المؤلفون: Annalisa Graceffa, Salvatore Novo, Matteo Cameli, Marco Matteo Ciccone, Maria Maiello, Pietro A Modesti, Maria Lorenza Muiesan, Ida Muratori, Giuseppina Novo, Pasquale Palmiero, Angelica Peritore, Pier Sergio Saba, Pietro Scicchitano, Rosalinda Trovato, Roberto Pedrinelli

المصدر: International Journal of Sciences

الوصف: The CVD represent nowadays the first cause of mortality and disability in western country. But atherosclerosis disease is a gradually process that develops over decades, giving the time to carry out prevention and intervention strategy. Great attention should be made on the analysis of RF and on their correction, especially when they are clustered in a manner that enhances them. For this reason, it’s important to prevent the development of MetS abnormalities (for example with daily physical activity and Mediterranean diet) and to detect it early so as start pharmacological treatment of modifiable risk factors. Moreover, in order to address the therapeutic efforts to the subjects that can receive greater benefit, it is important to have tool to identify subjects affected but non symptomatic yet. For this purpose, non-invasive techniques capable of evaluating arterial wall and endothelial function should enter in routinely evaluation of cardiovascular risk. In particular, according to ESC guidelines (1), carotid ultrasonography, brachial-ankle index measurement and computed tomography for coronary calcium assessment should be taken in mind for further risk stratification of asymptomatic adults at moderate risk. The detection of subclinical lesions indicates the need of a more aggressive management of risk factors, possibly with the help of drug treatment.

وصف الملف: text/html

العلاقة: https://www.ijsciences.com/pub/article/514Test; http://dx.doi.org/10.18483/ijSci.514Test; https://www.ijsciences.com/pub/pdf/V320140711.pdfTest

الإتاحة: https://doi.org/10.18483/ijSci.514Test
https://www.ijsciences.com/pub/article/514Test
https://www.ijsciences.com/pub/pdf/V320140711.pdfTest

المؤلفون: Cuneo, Antonio, Cavazzini, Francesco, Ciccone, Maria, Daghia, Giulia, Sofritti, Olga, Saccenti, Elena, Negrini, Massimo, Rigolin, Gian Matteo

المصدر: Cancer Medicine ; volume 3, issue 3, page 555-564 ; ISSN 2045-7634 2045-7634

الوصف: Treatment of chronic lymphocytic leukemia ( CLL ) has dramatically changed over the last years, with significant improvement in overall survival (OS) and increased efficacy in genetically defined “high‐risk” disease. Besides prospective clinical trials usually enrolling young and fit patients, retrospective studies were performed comparing the outcome of patients belonging to different age groups and showing longer survival in patients diagnosed in the most recent periods. In patients younger than 70 years the 10‐year relative survival was 43–53% in the 1980s as compared with 59–63% in the 2000s. Likewise, the 10‐year relative survival in patients >70 years was 22–42% in the 1980s and 46–55% in the 2000s. Improved outcome derived in part by the introduction of effective regimens in genetically defined “high‐risk” disease (i.e., 17p−, 11q−, TP53 , NOTCH1 , SF3B1 mutations), especially in the younger and/or fit patients. The unfavorable prognostic significance of 11q− was overcome by chemoimmunotherapy. High‐dose steroids with anti‐CD52 appeared to improve the response rate in 17p‐/ TP53 mutated cases and allogeneic transplantation achieved prolonged disease control irrespective of high‐risk disease. Further improvement is being generated by the new anti‐CD20 obinutuzumab in the elderly and by mechanism‐based treatment using kinase‐targeting agents or anti‐ BCL 2 molecules yielding high‐response rate and impressive progression‐free survival in the chemorefractory setting as well as in previously untreated patients.

الإتاحة: https://doi.org/10.1002/cam4.226Test

المؤلفون: Ciccone, Maria, Ferrajoli, Alessandra, Keating, Michael J., Calin, George A.

