المؤلفون: Bi, Qingqing C., Collins, Jamie

المصدر: Journal of the Royal Society of New Zealand, Oct 2022; v.52 n.5:p.526-538

الوصول الحر: http://www.tandfonline.com/doi/pdf/10.1080/03036758.2021.1999993Test

المؤلفون: Roemer, Frank W., Guermazi, Ali, Collins, Jamie E., Losina, Elena, Nevitt, Michael C., Lynch, John A., Katz, Jeffrey N., Kwoh, C. Kent, Kraus, Virginia B., Hunter, David J.

مرشدي الرسالة: Univ Arizona, Coll Med, Arthrit Ctr, Univ Arizona, Coll Med, Div Rheumatol

مصطلحات موضوعية: Osteoarthritis, MRI, Progression, Scoring, Biomarkers

الوصف: Background: To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study. Methods: We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time. Results: Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively). Conclusions: A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.

العلاقة: http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-1310-6Test

الإتاحة: http://hdl.handle.net/10150/623126Test
http://arizona.openrepository.com/arizona/handle/10150/623126Test

المؤلفون: Collins, Jamie D.

مرشدي الرسالة: Hitt, Michael A.

مصطلحات موضوعية: social capital, undesirable firm behavior, legal action, lawsuit, joint venture, board of directors

الوصف: Social capital resources for the firm can be conceptualized as those executive-to-executive connections held by a firm’s top management team, as well as firm-to-firm relationships that exist fairly independently of particular individuals. This type of resource can compose an important portion of any firm’s overall resource portfolio. The potential benefits associated with social capital include enhanced economic exchange opportunities, improved innovation capabilities and increased firm survival rates, among others. This study adds to the literature stream focusing on the positive consequences of social capital by demonstrating the cross-level influence of social capital on the development of reciprocity within a joint venture network. It also highlights the link between social capital resources and the quality of knowledge available to a firm via its joint venture partnerships. More importantly, though, we specifically investigate the conditions under which a firm’s social capital (firm-to-firm relationships or the social capital held by key executives) can contribute to undesirable firm-level behaviors. One often mentioned, yet rarely explored dimension of social capital is the phenomenon frequently called the ‘dark side’ of social capital. This dark side of social capital is argued to exist whenever the behavioral expectations accompanying social capital limit contribute to undesirable outcomes for the firm. Several hypotheses are tested in the context of joint ventures among S&P 500 firms. The likelihood of a firm having legal action taken against it by federal regulatory agencies or other firms is demonstrated herein to be related to the number and strength of social capital relationships. In general this research supports the view that having a large number of weak ties is beneficial for firms. More specifically, we found that in the wake of the passage of the Sarbanes-Oxley Act of 2002, an inverse relationship exists between the likelihood of firms engaging in the undesirable behaviors investigated and the number of Boards of Directors on which the firms’ respective executives held seats. Conversely, firms were more likely to engage in these undesirable behaviors whenever the firm-to-firm ties within their network of joint ventures were strongest. Furthermore, executive discretion was highly related to the likelihood of firms engaging in undesirable behaviors.

وصف الملف: electronic; application/pdf; born digital

الإتاحة: http://hdl.handle.net/1969.1/ETD-TAMU-1163Test

المؤلفون: Collins, Jamie Lynne

مرشدي الرسالة: Everett, Mark

مصطلحات موضوعية: electromagnetics, anisotropy, schist

الوصف: Controlled-source, azimuthal, time-domain, electromagnetic (TDEM) surveys were conducted over a schist formation with uniformly striking, nearly vertical foliation. Direct current electrical resistivity and seismic refraction surveys provided additional independent assessment of the field site. Quantitative interpretation of the TDEM survey used a theoretical electromagnetic model of a vertical transverse anisotropic conducting half-space. The combination of forward modeling and azimuthal acquisition geometry provides an innovative geophysical technique useful for mapping poorly exposed metamorphic terrains, and possibly determining fracture system orientations and assessing anisotropic hydraulic conductivity. Metamorphic rocks may exhibit transverse electrical anisotropy detectable by time-domain electromagnetics due to the characteristics of foliated rocks. For this reason, the field site was chosen within the Packsaddle Schist exposed in Mason County, Texas. Foliation of the Packsaddle Schist at the survey site strikes 146? and dips 82? NE. Polar plots of early-time, TDEM voltages, measured at large transmitter-receiver separations (> 40m) exhibit a symmetric two-lobed curve that agrees with theoretical model responses calculated for a vertical transverse anisotropic half space. The long axis of the symmetric two lobe response function is oriented 137?, which is nearly parallel to schist foliation of 146?. A best-fit forward model to the data indicates the electrical conductivity parallel and perpendicular to foliation are 0.015 S/m and 0.0012 S/m, respectively. Small transmitter-receiver separations (< 40m) exhibit azimuthal responses typical of an isotropic half space, which indicates the presence of a layer overlying the schist probably produced by weathering. An additional independent azimuthal Wenner resistivity survey exhibits apparent resistivity in the form of an ellipse with the major axis (direction of maximum conductivity) oriented 149?, which is nearly parallel to schist foliation of 146?. Analysis of data indicates the apparent electrical conductivity parallel and perpendicular to foliation are 0.0163 S/m and 0.0094 S/m, respectively. Results of TDEM and direct current resistivity closely match in both orientation and electrical conductivity values. Preliminary seismic refraction data were compatible with the TDEM data and also indicated anisotropy, but were not as conclusive.

