المؤلفون: Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C. Duke, Andrew Karanja Githeko, Obed M. Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T. Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo

المصدر: Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Climate change, Vector-borne diseases, Africa, Environmental justice, Research and development, Pan-African funding initiatives, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270

الوصف: Abstract We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2049-9957Test

الوصول الحر: https://doaj.org/article/c9492d85a70249e392a32c25038fe09cTest

المؤلفون: Lemonde Bouafou, Boris K. Makanga, Nil Rahola, Marilou Boddé, Marc F. Ngangué, Josquin Daron, Audric Berger, Theo Mouillaud, Alex Makunin, Petra Korlević, Joachim Nwezeobi, Pierre Kengne, Christophe Paupy, Mara K. N. Lawniczak, Diego Ayala

المصدر: Evolutionary Applications, Vol 17, Iss 6, Pp n/a-n/a (2024)

مصطلحات موضوعية: Anopheles, Gabon, host preference, malaria, phenotypic plasticity, protected areas, Evolution, QH359-425

الوصف: Abstract The adaptation of Anopheles malaria vectors to domestic settings is directly linked to their ability to feed on humans. The strength of this species–habitat association is unequal across the species within the genus, with the major vectors being particularly dependent on humans. However, our understanding of how blood‐feeding behavior interacts with and adapts to environmental settings, including the presence of humans, remains limited. Using a field‐based approach, we first investigated Anopheles community structure and feeding behavior patterns in domestic and sylvatic settings in La Lopé National Park in Gabon, Central Africa. We characterized the preference indices using a dual‐host choice sampling approach across mosquito species, habitats, and seasons. We then quantified the plastic biting behavior of mosquito species in each habitat. We collected individuals from 16 Anopheles species that exhibited significant differences in species composition and abundance between sylvatic and domestic settings. The host‐seeking behavior also varied among the seven most abundant species. The general attractiveness to each host, human or animal, remained relatively constant for each species, but with significant variations between habitats across species. These variations, to more generalist and to more anthropophilic behavior, were related to seasonal changes and distance from the village, respectively. Finally, we pointed out that the host choice of major malaria vectors changed in the absence of humans, revealing a plastic feeding behavior of these species. This study highlights the effect of humans on Anopheles distribution and feeding evolution. The characterization of feeding behavior in wild and domestic settings provides opportunities to better understand the interplay between genetic determinants of host preference and ecological factors. Our findings suggest that protected areas may offer alternative thriving conditions to major malaria vectors.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1752-4571Test

الوصول الحر: https://doaj.org/article/6fb7e40434534003a666e84d4c9eeb65Test

المؤلفون: Stéphanie Dabo, Annabelle Henrion-Lacritick, Alicia Lecuyer, Davy Jiolle, Christophe Paupy, Diego Ayala, Silvânia da Veiga Leal, Athanase Badolo, Anubis Vega-Rúa, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John-Paul Mutebi, Maria-Carla Saleh, Noah H Rose, Carolyn S McBride, Louis Lambrechts

المصدر: PLoS Neglected Tropical Diseases, Vol 18, Iss 3, p e0011862 (2024)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

الوصف: African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it is true for dengue virus (DENV), the most prevalent flavivirus of humans. Addressing this question is complicated by substantial genetic diversity among DENV strains, most notably in the form of four genetic types (DENV1 to DENV4), that can lead to genetically specific interactions with mosquito populations. Here, we carried out a survey of DENV susceptibility using a panel of seven field-derived Ae. aegypti colonies from across the African range of the species and a colony from Guadeloupe, French West Indies as non-African reference. We found considerable variation in the ability of African Ae. aegypti populations to acquire and replicate a panel of six DENV strains spanning the four DENV types. Although African Ae. aegypti populations were generally less susceptible than the reference non-African population from Guadeloupe, in several instances some African populations were equally or more susceptible than the Guadeloupe population. Moreover, the relative level of susceptibility between African mosquito populations depended on the DENV strain, indicating genetically specific interactions. We conclude that unlike ZIKV susceptibility, there is no clear-cut dichotomy in DENV susceptibility between African and non-African Ae. aegypti. DENV susceptibility of African Ae. aegypti populations is highly heterogeneous and largely governed by the specific pairing of mosquito population and DENV strain.

