المؤلفون: Sirin Dhifallah, Anis Attour, Christophe Vial, Fehti Zagrouba, Fabrice Audonnet

المصدر: Water Supply, Vol 24, Iss 4, Pp 1409-1424 (2024)

مصطلحات موضوعية: electrocoagulation, fluoride ions, human health, physical adsorption, water treatment, Water supply for domestic and industrial purposes, TD201-500, River, lake, and water-supply engineering (General), TC401-506

الوصف: Overload of fluoride ions in water is observed in several regions of southern Tunisia, mainly the regions close to the mining basin of Gafsa: Metlaoui, Omlarayes and Redayef. This study concerns fluoride removal from Metlaoui's tap water by electrocoagulation (EC) using aluminum electrodes in a batch reactor. This water contains 3.5 mg·L−1 of fluoride, the highest concentration observed in these basins. The effect of the operating conditions of EC treatment on tap water defluoridation was analyzed, namely, current density, temperature and interelectrode distance. Hydroxide aluminum flocs, formed with different durations of EC, were used as sorbents in fluorinated deionized water ([F−] = 3.5 mg·L−1) and Metlaoui's tap water. Flocs formed after 30 min of EC, produced by dissolving (79 ± 1) mg·L−1 of aluminum and adjusted at pH = 6.5, allowed the adsorption of (98 ± 1)% of fluoride ions from deionized fluorinated water. Flocs adjusted at different pH, from 5 to 9, were used as sorbents in fluorinated deionized water and Metlaoui's tap water. Acidic and neutral flocs allowed the best yields of fluoride adsorption. Contrary to the literature, this work highlighted the absence of ion exchange of hydroxide anion by fluoride anion in water, highlighting a mechanism of physical adsorption on aluminum hydroxide flocs. HIGHLIGHTS Electrocoagulation (EC) was studied for the defluoridation of Tunisian groundwater.; Defluoridation was also evaluated through adsorption onto Al(OH)3 flocs generated by EC.; Fluorides in synthetic water were predominantly removed through physical adsorption.; In Tunisian groundwater, the adsorption of F− competed with the adsorption of other anions.; The EC defluoridation process could be scaled up at a constant current/volume ratio.;

وصف الملف: electronic resource

العلاقة: http://ws.iwaponline.com/content/24/4/1409Test; https://doaj.org/toc/1606-9749Test; https://doaj.org/toc/1607-0798Test

الوصول الحر: https://doaj.org/article/faf94f55399d4ec190cee3edf7fdb84cTest

المؤلفون: Jean-Sébastien Guez, Pierre-Yves Lacroix, Thierry Château, Christophe Vial

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract An in situ microscope based on pulsed transmitted light illumination via optical fiber was combined to artificial-intelligence to enable for the first time an online cell classification according to well-known cellular morphological features. A 848 192-image database generated during a lab-scale production process of antibodies was processed using a convolutional neural network approach chosen for its accurate real-time object detection capabilities. In order to induce different cell death routes, hybridomas were grown in normal or suboptimal conditions in a stirred tank reactor, in the presence of substrate limitation, medium addition, pH regulation problem or oxygen depletion. Using such an optical system made it possible to monitor real-time the evolution of different classes of animal cells, among which viable, necrotic and apoptotic cells. A class of viable cells displaying bulges in feast or famine conditions was also revealed. Considered as a breakthrough in the catalogue of process analytical tools, in situ microscopy powered by artificial-intelligence is also of great interest for research.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/802c852aaacd4e5aa8e6041d9fe0d41cTest

المؤلفون: Pierre-François Pradat, Emilien Bernard, Philippe Corcia, Philippe Couratier, Christel Jublanc, Giorgia Querin, Capucine Morélot Panzini, François Salachas, Christophe Vial, Karim Wahbi, Peter Bede, Claude Desnuelle, on behalf of the French Kennedy’s Disease Writing Group

المصدر: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-21 (2020)

مصطلحات موضوعية: Kennedy disease, Spinal and bulbar muscular atrophy, Guidelines, Polyglutamine, Androgen receptor, Androgen insensitivity, Medicine

