المؤلفون: Floridia M., Masuelli G., Ravizza M., Tassis B., Cetin I., Sansone M., Antoni A. D., Simonazzi G., Maccabruni A., Francisci D., Frisina V., Liuzzi G., Dalzero S., Tamburrini E., Di Lorenzo F., Sterrantino G., Meli M., Campolmi I., Vichi F., Del Pin B., Marocco R., Mastroianni C., S. Mercurio V., Zanaboni D., Guaraldi G., Nardini G., Stentarelli C., Beghetto B., Antoni A. M. D., Molinari A., Crisalli M. P., Donisi A., Piepoli M., Cerri V., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Placido G., Milini P., Savalli F., Portelli V., Sabbatini F., Papalini C., Bernini L., Grossi P., Rizzi L., Bernardon M., Maso G., Rizzante E., Belcaro C., Meloni A., Dedoni M., Ortu F., Piano P., Citernesi A., BordoniVicini I., Luzi K., Spinillo A., Roccio M., Vimercati A., Crupano F. M., Calabretti D., Cervi F., Margarito E., Capretti M. G., Marsico C., Faldella G., Martinelli P., Agangi A., Capone A., Maruotti G. M., Tibaldi C., Trentini L., Todros T., Brambilla T., Savasi V., Personeni C., Giaquinto C., Fiscon M., Rubino E., Franceschetti L., Badolato R., Tiso G. C., Genovese O., Cafforio C., Pinnetti C., Casadei A. M., Cavaliere A. F., Cellini M., Marconi A. M., Sacchi V., Ierardi M., Polizzi C., Mattei A., Pirillo M. F., Amici R., Galluzzo C. M., Donnini S., Baroncelli S., Villani P., Cusato M., Cerioli A., De Martino M., Parazzini F., Vella S.

المساهمون: Floridia, M., Masuelli, G., Ravizza, M., Tassis, B., Cetin, I., Sansone, M., Antoni, A. D., Simonazzi, G., Maccabruni, A., Francisci, D., Frisina, V., Liuzzi, G., Dalzero, S., Tamburrini, E., Di Lorenzo, F., Sterrantino, G., Meli, M., Campolmi, I., Vichi, F., Del Pin, B., Marocco, R., Mastroianni, C., S. Mercurio, V., Zanaboni, D., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Antoni, A. M. D., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Milini, P., Savalli, F., Portelli, V., Sabbatini, F., Papalini, C., Bernini, L., Grossi, P., Rizzi, L., Bernardon, M., Maso, G., Rizzante, E., Belcaro, C., Meloni, A., Dedoni, M., Ortu, F., Piano, P., Citernesi, A., Bordonivicini, I., Luzi, K., Spinillo, A., Roccio, M., Vimercati, A., Crupano, F. M., Calabretti, D., Cervi, F., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Franceschetti, L., Badolato, R., Tiso, G. C., Genovese, O., Cafforio, C., Pinnetti, C., Casadei, A. M., Cavaliere, A. F., Cellini, M., Marconi, A. M., Sacchi, V., Ierardi, M., Polizzi, C., Mattei, A., Pirillo, M. F., Amici, R., Galluzzo, C. M., Donnini, S.

الوصف: Background: Atazanavir and darunavir represent the main HIV PIs recommended in pregnancy, but comparativedata in pregnant women are limited.We assessed the safety and activity profile of these two drugs in pregnancyusing data from a national observational study.Methods: Women with atazanavir or darunavir exposure in pregnancy were evaluated for laboratory measuresand main pregnancy outcomes (e.g. preterm delivery, low birthweight, non-elective caesarean section and neonatalgestational age-adjusted birthweight Z-score).Results: Final analysis included 500 pregnancies with either atazanavir (n"409) or darunavir (n"91) exposure.No differences in pregnancy outcomes, weight gain in pregnancy, drug discontinuations, undetectable HIV-RNA,haemoglobin, ALT, total cholesterol, HDL cholesterol and LDL cholesterol were observed between the twogroups. At third trimester, exposure to darunavir was associated with higher levels of plasma triglycerides(median 235.5 versus 179 mg/dL; P"0.032) and a higher total cholesterol/HDL cholesterol ratio (median 4.03versus 3.27; P"0.028) and exposure to atazanavir was associated with higher levels of plasma bilirubin (1.54versus 0.32 mg/dL; P<0.001).Conclusions: In this observational study, the two main HIV PIs currently recommended by perinatal guidelinesshowed similar safety and activity in pregnancy, with no evidence of differences between the two drugs in termsof main pregnancy outcomes. Based on the minor differences observed in laboratory measures, prescribingphysicians might prefer either drug in some particular situations where the different impacts of treatment onlipid profile and bilirubin may have clinical relevance.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29244115; info:eu-repo/semantics/altIdentifier/wos/WOS:000429019600026; volume:73; issue:4; firstpage:1025; lastpage:1030; numberofpages:6; journal:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY; http://hdl.handle.net/11380/1221117Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85044864905