وصف الملف: electronic resource

العلاقة: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011862&type=printableTest; https://doaj.org/toc/1935-2727Test; https://doaj.org/toc/1935-2735Test

الوصول الحر: https://doaj.org/article/887770f33d474eec85dd8da7c51b7489Test

المؤلفون: Sara Šiljegović, Théo Mouillaud, Davy Jiolle, Dušan Petrić, Aleksandra Ignjatović-Ćupina, Ana Vasić, Christophe Paupy, Mihaela Kavran

المصدر: Animals, Vol 14, Iss 9, p 1255 (2024)

مصطلحات موضوعية: Dirofilaria sp., Setaria tundra, mosquito surveillance, Cox1 gene, Veterinary medicine, SF600-1100, Zoology, QL1-991

الوصف: Dirofilaria immitis and D. repens are the two most widespread and important species of mosquito-borne nematodes, posing a significant threat to veterinary health and particularly affecting canines and felines. While D. immitis causes cardiopulmonary dirofilariasis, D. repens causes subcutaneous infections in dogs and other carnivores. Despite the extensive knowledge on these parasites, little is known about their natural vectors in Serbia. The parasite Setaria tundra, known to infect deer, has not yet been detected in Serbia but has been documented in neighboring countries. Thus, the aim of this study was to (i) further map out Dirofilaria sp. hotspots in the Vojvodina Province and detect S. tundra for the first time, (ii) detect positive mosquito species that can provide insights into how the nematodes spread in Serbia, and (iii) analyze the blood-fed female mosquitoes of species found to be infected, in order to identify the potential source of parasite infection. A total of 2902 female mosquitoes were collected across 73 locations during 2021 and 2022. Molecular biology methods, based on conventional PCR, were used to analyze non-blood-fed (2521 specimens) and blood-fed (381 specimens) female mosquitos, in order to detect filarial nematode presence and identify blood-meal sources, respectively. When the parasite genome was detected, the amplicon (cox1 gene, 650 bp fragment) was sent for Sanger sequencing, further confirming the presence of nematodes and species assignation. D. immitis was detected in three Culex pipiens mosquitoes collected in Zrenjanin (August 2021) and Glogonj and Svetozar Miletić (both in July 2021). Additionally, Setaria tundra was detected in Aedes vexans collected in Iđoš (mid-August 2021) and Aedes caspius, which was collected in Mali Iđoš (end of July 2021). This work identifies two new locations where D. immitis occurs in Vojvodina, and is the first report of S. tundra in Serbian territory. Blood-meal analysis provided insights into the preferences of mosquitoes that were positive for Dirofilaria sp. and S. tundra.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-2615/14/9/1255Test; https://doaj.org/toc/2076-2615Test

الوصول الحر: https://doaj.org/article/7eb36bb344c942e2b89f852ef1f8ed60Test

المؤلفون: Judicaël Obame-Nkoghe, David Roiz, Marc-Flaubert Ngangue, Carlo Costantini, Nil Rahola, Davy Jiolle, David Lehmann, Loïc Makaga, Diego Ayala, Pierre Kengne, Christophe Paupy

المصدر: PLoS Neglected Tropical Diseases, Vol 17, Iss 8, p e0011501 (2023)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

الوصف: BackgroundSince its first record in urban areas of Central-Africa in the 2000s, the invasive mosquito, Aedes albopictus, has spread throughout the region, including in remote villages in forested areas, causing outbreaks of Aedes-borne diseases, such as dengue and chikungunya. Such invasion might enhance Ae. albopictus interactions with wild animals in forest ecosystems and favor the spillover of zoonotic arboviruses to humans. The aim of this study was to monitor Ae. albopictus spread in the wildlife reserve of La Lopé National Park (Gabon), and evaluate the magnitude of the rainforest ecosystem colonization.MethodologyFrom 2014 to 2018, we used ovitraps, larval surveys, BG-Sentinel traps, and human landing catches along an anthropization gradient from La Lopé village to the natural forest in the Park.ConclusionsWe detected Ae. albopictus in gallery forest up to 15 km away from La Lopé village. However, Ae. albopictus was significantly more abundant at anthropogenic sites than in less anthropized areas. The number of eggs laid by Ae. albopictus decreased progressively with the distance from the forest fringe up to 200m inside the forest. Our results suggested that in forest ecosystems, high Ae. albopictus density is mainly observed at interfaces between anthropized and natural forested environments. Additionally, our data suggested that Ae. albopictus may act as a bridge vector of zoonotic pathogens between wild and anthropogenic compartments.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1935-2727Test; https://doaj.org/toc/1935-2735Test