الوصف: Abstract Background Kennedy’s disease (KD), also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, X-linked recessive neuromuscular disease caused by CAG expansions in exon 1 of the androgen receptor gene (AR). The objective of the French national diagnostic and management protocol is to provide evidence-based best practice recommendations and outline an optimised care pathway for patients with KD, based on a systematic literature review and consensus multidisciplinary observations. Results The initial evaluation, confirmation of the diagnosis, and management should ideally take place in a tertiary referral centre for motor neuron diseases, and involve an experienced multidisciplinary team of neurologists, endocrinologists, cardiologists and allied healthcare professionals. The diagnosis should be suspected in an adult male presenting with slowly progressive lower motor neuron symptoms, typically affecting the lower limbs at onset. Bulbar involvement (dysarthria and dysphagia) is often a later manifestation of the disease. Gynecomastia is not a constant feature, but is suggestive of a suspected diagnosis, which is further supported by electromyography showing diffuse motor neuron involvement often with asymptomatic sensory changes. A suspected diagnosis is confirmed by genetic testing. The multidisciplinary assessment should ascertain extra-neurological involvement such as cardiac repolarisation abnormalities (Brugada syndrome), signs of androgen resistance, genitourinary abnormalities, endocrine and metabolic changes (glucose intolerance, hyperlipidemia). In the absence of effective disease modifying therapies, the mainstay of management is symptomatic support using rehabilitation strategies (physiotherapy and speech therapy). Nutritional evaluation by an expert dietician is essential, and enteral nutrition (gastrostomy) may be required. Respiratory management centres on the detection and treatment of bronchial obstructions, as well as screening for aspiration pneumonia (chest physiotherapy, drainage, positioning, breath stacking, mechanical insufflation-exsufflation, cough assist machnie, antibiotics). Non-invasive mechanical ventilation is seldom needed. Symptomatic pharmaceutical therapy includes pain management, endocrine and metabolic interventions. There is no evidence for androgen substitution therapy. Conclusion The French national Kennedy’s disease protocol provides management recommendations for patients with KD. In a low-incidence condition, sharing and integrating regional expertise, multidisciplinary experience and defining consensus best-practice recommendations is particularly important. Well-coordinated collaborative efforts will ultimately pave the way to the development of evidence-based international guidelines.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13023-020-01366-zTest; https://doaj.org/toc/1750-1172Test

الوصول الحر: https://doaj.org/article/53385653b6f54dc88c82f8af909bb4bcTest

المؤلفون: Yassine Kadmi, Lidia Favier, Tania Yehya, Isabelle Soutrel, Andrei Ionuţ Simion, Christophe Vial, Dominique Wolbert

المصدر: Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2905-2913 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

الوصف: Recently, environmental scientists have been focused their attention on the occurrence of emerging contaminants in water, such as disinfection by products (DBPs), including chlorophenols. These pollutants can be a public health problem due to their carcinogenic properties. In this work, ultra-high pressure liquid chromatography (UHPLC) coupled to a photodiode array detector (PDA) was used for the development of an analytical method capable of simultaneous identification and quantification of two chlorophenols namely, 2-chlorophenol and 2,4-dichlorophenol in water samples. In addition, a solid phase extraction (SPE) procedure for the extraction of these compounds was optimized. The chlorophenols were separated by an Acquity BEH C18 (100 × 2.1 mm, 1.7 μm) column with a mobile phase of acetonitrile/ultrapure water/formic acid (55/45/0.1, v/v/v). The flow rate of the mobile phase was 0.4 mL min−1. The optimized SPE–UHPLC/PDA technique was evaluated in terms of robustness, considering the enrichment factor for all of the studied chlorophenols. Linear calibration was obtained with correlation coefficients r2 ⩾ 0.998. Intra-day and inter-day precision was less than 5% and accuracy ranged from 99.95% to 103.32%, respectively. The obtained extraction recoveries were higher than 98%. The pre-concentration factor was 2.500 for the both analytes. Under optimized conditions, the detection limits of the overall SPE–UHPLC/PDA method were in the ng L−1 level. The excellent performance of the developed method, as well as the short analysis time makes it a promising analytical tool for the screening of chlorophenols in environmental water samples. Keywords: Water quality, Chlorophenols, Extraction, Liquid chromatography

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1878535215001768Test; https://doaj.org/toc/1878-5352Test

الوصول الحر: https://doaj.org/article/2f884baf3b1f4d808f016291ff7873dfTest

المؤلفون: Montse Olivé, Martin Engvall, Gianina Ravenscroft, Macarena Cabrera-Serrano, Hong Jiao, Carlo Augusto Bortolotti, Marcello Pignataro, Matteo Lambrughi, Haibo Jiang, Alistair R. R. Forrest, Núria Benseny-Cases, Stefan Hofbauer, Christian Obinger, Gianantonio Battistuzzi, Marzia Bellei, Marco Borsari, Giulia Di Rocco, Helena M. Viola, Livia C. Hool, Josep Cladera, Kristina Lagerstedt-Robinson, Fengqing Xiang, Anna Wredenberg, Francesc Miralles, Juan José Baiges, Edoardo Malfatti, Norma B. Romero, Nathalie Streichenberger, Christophe Vial, Kristl G. Claeys, Chiara S. M. Straathof, An Goris, Christoph Freyer, Martin Lammens, Guillaume Bassez, Juha Kere, Paula Clemente, Thomas Sejersen, Bjarne Udd, Noemí Vidal, Isidre Ferrer, Lars Edström, Anna Wedell, Nigel G. Laing