الإتاحة: https://doi.org/10.1093/jac/dkx478Test
http://hdl.handle.net/11380/1221117Test

المؤلفون: Floridia, M., Masuelli, G., Meloni, A., Cetin, I., Tamburrini, E., Cavaliere, A. F., Dalzero, S., Sansone, M., Alberico, S., Guerra, B., Spinillo, A., Chiadò Fiorio Tin, M., Ravizza, M., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Maso, G., Airoud, M., Soppelsa, G., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Frisina, V., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R., Scaravelli, G., Genovese, O., Cafforio, C., Pinnetti, C., Liuzzi, G., Tozzi, V., Massetti, P., Casadei, A. M., Cellini, M., Castelli Gattinara, G., Marconi, A. M., Sacchi, V., Ierardi, M., Polizzi, C., Mattei, A., Pirillo, M. F., Amici, R., Galluzzo, C. M., Donnini, S., Baroncelli, S., Villani, P., Cusato, M., Cerioli, A., De Martino, M., Mastroiacovo, P., Parazzini, F., Vella, S.

المساهمون: Floridia, M., Masuelli, G., Meloni, A., Cetin, I., Tamburrini, E., Cavaliere, A. F., Dalzero, S., Sansone, M., Alberico, S., Guerra, B., Spinillo, A., Chiadò Fiorio Tin, M., Ravizza, M., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Maso, G., Airoud, M., Soppelsa, G., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Frisina, V., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R.

مصطلحات موضوعية: Amniocentesi, birth defect, chorionic villus sampling, HIV, invasive testing, mother-to child HIV transmission, pregnancy, prenatal diagnosi, Obstetrics and Gynecology

الوصف: Objectives To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures. Design Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used. Setting University and hospital clinics. Population Pregnant women with HIV. Methods Temporal trends were analysed by analysis of variance and by the Chi-square test for trend. Quantitative variables were compared by Student’s t-test and categorical data by the Chisquare test, with odds ratios and 95% confidence intervals calculated. Main outcome measures Rate of invasive testing, intrauterine death, HIV transmission.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27319948; info:eu-repo/semantics/altIdentifier/wos/WOS:000403938600021; volume:124; issue:8; firstpage:1218; lastpage:1223; numberofpages:6; journal:BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY; http://hdl.handle.net/11573/1092177Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84994115496; http://onlinelibrary.wiley.com/journal/10.1111Test/(ISSN)1471-0528

الإتاحة: https://doi.org/10.1111/1471-0528.14183Test
http://hdl.handle.net/11573/1092177Test

المؤلفون: Floridia, M, Masuelli, G., Tamburrini, E., Cetin, I., Liuzzi, G., Martinelli, P., Guaraldi, G., Spinillo, A., VIMERCATI, antonella, Maso, G., Pinnetti, C., Frisina, V., Dalzero, S., Ravizza, M., Di Lorenzo, F., Sterrantino, G., Meli, M., Campolmi, I., Vichi, F., Del Pin, B., Marocco, R., Mastroianni, C., Mercurio, V. S., Maccabruni, A., Zaramella, M., Mariani, B., Nardini, G., Stentarelli, C., Beghetto, B., Antoni, A. M. Degli, Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Milini, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Angeli, G., Bernini, L., Grossi, P., Rizzi, L., Bernardon, M., Rizzante, E., Belcaro, C., Meloni, A., Dedoni, M., Ortu, F., Piano, P., Citernesi, A., Vicini, I. Bordoni, Luzi, K., Roccio, M., MICCOLIS, ANGELICA, DE GENNARO, ALESSANDRA CATERINA, Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Franceschetti, L., Tassis, B., Genovese, O., Cafforio, C., Casadei, A. M., Cavaliere, A. F., Cellini, M., Marconi, A. M., Sacchi, V., Ierardi, M., Polizzi, C., Mattei, A., Pirillo, M. F., Amici, R., Galluzzo, C. M., Donnini, S., Baroncelli, S., Cerioli, A., De Martino, M., Parazzini, F., Vella, S.

