المؤلفون: Guanjun Wan, Weiwei Yan, Chenbing Wu, Yungong Xiao, Jingdian Lin, Shengyi Zhang

المصدر: Frontiers in Energy Research, Vol 10 (2023)

مصطلحات موضوعية: energy measurement, data center, flow rate measurement, gas turbine flowmeter, artificial intelligence, General Works

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fenrg.2022.977140/fullTest; https://doaj.org/toc/2296-598XTest

الوصول الحر: https://doaj.org/article/6cedeba4c15b42268b63864268a881f0Test

المؤلفون: Weizhuo Yuan, Tianming Qiu, Xiaofeng Yao, Chenbing Wu, Yan Shi, Ningning Wang, Jingyuan Zhang, Liping Jiang, Xiaofang Liu, Guang Yang, Jie Bai, Xiance Sun

المصدر: Toxicology letters. 370

مصطلحات موضوعية: Liver Cirrhosis, Inflammasomes, NLR Family, Pyrin Domain-Containing 3 Protein, Hepatic Stellate Cells, Humans, General Medicine, Toxicology, HSP47 Heat-Shock Proteins, Arsenic

الوصف: The activation of hepatic stellate cells (HSCs) is a key event during the progression of liver fibrosis (LF). We have previously indicated that NLRP3 inflammasome plays a crucial role in arsenic-induced HSCs activation. However, the mechanism of cascade responses between NLRP3 inflammasome and HSCs activation is unclear. Here, we showed that the transcription and protein level of Hsp47 was upregulated after 4 μM arsenic treatment, both in vivo and in vitro. Additionally, arsenic-induced HSCs activation was remarkably alleviated by the interference of Hsp47. Furthermore, blockage of NLRP3 significantly mitigated the activation of the NLRP3 inflammasome and decreased the expression of Hsp47, thereby attenuating the arsenic-induced HSCs activation. However, the ablation of Hsp47 did not affect the activation of the NLRP3 inflammasome. Notably, the protein-protein interaction between NLRP3 and Hsp47 was observed both in vivo and in vitro, and the target amino acid sequences were further identified. In summary, the present study indicated that NaAsO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18fa0f260bb14af96d7731c9d0521bfTest
https://pubmed.ncbi.nlm.nih.gov/35963424Test

المؤلفون: Chenbing Wu, Tianming Qiu, Weizhuo Yuan, Yan Shi, Xiaofeng Yao, Liping Jiang, Jingyuan Zhang, Guang Yang, Xiaofang Liu, Jie Bai, Danyi Zhao, Xiance Sun

المصدر: Environmental toxicology and pharmacology. 96

مصطلحات موضوعية: Pharmacology, Inflammasomes, Health, Toxicology and Mutagenesis, NLR Proteins, General Medicine, Toxicology, Rats, Arsenic, Diabetes Mellitus, Type 2, Liver, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Insulin Resistance, Annexin A1

الوصف: Hepatic insulin resistance (IR) is the primary pathology of type 2 diabetes (T2D). The role of the NOD-like receptor protein 3 (NLRP3) inflammasome in arsenic-induced hepatic IR has been previously demonstrated. However, the mechanism of the arsenic-induced activation of the NLRP3 inflammasome is still unclear. Here, we demonstrate that NaAsO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a24f575c4b8ba9b4492ace8bf1b7c00Test
https://pubmed.ncbi.nlm.nih.gov/36182042Test

المؤلفون: Tianming Qiu, Chenbing Wu, Xiaofeng Yao, Qiuyue Han, Ningning Wang, Weizhuo Yuan, Jingyuan Zhang, Yan Shi, Liping Jiang, Xiaofang Liu, Guang Yang, Xiance Sun

المصدر: Cell Biology and Toxicology.

مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Cell Biology, Toxicology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8d3146fa14c088e341d31640d9ec5147Test
https://doi.org/10.1007/s10565-022-09703-7Test

المؤلفون: Tianming, Qiu, Chenbing, Wu, Xiaofeng, Yao, Qiuyue, Han, Ningning, Wang, Weizhuo, Yuan, Jingyuan, Zhang, Yan, Shi, Liping, Jiang, Xiaofang, Liu, Guang, Yang, Xiance, Sun

المصدر: Cell biology and toxicology.

