المؤلفون: Kopańska Marta, Chojdak-Łukasiewicz Justyna, Sochocka Marta, Leszek Jerzy, Podgórska-Bednarz Justyna, Banaś-Ząbczyk̨ Agnieszka, Ochojska Danuta

المصدر: Frontiers in Psychiatry, Vol 13 (2022)

مصطلحات موضوعية: autism spectrum disorder, therapeutic methods, biofeedback, symptoms, patients, Psychiatry, RC435-571

الوصف: In this review we present the behavioral aspects of interaction in people with autism spectrum disorders (ASD), taking into account some aspects of pharmacotherapy. In the treatment of people with ASD, an individual approach to emotional, social and cognitive functioning is very important. The specificity of symptoms and their severity in people with ASD results from deficits/disfunction of various areas of the brain and is associated with different levels of intelligence. This manuscript considers selected methods of interaction with ASD patients with normal IQ. Due to the different ways of functioning, these people often find it difficult to adapt to social expectations. The most important thing is to understand their perception of themselves and the world around them in order to support them in coping with the daily challenges. Due to the increasing problem, more and more attention is being focused on early detection of ASD, what allows to intervene as fast as possible and in consequence affect the quality of life of people with this dysfunctions. However, participants with mild autism symptoms are still difficult to diagnose in the practice. The effectiveness of the therapy depends largely on the cooperation of educational institutions. It is also necessary to contact specialist clinics, including a mental health counseling center. However, in the case of children and adolescents, the cooperation between the therapist and their parents is the basis. Systemic family therapy is also important in adults with ASD. An overview of the methods of therapeutic interactions in ASD, what may be helpful in diagnosing of mild ASD, were presented in our manuscript.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.942218/fullTest; https://doaj.org/toc/1664-0640Test

الوصول الحر: https://doaj.org/article/e4667694e2cd4be8bfa6b8a2ec5cca67Test

المؤلفون: Zadka, Łukasz, Sochocka, Marta, Hachiya, Naomi, Chojdak-Łukasiewicz, Justyna, Dzięgiel, Piotr, Piasecki, Egbert, Leszek, Jerzy

المصدر: GeroScience ; volume 46, issue 1, page 71-85 ; ISSN 2509-2723

مصطلحات موضوعية: Geriatrics and Gerontology, Aging

الوصف: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The pathogenesis of AD still remains unclear, including two main hypotheses: amyloid cascade and tau hyperphosphorylation. The hallmark neuropathological changes of AD are extracellular deposits of amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Endocytosis plays an important role in a number of cellular processes including communication with the extracellular environment, nutrient uptake, and signaling by the cell surface receptors. Based on the results of genetic and biochemical studies, there is a link between neuronal endosomal function and AD pathology. Taking this into account, we can state that in the results of previous research, endolysosomal abnormality is an important cause of neuronal lesions in the brain. Endocytosis is a central pathway involved in the regulation of the degradation of amyloidogenic components. The results of the studies suggest that a correlation between alteration in the endocytosis process and associated protein expression progresses AD. In this article, we discuss the current knowledge about endosomal abnormalities in AD.

الإتاحة: https://doi.org/10.1007/s11357-023-00923-1Test

المؤلفون: Kołtuniuk, Aleksandra, Pawlak, Beata, Krówczyńska, Dorota, Chojdak-Łukasiewicz, Justyna