المساهمون: Floridia, M, Masuelli, G., Tamburrini, E., Cetin, I., Liuzzi, G., Martinelli, P., Guaraldi, G., Spinillo, A., Vimercati, Antonella, Maso, G., Pinnetti, C., Frisina, V., Dalzero, S., Ravizza, M., Di Lorenzo, F., Sterrantino, G., Meli, M., Campolmi, I., Vichi, F., Del Pin, B., Marocco, R., Mastroianni, C., Mercurio, V. S., Maccabruni, A., Zaramella, M., Mariani, B., Nardini, G., Stentarelli, C., Beghetto, B., Antoni, A. M. Degli, Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Milini, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Angeli, G., Bernini, L., Grossi, P., Rizzi, L., Bernardon, M., Rizzante, E., Belcaro, C., Meloni, A., Dedoni, M., Ortu, F., Piano, P., Citernesi, A., Vicini, I. Bordoni, Luzi, K., Roccio, M., Miccolis, Angelica, DE GENNARO, ALESSANDRA CATERINA, Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Franceschetti, L., Tassis, B., Genovese, O., Cafforio, C., Casadei, A. M., Cavaliere, A. F., Cellini, M., Marconi, A. M., Sacchi, V., Ierardi, M., Polizzi, C., Mattei, A., Pirillo, M. F., Amici, R., Galluzzo, C. M., Donnini, S., Baroncelli, S.

مصطلحات موضوعية: Antiretroviral treatment, HIV diagnosi, HIV testing, pregnancy, women's health, Adolescent, Cohort Studie, Female, HIV Infection, Human, Italy, Odds Ratio, Young Adult, Epidemiology, Infectious Diseases

الوصف: Young pregnant women with HIV may be at significant risk of unplanned pregnancy, lower treatment coverage, and other adverse pregnancy outcomes. In a large cohort of pregnant women with HIV in Italy, among 2979 pregnancies followed in 2001-2016, 9.0% were in women <25 years, with a significant increase over time (2001-2005: 7.0%; 2006-2010: 9.1%; 2011-2016: 12.2%, P < 0.001). Younger women had a lower rate of planned pregnancy (23.2% vs. 37.7%, odds ratio (OR) 0.50, 95% confidence interval (CI) 0.36-0.69), were more frequently diagnosed with HIV in pregnancy (46.5% vs. 20.9%, OR 3.29, 95% CI 2.54-4.25), and, if already diagnosed with HIV before pregnancy, were less frequently on antiretroviral treatment at conception (<25 years: 56.3%; ≥25 years: 69.0%, OR 0.58, 95% CI 0.41-0.81). During pregnancy, treatment coverage was almost universal in both age groups (98.5% vs. 99.3%), with no differences in rate of HIV viral suppression at third trimester and adverse pregnancy outcomes. The data show that young women represent a growing proportion of pregnant women with HIV, and are significantly more likely to have unplanned pregnancy, undiagnosed HIV infection, and lower treatment coverage at conception. During pregnancy, antiretroviral treatment, HIV suppression, and pregnancy outcomes are similar compared with older women. Earlier intervention strategies may provide additional benefits in the quality of care for women with HIV.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28712385; info:eu-repo/semantics/altIdentifier/wos/WOS:000409124100021; volume:145; issue:11; firstpage:2360; lastpage:2365; numberofpages:6; journal:EPIDEMIOLOGY AND INFECTION; http://hdl.handle.net/11586/199453Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85026872682; http://journals.cambridge.org/action/displayJournal?jid=HYGTest

الإتاحة: https://doi.org/10.1017/S0950268817001340Test
http://hdl.handle.net/11586/199453Test
http://journals.cambridge.org/action/displayJournal?jid=HYGTest

المؤلفون: Floridia M., Tamburrini E., Masuelli G., Martinelli P., Spinillo A., Liuzzi G., Vimercati A., Alberico S., Maccabruni A., Pinnetti C., Frisina V., Dalzero S., Ravizza M., Mori F., Ortolani P., dalle Nogare E. R., Di Lorenzo F., Sterrantino G., Meli M., Polemi S., Nocentini J., Baldini M., Montorzi G., Mazzetti M., Rogasi P., Borchi B., Vichi F., Del Pin B., Pinter E., Anzalone E., Marocco R., Mastroianni C., Mercurio V. S., Carocci A., Grilli E., Zaramella M., Mariani B., Natalini Raponi G., Guaraldi G., Nardini G., Stentarelli C., Beghetto B., Degli Antoni A. M., Molinari A., Crisalli M. P., Donisi A., Piepoli M., Cerri V., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Placido G., Vivarelli A., Castelli P., Savalli F., Portelli V., Sabbatini F., Francisci D., Bernini L., Grossi P., Rizzi L., Maso G., Airoud M., Soppelsa G., Meloni A., Dedoni M., Cuboni C., Ortu F., Piano P., Citernesi A., Bordoni Vicini I., Luzi K., Roccio M., Miccolis A., De Gennaro A., Guerra B., Cervi F., Simonazzi G., Margarito E., Capretti M. G., Marsico C., Faldella G., Sansone M., Agangi A., Capone A., Maruotti M., Tibaldi C., Trentini L., Todros T., Cetin I., Brambilla T., Savasi V., Personeni C., Giaquinto C., Fiscon M., Rubino E., Bucceri A., Matrone R., Scaravelli G., Genovese O., Cafforio C., Tozzi V., Massetti P., Casadei A. M., Cavaliere A. F., Cellini M., Castelli Gattinara G., Marconi A. M., Sacchi V., Ierardi M., Polizzi C., Mattei A., Pirillo M. F., Amici R., Galluzzo C. M., Donnini S., Baroncelli S., Villani P., Cusato M., Cerioli A., De Martino M., Mastroiacovo P., Parazzini F., Vella S.

