المؤلفون: Kim, Sunghwan, Wang, Sheng‐Min, Kang, Dong Woo, Um, Yoo Hyun, Yoon, Han Min, Lee, Soyoung, Choe, Yeong Sim, Kim, Regina EY, Kim, Donghyeon, Lee, Chang Uk, Lim, Hyun Kook

المساهمون: Catholic University of Korea

المصدر: Alzheimer's & Dementia ; ISSN 1552-5260 1552-5279

الوصف: INTRODUCTION Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking. METHODS We used data from 528 non‐demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit‐to‐stand test (5STS). RESULTS All components of sarcopenia were significantly correlated with global cognitive function, but cortical thickness and amyloid‐beta (Aβ) retention had distinctive relationships with each measure. In the path model, brain atrophy resulting in cognitive impairment was mediated by Aβ retention for SMI and periventricular white matter hyperintensity for HGS, but directly affected by the 5STS. DISCUSSION Treatments targeting each sub‐domain of sarcopenia should be considered to prevent cognitive decline. Highlights We identified distinct impacts of three sarcopenia measures on brain structure and Aβ. Muscle mass is mainly associated with Aβ and has an influence on the brain atrophy. Muscle strength linked with periventricular WMH and brain atrophy. Muscle function associated with cortical thinning in specific brain regions. Interventions on sarcopenia may be important to ease cognitive decline in the elderly.

الإتاحة: https://doi.org/10.1002/alz.14054Test

المؤلفون: Chun, Min Young, Jang, Hyemin, Kim, Soo-Jong, Park, Yu Hyun, Yun, Jihwan, Lockhart, Samuel N, Weiner, Michael, De Carli, Charles, Moon, Seung Hwan, Choi, Jae Yong, Nam, Kyung Rok, Byun, Byung-Hyun, Lim, Sang-Moo, Kim, Jun Pyo, Choe, Yeong Sim, Kim, Young Ju, Na, Duk L, Kim, Hee Jin, Seo, Sang Won

مصطلحات موضوعية: Cognitive neurology

الوصف: Objectives Alzheimer’s disease (AD) is characterised by amyloid-beta accumulation (A), tau aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found concomitantly with AD pathology and has synergistic effects on cognitive decline with AD biomarkers. We determined whether cognitive trajectories of AT(N) categories differed according to vascular (V) burden. Methods We prospectively recruited 205 participants and classified them into groups based on the AT(N) system using neuroimaging markers. Abnormal V markers were identified based on the presence of severe white matter hyperintensities. Results In A+ category, compared with the frequency of Alzheimer’s pathological change category (A+T–), the frequency of AD category (A+T+) was significantly lower in V+ group (31.8%) than in V– group (64.4%) (p=0.004). Each AT(N) biomarker was predictive of cognitive decline in the V+ group as well as in the V– group (p<0.001). Additionally, the V+ group showed more severe cognitive trajectories than the V– group in the non-Alzheimer’s pathological changes (A–T+, A–N+; p=0.002) and Alzheimer’s pathological changes (p<0.001) categories. Conclusion The distribution and longitudinal outcomes of AT(N) system differed according to vascular burdens, suggesting the importance of incorporating a V biomarker into the AT(N) system.

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العلاقة: http://jnnp.bmj.com/cgi/content/short/95/1/44Test; http://dx.doi.org/10.1136/jnnp-2023-331603Test

الإتاحة: https://doi.org/10.1136/jnnp-2023-331603Test
http://jnnp.bmj.com/cgi/content/short/95/1/44Test

المؤلفون: Chun, Min Young, Jang, Hyemin, Kim, Soo-Jong, Park, Yu Hyun, Yun, Jihwan, Lockhart, Samuel N., Weiner, Michael, De Carli, Charles, Moon, Seung Hwan, Choi, Jae Yong, Nam, Kyung Rok, Byun, Byung-Hyun, Lim, Sang-Moo, Kim, Jun Pyo, Choe, Yeong Sim, Kim, Young Ju, Na, Duk L., Kim, Hee Jin, Seo, Sang Won