المصدر: Cancer Cell ; volume 26, issue 5, page 770-770.e1 ; ISSN 1535-6108

مصطلحات موضوعية: Cancer Research, Cell Biology, Oncology

الإتاحة: https://doi.org/10.1016/j.ccell.2014.10.020Test
https://api.elsevier.com/content/article/PII:S1535610814004243?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1535610814004243?httpAccept=text/plainTest

المؤلفون: Vitale, Candida, Falchi, Lorenzo, Ciccone, Maria, Burger, Jan, Pemmaraju, Naveen, Borthakur, Gautam, Wierda, William G., Keating, Michael J., Ferrajoli, Alessandra

المساهمون: Vitale, Candida, Falchi, Lorenzo, Ciccone, Maria, Burger, Jan, Pemmaraju, Naveen, Borthakur, Gautam, Wierda, William G., Keating, Michael J., Ferrajoli, Alessandra*

مصطلحات موضوعية: Oncology, Geriatrics and Gerontology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31005650; info:eu-repo/semantics/altIdentifier/wos/WOS:000508493000004; firstpage:N/A; lastpage:N/A; numberofpages:N/A; journal:JOURNAL OF GERIATRIC ONCOLOGY; http://hdl.handle.net/2318/1700246Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85064323505; http://www.elsevier.com/wps/find/journaldescription.cws_home/723463/description#descriptionTest

الإتاحة: https://doi.org/10.1016/j.jgo.2019.04.002Test
http://hdl.handle.net/2318/1700246Test
http://www.elsevier.com/wps/find/journaldescription.cws_home/723463/description#descriptionTest

المؤلفون: Dragani, Matteo, Agrippino, Roberta, Cambrin, Giovanna Rege, Mancini, Valentina, Annunziata, Mario, Lunghi, Monia, Ciccone, Maria, Malato, Alessandra, Chiusolo, Patrizia, Fava, Carmen, Berchialla, Paola, Foà, Roberto, Chiaretti, Sabina

المصدر: Clinical Lymphoma Myeloma and Leukemia ; volume 20, page S162 ; ISSN 2152-2650

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

الإتاحة: https://doi.org/10.1016/s2152-2650Test(20)30680-7
https://api.elsevier.com/content/article/PII:S2152265020306807?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2152265020306807?httpAccept=text/plainTest

المؤلفون: Foà, Robin, Bonifacio, Massimiliano, Chiaretti, Sabina, Curti, Antonio, Candoni, Anna, Fava, Carmen, Ciccone, Maria, Pizzolo, Giovanni, Ferrara, Felicetto

المصدر: British Journal of Haematology

مصطلحات موضوعية: Adult, Male, Letter, Pneumonia, Viral, COVID-19, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Italy, Antibodies, Bispecific, Antineoplastic Combined Chemotherapy Protocols, Ambulatory Care, Imatinib Mesylate, Humans, Female, Philadelphia Chromosome, Letters, Coronavirus Infections, Pandemics, Aged

الوصف: The recent spread of the Covid‐19 infection has raised important questions within the haematology community on how best to manage and treat patients with haematological malignancies, particularly acute leukaemias. Italy has witnessed a dramatic raise in infections and death rates, that has hit in particular certain areas of the most populated Northern regions of the country (Lombardia, Veneto, Piemonte, Emilia Romagna). Within the nationwide Campus ALL programme in the last week of March we sent a questionnaire addressing different issues related to the management of adult ALL patients during the Covid‐19 pandemic to 40 haematology centres located on the entire territory.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::3eea6dd477c9187cc1c3bedb7983d4a9Test
http://europepmc.org/articles/PMC7267647Test

المؤلفون: Dragani, Matteo, Agrippino, Roberta, Cambrin, Giovanna Rege, Mancini, Valentina, Annunziata, Mario, Lunghi, Monia, Ciccone, Maria, Malato, Alessandra, Patrizia Chiusolo, Fava, Carmen, Berchialla, Paola, Foa, Roberto, Chiaretti, Sabina

المصدر: Publons

مصطلحات موضوعية: real life, acute lymphoblastic leukemia, ALL, Philadelphia-positive leukemia, TKI

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8599d3703080ca9e918009625f5cbe1fTest
http://hdl.handle.net/2318/1796935Test

المؤلفون: Lupini Laura, Saccenti Elena, Ciccone Maria, Veronese Angelo, Cavazzini Francesco, Rizzotto Lara, Zagatti Barbara, Ferracin Manuela, Grilli Andrea, De Angeli Cristiano, Negrini Massimo, Cuneo Antonio