المساهمون: Floridia, M., Tamburrini, E., Masuelli, G., Martinelli, P., Spinillo, A., Liuzzi, G., Vimercati, A., Alberico, S., Maccabruni, A., Pinnetti, C., Frisina, V., Dalzero, S., Ravizza, M., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Maso, G., Airoud, M., Soppelsa, G., Meloni, A., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Roccio, M., Miccolis, A., De Gennaro, A., Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Agangi, A., Capone, A., Maruotti, M., Tibaldi, C., Trentini, L., Todros, T., Cetin, I., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R.

مصطلحات موضوعية: hiv and pregnancy

الوصف: Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10–1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35–2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06–1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28000379; info:eu-repo/semantics/altIdentifier/wos/WOS:000405317000008; volume:18; issue:6; firstpage:440; lastpage:443; numberofpages:4; journal:HIV MEDICINE; http://hdl.handle.net/11586/180587Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85007326986

الإتاحة: https://doi.org/10.1111/hiv.12473Test
http://hdl.handle.net/11586/180587Test

المؤلفون: Ravizza, M., Tamburrini, E., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Alberico, S., DAL MASO, GIANNI, Airoud, M., Soppelsa, G., Meloni, A., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Spinillo, A., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Masuelli, G., Frisina, V., Cetin, I., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R., Scaravelli, G., Genovese, O., Cafforio, C., Pinnetti, C., Liuzzi, G., Tozzi, V., Massetti, P., Casadei, A. M., Cavaliere, A. F., Cellini, M., Castelli Gattinara, G., Marconi, A. M., Dalzero, S., Sacchi, V., Ierardi, M., Polizzi, C., Mattei, A., Pirillo, M. F., Amici, R., Galluzzo, C. M., Donnini, S., Baroncelli, S., Floridia, M., Villani, P., Cusato, M., Cerioli, A., De Martino, M., Mastroiacovo, P., Parazzini, F., Vella, S.

المساهمون: Ravizza, M., Tamburrini, E., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Alberico, S., Maso, G., Airoud, M., Soppelsa, G., Meloni, A., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Spinillo, A., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Masuelli, G., Frisina, V., Cetin, I., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R., Scaravelli, G., Genovese, O., Cafforio, C., Pinnetti, C.

مصطلحات موضوعية: Cytomegalovirus Infection, Female, Human, Italy, Population Surveillance, Pregnancy, Pregnancy Outcome, Prevalence, Coinfection, Cytomegaloviru, HIV Infection, Pregnancy Complications, Infectiou, Viremia, Microbiology (medical), Infectious Diseases

الوصف: It is well known that cytomegalovirus (CMV) coinfection affects a large proportion of people with HIV, with a significant impact on disease progression and survival [1]. In HIV-CMV coinfected pregnant women, however, few studies have been conducted: maternal immunosuppression has been linked to a higher risk of CMV infant infection, and CMV DNAaemia to higher maternal and infant mortality [2,3]. Overall, little is known about pregnancy outcomes and CMV viraemia in CMV-coinfected pregnant women with HIV. To further explore this issue, the impact of CMV coinfection was evaluated on pregnancy outcomes in a national cohort of pregnant women with HIV, assessing in a study subsample the prevalence and correlates of CMV DNAaemia in HIV-CMV coinfected pregnant women.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27404366; info:eu-repo/semantics/altIdentifier/wos/WOS:000388118300023; volume:22; issue:9; firstpage:818; lastpage:820; numberofpages:3; journal:CLINICAL MICROBIOLOGY AND INFECTION; http://hdl.handle.net/11573/1092155Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84995553616; http://onlinelibrary.wiley.com/journal/10.1111Test/(ISSN)1469-0691

