المؤلفون: Kim, Joseph, Chin, Hee Seung

المساهمون: Inha University Hospital

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: To generate and evaluate synthesized postoperative OCT images of epiretinal membrane (ERM) based on preoperative OCT images using deep learning methodology. This study included a total 500 pairs of preoperative and postoperative optical coherence tomography (OCT) images for training a neural network. 60 preoperative OCT images were used to test the neural networks performance, and the corresponding postoperative OCT images were used to evaluate the synthesized images in terms of structural similarity index measure (SSIM). The SSIM was used to quantify how similar the synthesized postoperative OCT image was to the actual postoperative OCT image. The Pix2Pix GAN model was used to generate synthesized postoperative OCT images. Total 60 synthesized OCT images were generated with training values at 800 epochs. The mean SSIM of synthesized postoperative OCT to the actual postoperative OCT was 0.913. Pix2Pix GAN model has a possibility to generate predictive postoperative OCT images following ERM removal surgery.

الإتاحة: https://doi.org/10.1038/s41598-023-46063-6Test
https://www.nature.com/articles/s41598-023-46063-6.pdfTest
https://www.nature.com/articles/s41598-023-46063-6Test

المؤلفون: Kim, Joseph, Chin, Hee Seung

المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41598-023-47940-wTest
https://www.nature.com/articles/s41598-023-47940-w.pdfTest
https://www.nature.com/articles/s41598-023-47940-wTest

المؤلفون: Kim, Jae Hui, Choi, Mihyun, Kim, Seong-Woo, Park, Kyu Hyung, Nam, Dong Heun, Lee, Dae Yeong, Park, Young-Hoon, Park, Young-Gun, Kim, Mirinae, Lee, Mee Yon, Choi, Soon-Il, Kim, Min, Lee, Junwon, Moon, Sang Woong, Chung, Hyewon, Lee, Young Hoon, Lee, Min Woo, Shin, Jae Pil, Park, Dong Ho, Park, Han Sang, Kang, Yong Koo, Chung, In Young, Yoo, Woong-Sun, Cho, Yong-Wun, Kim, Yu Cheol, Kang, Kyung Tae, Jang, Ji Hye, Kim, Seong-Woo, Choi, Kwang-Eon, Choi, Mihyun, Nam, Ki Tae, Kim, Young Ho, Ahn, So Min, Lee, Sang Joon, Lim, Jae Wan, Ku, Hee Chan, Yoo, Su Jin, Choi, Moon Jung, Lew, Young Ju, Kim, Jae Hui, Kim, Joo Yeon, Hwang, Jae Hyung, Lee, Seung Woo, Bae, Kunho, Jeong, Woo Jin, Kwon, Yoon Hyung, An, Seoung Hyun, Ahn, Jeeyun, Shin, Joo Young, Byon, Ik Soo, Park, Sung Who, Park, Kyu Hyung, Kang, Se Woong, Ham, Don-Il, Kim, Sang Jin, Park, Un Chul, Oh, Baek Lok, Kim, June-Gone, Lee, Joo Yong, Lee, Jun Yeop, Kim, Yoon Jeon, Chae, Ju Byung, Kim, Dong Yoon, Lee, Christopher Seungkyu, Cho, Kwan Hyuk, Kim, Min Seok, Kim, Seong Wook, Lee, Jung Pil, Kim, Hoon Dong, Cho, In Hwan, Song, Ji Hun, Lee, Ki Hwang, Kwon, Han Jo, Lee, Seung Min, Sagong, Min, Lee, Tae Gon, Han, Jung Il, Chang, Young Suk, Min, Jung Kee, Yang, Yun Sik, Kim, Soo Han, Chin, Hee Seung, Ji, Yong Sok, Lee, Jong Young, Kim, Seong Taeck, Shin, Min Ho, Kim, Jee Taek, Han, Yong Seop, Lee, Woo Hyuk, Jo, Young Joon, Kim, Jung Yeul, Kim, Kyung Tae, Seo, Eoi Jong, Lim, Sun Taek, Lee, Jun Sung, Kim, Chang Ryong, Duck-Jin Hwang, Daniel, Kim, Ha Kyoung, Ma, Dae Joong, Hong, In Hwan, Cho, Bum Joo, Shin, Yong Un, Cho, Heeyoon, Ahn, Seong Joon

المصدر: Ophthalmology Retina; May 2024, Vol. 8 Issue: 5 p473-480, 8p

مستخلص: To investigate the factors associated with treatment outcomes of postcataract surgery fungal endophthalmitis outbreaks related to contaminated viscoelastics.

