نتائج البحث - "Cleveland, Rebecca J."

1

دورية أكاديمية

Budget impact of the Walk With Ease program for knee osteoarthritis

المؤلفون: Kumara, Mahima T., Cleveland, Rebecca J., Kostic, Aleksandra M., Weisner, Serena E., Allen, Kelli D., Golightly, Yvonne M., Welch, Heather, Dale, Melissa, Messier, Stephen P., Hunter, David J., Katz, Jeffrey N., Callahan, Leigh F., Losina, Elena

المساهمون: CDC, National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 2, page 100463 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016Test/j.ocarto.2024.100463
https://api.elsevier.com/content/article/PII:S266591312400030X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S266591312400030X?httpAccept=text/plainTest

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2

تقرير

Technical Background for 'A Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight Loss Treatments for Overweight and Obese Adults with Knee Osteoarthritis'

المؤلفون: Jiang, Xiaotong, Nelson, Amanda E., Cleveland, Rebecca J., Beavers, Daniel P., Schwartz, Todd A., Arbeeva, Liubov, Alvarez, Carolina, Callahan, Leigh F., Messier, Stephen, Loeser, Richard, Kosorok, Michael R.

مصطلحات موضوعية: Statistics - Machine Learning, Computer Science - Machine Learning, Statistics - Applications

الوصف: We provide additional statistical background for the methodology developed in the clinical analysis of knee osteoarthritis in "A Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight Loss Treatments for Overweight and Obese Adults with Knee Osteoarthritis" (Jiang et al. 2020). Jiang et al. 2020 proposed a pipeline to learn optimal treatment rules with precision medicine models and compared them with zero-order models with a Z-test. The model performance was based on value functions, a scalar that predicts the future reward of each decision rule. The jackknife (i.e., leave-one-out cross validation) method was applied to estimate the value function and its variance of several outcomes in IDEA. IDEA is a randomized clinical trial studying three interventions (exercise (E), dietary weight loss (D), and D+E) on overweight and obese participants with knee osteoarthritis. In this report, we expand the discussion and justification with additional statistical background. We elaborate more on the background of precision medicine, the derivation of the jackknife estimator of value function and its estimated variance, the consistency property of jackknife estimator, as well as additional simulation results that reflect more of the performance of jackknife estimators. We recommend reading Jiang et al. 2020 for clinical application and interpretation of the optimal ITR of knee osteoarthritis as well as the overall understanding of the pipeline and recommend using this article to understand the underlying statistical derivation and methodology.

الوصول الحر: http://arxiv.org/abs/2001.09930Test

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3

دورية أكاديمية

Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data

المؤلفون: Leyland, Kirsten M, Gates, Lucy S, Sanchez-Santos, Maria T, Nevitt, Michael C, Felson, David, Jones, Graeme, Jordan, Joanne M, Judge, Andrew, Prieto-Alhambra, Dani, Yoshimura, Noriko, Newton, Julia L, Callahan, Leigh F, Cooper, Cyrus, Batt, Mark E, Lin, Jianhao, Liu, Qiang, Cleveland, Rebecca J, Collins, Gary S, Arden, Nigel K

المصدر: Aging Clinical and Experimental Research. 33(3)

الوصف: BackgroundOsteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods. We seek to overcome limitations introduced when using aggregate results by gathering individual participant-level data (IPD) from international observational studies and standardising methods to determine the association of knee OA with mortality in the general population.MethodsSeven community-based cohorts were identified containing knee OA-related pain, radiographs, and time-to-mortality, six of which were available for analysis. A two-stage IPD meta-analysis framework was applied: (1) Cox proportional hazard models assessed time-to-mortality of participants with radiographic OA (ROA), OA-related pain (POA), and a combination of pain and ROA (PROA) against pain and ROA-free participants; (2) hazard ratios (HR) were then pooled using the Hartung-Knapp modification for random-effects meta-analysis.Findings10,723 participants in six cohorts from four countries were included in the analyses. Multivariable models (adjusting for age, sex, race, BMI, smoking, alcohol consumption, cardiovascular disease, and diabetes) showed a pooled HR, compared to pain and ROA-free participants, of 1.03 (0.83, 1.28) for ROA, 1.35 (1.12, 1.63) for POA, and 1.37 (1.22, 1.54) for PROA.DiscussionParticipants with POA or PROA had a 35-37% increased association with reduced time-to-mortality, independent of confounders. ROA showed no association with mortality, suggesting that OA-related knee pain may be driving the association with time-to-mortality.FundingVersus Arthritis Centre for Sport, Exercise and Osteoarthritis and Osteoarthritis Research Society International.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4x0982knTest

