المؤلفون: Chang Seok Lee, Jong-Su Jeon

المصدر: Engineering Structures. 289:116295

مصطلحات موضوعية: Civil and Structural Engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e56ec079afd76073d5fd9361672a77e6Test
https://doi.org/10.1016/j.engstruct.2023.116295Test

المؤلفون: Jong-Su Jeon, Chang Seok Lee

المصدر: Earthquake Engineering & Structural Dynamics. 51:1994-2015

مصطلحات موضوعية: Earth and Planetary Sciences (miscellaneous), Geotechnical Engineering and Engineering Geology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::caddd5315e43853cf20f2e75c0f5b025Test
https://doi.org/10.1002/eqe.3650Test

المؤلفون: Minjeong Kim, Chang-Seok Lee, Kyung-Min Lim

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 22; Pages: 5665

مصطلحات موضوعية: rhododenol, melanocytes, Melanoderm™, leukoderma, cytoskeleton, morphology

جغرافية الموضوع: agris

الوصف: Rhododenol (RD), a whitening cosmetic ingredient, was withdrawn from the market due to RD-induced leukoderma (RIL). While many attempts have been made to clarify the mechanism underlying RIL, RIL has not been fully understood yet. Indeed, affected subjects showed uneven skin pigmentation, but the features are different from vitiligo, a skin hypopigmentary disorder, alluding to events more complex than simple melanocyte cytotoxicity. Here, we discovered that rhododenol treatment reduced the number of melanocytes in a pigmented 3D human skin model, Melanoderm™, confirming the melanocyte toxicity of RD. Of note, melanocytes that survived in the RD treated tissues exhibited altered morphology, such as extended dendrites and increased cell sizes. Consistently with this, sub-cytotoxic level of RD increased cell size and elongated dendrites in B16 melanoma cells. Morphological changes of B16 cells were further confirmed in the immunocytochemistry of treated cells for actin and tubulin. Even more provoking, RD up-regulated the expression of tyrosinase and TRP1 in the survived B16 cells. Evaluation of mRNA expression of cytoskeletal proteins suggests that RD altered the cytoskeletal dynamic favoring cell size expansion and melanosome maturation. Collectively, these results suggest that RD not only induces cytotoxicity in melanocytes but also can lead to a profound perturbation of melanocyte integrity even at sub-cytotoxic levels.

وصف الملف: application/pdf

العلاقة: Bioactives and Nutraceuticals; https://dx.doi.org/10.3390/ijms20225665Test

الإتاحة: https://doi.org/10.3390/ijms20225665Test

المؤلفون: Sang Whan Han, Chang Seok Lee, Mary Ann Paz Zambrana, Kihak Lee

المصدر: Applied Sciences; Volume 9; Issue 23; Pages: 5193

مصطلحات موضوعية: columns, cyclic behavior, low height-to-depth ratio, modeling parameters, calibration

جغرافية الموضوع: agris

الوصف: Existing old reinforced concrete (RC) buildings could be vulnerable to large earthquake events. Most columns in such buildings have insufficient reinforcement details, which may experience failure during an early loading stage. The failure of columns may lead to partial or complete collapse of entire building systems. To prepare for an adequate retrofit plan for columns, it is necessary to simulate the cyclic behavior of columns using a numerical model with adequate values of constituent modeling parameters. The nonlinear component modeling parameters are specified in ASCE 41-17. However, the experiments on stocky RC columns suggest that ASCE 41-17 nonlinear component modeling parameters do not reflect the RC column behavior adequately. To accurately simulate the nonlinear load–deformation responses of stocky RC columns with low span-to-depth ratio, this study proposes a calibration factor for ASCE 41-17 RC column modeling parameters. For this purpose, this study collected test data of 47 stocky column specimens. Based on the test data, empirical equations including the calibration factor for modeling parameters “a” and “b” in ASCE 41-17 were proposed. The accuracy of the proposed equation was verified by comparing the measured and calculated envelope curves.