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

الوصف: Myoglobin is a hemeprotein that reversibly binds oxygen and gives muscle its red color. Here, the authors report a genetic variant in the MB gene that associates with myoglobinopathy, an autosomal dominant progressive myopathy, and altered oxygen binding properties of the mutant protein.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/66b676bb69fb44be94c22654e712d730Test

المؤلفون: Tania Yehya, Lidia Favier, Fabrice Audonnet, Nidal Fayad, Hajar Bahry, Gabriela Elena Bahrim, Christophe Vial

المصدر: Applied Sciences, Vol 10, Iss 22, p 8034 (2020)

مصطلحات موضوعية: carbamazepine, microalgae, micropollutant, phycoremediation, water treatment, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

الوصف: Nowadays, water pollution by pharmaceuticals is a major issue that needs an urgent solution, as these compounds, even when found at trace or ultra-trace levels, could have harmful effects on organisms. Carbamazepine (CBZ) is a pharmaceutical product that is detected as a micropollutant in many water resources. Different treatment methods were lately employed for the removal of CBZ, which are often cheap but inefficient or efficient but expensive. Yet, there are limited available studies on the elimination of this molecule by algae despite their well-known highly adaptive abilities. In this study, the biological treatment of CBZ was carried out using the green microalgae, Ankistrodesmus braunii (A. braunii), which has been reported to be particularly resistant to CBZ toxicity in the literature. The respective effects of the culture medium, the initial inoculum, and CBZ concentrations were studied on CBZ removal. Lastly, the mechanism of CBZ elimination by A. braunii was investigated. The presented data clearly demonstrates that the presence of this molecule did not completely repress A. braunii growth or the ability of these algae to remove CBZ; after 60 days of incubation, the highest percentage of CBZ elimination achieved was 87.6%. Elimination was more successful in Bold’s basal medium than in proteose peptone medium. Finally, the removal mechanism was also investigated to provide a better understanding of the transformation mechanism of this molecule. It was shown that the main removal mechanism was the bioaccumulation of CBZ by A. braunii cells, but the biotransformation of the initial CBZ into metabolites was also observed.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3417/10/22/8034Test; https://doaj.org/toc/2076-3417Test

الوصول الحر: https://doaj.org/article/9fc7e1815ade442d89a0082a0e03b16cTest

المؤلفون: Celine Dogan, Marie De Antonio, Dalil Hamroun, Hugo Varet, Marianne Fabbro, Felix Rougier, Khadija Amarof, Marie-Christine Arne Bes, Anne-Laure Bedat-Millet, Anthony Behin, Remi Bellance, Françoise Bouhour, Celia Boutte, François Boyer, Emmanuelle Campana-Salort, Françoise Chapon, Pascal Cintas, Claude Desnuelle, Romain Deschamps, Valerie Drouin-Garraud, Xavier Ferrer, Helene Gervais-Bernard, Karima Ghorab, Pascal Laforet, Armelle Magot, Laurent Magy, Dominique Menard, Marie-Christine Minot, Aleksandra Nadaj-Pakleza, Sybille Pellieux, Yann Pereon, Marguerite Preudhomme, Jean Pouget, Sabrina Sacconi, Guilhem Sole, Tanya Stojkovich, Vincent Tiffreau, Andoni Urtizberea, Christophe Vial, Fabien Zagnoli, Gilbert Caranhac, Claude Bourlier, Gerard Riviere, Alain Geille, Romain K Gherardi, Bruno Eymard, Jack Puymirat, Sandrine Katsahian, Guillaume Bassez

المصدر: PLoS ONE, Vol 11, Iss 2, p e0148264 (2016)