المؤلفون: Kim, Jae Hui, Sagong, Min, Woo, Se Joon, Kim, Yu Cheol, Cho, Heeyoon, Lee, Young Hoon, Byon, Iksoo, Jo, Young Joon, Chin, Hee Seung, Lee, Youkyung, Chae, Jae Eun, Kang, Se Woong

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

مصطلحات موضوعية: Multidisciplinary

الوصف: To evaluate the real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) in Korea, focusing on retinal fluid resolution. This multi-institutional retrospective chart review study, analyzed medical records of patients with nAMD (age ≥ 50 years) who received their first anti-vascular endothelial growth factor (VEGF) treatment in ophthalmology clinics across South Korea between January 2017 and March 2019. The primary endpoint was the proportion of patients with retinal fluid after 12 months of anti-VEGF treatment. The association between fluid-free period and VA gains was also evaluated. A total of 600 patients were enrolled. At baseline, 97.16% of patients had retinal fluid; after 12 months of anti-VEGF treatment, 58.10% of patients had persistent retinal fluid. VA improvements were relatively better in patients with absence of retinal fluid compared with presence of retinal fluid (+ 12.29 letters vs. + 6.45 letters at month 12; P < .0001). Longer duration of absence of retinal fluid over first 12 months correlated with better VA gains at month 12 ( P < .01). More than half of the study patients with nAMD had retinal fluid even after 12 months of treatment with their current anti-VEGF. Presence of retinal fluid was associated with relatively worse VA outcomes.

الإتاحة: https://doi.org/10.1038/s41598-022-18158-zTest
https://www.nature.com/articles/s41598-022-18158-z.pdfTest
https://www.nature.com/articles/s41598-022-18158-zTest

المؤلفون: Lee, Kanghoon, Jung, Soyeon, Chin, Hee Seung

المصدر: Ocular Immunology & Inflammation; Jan2024, Vol. 32 Issue 1, p31-39, 9p

مصطلحات موضوعية: LITERATURE reviews, VASCULITIS, SURGICAL complications, WOMEN patients, EXUDATES & transudates

مستخلص: Frosted branch angiitis (FBA) is a rare form of retinal vasculitis. Four case series and an extensive literature review of 236 cases were conducted to clarify the characteristics of this rare condition. Case series and literature review. An analysis of the reported cases revealed that a majority (54.6%) developed FBA in the presence of an underlying disease, with recurrence and complications requiring surgical intervention being rare. The frequency of bilateral occurrence (55.0%) and prevalence in female patients (45.0%) were noted to be lower than previously reported. In general, idiopathic FBAs are more likely to be bilateral and diagnosed at a younger age than secondary FBAs. In idiopathic FBA, fundus involvement is more generalized, exudates tend to be more translucent, and extensive retinal hemorrhage tends to be less frequent. However, there were no differential characteristic fundus features that clearly distinguished idiopathic FBA from secondary FBA. [ABSTRACT FROM AUTHOR]

: Copyright of Ocular Immunology & Inflammation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Lee, Kanghoon, Lee, Soyoung, Jung, Soyeon, Chin, Hee Seung

المصدر: Graefe's Archive of Clinical & Experimental Ophthalmology; Dec2023, Vol. 261 Issue 12, p3581-3587, 7p

مصطلحات موضوعية: MACULAR degeneration, ENZYME-linked immunosorbent assay, AQUEOUS humor, IMMUNOGLOBULINS, BLOOD collection

مستخلص: Purpose: To evaluate whether anti-drug antibodies (ADAs) are present in the ocular fluid of patients with ranibizumab-recalcitrant neovascular age-related macular degeneration (nAMD). Methods: Two serum ADA-positive ranibizumab-recalcitrant patients and two serum ADA-negative controls were recruited from patients with nAMD treated with ranibizumab monotherapy. Recalcitrance was defined as persistent fluid after ≥6 monthly ranibizumab injections. Serum and aqueous humor ADAs were detected by enzyme-linked immunosorbent assay and immunoprecipitation, respectively. Results: Two of 156 ranibizumab-treated patients were ADA-positive. The patients received six and 14 ranibizumab injections, respectively, up to 4 weeks prior to blood collection. The serum ADA concentration was estimated to be approximately 50,000 ng/mL. Neutralizing ADAs were confirmed in both samples. A specific band was detected by immunoprecipitation only in ADA-positive samples, consistent with the results of enzyme-linked immunosorbent assay. Based on an assessment of the degree of sensitivity of commercially available anti-ranibizumab antibodies, it was estimated that the immunoprecipitation method could detect ADA levels >30 ng. Nevertheless, ADAs were not detected in the aqueous humor of either the experimental or control group. Conclusion: In the aqueous humor, ADAs are either not present or are present at a lower concentration than that which can be detected by immunoprecipitation. This presumably reflects the fact that blood ADA is the product of systemic circulation clearance through anterior elimination of intravitreal ranibizumab. Based on our results, ADAs do not return to the eye in sufficient quantities to interfere with the action of ranibizumab in the vitreous cavity. [ABSTRACT FROM AUTHOR]