الإتاحة: https://doi.org/10.1016/j.cmi.2016.06.017Test
http://hdl.handle.net/11573/1092155Test

المؤلفون: Floridia M., Pirillo M. F., Amici R., Ortolani P., dalle Nogare E. R., Di Lorenzo F., Sterrantino G., Meli M., Polemi S., Nocentini J., Baldini M., Montorzi G., Mazzetti M., Rogasi P., Borchi B., Vichi F., Del Pin B., Pinter E., Anzalone E., Marocco R., Mastroianni C., Mercurio V. S., Carocci A., Grilli E., Maccabruni A., Zaramella M., Mariani B., Natalini Raponi G., Guaraldi G., Nardini G., Stentarelli C., Beghetto B., Degli Antoni A. M., Molinari A., Crisalli M. P., Donisi A., Piepoli M., Cerri V., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Placido G., Vivarelli A., Castelli P., Savalli F., Portelli V., Sabbatini F., Francisci D., Bernini L., Grossi P., Rizzi L., Alberico S., Maso G., Airoud M., Soppelsa G., Meloni A., Dedoni M., Cuboni C., Ortu F., Piano P., Citernesi A., Bordoni Vicini I., Luzi K., Spinillo A., Roccio M., Vimercati A., Miccolis A., De Gennaro A., Guerra B., Cervi F., Simonazzi G., Margarito E., Capretti M. G., Marsico C., Faldella G., Sansone M., Martinelli P., Agangi A., Capone A., Maruotti G. M., Tibaldi C., Trentini L., Todros T., Masuelli G., Frisina V., Cetin I., Brambilla T., Savasi V., Personeni C., Giaquinto C., Fiscon M., Rubino E., Bucceri A., Matrone R., Scaravelli G., Genovese O., Cafforio C., Pinnetti C., Liuzzi G., Tozzi V., Massetti P., Casadei A. M., Cavaliere A. F., Cellini M., Castelli Gattinara G., Marconi A. M., Dalzero S., Sacchi V., Ierardi M., Polizzi C., Mattei A., Galluzzo C. M., Donnini S., Baroncelli S., Villani P., Cusato M., Cerioli A., De Martino M., Mastroiacovo P., Parazzini F., Vella S.

المساهمون: Floridia, M., Pirillo, M. F., Amici, R., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Alberico, S., Maso, G., Airoud, M., Soppelsa, G., Meloni, A., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Spinillo, A., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Martinelli, P., Agangi, A., Capone, A., Maruotti, G. M., Tibaldi, C., Trentini, L., Todros, T., Masuelli, G., Frisina, V., Cetin, I., Brambilla, T., Savasi, V., Personeni, C., Giaquinto, C., Fiscon, M., Rubino, E., Bucceri, A., Matrone, R., Scaravelli, G., Genovese, O., Cafforio, C., Pinnetti, C.

مصطلحات موضوعية: cmv prenatal diagnosis

الوصف: no disponibile

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27404366; info:eu-repo/semantics/altIdentifier/wos/WOS:000388118300023; volume:22; issue:9; firstpage:818; lastpage:820; numberofpages:3; journal:CLINICAL MICROBIOLOGY AND INFECTION; http://hdl.handle.net/11586/179370Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84995553616

الإتاحة: https://doi.org/10.1016/j.cmi.2016.06.017Test
http://hdl.handle.net/11586/179370Test

المؤلفون: Floridia, M, Masuelli, G, Ravizza, M, Tassis, B, Cetin, I, Sansone, M, Degli Antoni, A, Simonazzi, G, Maccabruni, A, Francisci, D, Frisina, V, Liuzzi, G, Dalzero, S, Tamburrini, E, Di Lorenzo, F, Sterrantino, G, Meli, M, Campolmi, I, Vichi, F, Del Pin, B, Marocco, R, Mastroianni, C, Mercurio, V S, Zanaboni, D, Guaraldi, G, Nardini, G, Stentarelli, C, Beghetto, B, Degli Antoni, A M, Molinari, A, Crisalli, M P, Donisi, A, Piepoli, M, Cerri, V, Zuccotti, G, Giacomet, V, Coletto, S, Di Nello, F, Madia, C, Placido, G, Milini, P, Savalli, F, Portelli, V, Sabbatini, F

المساهمون: Italian Medicines Agency

المصدر: Journal of Antimicrobial Chemotherapy ; volume 73, issue 4, page 1025-1030 ; ISSN 0305-7453 1460-2091

مصطلحات موضوعية: Infectious Diseases, Pharmacology (medical), Pharmacology, Microbiology (medical)