المساهمون: Radiology and Imaging Sciences, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Alzheimer’s disease, Amyloid, Cerebrovascular disease, Cognition, Dementia

الوصف: Objectives: Alzheimer's disease (AD) is characterised by amyloid-beta accumulation (A), tau aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found concomitantly with AD pathology and has synergistic effects on cognitive decline with AD biomarkers. We determined whether cognitive trajectories of AT(N) categories differed according to vascular (V) burden. Methods: We prospectively recruited 205 participants and classified them into groups based on the AT(N) system using neuroimaging markers. Abnormal V markers were identified based on the presence of severe white matter hyperintensities. Results: In A+ category, compared with the frequency of Alzheimer's pathological change category (A+T-), the frequency of AD category (A+T+) was significantly lower in V+ group (31.8%) than in V- group (64.4%) (p=0.004). Each AT(N) biomarker was predictive of cognitive decline in the V+ group as well as in the V- group (p<0.001). Additionally, the V+ group showed more severe cognitive trajectories than the V- group in the non-Alzheimer's pathological changes (A-T+, A-N+; p=0.002) and Alzheimer's pathological changes (p<0.001) categories. Conclusion: The distribution and longitudinal outcomes of AT(N) system differed according to vascular burdens, suggesting the importance of incorporating a V biomarker into the AT(N) system.

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العلاقة: Journal of Neurology, Neurosurgery, and Psychiatry; Chun MY, Jang H, Kim SJ, et al. Emerging role of vascular burden in AT(N) classification in individuals with Alzheimer's and concomitant cerebrovascular burdens. J Neurol Neurosurg Psychiatry. 2023;95(1):44-51. Published 2023 Dec 14. doi:10.1136/jnnp-2023-331603; https://hdl.handle.net/1805/41035Test

الإتاحة: https://doi.org/10.1136/jnnp-2023-331603Test
https://hdl.handle.net/1805/41035Test

المؤلفون: Kim, Jaeho, Choe, Yeong Sim, Park, Yuhyun, Kim, Yeshin, Kim, Jun Pyo, Jang, Hyemin, Kim, Hee Jin, Na, Duk L., Cho, Soo-Jin, Moon, Seung Hwan, Seo, Sang Won

المساهمون: Radiology and Imaging Sciences, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Amyloid PET imaging, Florbetaben, Flutemetamol, Alzheimer’s disease, Focal amyloid uptake

الوصف: Background: Although the standardized uptake value ratio (SUVR) method is objective and simple, cut-off optimization using global SUVR values may not reflect focal increased uptake in the cerebrum. The present study investigated clinical and neuroimaging characteristics according to focally increased β-amyloid (Aβ) uptake and global Aβ status. Methods: We recruited 968 participants with cognitive continuum. All participants underwent neuropsychological tests and 498 18F-florbetaben (FBB) amyloid positron emission tomography (PET) and 470 18F-flutemetamol (FMM) PET. Each PET scan was assessed in 10 regions (left and right frontal, lateral temporal, parietal, cingulate, and striatum) with focal-quantitative SUVR-based cutoff values for each region by using an iterative outlier approach. Results: A total of 62 (6.4%) subjects showed increased focal Aβ uptake with subthreshold global Aβ status [global (-) and focal (+) Aβ group, G(-)F(+) group]. The G(-)F(+) group showed worse performance in memory impairment (p < 0.001), global cognition (p = 0.009), greater hippocampal atrophy (p = 0.045), compared to those in the G(-)F(-). Participants with widespread Aβ involvement in the whole region [G(+)] showed worse neuropsychological (p < 0.001) and neuroimaging features (p < 0.001) than those with focal Aβ involvement G(-)F(+). Conclusion: Our findings suggest that individuals show distinctive clinical outcomes according to focally increased Aβ uptake and global Aβ status. Thus, researchers and clinicians should pay more attention to focal increased Aβ uptake in addition to global Aβ status.