الوصول الحر: https://doaj.org/article/d416fefc4079427d8a31114b78936460Test

المؤلفون: Thomas Obadia, Gladys Gutierrez-Bugallo, Veasna Duong, Ana I. Nuñez, Rosilainy S. Fernandes, Basile Kamgang, Liza Hery, Yann Gomard, Sandra R. Abbo, Davy Jiolle, Uros Glavinic, Myrielle Dupont-Rouzeyrol, Célestine M. Atyame, Nicolas Pocquet, Sébastien Boyer, Catherine Dauga, Marie Vazeille, André Yébakima, Michael T. White, Constantianus J. M. Koenraadt, Patrick Mavingui, Anubis Vega-Rua, Eva Veronesi, Gorben P. Pijlman, Christophe Paupy, Núria Busquets, Ricardo Lourenço-de-Oliveira, Xavier De Lamballerie, Anna-Bella Failloux

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)

مصطلحات موضوعية: Science

الوصف: Zika virus (ZIKV), the causative agent of virus-induced brain damage in newborns, is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus. Here, Obadia et al. characterize ZIKV vector competence of 50 mosquito populations from six species collected in 12 different countries to inform about epidemic risk. They find that African ZIKV strain shows higher transmission efficiency compared to American and Asian ZIKV strains and that Ae. aegypti mosquitoes have highest susceptibility to infections, while Culexmosquitoes are largely non-susceptible.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/5bc19ec268b64361a9cc23ed74b6e5c4Test

المؤلفون: Davy Jiolle, Isabelle Moltini-Conclois, Judicaël Obame-Nkoghe, Patrick Yangari, Angélique Porciani, Bethsabée Scheid, Pierre Kengne, Diego Ayala, Anna-Bella Failloux, Christophe Paupy

المصدر: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1244-1253 (2021)

مصطلحات موضوعية: Zika virus, African and Asian lineages, Aedes aegypti, Aedes albopictus, Gabon, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

الوصف: The two main Zika virus (ZIKV) vectors, Aedes albopictus and Aedes aegypti (invasive and native species, respectively), are present in Gabon (Central Africa). The aim of this study was to determine the entomological ZIKV risk associated with these mosquito species in Gabon by evaluating their vector competence for an African (i.e. representative of the endemic strains circulating in sub-Saharan Africa) and two Asian (i.e. representatives of exogenous epidemic strains that could be introduced) ZIKV strains. The transmission efficiency of one Ae. aegypti and two Ae. albopictus field-collected populations from Libreville and Franceville was assayed at day 7, 14 and 21 after experimental oral infection. The two mosquito species could transmit all three ZIKV strains already at day 7 post-infection, but transmission efficiency was higher for the African strain than the non-African strains (>60% versus

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2222-1751Test

الوصول الحر: https://doaj.org/article/b59691a3e4c54d779e20c8c0179522e7Test

المؤلفون: Diego Ayala, Ousman Akone‐Ella, Nil Rahola, Pierre Kengne, Marc F. Ngangue, Fabrice Mezeme, Boris K. Makanga, Martha Nigg, Carlo Costantini, Frédéric Simard, Franck Prugnolle, Benjamin Roche, Olivier Duron, Christophe Paupy

المصدر: Evolutionary Applications, Vol 12, Iss 8, Pp 1583-1594 (2019)

مصطلحات موضوعية: Anopheles, co‐evolution, disease control, diversity, Wolbachia, Evolution, QH359-425

الوصف: Abstract During the last decade, the endosymbiont bacterium Wolbachia has emerged as a biological tool for vector disease control. However, for long time, it was believed that Wolbachia was absent in natural populations of Anopheles. The recent discovery that species within the Anopheles gambiae complex host Wolbachia in natural conditions has opened new opportunities for malaria control research in Africa. Here, we investigated the prevalence and diversity of Wolbachia infection in 25 African Anopheles species in Gabon (Central Africa). Our results revealed the presence of Wolbachia in 16 of these species, including the major malaria vectors in this area. The infection prevalence varied greatly among species, confirming that sample size is a key factor to detect the infection. Moreover, our sequencing and phylogenetic analyses showed the important diversity of Wolbachia strains that infect Anopheles. Co‐evolutionary analysis unveiled patterns of Wolbachia transmission within some Anopheles species, suggesting that past independent acquisition events were followed by co‐cladogenesis. The large diversity of Wolbachia strains that infect natural populations of Anopheles offers a promising opportunity to select suitable phenotypes for suppressing Plasmodium transmission and/or manipulating Anopheles reproduction, which in turn could be used to reduce the malaria burden in Africa.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1752-4571Test