الإتاحة: https://doi.org/10.1093/jac/dkx478Test
http://academic.oup.com/jac/article-pdf/73/4/1025/24269492/dkx478.pdfTest

المؤلفون: Floridia M., Mastroiacovo P., Ravizza M., Todros T., Chiado Fiorio Tin M., Marconi A. M., Cetin I., Maruotti G. M., Liuzzi G., Pinnetti C., Degli Antoni A., Spinillo A., Guerra B., Tamburrini E., Mori F., Ortolani P., dalle Nogare E. R., Di Lorenzo F., Sterrantino G., Meli M., Polemi S., Nocentini J., Baldini M., Montorzi G., Mazzetti M., Rogasi P., Borchi B., Vichi F., Del Pin B., Pinter E., Anzalone E., Marocco R., Mastroianni C., Mercurio V. S., Carocci A., Grilli E., Maccabruni A., Zaramella M., Mariani B., Natalini Raponi G., Guaraldi G., Nardini G., Stentarelli C., Beghetto B., Degli Antoni A. M., Molinari A., Crisalli M. P., Donisi A., Piepoli M., Cerri V., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Placido G., Vivarelli A., Castelli P., Savalli F., Portelli V., Sabbatini F., Francisci D., Bernini L., Grossi P., Rizzi L., Alberico S., Maso G., Airoud M., Soppelsa G., Meloni A., Dedoni M., Cuboni C., Ortu F., Piano P., Citernesi A., Bordoni Vicini I., Luzi K., Roccio M., Vimercati A., Miccolis A., De Gennaro A., Cervi F., Puccetti C., Margarito E., Contoli M., Capretti M. G., Marsico C., Faldella G., Sansone M., Martinelli P., Agangi A., Capone A., Tibaldi C., Trentini L., Masuelli G., Frisina V., Brambilla T., Savasi V., Personeni C., Giaquinto C., Fiscon M., Rinaldi R., Rubino E., Bucceri A., Matrone R., Scaravelli G., Fundaro C., Genovese O., Cafforio C., Tozzi V., Massetti P., Casadei A. M., Cavaliere A. F., Finelli V., Cellini M., Castelli Gattinara G., Dalzero S., Sacchi V., Ierardi M., Polizzi C., Mattei A., Pirillo M. F., Amici R., Galluzzo C. M., Donnini S., Baroncelli S., Villani P., Cusato M., Cerioli A., De Martino M., Parazzini F., Vella S.

المساهمون: Floridia, M., Mastroiacovo, P., Ravizza, M., Todros, T., Chiado Fiorio Tin, M., Marconi, A. M., Cetin, I., Maruotti, G. M., Liuzzi, G., Pinnetti, C., Degli Antoni, A., Spinillo, A., Guerra, B., Tamburrini, E., Mori, F., Ortolani, P., dalle Nogare, E. R., Di Lorenzo, F., Sterrantino, G., Meli, M., Polemi, S., Nocentini, J., Baldini, M., Montorzi, G., Mazzetti, M., Rogasi, P., Borchi, B., Vichi, F., Del Pin, B., Pinter, E., Anzalone, E., Marocco, R., Mastroianni, C., Mercurio, V. S., Carocci, A., Grilli, E., Maccabruni, A., Zaramella, M., Mariani, B., Natalini Raponi, G., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Degli Antoni, A. M., Molinari, A., Crisalli, M. P., Donisi, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Placido, G., Vivarelli, A., Castelli, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Bernini, L., Grossi, P., Rizzi, L., Alberico, S., Maso, G., Airoud, M., Soppelsa, G., Meloni, A., Dedoni, M., Cuboni, C., Ortu, F., Piano, P., Citernesi, A., Bordoni Vicini, I., Luzi, K., Roccio, M., Vimercati, A., Miccolis, A., De Gennaro, A., Cervi, F., Puccetti, C., Margarito, E., Contoli, M., Capretti, M. G., Marsico, C., Faldella, G., Sansone, M., Martinelli, P., Agangi, A., Capone, A.