: Copyright of Graefe's Archive of Clinical & Experimental Ophthalmology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kim, Ji Eun, Kim, Na Rae, Chin, Hee Seung, Seo, Kyoung Yul, Kim, Tae-im, Jung, Ji Won

المساهمون: National Research Foundation of Korea

المصدر: BMC Ophthalmology ; volume 21, issue 1 ; ISSN 1471-2415

مصطلحات موضوعية: Ophthalmology, General Medicine

الوصف: Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined. Results In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049). Conclusions Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

الإتاحة: https://doi.org/10.1186/s12886-021-01871-0Test

المؤلفون: Lee, Kanghoon, Jung, Soyeon, Chin, Hee Seung

المصدر: Ocular Immunology and Inflammation. :1-9

مصطلحات موضوعية: Ophthalmology, Immunology and Allergy

الوصف: Frosted branch angiitis (FBA) is a rare form of retinal vasculitis. Four case series and an extensive literature review of 236 cases were conducted to clarify the characteristics of this rare condition. Case series and literature review. An analysis of the reported cases revealed that a majority (54.6%) developed FBA in the presence of an underlying disease, with recurrence and complications requiring surgical intervention being rare. The frequency of bilateral occurrence (55.0%) and prevalence in female patients (45.0%) were noted to be lower than previously reported. In general, idiopathic FBAs are more likely to be bilateral and diagnosed at a younger age than secondary FBAs. In idiopathic FBA, fundus involvement is more generalized, exudates tend to be more translucent, and extensive retinal hemorrhage tends to be less frequent. However, there were no differential characteristic fundus features that clearly distinguished idiopathic FBA from secondary FBA.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4451e141a4c6ae2564211b34c319c6cTest
https://doi.org/10.1080/09273948.2022.2148112Test

المؤلفون: Kim, Se Young, Lee, Seung Hyun, Kim, Na Rae, Chin, Hee Seung, Jung, Ji Won

المساهمون: Grulkowski, Ireneusz

المصدر: PLOS ONE ; volume 15, issue 1, page e0227638 ; ISSN 1932-6203

الإتاحة: https://doi.org/10.1371/journal.pone.0227638Test

المؤلفون: Kim, Jieun, Kim, Jung Yong, Seo, Kyoung Yul, Kim, Tae‐im, Chin, Hee Seung, Jung, Ji Won

المساهمون: Ministry of Education

المصدر: Acta Ophthalmologica ; volume 97, issue 8 ; ISSN 1755-375X 1755-3768

الوصف: Purpose To compare the non‐invasive keratographic tear film break‐up time ( NIKBUT ) and the location and pattern of non‐invasive keratographic tear film break‐up between normal group and each group of three dry eye disease ( DED ) subtypes . Methods We enrolled 55 normal subjects and 250 patients with DED , who underwent tear meniscus height and NIKBUT measurements using the Keratograph ® 5M. Ocular surface parameter assessments such as the fluorescein tear break‐up time, ocular surface staining, Schirmer's test, and lid margin and meibomian gland examinations were performed, and the ocular surface disease index was determined. These parameters, including the proportion of the first tear film break‐up location and simultaneous multiple tear film break‐up pattern, were compared amongst the normal and DED subtypes. Results Aqueous‐deficient dry eye disease ( ADDE ) and ADDE /meibomian gland dysfunction ( MGD ) subtypes showed lower NIKBUT s than those of the normal group, whilst NIKBUT s of the MGD subtype did not differ from those of the normal group. The NIKBUT s showed a good diagnostic ability in diagnosing dry eye except MGD only. The occurrence of the first tear film break‐up in the central location was significantly higher in both the ADDE and ADDE / MGD subtypes, comprising approximately 40% in both subtypes (p < 0.001). The proportion of a simultaneous multiple tear film break‐up pattern was higher in the ADDE and ADDE / MGD subtypes, at 60.9% and 45.5%, respectively (p < 0.001). Conclusion The NIKBUT s and the location and pattern of non‐invasive tear film break‐up were different between normal group and each group of three DED subtypes.

الإتاحة: https://doi.org/10.1111/aos.14129Test