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4

دورية أكاديمية

Genetic polymorphisms of diabetes‐related genes, their interaction with diabetes status, and breast cancer incidence and mortality: The Long Island Breast Cancer Study Project

المؤلفون: Parada, Humberto, Cleveland, Rebecca J, North, Kari E, Stevens, June, Teitelbaum, Susan L, Neugut, Alfred I, Santella, Regina M, Martinez, Maria E, Gammon, Marilie D

المصدر: Molecular Carcinogenesis. 58(3)

الوصف: To examine 143 diabetes risk single nucleotide polymorphisms (SNPs), identified from genome-wide association studies, in association with breast cancer (BC) incidence and subsequent mortality. A population-based sample of Caucasian women with first primary invasive BC (n = 817) and controls (n = 1021) were interviewed to assess diabetes status. Using the National Death Index, women with BC were followed for >18 years during which 340 deaths occurred (139 BC deaths). Genotyping was done using DNA extracted from blood samples. We used unconditional logistic regression to estimate age-adjusted odds ratios and 95% confidence intervals (CIs) for BC incidence, and Cox regression to estimate age-adjusted hazard ratios and CIs for all-cause and BC-specific mortality. Twelve SNPs were associated with BC risk in additive genotype models, at α = 0.05. The top three significant SNPs included SLC30A8-rs4876369 (P = 0.0034), HHEX-rs11187146 (P = 0.0086), and CDKN2A/CDKN2B-rs1333049 (P = 0.0094). Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. Six SNPs were associated with all-cause (CDKAL1-rs981042, P = 0.0032; HHEX-rs1111875, P = 0.0361; and INSR-rs919275, P = 0.0488) or BC-specific (CDKN2A/CDKN2B-rs3218020, P = 0.0225; CDKAL1-rs981042, P = 0.0246; and TCF2/HNF1B-rs3094508, P = 0.0344) mortality in additive genotype models, at α = 0.05. Genetic polymorphisms that increase the risk of developing diabetes may also increase the risk of developing and dying from BC.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3jd483j9Test

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5

دورية أكاديمية

Evaluating Osteoarthritis Management Programs: Outcome Domain Recommendations from the OARSI Joint Effort Initiative

المصدر: Allen , K D , Huffman , K , Cleveland , R J , van der Esch , M , Abbott , J H , Abbott , A , Bennell , K , Bowden , J L , Eyles , J , Healey , E L , Holden , M A , Jayakumar , P , Koenig , K , Lo , G , Losina , E , Miller , K , Østerås , N , Pratt , C , Quicke , J G , Sharma , S , Skou , S T , Tveter , A T , ....

مصطلحات موضوعية: Delphi, Implementation, Osteoarthritis, Outcomes

الوصف: Objective: To develop sets of core and optional recommended domains for describing and evaluating Osteoarthritis Management Programs (OAMPs), with a focus on hip and knee Osteoarthritis (OA). Design: We conducted a 3-round modified Delphi survey involving an international group of researchers, health professionals, health administrators and people with OA. In Round 1, participants ranked the importance of 75 outcome and descriptive domains in five categories: patient impacts, implementation outcomes, and characteristics of the OAMP and its participants and clinicians. Domains ranked as “important” or “essential” by ≥80% of participants were retained, and participants could suggest additional domains. In Round 2, participants rated their level of agreement that each domain was essential for evaluating OAMPs: 0 = strongly disagree to 10 = strongly agree. A domain was retained if ≥80% rated it ≥6. In Round 3, participants rated remaining domains using same scale as in Round 2; a domain was recommended as “core” if ≥80% of participants rated it ≥9 and as “optional” if ≥80% rated it ≥7. Results: A total of 178 individuals from 26 countries participated; 85 completed all survey rounds. Only one domain, “ability to participate in daily activities”, met criteria for a core domain; 25 domains met criteria for an optional recommendation: 8 Patient Impacts, 5 Implementation Outcomes, 5 Participant Characteristics, 3 OAMP Characteristics and 4 Clinician Characteristics. Conclusion: The ability of patients with OA to participate in daily activities should be evaluated in all OAMPs. Teams evaluating OAMPs should consider including domains from the optional recommended set, with representation from all five categories and based on stakeholder priorities in their local context.