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العلاقة: Frontiers in Aging Neuroscience; Kim J, Choe YS, Park Y, et al. Clinical outcomes of increased focal amyloid uptake in individuals with subthreshold global amyloid levels. Front Aging Neurosci. 2023;15:1124445. Published 2023 Mar 2. doi:10.3389/fnagi.2023.1124445; https://hdl.handle.net/1805/37057Test

الإتاحة: https://doi.org/10.3389/fnagi.2023.1124445Test
https://hdl.handle.net/1805/37057Test

المؤلفون: Kim, Hak-Bin, Kim, Sung-Hwan, Um, Yoo Hyun, Wang, Sheng-Min, Kim, Regina E. Y., Choe, Yeong Sim, Lee, Jiyeon, Kim, Donghyeon, Lim, Hyun Kook, Lee, Chang Uk, Kang, Dong Woo

المصدر: Frontiers in Aging Neuroscience ; volume 15 ; ISSN 1663-4365

مصطلحات موضوعية: Cognitive Neuroscience, Aging

الوصف: Background Education years, as a measure of cognitive reserve, have been shown to affect the progression of Alzheimer’s disease (AD), both pathologically and clinically. However, inconsistent results have been reported regarding the association between years of education and intermediate structural changes in AD-vulnerable brain regions, particularly when AD risk factors were not considered during the preclinical phase. Objective This study aimed to examine how Aβ deposition and APOE ε4 carrier status moderate the relationship between years of education and cortical volume in AD-vulnerable regions among cognitively normal older adults. Methods A total of 121 participants underwent structural MRI, [ 18 F] flutemetamol PET-CT imaging, and neuropsychological battery assessment. Multiple regression analysis was conducted to examine the interaction between years of education and the effects of potential modifiers on cortical volume. The associations between cortical volume and neuropsychological performance were further explored in subgroups categorized based on AD risk factors. Results The cortical volume of the left lateral occipital cortex and bilateral fusiform gyrus demonstrated a significant differential association with years of education, depending on the presence of Aβ deposition and APOE ε4 carrier status. Furthermore, a significant relationship between the cortical volume of the bilateral fusiform gyrus and AD-nonspecific cognitive function was predominantly observed in individuals without AD risk factors. Conclusion AD risk factors exerted varying influences on the association between years of education and cortical volume during the preclinical phase. Further investigations into the long-term implications of these findings would enhance our understanding of cognitive reserves in the preclinical stages of AD.

الإتاحة: https://doi.org/10.3389/fnagi.2023.1248531Test

المؤلفون: Lee, Min-Woo, Kim, Hye Weon, Choe, Yeong Sim, Yang, Hyeon Sik, Lee, Jiyeon, Lee, Hyunji, Yong, Jung Hyeon, Kim, Donghyeon, Lee, Minho, Kang, Dong Woo, Jeon, So Yeon, Son, Sang Joon, Lee, Young-Min, Kim, Hyug-Gi, Kim, Regina E. Y., Lim, Hyun Kook

المصدر: Scientific Reports; 5/28/2024, Vol. 14 Issue 1, p1-10, 10p

مستخلص: Alzheimer’s disease (AD) accounts for 60–70% of the population with dementia. Mild cognitive impairment (MCI) is a diagnostic entity defined as an intermediate stage between subjective cognitive decline and dementia, and about 10–15% of people annually convert to AD. We aimed to investigate the most robust model and modality combination by combining multi-modality image features based on demographic characteristics in six machine learning models. A total of 196 subjects were enrolled from four hospitals and the Alzheimer’s Disease Neuroimaging Initiative dataset. During the four-year follow-up period, 47 (24%) patients progressed from MCI to AD. Volumes of the regions of interest, white matter hyperintensity, and regional Standardized Uptake Value Ratio (SUVR) were analyzed using T1, T2-weighted-Fluid-Attenuated Inversion Recovery (T2-FLAIR) MRIs, and amyloid PET (αPET), along with automatically provided hippocampal occupancy scores (HOC) and Fazekas scales. As a result of testing the robustness of the model, the GBM model was the most stable, and in modality combination, model performance was further improved in the absence of T2-FLAIR image features. Our study predicts the probability of AD conversion in MCI patients, which is expected to be useful information for clinician’s early diagnosis and treatment plan design. [ABSTRACT FROM AUTHOR]

: Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Um, Yoo Hyun, Wang, Sheng-Min, Kang, Dong Woo, Kim, Sunghwan, Lee, Chang Uk, Kim, Donghyeon, Choe, Yeong Sim, Kim, Regina E.Y., Lee, Soyoung, Lee, Min-Kyung, Lim, Hyun Kook

المصدر: Journal of Alzheimer's Disease; 2024, Vol. 99 Issue 2, p705-714, 10p

مصطلحات موضوعية: APOLIPOPROTEIN E4, APOLIPOPROTEIN E, LOCUS coeruleus, ALZHEIMER'S disease, FUNCTIONAL connectivity

مستخلص: Background: Recent interest has surged in the locus coeruleus (LC) for its early involvement in Alzheimer's disease (AD), notably concerning the apolipoprotein ɛ4 allele (APOE4). Objective: This study aimed to discern LC functional connectivity (FC) variations in preclinical AD subjects, dissecting the roles of APOE4 carrier status and amyloid-β (Aβ) deposition. Methods: A cohort of 112 cognitively intact individuals, all Aβ-positive, split into 70 APOE4 noncarriers and 42 carriers, underwent functional MRI scans, neuropsychological assessments, and APOE genotyping. The research utilized seed to voxel analysis for illustrating LC rsFC discrepancies between APOE4 statuses and employed a general linear model to examine the interactive influence of APOE4 carrier status and Aβ deposition on LC FC values. Results: The investigation revealed no significant differences in sex, age, or SUVR between APOE4 carriers and noncarriers. It found diminished LC FC with the occipital cortex in APOE4 carriers and identified a significant interaction between APOE4 carrier status and temporal lobe SUVR in LC FC with the occipital cortex. This interaction suggested a proportional increase in LC FC for APOE4 carriers. Additional notable interactions were observed affecting LC FC with various brain regions, indicating a proportional decrease in LC FC for APOE4 carriers. Conclusions: These findings confirm that APOE4 carrier status significantly influences LC FC in preclinical AD, showcasing an intricate relationship with regional Aβ deposition. This underscores the critical role of genetic and pathological factors in early AD pathophysiology, offering insights into potential biomarkers for early detection and intervention strategies. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Choe, Yeong Sim, Kim, Regina E Y, Kim, Hye Weon, Kim, JeeYoung, Lee, Hyunji, Lee, Min Kyoung, Lee, Minho, Kim, Keun You, Kim, Se-Hong, Kim, Ji-Hoon, Lee, Jun-Young, Kim, Eosu, Kim, Donghyeon, Lim, Hyun Kook

المصدر: J Alzheimers Dis Rep ; ISSN:2542-4823 ; Volume:8 ; Issue:1

مصطلحات موضوعية: Alzheimer’s disease, atrophy, cognitive dysfunction, magnetic resonance imaging, visual scoring

الوصف: Application of visual scoring scales for regional atrophy in Alzheimer's disease (AD) in clinical settings is limited by their high time cost and low intra/inter-rater agreement.

العلاقة: https://doi.org/10.3233/ADR-230105Test; https://pubmed.ncbi.nlm.nih.gov/38910943Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191633Test/

الإتاحة: https://doi.org/10.3233/ADR-230105Test
https://pubmed.ncbi.nlm.nih.gov/38910943Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191633Test/

المؤلفون: Park, Chae Jung, Seo, Younghoon, Choe, Yeong Sim, Jang, Hyemin, Lee, Hyejoo, Kim, Jun Pyo, Alzheimer’s Disease Neuroimaging Initiative

المساهمون: Radiology and Imaging Sciences, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Alzheimer’s disease, Dementia, Amyloid PET, Prediction model, Machine learning

