, Peters, Stephen P, Pippins, Anna, Rank, Matthew A, Schunk, Ronald, Skeps, Raymond, Wright, Benjamin, Banzon, Tina M, Bartnikas, Lisa M, Baxi, Sachin N, Betapudi, Vishwanath, Brick, Isabelle, Brockway, Conor, Casale, Thomas B, Castillo-Ruano, Kathleen, Cinelli, Maria Angeles, Crestani, Elena, Cunningham, Amparito, Day-Lewis, Megan, Diaz-Cabrera, Natalie, DiMango, Angela, Esty, Brittany, Fandozzi, Eva, Fernandez, Jesse, Fitzpatrick, Elizabeth

المصدر: Journal of Allergy and Clinical Immunology. 149(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Research, Clinical Trials and Supportive Activities, Asthma, Respiratory, Good Health and Well Being, Advisory Committees, Biomarkers, Clinical Protocols, Clinical Trials, Phase II as Topic, Humans, Precision Medicine, Research Design, Severity of Illness Index, Tomography, X-Ray Computed, Severe asthma, precision medicine, adaptive clinical trial design, asthma exacerbation, type 2 asthma, non-type 2 asthma, patient advisory committee, biomarker, PrecISE Study Team, non–type 2 asthma, Immunology, Allergy

الوصف: Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network, a groundbreaking collaborative effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4n8620m5Test

المؤلفون: Conway, Michelle R., Marshall, Mallory R. (ORCID 0000-0003-4219-4563), Schlaff, Rebecca A., Talge, Nicole M., Pfeiffer, Karin A., Pivarnik, James M.

المصدر: Measurement in Physical Education and Exercise Science. 2020 24(4):264-272.

تمت مراجعته من قبل الزملاء: Y

Page Count: 9

الواصفات: Test Validity, Questionnaires, Pregnancy, Physical Activity Level, Recall (Psychology), Mothers, Long Term Memory, Physical Activities

مستخلص: To evaluate the validity of the Pregnancy Physical Activity (PA) Questionnaire (PPAQ) for long-term PA recall. Forty-eight women completed the PPAQ at 21, 32 weeks gestation, and 12 weeks postpartum. These women were emailed three separate PPAQs between two months and eight years after originally completing the questionnaires to recall their PA during those same time periods. Total number of metabolic (MET) minutes per week (MET-min*wk[superscript -1]) and percent time spent in light (%L), moderate (%M), and vigorous (%V) activity were compared between the original and long-term recall PPAQ values. Total MET-min*wk[superscript -1] and %M were significantly underestimated by 3000-4000 MET-min*wk[superscript -1] and 6%, respectively, and %L was overestimated by 4-6% (p < 0.05). Women reported spending little time in vigorous intensity activity (2-4%). Spearman correlations were lower for women who recalled PA [greater than or equal to] five years postpartum compared to women who recalled their PA 0.05).

Abstractor: As Provided

المؤلفون: Francisco, Dave, Wang, Ying, Marshall, Craig, Conway, Michelle, Addison, Kenneth J., Billheimer, Dean, Kimura, Hiroki, Numata, Mari, Chu, Hong W., Voelker, Dennis R., Kraft, Monica, Ledford, Julie G.

المساهمون: National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, Arizona Biomedical Research Commission

المصدر: Frontiers in Immunology ; volume 13 ; ISSN 1664-3224

مصطلحات موضوعية: Immunology, Immunology and Allergy

الوصف: Surfactant Protein-A (SP-A) is an innate immune modulator that regulates a variety of pulmonary host defense functions. We have shown that SP-A is dysfunctional in asthma, which could be partly due to genetic heterogeneity. In mouse models and primary bronchial epithelial cells from asthmatic participants, we evaluated the functional significance of a particular single nucleotide polymorphism of SP-A2, which results in an amino acid substitution at position 223 from glutamine (Q) to lysine (K) within the carbohydrate recognition domain (CRD). We found that SP-A 223Q humanized mice had greater protection from inflammation and mucin production after IL-13 exposure as compared to SP-A-2 223K mice. Likewise, asthmatic participants with two copies the major 223Q allele demonstrated better lung function and asthma control as compared to asthmatic participants with two copies of the minor SP-A 223K allele. In primary bronchial epithelial cells from asthmatic participants, full-length recombinant SP-A 223Q was more effective at reducing IL-13-induced MUC5AC gene expression compared to SP-A 223K. Given this activity, we developed 10 and 20 amino acid peptides of SP-A2 spanning position 223Q. We show that the SP-A 223Q peptides reduce eosinophilic inflammation, mucin production and airways hyperresponsiveness in a house dust mite model of asthma, protect from lung function decline during an IL-13 challenge model in mice, and decrease IL-13-induced MUC5AC gene expression in primary airway epithelial cells from asthmatic participants. These results suggest that position 223 within the CRD of SP-A2 may modulate several outcomes relevant to asthma, and that short peptides of SP-A2 retain anti-inflammatory properties similar to that of the endogenous protein.