المساهمون: Ministry of Health

المصدر: Frontiers in Psychology ; volume 13 ; ISSN 1664-1078

الوصف: Background Patients with multiple sclerosis (MS) experience disabilities which significantly affect their quality of life (QOL) and mental health. Mood disorders and depressive symptoms are one of the most common psychiatric conditions in MS patients. This study aimed to evaluate the level of QOL in MS patients and to assess the influence of depressive symptoms and physical disability on QOL. Methods This prospective and observational study was conducted among 100 MS patients (mean age of 36.23 ± 11.77) recruited from the Lower Silesian Unit of the Polish Association for Multiple Sclerosis. This study used a questionnaire designed by the authors, which contained questions about sociodemographic and clinical data, as well as the following standardized questionnaires: the Activities of Daily Living questionnaire (ADL), the Instrumental Activities of Daily Living questionnaire (IADL), the Expanded Disability Status Scale (EDSS), the Beck Depression Inventory (BDI) and Multiple Sclerosis International Quality of Life Questionnaire (MusiQOL). Results The average EDSS score among patients was 3.13 ± 2.38 points. More than half of the respondents (68%) suffered from depression of varying severity. The univariate linear regression models showed that the independent ( p < 0.05) QOL predictors (total MusiQOL) were as follows: the number of complaints, IADL results, BDI results, EDSS score, higher education, and material status >2000 PLN. In addition, the multiple linear regression model showed that the BDI result was a significant predictor of QOL ( p < 0.005). Conclusion Depressive symptoms significantly affect the QOL of MS patients.

الإتاحة: https://doi.org/10.3389/fpsyg.2022.1068421Test

المؤلفون: Niedzielska, Joanna, Chaszczewska-Markowska, Monika, Chojdak-Łukasiewicz, Justyna, Berezowski, Jakub, Kalra, Seema, Jazwiec, Przemysław

المصدر: Frontiers in Neurology ; volume 14 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a major challenge for clinicians. SARS-CoV-2 infection results in coronavirus disease 2019 (COVID-19), and it is best known for its respiratory symptoms. It can also result in several extrapulmonary manifestations such as neurological complications potentially experienced during the course of COVID-19. The association of dermatomyositis (DM) with COVID-19 pathogenesis has not been well-studied. This study aimed to present a previously healthy 37-year-old man, a soldier by profession, with symptoms of DM on the 4th day from the onset of COVID-19. The patient presented DM symptoms with both skin and muscle manifestations. The patient suffered from cough, fever, and fatigue to begin with, and reverse-transcription polymerase chain reaction (RT-PCR) reported positive for SARS-CoV-2 infection. The laboratory findings showed, intra alia, elevated muscle enzymes CK 8253 U/l (N: <145 U/l), a positive test for myositis-specific autoantibodies (anti-Mi-2), electrodiagnostic tests exhibited features of myopathy, with the presence of muscle and skin symptoms. The patient improved with corticosteroids and immunosuppressive agent therapy. In summary, the association between COVID-19 and the development of multi-system autoimmune disorders such as DM remains unclear. Nevertheless, viral infections such as SARS-CoV-2 may likely serve as a trigger.

الإتاحة: https://doi.org/10.3389/fneur.2023.1122475Test

المؤلفون: Pszczołowska, Magdalena, Walczak, Kamil, Miśków, Weronika, Mroziak, Magdalena, Chojdak-Łukasiewicz, Justyna, Leszek, Jerzy

المصدر: GeroScience; Jun2024, Vol. 46 Issue 3, p2977-2988, 12p

مصطلحات موضوعية: ALZHEIMER'S disease, MITOCHONDRIAL pathology, MITOCHONDRIAL dynamics, TAU proteins, REACTIVE oxygen species

مستخلص: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. The pathogenesis of AD remains still unclear. The three main features of AD are extracellular deposits of amyloid beta (Aβ) plaque, accumulation of abnormal formation hyper-phosphorylated tau protein, and neuronal loss. Mitochondrial impairment plays an important role in the pathogenesis of AD. There are problems with decreased activity of multiple complexes, disturbed mitochondrial fusion, and fission or formation of reactive oxygen species (ROS). Moreover, mitochondrial transport is impaired in AD. Mouse models in many research show disruptions in anterograde and retrograde transport. Both mitochondrial transportation and network impairment have a huge impact on synapse loss and, as a result, cognitive impairment. One of the very serious problems in AD is also disruption of insulin signaling which impairs mitochondrial Aβ removal. Discovering precise mechanisms leading to AD enables us to find new treatment possibilities. Recent studies indicate the positive influence of metformin or antioxidants such as MitoQ, SS-31, SkQ, MitoApo, MitoTEMPO, and MitoVitE on mitochondrial functioning and hence prevent cognitive decline. Impairments in mitochondrial fission may be treated with mitochondrial division inhibitor-1 or ceramide. (Graphic content via Canva Pro) [ABSTRACT FROM AUTHOR]

: Copyright of GeroScience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Chojdak-Łukasiewicz, Justyna¹ (AUTHOR) justyna.chojdak-lukasiewicz@umw.edu.pl, Dziadkowiak, Edyta¹ (AUTHOR) edyta.dziadkowiak@umw.edu.pl

المصدر: Journal of Clinical Medicine. Mar2024, Vol. 13 Issue 5, p1373. 10p.