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/e846bb75-641d-4e02-8cb9-96b7c88b428aTest

الإتاحة: https://doi.org/10.1016Test/j.joca.2023.02.078
https://portal.findresearcher.sdu.dk/da/publications/e846bb75-641d-4e02-8cb9-96b7c88b428aTest
https://findresearcher.sdu.dk/ws/files/224957483/OARSI_JEI_manuscript_REVISION.pdfTest

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6

دورية أكاديمية

Walk with ease for knee osteoarthritis: A cost-effectiveness analysis

المؤلفون: Zimmerman, Zoe E., Cleveland, Rebecca J., Kostic, Aleksandra M., Leifer, Valia P., Weisner, Serena E., Allen, Kelli D., Golightly, Yvonne M., Welch, Heather, Dale, Melissa, Messier, Stephen P., Hunter, David J., Katz, Jeffrey N., Callahan, Leigh F., Losina, Elena

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centers for Disease Control and Prevention

المصدر: Osteoarthritis and Cartilage Open ; volume 5, issue 3, page 100368 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016Test/j.ocarto.2023.100368
https://api.elsevier.com/content/article/PII:S2665913123000353?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913123000353?httpAccept=text/plainTest

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7

دورية أكاديمية

Occupational tasks associated with shoulder pain and upper extremity disability: a cross-sectional study in the Johnston County Osteoarthritis Project.

المؤلفون: Yanik, Elizabeth L., Alvarez, Carolina, Cleveland, Rebecca J., Nelson, Amanda E., Golightly, Yvonne M.

المصدر: BMC Musculoskeletal Disorders; 5/11/2024, Vol. 25 Issue 1, p1-11, 11p

مصطلحات موضوعية: SHOULDER pain, FORELIMB, WORKING class white people, SHOULDER disorders, DISABILITY studies, CROSS-sectional method, PROFESSIONAL athletes, PEOPLE with disabilities

مستخلص: Background: Shoulder pain is a leading cause of disability. Occupations requiring high upper extremity demands may put workers at greater risk of shoulder injury and resulting pain. We examined associations of occupation with shoulder pain and upper extremity disability in the Johnston County Osteoarthritis Project. Methods: Work industry and occupational tasks for the longest job held were collected from participants. At follow-up ranging from 4–10 years later, participants were asked about shoulder symptoms (pain, aching, or stiffness occurring most days of 1 month in the last year) and given a 9-item, modified Disabilities Arm Shoulder and Hand (DASH) questionnaire to categorize disability from 0–4 (none-worst). Logistic regression and cumulative logit regression models were used to estimate associations with prevalent shoulder symptoms and with worse disability category, respectively. Models were adjusted for cohort, age, sex, race, education and time to follow-up. Sex- and race-stratified associations were evaluated. Results: Among 1560 included participants, mean age was 62 years (standard deviation ± 9 years); 32% were men, and 31% were Black. Compared to the managerial/professional industry, higher odds of both shoulder symptoms and worse upper extremity disability were seen for most industrial groups with physically demanding jobs, particularly the service industry. Work that often or always required lifting/moving > 10 lbs. was associated with higher odds of shoulder symptoms. Work that sometimes or always required heavy work while standing was associated with higher odds of shoulder symptoms, and this association was stronger among men and White workers. Conclusion: Physically demanding occupations were associated with increased occurrence of shoulder pain and disability. Mitigating specific physical work demands may reduce shoulder-related disability. [ABSTRACT FROM AUTHOR]

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