مصطلحات موضوعية: hiv and pregnancy

الوصف: What's already known about this topic? Exposure to antiretroviral treatment in pregnancy does not seem to increase the risk of birth defects, but there is no information on the rate of prenatal detection of such defects. What does this study adds? We provide for the first time, in a national case series, information about prenatal detection rate in women with HIV (51.6% for any major defect, 66.7% for chromosomal abnormalities, and 85% for severe structural defects

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26407161; info:eu-repo/semantics/altIdentifier/wos/WOS:000368445100017; volume:35; issue:13; firstpage:1374; lastpage:1378; numberofpages:5; journal:PRENATAL DIAGNOSIS; http://hdl.handle.net/11586/179376Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84954369562

الإتاحة: https://doi.org/10.1002/pd.4696Test
http://hdl.handle.net/11586/179376Test

المؤلفون: Floridia M., Tamburrini E., Masuelli G., Martinelli P., Spinillo A., Liuzzi G., Vimercati A., Alberico S., Maccabruni A., Pinnetti C., Frisina V., Dalzero S., Ravizza M., Mori F., Ortolani P., dalle Nogare E. R., Di Lorenzo F., Sterrantino G., Meli M., Polemi S., Nocentini J., Baldini M., Montorzi G., Mazzetti M., Rogasi P., Borchi B., Vichi F., Del Pin B., Pinter E., Anzalone E., Marocco R., Mastroianni C., Mercurio V. S., Carocci A., Grilli E., Zaramella M., Mariani B., Natalini Raponi G., Guaraldi G., Nardini G., Stentarelli C., Beghetto B., Degli Antoni A. M., Molinari A., Crisalli M. P., Donisi A., Piepoli M., Cerri V., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Placido G., Vivarelli A., Castelli P., Savalli F., Portelli V., Sabbatini F., Francisci D., Bernini L., Grossi P., Rizzi L., Maso G., Airoud M., Soppelsa G., Meloni A., Dedoni M., Cuboni C., Ortu F., Piano P., Citernesi A., Bordoni Vicini I., Luzi K., Roccio M., Miccolis A., De Gennaro A., Guerra B., Cervi F., Simonazzi G., Margarito E., Capretti M. G., Marsico C., Faldella G., Sansone M., Agangi A., Capone A., Maruotti M., Tibaldi C., Trentini L., Todros T., Cetin I., Brambilla T., Savasi V., Personeni C., Giaquinto C., Fiscon M., Rubino E., Bucceri A., Matrone R., Scaravelli G., Genovese O., Cafforio C., Tozzi V., Massetti P., Casadei A. M., Cavaliere A. F., Cellini M., Castelli Gattinara G., Marconi A. M., Sacchi V., Ierardi M., Polizzi C., Mattei A., Pirillo M. F., Amici R., Galluzzo C. M., Donnini S., Baroncelli S., Villani P., Cusato M., Cerioli A., De Martino M., Mastroiacovo P., Parazzini F., Vella S.

المساهمون: M. Floridia, E. Tamburrini, G. Masuelli, P. Martinelli, A. Spinillo, G. Liuzzi, A. Vimercati, S. Alberico, A. Maccabruni, C. Pinnetti, V. Frisina, S. Dalzero, M. Ravizza, F. Mori, P. Ortolani, E.R. dalle Nogare, F. Di Lorenzo, G. Sterrantino, M. Meli, S. Polemi, J. Nocentini, M. Baldini, G. Montorzi, M. Mazzetti, P. Rogasi, B. Borchi, F. Vichi, B. Del Pin, E. Pinter, E. Anzalone, R. Marocco, C. Mastroianni, V.S. Mercurio, A. Carocci, E. Grilli, M. Zaramella, B. Mariani, G. Natalini Raponi, G. Guaraldi, G. Nardini, C. Stentarelli, B. Beghetto, A.M. Degli Antoni, A. Molinari, M.P. Crisalli, A. Donisi, M. Piepoli, V. Cerri, G. Zuccotti, V. Giacomet, S. Coletto, F. Di Nello, C. Madia, G. Placido, A. Vivarelli, P. Castelli, F. Savalli, V. Portelli, F. Sabbatini, D. Francisci, L. Bernini, P. Grossi, L. Rizzi, G. Maso, M. Airoud, G. Soppelsa, A. Meloni, M. Dedoni, C. Cuboni, F. Ortu, P. Piano, A. Citernesi, I. Bordoni Vicini, K. Luzi, M. Roccio, A. Miccoli, A. De Gennaro, B. Guerra, F. Cervi, G. Simonazzi, E. Margarito, M.G. Capretti, C. Marsico, G. Faldella, M. Sansone, A. Agangi, A. Capone, M. Maruotti, C. Tibaldi, L. Trentini, T. Todro, I. Cetin, T. Brambilla, V. Savasi, C. Personeni, C. Giaquinto, M. Fiscon, E. Rubino, A. Bucceri, R. Matrone

مصطلحات موضوعية: birth weight, HIV, HIV RNA, pregnancy, preterm delivery, health policy, pharmacology (medical), infectious diseases, Settore MED/40 - Ginecologia e Ostetricia