مصطلحات موضوعية: *LITERATURE reviews, *MIGRAINE aura, *MIGRAINE, *VISUAL fields, *VISION disorders, *SYNDROMES

مستخلص: Visual snow syndrome (VSS) is a rarely diagnosed neurological phenomenon. It is a visual disorder characterised by the presence of numerous white, black, or translucent dots in the visual field, resembling the 'snow' of an analogue TV set experiencing reception interference. According to The International Classification of Headache Disorders, 3rd edition, visual snow is defined as a pattern of continuous small dots across the visual field lasting >3 months and accompanied by at least two of the following four additional symptoms: palinopsia, increased entoptic phenomena, photophobia, and nyctalopia. These complaints are not consistent with a typical migraine with visual aura and cannot be better explained by another disorder. The authors present the case of a 39-year-old woman who was diagnosed with VSS. The symptoms appeared after a migraine attack and had not alleviated. The patient reported a sensation of constant 'TV screen snow'. A neurological examination found no signs of focal damage to the nervous system. The results of the ophthalmological examination, MRI of the brain with contrast, MRI of the eye sockets, and EEG were normal. VSS is a phenomenon that is still not fully understood, different from migraine aura and associated with a number of additional symptoms. VSS is very difficult to treat. In this case, a lot of drugs were used without improvement. Further research must be conducted to determine the best treatment options for these patients. [ABSTRACT FROM AUTHOR]

المؤلفون: Zadka, Łukasz, Sochocka, Marta, Hachiya, Naomi, Chojdak-Łukasiewicz, Justyna, Dzięgiel, Piotr, Piasecki, Egbert, Leszek, Jerzy

المصدر: GeroScience; Feb2024, Vol. 46 Issue 1, p71-85, 15p

مصطلحات موضوعية: ALZHEIMER'S disease, ENDOCYTOSIS, CELL receptors, NEUROFIBRILLARY tangles, NUTRIENT uptake, CO-cultures

مستخلص: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The pathogenesis of AD still remains unclear, including two main hypotheses: amyloid cascade and tau hyperphosphorylation. The hallmark neuropathological changes of AD are extracellular deposits of amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Endocytosis plays an important role in a number of cellular processes including communication with the extracellular environment, nutrient uptake, and signaling by the cell surface receptors. Based on the results of genetic and biochemical studies, there is a link between neuronal endosomal function and AD pathology. Taking this into account, we can state that in the results of previous research, endolysosomal abnormality is an important cause of neuronal lesions in the brain. Endocytosis is a central pathway involved in the regulation of the degradation of amyloidogenic components. The results of the studies suggest that a correlation between alteration in the endocytosis process and associated protein expression progresses AD. In this article, we discuss the current knowledge about endosomal abnormalities in AD. [ABSTRACT FROM AUTHOR]

: Copyright of GeroScience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Pawłowski, Marcin, Fila-Witecka, Karolina, Rymaszewska, Julia Ewa, Kamińska, Dorota, Poznański, Paweł, Augustyniak-Bartosik, Hanna, Zielińska, Dorota, Krajewska, Magdalena, Krajewski, Piotr K, Stefaniak, Aleksandra, Szepietowski, Jacek C, Pokryszko-Dragan, Anna, Chojdak-Łukasiewicz, Justyna, Budrewicz, Sławomir, Pawłowski, Tomasz, Szcześniak, Dorota, Rymaszewska, Joanna

المصدر: Psychology Research and Behavior Management ; volume Volume 15, page 2659-2669 ; ISSN 1179-1578