الإتاحة: https://doi.org/10.3389/fimmu.2022.900022Test

المؤلفون: Pivniouk, Vadim, Pivniouk, Oksana, DeVries, Avery, Uhrlaub, Jennifer L., Michael, Ashley, Pivniouk, Denis, VanLinden, Sydney R., Conway, Michelle Y., Hahn, Seongmin, Malone, Sean P., Ezeh, Peace, Churko, Jared M., Anderson, Dayna, Kraft, Monica, Nikolich-Zugich, Janko, Vercelli, Donata

المساهمون: NIH

المصدر: Journal of Allergy and Clinical Immunology ; volume 149, issue 3, page 923-933.e6 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2021.11.019Test
https://api.elsevier.com/content/article/PII:S0091674921025811?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674921025811?httpAccept=text/plainTest

المؤلفون: Rhodes-Conway, Michelle. Autor

المساهمون: Galloway, Fhiona., Goreń, Michał., Dressler Dublin. Wydawca pbl

الوصول الحر: http://katalog.nukat.edu.pl/lib/item?id=chamo:5104668&theme=nukatTest

المؤلفون: Kimura, Hiroki, Francisco, Dave, Conway, Michelle, Martinez, Fernando D., Vercelli, Donata, Polverino, Francesca, Billheimer, Dean, Kraft, Monica

المساهمون: Arizona Department of Health Services, MSD Life Science Foundation, Public Interest Incorporated Foundation, National Institutes of Health

المصدر: Journal of Allergy and Clinical Immunology ; volume 146, issue 1, page 80-88.e8 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2020.05.004Test
https://api.elsevier.com/content/article/PII:S0091674920306473?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674920306473?httpAccept=text/plainTest

المؤلفون: CONWAY, MICHELLE R., MARSHALL, MALLORY R., SCHLAFF, REBECCA A., PFEIFFER, KARIN A., PIVARNIK, JAMES M.

المصدر: Medicine & Science in Sports & Exercise ; volume 50, issue 3, page 617-623 ; ISSN 0195-9131

الإتاحة: https://doi.org/10.1249/mss.0000000000001469Test
https://journals.lww.com/00005768-201803000-00027Test

المؤلفون: Tawil Bill, Vega Huerta Salvador, Garcia Victor, Adriatico Aileen, Conway Michelle

المصدر: Acta Scientific Medical Sciences. 4:46-59

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Chemistry, Internal medicine, General Engineering, medicine, Cyanocobalamin, Vitamin B12, Vitamin b6, Pyridoxine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e3ebebc02f004a07d779a8980c7d5641Test
https://doi.org/10.31080/asms.2020.04.0716Test

المؤلفون: Marshall, Mallory R., Montoye, Alexander H. K., Conway, Michelle R., Schlaff, Rebecca A., Pfeiffer, Karin A., Pivarnik, James M.

المصدر: American Journal of Lifestyle Medicine; Jan2023, Vol. 17 Issue 1, p123-130, 8p

مصطلحات موضوعية: LEISURE, EVALUATION of medical care, STATISTICAL significance, STATISTICS, ANALYSIS of variance, GAIT in humans, ACCELEROMETERS, ACTIGRAPHY, PHYSICAL activity, PUERPERIUM, WALKING, EXERCISE intensity, DATA analysis, DATA analysis software, ALGORITHMS

مستخلص: As pregnancy progresses, physical changes may affect physical activity (PA) measurement validity. n = 11 pregnant women (30.1 ± 3.8 years) wore ActiGraph GT3X+ accelerometers on the right hip, right ankle, and non-dominant wrist for 3–7 days during the second and third trimesters (21 and 32 weeks, respectively) and 12 weeks postpartum. Data were downloaded into 60-second epochs from which stepping cadence was calculated; repeated-measures analysis of variance was used to determine significant differences among placements. At all time points, the wrist accelerometer measured significantly more daily steps (9930–10 452 steps/d) and faster average stepping cadence (14.5–14.6 steps/min) than either the hip (4972–5944 steps/d, 7.1–8.6 steps/min) or ankle (7161–8205 steps/d, 10.3–11.9 steps/min) placement, while moderate- to vigorous-intensity activity at the wrist (1.2–1.7 min/d) was significantly less than either hip (3.0–5.9 min/d) or ankle (6.1–7.3 min/d). Steps, cadence, and counts were significantly lower for the hip than the ankle at all time points. Kappa calculated for agreement in intensity classification between the various pairwise comparisons ranged from.06 to.41, with Kappa for hip–ankle agreement (.34–.41) significantly higher than for wrist–ankle (.09–.11) or wrist–hip (.06–.16). These data indicate that wrist accelerometer placement during pregnancy likely results in over counting of PA parameters and should be used with caution. [ABSTRACT FROM AUTHOR]

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