الوصف: N6-methyladenosine (m

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::6b71c0b84053454c798dd7ca8ffad786Test
https://pubmed.ncbi.nlm.nih.gov/35226250Test

المؤلفون: Yuhan, Zhu, Jingyuan, Zhang, Xiaofeng, Yao, Tianming, Qiu, Liping, Jiang, Ningning, Wang, Yan, Shi, Chenbing, Wu, Weizhuo, Yuan, Guang, Yang, Xiaofang, Liu, Jie, Bai, Lili, Men, Xiance, Sun

المصدر: Food and Chemical Toxicology. 160:112771

مصطلحات موضوعية: Male, Pore Forming Cytotoxic Proteins, Arsenites, Ubiquitination, General Medicine, Phosphate-Binding Proteins, Toxicology, Sodium Compounds, Cell Line, Rats, Rats, Sprague-Dawley, Liver, NLR Family, Pyrin Domain-Containing 3 Protein, Hepatocytes, Pyroptosis, Animals, Humans, Insulin Resistance, Food Science

الوصف: As an environmental toxicant, arsenic exposure may cause insulin resistance (IR). Previous studies have shown that pyroptosis plays an important role in the occurrence and development of IR. Although gasdermin D (GSDMD) functions as an executor of pyroptosis, the relationship between GSDMD-mediated pyroptosis and hepatic IR remains unclear. Here, we observed that sodium arsenite (NaAsO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735fb184bdef1ad96575515e3936262aTest
https://doi.org/10.1016/j.fct.2021.112771Test

المؤلفون: Chenbing Wu, Weiwei Yan, Chen Rou, Guozhan Li, Yang Liu

المصدر: Powder Technology. 397:116984

مصطلحات موضوعية: Materials science, Targeted drug delivery, General Chemical Engineering, Drug delivery, Particle, Deposition (phase transition), Magnetic nanoparticles, Magnetic particle inspection, respiratory system, Airway, respiratory tract diseases, Biomedical engineering, Particle deposition

الوصف: Inhalation of medical drug particles through human airway is widely utilized for the remedy of lung diseases. Due to the complexities of airway morphology, flow turbulence and particle deposition, the drug delivery efficiency to the morbid region of lung is always unsatisfactory. In this research, a 3D anatomically accurate human airway model from oral cavity to lung is reconstructed, and the large eddy simulation-discrete phase model (LES-DPM) is adopted to simulate the airway flow and drug particles transport. To improve the particle delivery to the targeted region of the left lung, a magnetic drug targeting (MDT) system is established. It is found that the LES-DPM in conjunction with MDT system is an effective tool to study airway flow patterns and magnetic particle deposition features. Moreover, the magnetic source layout, magnetic particle size and magnetic field intensity all have significant impacts on the particle deposition efficiency in the left lung. Optimal combination factors for drug particle delivery results are successfully achieved. The total deposition efficiency of magnetic particles in the left lung can be increased to more than 5 times. This work not only could provide a better understanding of air-particle dynamics, but also could contribute toward improved strategies for more efficient drug delivery in the realistic human lungs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6a90a6284b184b7adb39cad7eb0864c3Test
https://doi.org/10.1016/j.powtec.2021.11.028Test

المؤلفون: Xuejin Li, Chenbing Wu, Xiaojing Qi, Shuo Wang, Weiwei Yan

المصدر: Physics of Fluids. 33:111906

مصطلحات موضوعية: Fluid Flow and Transfer Processes, Physics, Mechanical Engineering, Computational Mechanics, Deformation (meteorology), Condensed Matter Physics, Red blood cell, medicine.anatomical_structure, Shear (geology), Mechanics of Materials, Ultimate tensile strength, medicine, Relaxation (physics), Elongation, Composite material

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3d535dd4034f78f90bd7874998c033e5Test
https://doi.org/10.1063/5.0071441Test

المؤلفون: Cong Lyu, Jiacheng Li, Chenbing Wu

مصطلحات موضوعية: Economic growth, Urbanization, Political science, Rural education, Context (language use)

الوصف: With the speeding-up of the Chinese economy, China is experiencing the rapid urbanization. Meanwhile, the Chinese rural education is also developing, which has made great progress in recent years. However, inequity between urban and rural education prevalently exists in China, and the unbalanced development of urban and rural areas still influences the Chinese education. However, the Chinese have taken a lot of measures to enhance the quality of rural education, such as ad hoc post policy, the school meal program, and so on. In addition, the rural schools have also launched some activities to develop the students and to serve the society.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cc1f8f25aa6e492b80b4eb77be9f50ccTest
https://doi.org/10.4018/978-1-5225-7158-2.ch016Test

المؤلفون: Jiacheng Li, Yingming Liu, Chenbing Wu

مصطلحات موضوعية: Learning to teach, Mathematics education, China, Psychology

الوصف: The novice teacher's training is playing an important role in the education reform. In Xi'an Gaoxin No.1 Primary School, the school leaders host a pilot way of training the new teachers. The new teacher training of the school is special and meaningful. The training not only includes professional skill, student management, and teacher's ethics, but also includes art, calligraphy, reading, and so on. The authors invested 73 teachers (male=9, female=64) who had got the job one year ago. After one year's training, 73.97% of novice teachers express full agreement about the training and are quite satisfied with the training. Comparing with the beginning of the career, the novice teachers have improved the teaching abilities a lot.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::879540b4951eef6549dd727ff48d5499Test
https://doi.org/10.4018/978-1-5225-5228-4.ch001Test