الوصف: Objectives: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. Methods: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. Results: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). Conclusions: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28000379; info:eu-repo/semantics/altIdentifier/wos/WOS:000405317000008; journal:HIV MEDICINE; http://hdl.handle.net/2434/484863Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85007326986

الإتاحة: https://doi.org/10.1111/hiv.12473Test
http://hdl.handle.net/2434/484863Test

المؤلفون: Tibaldi C., Masuelli G., Sansone M., Tassis B., Cetin I., Franceschetti L., Spinillo A., Simonazzi G., Vimercati A., Dalzero S., Meloni A., Bernardon M., Frisina V., Polizzi C., Todros T., Martinelli P., Floridia M., Ravizza M., Trentini L., Tiso G., Brambilla T., Savasi V., Personeni C., Zuccotti G., Giacomet V., Coletto S., Di Nello F., Madia C., Forleo M. A., Badolato R., Roccio M., Zanaboni D., Sirico A., Maruotti G. M., Capone A., Guerra B., Cervi F., Margarito E., Capretti M. G., Marsico C., Faldella G., Crupano F. M., Calabretti D., Ravizz M., Marconi A. M., Galiano V., Ierardi S. C. S. M., Chiodo A., Ortu F., Piano P., Dedoni I. M., Maso G., Belcaro C., Rizzante E., Alberico S., Citernesi A., Vicini I. B., Luzi K.

المساهمون: Tibaldi, C., Masuelli, G., Sansone, M., Tassis, B., Cetin, I., Franceschetti, L., Spinillo, A., Simonazzi, G., Vimercati, A., Dalzero, S., Meloni, A., Bernardon, M., Frisina, V., Polizzi, C., Todros, T., Martinelli, P., Floridia, M., Ravizza, M., Trentini, L., Tiso, G., Brambilla, T., Savasi, V., Personeni, C., Zuccotti, G., Giacomet, V., Coletto, S., Di Nello, F., Madia, C., Forleo, M. A., Badolato, R., Roccio, M., Zanaboni, D., Sirico, A., Maruotti, G. M., Capone, A., Guerra, B., Cervi, F., Margarito, E., Capretti, M. G., Marsico, C., Faldella, G., Crupano, F. M., Calabretti, D., Ravizz, M., Marconi, A. M., Galiano, V., Ierardi, S. C. S. M., Chiodo, A., Ortu, F., Piano, P., Dedoni, I. M., Maso, G., Belcaro, C., Rizzante, E., Alberico, S., Citernesi, A., Vicini, I. B., Luzi, K.

مصطلحات موضوعية: Delivery complication, HIV, Mode of delivery, Pregnancy, Adult, Cesarean Section, Delivery, Obstetric, Female, HIV Infection, Human, Italy, Young Adult, Viral Load

الوصف: Purpose: To evaluate the maternal and neonatal safety of vaginal delivery in women with HIV following the implementation of a national protocol in Italy. Methods: Vaginal delivery was offered to all eligible women who presented antenatally at twelve participating clinical sites. Data collection and definition of outcomes followed the procedures of the National Program on Surveillance on Antiretroviral Treatment in Pregnancy. Pregnancy outcomes were compared according to the mode of delivery, classified as vaginal, elective cesarean (ECS) and non-elective cesarean section (NECS). Results: Among 580 women who delivered between January 2012 and September 2017, 142 (24.5%) had a vaginal delivery, 323 (55.7%) had an ECS and 115 (19.8%) had an NECS. The proportion of vaginal deliveries increased significantly over time, from 18.9% in 2012 to 35.3% in 2017 (p < 0.001). Women who delivered vaginally were younger, more commonly nulliparous, diagnosed with HIV during current pregnancy, and antiretroviral-naïve, but had a slightly longer duration of pregnancy, with significantly higher birthweight of newborns. NECS was associated with adverse pregnancy outcomes. The rate of HIV transmission was minimal (0.4%). There were no differences between vaginal and ECS about delivery complications, while NECS was more commonly associated with complications compared to ECS. Conclusions: Vaginal delivery in HIV-infected women with suppressed viral load appears to be safe for mother and children. No cases of HIV transmission were observed. Despite an ongoing significant increase, the rate of vaginal delivery remains relatively low compared to other countries, and further progress is needed to promote this mode of delivery in clinical practice.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31286456; info:eu-repo/semantics/altIdentifier/wos/WOS:000509102000012; volume:47; issue:6; firstpage:981; lastpage:990; numberofpages:10; journal:INFECTION; http://hdl.handle.net/11379/538919Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85068877602

الإتاحة: https://doi.org/10.1007/s15010-019-01336-zTest
http://hdl.handle.net/11379/538919Test