الإتاحة: https://doi.org/10.2147/prbm.s362918Test
https://www.dovepress.com/getfile.php?fileID=83982Test

المؤلفون: Dziadkowiak, Edyta, Wieczorek, Małgorzata, Zagrajek, Mieszko, Chojdak-Łukasiewicz, Justyna, Gruszka, Ewa, Budrewicz, Sławomir, Pokryszko-Dragan, Anna

المصدر: Frontiers in Neurology ; volume 12 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: Objective There is an ongoing search for markers useful in monitoring and predicting disease activity at the early stage of multiple sclerosis (MS). The goals of this study were to prospectively evaluate the changes in parameters of multimodal evoked potentials (EP) and cognition within a 3-year follow-up period in patients with clinically isolated syndrome (CIS), and to assess the prognostic value of baseline findings with regard to the disease outcomes. Methods In 29 patients (20 women, nine men, mean age 31.1) multimodal (visual, brainstem auditory, somatosensory, event-related) EP and neuropsychological tests (NT) were performed at baseline (T0) and after 1 (T1) and 3 (T3) years. Their results were compared longitudinally between baseline, T1, and T3. Baseline results confirmed conversion of CIS into multiple sclerosis (MS) and disability level at T1 and T3 using multiple comparisons and a logistic regression model. Results Apart from mean N13/P16 SEP (somatosensory evoked potentials) amplitude (lower at T1 and T3 than at baseline (T0 1.02 ± 0.37 μV, T1 0.90 ± 0.26 μV, T3 0.74 ± 0.32 μV, p < 0.05 for both comparisons), no significant changes of EP or NT parameters were found in longitudinal assessment. Baseline P300 Pz latency was longer for the patients with MS than for those with CIS at T1 (352.69 vs. 325.56 ms). No predictive value was shown for any of the analyzed baseline variables with regard to conversion from CIS into MS. Significance Baseline ERP abnormalities were associated with their short-term conversion into MS. ERP are worth considering in multimodal EP evaluation at the early stage of MS.

الإتاحة: https://doi.org/10.3389/fneur.2021.678035Test

المؤلفون: Czarnowska, Agata, Tarasiuk, Joanna, Zajkowska, Olga, Wnuk, Marcin, Marona, Monika, Nowak, Klaudia, Słowik, Agnieszka, Jamroz-Wiśniewska, Anna, Rejdak, Konrad, Lech, Beata, Popiel, Małgorzata, Rościszewska-Żukowska, Iwona, Perenc, Adam, Bartosik-Psujek, Halina, Świderek-Matysiak, Mariola, Siger, Małgorzata, Ciach, Agnieszka, Walczak, Agata, Jurewicz, Anna, Stasiołek, Mariusz, Kania, Karolina, Dyczkowska, Klara, Kalinowska-Łyszczarz, Alicja, Galus, Weronika, Walawska-Hrycek, Anna, Krzystanek, Ewa, Chojdak-Łukasiewicz, Justyna, Ubysz, Jakub, Pokryszko-Dragan, Anna, Kapica-Topczewska, Katarzyna, Chorąży, Monika, Bazylewicz, Marcin, Mirończuk, Anna, Kulikowska, Joanna, Kochanowicz, Jan, Białek, Marta, Stolarz, Małgorzata, Kubicka-Bączyk, Katarzyna, Niedziela, Natalia, Warmus, Paweł, Adamczyk-Sowa, Monika, Podlecka-Piçtowska, Aleksandra, Nojszewska, Monika, Zakrzewska-Pniewska, Beata, Jasińska, Elżbieta, Zaborski, Jacek, Milewska-Jȩdrzejczak, Marta, Zwiernik, Jacek, Zwiernik, Beata, Potemkowski, Andrzej

المصدر: Frontiers in Neurology ; volume 13 ; ISSN 1664-2295

مصطلحات موضوعية: Neurology (clinical), Neurology

الوصف: Background and Objectives Since vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events. Methods We gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, t -test, and U -Menn-Whutney test. Results A total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as “red flag”, all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS ≤2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects. Conclusions According to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS.

الإتاحة: https://doi.org/10.3389/fneur.2022.913283Test