الوصول الحر: https://doaj.org/article/eba4176d77ba4d2ab4869bd2f21e6a74Test

المؤلفون: Filipe Vieira Santos de Abreu, Ieda Pereira Ribeiro, Anielly Ferreira-de-Brito, Alexandre Araujo Cunha dos Santos, Rafaella Moraes de Miranda, Iule de Souza Bonelly, Maycon Sebastião Alberto Santos Neves, Maria Ignez Bersot, Taissa Pereira dos Santos, Marcelo Quintela Gomes, José Luis da Silva, Alessandro Pecego Martins Romano, Roberta Gomes Carvalho, Rodrigo Fabiano do Carmo Said, Mario Sergio Ribeiro, Roberto da Costa Laperrière, Eduardo Oyama Lins Fonseca, Aloísio Falqueto, Christophe Paupy, Anna-Bella Failloux, Sara Moutailler, Marcia Gonçalves de Castro, Mariela Martínez Gómez, Monique de Albuquerque Motta, Myrna Cristina Bonaldo, Ricardo Lourenço-de-Oliveira

المصدر: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 218-231 (2019)

مصطلحات موضوعية: Yellow fever, Atlantic forest, Haemagogus, Aedes, Sabethes, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

الوصف: ABSTRACTThe yellow fever virus (YFV) caused a severe outbreak in Brazil in 2016–2018 that rapidly spread across the Atlantic Forest in its most populated region without viral circulation for almost 80 years. A comprehensive entomological survey combining analysis of distribution, abundance and YFV natural infection in mosquitoes captured before and during the outbreak was conducted in 44 municipalities of five Brazilian states. In total, 17,662 mosquitoes of 89 species were collected. Before evidence of virus circulation, mosquitoes were tested negative but traditional vectors were alarmingly detected in 82% of municipalities, revealing high receptivity to sylvatic transmission. During the outbreak, five species were found positive in 42% of municipalities. Haemagogus janthinomys and Hg. leucocelaenus are considered the primary vectors due to their large distribution combined with high abundance and natural infection rates, concurring together for the rapid spread and severity of this outbreak. Aedes taeniorhynchus was found infected for the first time, but like Sabethes chloropterus and Aedes scapularis, it appears to have a potential local or secondary role because of their low abundance, distribution and infection rates. There was no evidence of YFV transmission by Aedes albopictus and Aedes aegypti, although the former was the most widespread species across affected municipalities, presenting an important overlap between the niches of the sylvatic vectors and the anthropic ones. The definition of receptive areas, expansion of vaccination in the most affected age group and exposed populations and the adoption of universal vaccination to the entire Brazilian population need to be urgently implemented.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2222-1751Test

الوصول الحر: https://doaj.org/article/bb386c544ee441fab4bb4fd9a4bc7093Test

المؤلفون: Taissa Pereira dos Santos, David Roiz, Filipe Vieira Santos de Abreu, Sergio Luiz Bessa Luz, Marcelo Santalucia, Davy Jiolle, Maycon Sebastiao Alberto Santos Neves, Frédéric Simard, Ricardo Lourenço-de-Oliveira, Christophe Paupy

المصدر: Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-8 (2018)

مصطلحات موضوعية: Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

الوصف: Abstract The invasive species Aedes albopictus is present in 60% of Brazilian municipalities, including at the interfaces between urban settings and forests that are zoonotic arbovirus hotspots. We investigated Ae. albopictus colonization, adult dispersal and host feeding patterns in the anthropic-natural interface of three forested sites covering three biomes in Brazil in 2016. To evaluate whether an ecological overlap exists between Ae. albopictus and sylvatic yellow fever virus (YFV) in forests, we performed similar investigations in seven additional urban-forest interfaces where YFV circulated in 2017. We found Ae. albopictus in all forested sites. We detected eggs and adults up to 300 and 500 m into the forest, respectively, demonstrating that Ae. albopictus forest colonization and dispersal decrease with distance from the forest edge. Analysis of the host identity in blood-engorged females indicated that they fed mainly on humans and domestic mammals, suggesting rare contact with wildlife at the forest edge. Our results show that Ae. albopictus frequency declines as it penetrates into the forest and highlight its potential role as a bridge vector of zoonotic diseases at the edge of the Brazilian forests studied.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1038/s41426-018-0194-yTest; https://doaj.org/toc/2222-1751Test

الوصول الحر: https://doaj.org/article/de626da811c04a2bb85b861325252088Test