مصطلحات موضوعية: Medicine, Science

الوصف: Myotonic Dystrophy type 1 (DM1) is one of the most heterogeneous hereditary disease in terms of age of onset, clinical manifestations, and severity, challenging both medical management and clinical trials. The CTG expansion size is the main factor determining the age of onset although no factor can finely predict phenotype and prognosis. Differences between males and females have not been specifically reported. Our aim is to study gender impact on DM1 phenotype and severity.We first performed cross-sectional analysis of main multiorgan clinical parameters in 1409 adult DM1 patients (>18 y) from the DM-Scope nationwide registry and observed different patterns in males and females. Then, we assessed gender impact on social and economic domains using the AFM-Téléthon DM1 survey (n = 970), and morbidity and mortality using the French National Health Service Database (n = 3301).Men more frequently had (1) severe muscular disability with marked myotonia, muscle weakness, cardiac, and respiratory involvement; (2) developmental abnormalities with facial dysmorphism and cognitive impairment inferred from low educational levels and work in specialized environments; and (3) lonely life. Alternatively, women more frequently had cataracts, dysphagia, digestive tract dysfunction, incontinence, thyroid disorder and obesity. Most differences were out of proportion to those observed in the general population. Compared to women, males were more affected in their social and economic life. In addition, they were more frequently hospitalized for cardiac problems, and had a higher mortality rate.Gender is a previously unrecognized factor influencing DM1 clinical profile and severity of the disease, with worse socio-economic consequences of the disease and higher morbidity and mortality in males. Gender should be considered in the design of both stratified medical management and clinical trials.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC4744025?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/cf83b8ab743c4b25aa7cfa3285289205Test

المؤلفون: Alain Riaublanc, Catherine Loisel, Gholamreza Djelveh, Christophe Vial, Irina Nicorescu, Jack Legrand

المصدر: Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, Vol 12, Iss 1, Pp 49-58 (2011)

مصطلحات موضوعية: bubbling, protein aggregates, thermal treatment, whey proteins, Chemical technology, TP1-1185

الوصف: The food foams are "whipped" products that have recently experienced significant growth in the food industry. They are appreciated by consumers for their creamy texture, taste and visual aspect. Whey proteins are particularly common ingredients in the formulation of food foams because of their functional properties (foaming properties, interfacial, emulsifying). Denaturation and aggregation of whey proteins further to a heat treatment, allows the improvement of these properties by creating protein aggregates with targeted properties. The objective of this study is to understand the impact of the intensity of heat treatment applied to a protein solution on the aggregation of proteins (proportion, size and morphology of protein assemblies) and on their foaming properties in order to better control the use properties of foamed products stabilized by whey protein aggregates (WPI). In this work, a 2% w/v of whey proteins in the presence of salt (50 mM NaCl) was heated in an Actijoule type tubular heat exchanger at 80, 90 and 100 °C. Native and denatured solutions of WPI were characterized by microcalorimetry ( DSC), size exclusion chromatography (SEC), diffusion light scattering (DLS), electrophoresis (SDS-PAGE), optical microscopy and atomic force microscopy (AFM). To assess the impact of thermal treatment on the foaming ability of protein solutions, a bubbling method has been employed. The experimental results showed that as far as the heating temperature is increased, it promotes the aggregation of proteins into oligomers which then are forming soluble aggregates of about 160 nm in diameter. We have also observed that the increase of this fraction is a continuous function of temperature for solutions treated up to 100 °C. However, the amount of insoluble aggregates formed reaches a maximum when the heat treatment temperature is 90 °C. Finally, we showed by SDS-PAGE that the soluble and insoluble aggregates are stabilized by disulfide bridges and microscopically we found that insoluble aggregates are dense and highly branched. With regard to the foaming properties of proteins, the formation of the foam was very dependent on the thermal treatment applied to protein solutions. Our results demonstrate as well that the time of bubbling is clearly correlated with the proportion of insoluble proteins and for this reason, a thermal treatment at 90 °C that leads to a significant increase of the proportion of insoluble aggregates, retards foam formation. Also,  Lactoglobulin and -Lactalbumin monomers existing in the protein solutions before bubbling, appear to play a crucial role. Thus, we observed that native WPI solutions lead to the formation of dry foams, while the WPI solutions heated to temperatures of at least 80 °C lead rather to the formation of wet foams.

وصف الملف: electronic resource

العلاقة: http://pubs.ub.ro/dwnl.php?id=CSCC6201112V01S01A0009Test; https://doaj.org/toc/1582-540XTest

الوصول الحر: https://doaj.org/article/bcb881209e0e4807a3e31c9a4f62d04fTest

المؤلفون: Gholamreza Djelveh, Christophe Vial

المصدر: Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, Vol 11, Iss 1, Pp 161-182 (2010)

مصطلحات موضوعية: expansion, whipping, foamed foods, formulation, whipped products, aerated products, expansion ratio, Chemical technology, TP1-1185