الوصف: Background: Cortical deposition of β-amyloid (Aβ) plaque is one of the main hallmarks of Alzheimer's disease (AD). While Aβ positivity has been the main concern so far, predicting whether Aβ (-) individuals will convert to Aβ (+) has become crucial in clinical and research aspects. In this study, we aimed to develop a classifier that predicts the conversion from Aβ (-) to Aβ (+) using artificial intelligence. Methods: Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort regarding patients who were initially Aβ (-). We developed an artificial neural network-based classifier with baseline age, gender, APOE ε4 genotype, and global and regional standardized uptake value ratios (SUVRs) from positron emission tomography. Ten times repeated 10-fold cross-validation was performed for model measurement, and the feature importance was assessed. To validate the prediction model, we recruited subjects at the Samsung Medical Center (SMC). Results: A total of 229 participants (53 converters) from the ADNI dataset and a total of 40 subjects (10 converters) from the SMC dataset were included. The average area under the receiver operating characteristic values of three developed models are as follows: Model 1 (age, gender, APOE ε4) of 0.674, Model 2 (age, gender, APOE ε4, global SUVR) of 0.814, and Model 3 (age, gender, APOE ε4, global and regional SUVR) of 0.841. External validation result showed an AUROC of 0.900. Conclusion: We developed prediction models regarding Aβ positivity conversion. With the growing recognition of the need for earlier intervention in AD, the results of this study are expected to contribute to the screening of early treatment candidates.

وصف الملف: application/pdf

العلاقة: Alzheimer's Research & Therapy; Park CJ, Seo Y, Choe YS, et al. Predicting conversion of brain β-amyloid positivity in amyloid-negative individuals. Alzheimers Res Ther. 2022;14(1):129. Published 2022 Sep 12. doi:10.1186/s13195-022-01067-8; https://hdl.handle.net/1805/35145Test

الإتاحة: https://doi.org/10.1186/s13195-022-01067-8Test
https://hdl.handle.net/1805/35145Test

المؤلفون: Kang, Sung Hoon, Lee, Kyung Hyun, Chang, Yoosoo, Choe, Yeong Sim, Kim, Jun Pyo, Jang, Hyemin, Shin, Hee Young, Kim, Hee Jin, Koh, Seong-Beom, Na, Duk L., Seo, Sang Won, Kang, Mira

المصدر: Alzheimer's Research & Therapy ; volume 14, issue 1 ; ISSN 1758-9193

مصطلحات موضوعية: Cognitive Neuroscience, Neurology (clinical), Neurology

الوصف: Background The relationship of specific body composition in the thighs and brain amyloid-beta (Aβ) deposition remained unclear, although there were growing evidence that higher muscle and fat mass in thighs had a protective effect against cardiometabolic syndromes. To determine whether muscle mass and fat mass in the thighs affected amyloid-beta (Aβ) positivity differently in relation to gender, we investigated the association of muscle mass and fat mass with Aβ positivity using positron emission tomography (PET) in individuals without dementia. Methods We recruited 240 participants (134 [55.8%] males, 106 [44.2%] females) without dementia ≥45 years of age who underwent Aβ PET, bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) scans of the hip in the health promotion center at Samsung Medical Center in Seoul, Korea. Lower extremity skeletal muscle mass index (LASMI) was measured using BIA, and gluteofemoral fat percentage (GFFP) was estimated using DEXA scans of the hip. We investigated the associations of LASMI and GFFP with Aβ positivity using logistic regression analyses after controlling for age, APOE4 genotype, and cognitive stage. Results Higher muscle mass in the thighs, measured as LASMI (odds ratio [OR]=0.27, 95% confidence interval [CI] 0.08 to 0.84, p =0.031) was associated with a lesser risk of Aβ positivity in only females. Higher fat mass in the thighs, measured as GFFP (OR=0.84, 95% CI 0.73 to 0.95, p =0.008) was associated with a lesser risk of Aβ positivity in only males. However, the association between LAMSI ( p for interaction = 0.810), GFFP ( p for interaction = 0.075) and Aβ positivity did not significantly differ by gender. Furthermore, LAMSI only negatively correlated with centiloid (CL) values in females ( r =−0.205, p =0.037), and GFFP only negatively correlated with CL values only in males ( r =−0.253, p =0.004). Conclusions Our findings highlight the importance of recognizing that gender differences exist with respect to the specific body ...

الإتاحة: https://doi.org/10.1186/s13195-022-01086-5Test