المصدر: Molecular Cancer, Vol 9, Iss 1, p 123 (2010)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Background Fludarabine, is one of the most active single agents in the treatment of chronic lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become fludarabine-refractory. To elucidate whether microRNAs are involved in the development of fludarabine resistance, we analyzed the expression of 723 human miRNAs before and 5-days after fludarabine mono-therapy in 17 CLL patients which were classified as responder or refractory to fludarabine treatment based on NCI criteria. Results By comparing the expression profiles of these two groups of patients, we identified a microRNA signature able to distinguish refractory from sensitive CLLs. The expression of some microRNAs was also able to predict fludarabine resistance of 12 independent CLL patients. Among the identified microRNAs, miR-148a, miR-222 and miR-21 exhibited a significantly higher expression in non-responder patients either before and after fludarabine treatment. After performing messenger RNA expression profile of the same patients, the activation of p53-responsive genes was detected in fludarabine responsive cases only, therefore suggesting a possible mechanism linked to microRNA deregulation in non-responder patients. Importantly, inhibition of miR-21 and miR-222 by anti-miRNA oligonucleotides induced a significant increase in caspase activity in fludarabine-treated p53-mutant MEG-01 cells, suggesting that miR-21 and miR-222 up-regulation may be involved in the establishment of fludarabine resistance. Conclusions This is the first report that reveals the existence of a microRNA profile that differentiate refractory and sensitive CLLs, either before and after fludarabine mono-therapy. A p53 dysfunctional pathway emerged in refractory CLLs and could contribute in explaining the observed miRNA profile. Moreover, this work indicates that specific microRNAs can be used to predict fludarabine resistance and may potentially be used as therapeutic targets, therefore establishing an important starting point for future studies.

العلاقة: http://www.molecular-cancer.com/content/9/1/123Test; https://doaj.org/toc/1476-4598Test; https://doaj.org/article/d11bdca3ddc14ae093797a71b68e5939Test

الإتاحة: https://doi.org/10.1186/1476-4598-9-123Test
https://doaj.org/article/d11bdca3ddc14ae093797a71b68e5939Test

المؤلفون: Ferracin, Manuela, Zagatti, Barbara, Rizzotto, Lara, Cavazzini, Francesco, Veronese, Angelo, Ciccone, Maria, Saccenti, Elena, Lupini, Laura, Grilli, Andrea, De Angeli, Cristiano, Negrini, Massimo, Cuneo, Antonio

المصدر: Molecular Cancer ; volume 9, issue 1 ; ISSN 1476-4598

مصطلحات موضوعية: Cancer Research, Oncology, Molecular Medicine

الوصف: Background Fludarabine, is one of the most active single agents in the treatment of chronic lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become fludarabine-refractory. To elucidate whether microRNAs are involved in the development of fludarabine resistance, we analyzed the expression of 723 human miRNAs before and 5-days after fludarabine mono-therapy in 17 CLL patients which were classified as responder or refractory to fludarabine treatment based on NCI criteria. Results By comparing the expression profiles of these two groups of patients, we identified a microRNA signature able to distinguish refractory from sensitive CLLs. The expression of some microRNAs was also able to predict fludarabine resistance of 12 independent CLL patients. Among the identified microRNAs, miR-148a, miR-222 and miR-21 exhibited a significantly higher expression in non-responder patients either before and after fludarabine treatment. After performing messenger RNA expression profile of the same patients, the activation of p53-responsive genes was detected in fludarabine responsive cases only, therefore suggesting a possible mechanism linked to microRNA deregulation in non-responder patients. Importantly, inhibition of miR-21 and miR-222 by anti-miRNA oligonucleotides induced a significant increase in caspase activity in fludarabine-treated p53-mutant MEG-01 cells, suggesting that miR-21 and miR-222 up-regulation may be involved in the establishment of fludarabine resistance. Conclusions This is the first report that reveals the existence of a microRNA profile that differentiate refractory and sensitive CLLs, either before and after fludarabine mono-therapy. A p53 dysfunctional pathway emerged in refractory CLLs and could contribute in explaining the observed miRNA profile. Moreover, this work indicates that specific microRNAs can be used to predict fludarabine resistance and may potentially be used as therapeutic targets, therefore establishing an important starting point for future studies.

الإتاحة: https://doi.org/10.1186/1476-4598-9-123Test

المؤلفون: Ciccone, Maria, Calin, George A.

المصدر: Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs ; page 11-25 ; ISBN 9783319715520 9783319715537

الإتاحة: https://doi.org/10.1007/978-3-319-71553-7_2Test