الوصف: Mousses alimentaires sont un sous-ensemble des aliments connus sous le nom de produits fouettés ou des produits aérés. Ils sont des produits formulés avec des qualités telles que la légèreté et la souplesse et sont principalement consommés à l'apéritif ou au dessert. Les produits en mousse obtenue par dispersion d'un gaz dans une matrice alimentaire (la phase continue) ont connu un développement croissant au cours des années 80 et 90. Le processus d'aération liés à leurs activités de production est appelée l'expansion ou à fouetter. Le document présente les principaux-paramètres du procédé du point permanent de la formulation, la mise en œuvre processus dans les installations pilotes et à l'échelle industrielle, la caractérisation des produits finis, la base énergétique de l'échelle de processus en place, et le lien entre la formulation, émulsion préparation de l'expansion. Cette vue d'ensemble de l'opération d'expansion continue, nous a permis de mettre en évidence le fait qu'il ya des opérations de l'unité encore mal décrite par le génie des procédés et pour lesquels les méthodes et outils pour l'extrapolation et la prédiction sont encore à leurs balbutiements.

وصف الملف: electronic resource

العلاقة: http://pubs.ub.ro/dwnl.php?id=CSCC6201011V01S01A0009Test; https://doaj.org/toc/1582-540XTest

الوصول الحر: https://doaj.org/article/e90d0bd2aff348c6ab3f96f3c538e398Test

المؤلفون: Sirin Dhifallah, Anis Attour, Christophe Vial, Féthi Zagrouba, Fabrice Audonnet

مصطلحات موضوعية: Phosphorus Recovery and Sustainable Management, Industrial and Manufacturing Engineering, Environmental Science, Physical Sciences, Fluoride Contamination in Drinking Water and Defluoridation Methods, Water Science and Technology, Electrocoagulation, Adsorption, Hydroxide, Fluoride, Tap water, Chemistry, Aluminium, Inorganic chemistry, Environmental science, Environmental engineering, FOS Environmental engineering, Organic chemistry, Physical chemistry

الوصف: Overload of fluoride ions in water is observed in several regions of southern Tunisia, mainly the regions close to the mining basin of Gafsa: Metlaoui, Omlarayes and Redayef. This study concerns fluoride removal from Metlaoui's tap water by electrocoagulation (EC) using aluminum electrodes in a batch reactor. This water contains 3.5 mg·L−1 of fluoride, the highest concentration observed in these basins. The effect of the operating conditions of EC treatment on tap water defluoridation was analyzed, namely, current density, temperature and interelectrode distance. Hydroxide aluminum flocs, formed with different durations of EC, were used as sorbents in fluorinated deionized water ([F−] = 3.5 mg·L−1) and Metlaoui's tap water. Flocs formed after 30 min of EC, produced by dissolving (79 ± 1) mg·L−1 of aluminum and adjusted at pH = 6.5, allowed the adsorption of (98 ± 1)% of fluoride ions from deionized fluorinated water. Flocs adjusted at different pH, from 5 to 9, were used as sorbents in fluorinated ... : يُلاحظ وجود حمل زائد من أيونات الفلوريد في المياه في عدة مناطق من جنوب تونس، ولا سيما المناطق القريبة من حوض التعدين في قفصة: المطلاوي وأومالاراييس والردايف. تتعلق هذه الدراسة بإزالة الفلوريد من ماء صنبور المتلاوي عن طريق التخثير الكهربائي باستخدام أقطاب الألومنيوم في مفاعل دفعي. يحتوي هذا الماء على 3.5 ملغ من الفلورايد، وهو أعلى تركيز لوحظ في هذه الأحواض. تم تحليل تأثير ظروف تشغيل معالجة EC على إزالة فلورة ماء الصنبور، أي كثافة التيار ودرجة الحرارة ومسافة الإلكترود. تم استخدام ندف الألومنيوم الهيدروكسيد، التي تشكلت مع فترات مختلفة من المفوضية الأوروبية، كمادة ماصة في الماء المفلور منزوع الأيونات ([F -] = 3.5 ملغ·L-1) وماء صنبور المتلاوي. سمحت الندف التي تشكلت بعد 30 دقيقة من EC، والتي تم إنتاجها عن طريق إذابة (79 ± 1) ملغ•L-1 من الألومنيوم وتعديلها عند الرقم الهيدروجيني = 6.5، بامتزاز (98 ± 1)٪ من أيونات الفلورايد من الماء المفلور منزوع الأيونات. تم استخدام الكتل المعدلة عند درجة حموضة مختلفة، من 5 إلى 9، كمواد ماصة في الماء المفلور منزوع الأيونات ومياه صنبور المتلاوي. سمحت الندف الحمضية والمحايدة بأفضل ...

العلاقة: https://dx.doi.org/10.60692/0jh7g-5ep40Test

الإتاحة: https://doi.org/10.60692/qm1je-n1s1010.60692/0jh7g-5ep40Test