وصف الملف: 1497597 bytes; 121138 bytes; electronic; application/pdf; text/plain; born digital

الإتاحة: http://hdl.handle.net/1969.1/1070Test

المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Katz, Jeffrey N, Nevitt, Michael C, Lynch, John A, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Arthritis Care & Research. 74(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biomedical Imaging, Pain Research, Arthritis, Aging, Chronic Pain, Clinical Research, Musculoskeletal, Biomarkers, Cartilage, Articular, Disease Progression, Humans, Knee Joint, Magnetic Resonance Imaging, National Institutes of Health (U.S.), Osteoarthritis, Knee, Synovitis, United States, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science

الوصف: ObjectiveTo determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression.MethodsThe present study was a nested case-control trial from the Foundation of the National Institutes of Health OA Biomarkers Consortium that assessed study participants with a Kellgren/Lawrence grade of 1-3 who had complete biomarker data available (n = 539 to 550). Cases were participants' knees that had radiographic and pain progression between 24 and 48 months compared to baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) that had a P value of

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/64n63926Test

المؤلفون: Yu, Shirley P., Deveza, Leticia A., Kraus, Virginia B., Karsdal, Morten, Bay-Jensen, Anne-Christine, Collins, Jamie E., Guermazi, Ali, Roemer, Frank W., Ladel, Christoph, Bhagavath, Venkatesha, Hunter, David J.

المساهمون: University of Sydney, Foundation for the National Institutes of Health, National Institutes of Health, Else Kröner-Fresenius-Stiftung, Nordic Bioscience, National Health and Medical Research Council

المصدر: Arthritis Research & Therapy ; volume 26, issue 1 ; ISSN 1478-6362

الوصف: Background To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemical markers involved with tissue turnover and inflammation and BMLs on MRI. Methods Data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative ( n = 600) was analyzed. BMLs were measured according to the MRI Osteoarthritis Knee Score (MOAKS) system (0–3), in 15 knee subregions. Serum and urinary biochemical markers assessed were as follows: serum C-terminal crosslinked telopeptide of type I collagen (CTX-I), serum crosslinked N-telopeptide of type I collagen (NTX-I), urinary CTX-Iα and CTX-Iβ, urinary NTX-I, urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II), serum matrix metalloproteinase (MMP)-degraded type I, II, and III collagen (C1M, C2M, C3M), serum high sensitivity propeptide of type IIb collagen (hsPRO-C2), and matrix metalloproteinase-generated neoepitope of C-reactive protein (CRPM). The association between change in biochemical markers over 12 months and BMLs over 24 months was examined using regression models adjusted for covariates. The relationship between C1M, C2M, C3M, hsPRO-C2, and CRPM and BMLs at baseline and over 24 months was examined. Results Increases in serum CTX-I and urinary CTX-Iβ over 12 months were associated with increased odds of changes in the number of subregions affected by any BML at 24 months. Increase in hsPRO-C2 was associated with decreased odds of worsening in the number of subregions affected by any BML over 24 months. C1M and C3M were associated with BMLs affected at baseline. Conclusions Short-term changes in serum CTX-I, hsPRO-C2, and urinary CTX-Iβ hold the potential to be prognostic of BML progression on MRI. The association of C1M and C3M with baseline BMLs on MRI warrants further investigation.

الإتاحة: https://doi.org/10.1186/s13075-023-03253-xTest

المؤلفون: Collins, Jamie E., Roemer, Frank W., Guermazi, Ali

المساهمون: NIH

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 2, page 100465 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2024.100465Test
https://api.elsevier.com/content/article/PII:S2665913124000323?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913124000323?httpAccept=text/plainTest

المؤلفون: Warner, Tyler, Lowenstein, Natalie, Mazzocca, Jillian, Collins, Jamie, Matzkin, Elizabeth

المصدر: Arthroscopy, Sports Medicine, and Rehabilitation ; page 100926 ; ISSN 2666-061X

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Rehabilitation, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine

الإتاحة: https://doi.org/10.1016/j.asmr.2024.100926Test
https://api.elsevier.com/content/article/PII:S2666061X24000440?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666061X24000440?httpAccept=text/plainTest

المؤلفون: Jarraya, Mohamed, Bitoun, Olivier, Wu, Dufan, Balza, Rene, Guermazi, Ali, Collins, Jamie, Gupta, Rajiv, Nielsen, Gunnlaugur Petur, Guermazi, Elias, Simeone, F. Joseph, Omoumi, Patrick, Melnic, Christopher M., Yee, Seonghwan

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 1, page 100436 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2024.100436Test
https://api.elsevier.com/content/article/PII:S2665913124000037?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913124000037?httpAccept=text/plainTest

المؤلفون: Cheema, Haadiya, Brophy, Robert, Collins, Jamie, Cox, Charles L., Guermazi, Ali, Kumara, Mahima, Levy, Bruce A., MacFarlane, Lindsey, Mandl, Lisa A., Marx, Robert, Selzer, Faith, Spindler, Kurt, Katz, Jeffrey N., Murray, Eleanor J.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Osteoarthritis and Cartilage ; volume 32, issue 3, page 319-328 ; ISSN 1063-4584

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biomedical Engineering, Rheumatology

الإتاحة: https://doi.org/10.1016/j.joca.2023.10.007Test
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/plainTest