وصف الملف: application/pdf

العلاقة: Civil Engineering; https://dx.doi.org/10.3390/app9235193Test

الإتاحة: https://doi.org/10.3390/app9235193Test

المؤلفون: Chang Seok Lee, Jong-Su Jeon

المصدر: Journal of Korean Society of Steel Construction. 33:373-381

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ff455961887dce01129e06cee3b0edf2Test
https://doi.org/10.7781/kjoss.2021.33.6.373Test

المؤلفون: Jeeyoung Kim, Weon Jeong Bang, Jung Woo, Younghwa Kim, Hee Jung Shin, Junoh Kim, Min Gi Kim, Yung Hyup Joo, Chang-Seok Lee

المصدر: Archives of Biological Sciences; 2023, Vol. 75 Issue 3, p279-286, 8p

مصطلحات موضوعية: ALFALFA, POLYSACCHARIDES, FIBROBLASTS, BLACK cumin, KERATINOCYTES, TIGHT junctions, SEEDS

مستخلص: To protect the body against environmental threats, cosmetics can play important antiinflammatory and anti-aging roles. Many researchers have developed cosmetic ingredients using natural plant extracts or the active compounds of such extracts. In this study, we assessed the ability of extracts from the seeds of alfalfa (Medicago sativa L.) to affect skin cells. In a keratinocyte-derived cell line (HaCaT cells), alfalfa polysaccharide extract (APE) treatment triggered cornified envelope formation and increased the gene expression levels of filaggrin and involucrin, suggesting that APE increased epidermal cell differentiation. In addition, APE dramatically increased the mRNA and protein levels of claudin1, suggesting that it enhances tight junction formation. Finally, APE exerted antiinflammatory effects in keratinocytes by decreasing the LPSinduced production of proinflammatory cytokines. In primary normal human dermal fibroblasts (NHDF), APE increased procollagen synthesis and decreased elastase activity and metalloproteinase-1 (MMP) secretion. APE also showed superoxide dismutase (SOD)-like activity in a cell-free system, resulting in antioxidant effects. Finally, we found that the polysaccharides from alfalfa seeds used in our experiments consist mainly of galactose and mannose. Based on our findings, we conclude that APE may have potent skin-protective and skin-improving effects and could be developed as an important ingredient in cosmetics and medicines. [ABSTRACT FROM AUTHOR]

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المؤلفون: Chang Seok Lee, Jong-Su Jeon

المصدر: Earthquake Engineering & Structural Dynamics. 51:277-309

مصطلحات موضوعية: Materials science, Nickel titanium, Pseudoelasticity, Earth and Planetary Sciences (miscellaneous), Shape-memory alloy, Composite material, Geotechnical Engineering and Engineering Geology, Degradation (telecommunications)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1d440e458a287979d6ca2ba918f58770Test
https://doi.org/10.1002/eqe.3566Test

المؤلفون: Chang Seok Lee, Jong-Su Jeon

المصدر: Earthquake Engineering & Structural Dynamics. 50:4001-4031

مصطلحات موضوعية: Shear (sheet metal), OpenSees, business.industry, Earth and Planetary Sciences (miscellaneous), Structural engineering, Axial force, Reinforced concrete column, Geotechnical Engineering and Engineering Geology, business, Span (engineering), Reinforced concrete, Geology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1b7ad684a6f7d4c53cd5c60c1ef26484Test
https://doi.org/10.1002/eqe.3543Test

المؤلفون: Ik‐Soo Kim, Chae‐Eun Shim, Sang Won Kim, Chang‐Seok Lee, Junyoung Kwon, Kyung‐Eun Byun, Unyong Jeong

المصدر: Advanced materials (Deerfield Beach, Fla.).

مصطلحات موضوعية: Mechanics of Materials, Mechanical Engineering, General Materials Science

الوصف: While various crystalline carbon allotropes, including graphene, have been actively investigated, amorphous carbon (a-C) thin films have received relatively little attention. The a-C is a disordered form of carbon bonding with a broad range of the CC bond length and bond angle. Although accurate structural analysis and theoretical approaches are still insufficient, reproducible structure-property relationships have been accumulated. As the a-C thin film is now adapted as a hardmask in the semiconductor industry and new properties are reported continuously, expectations are growing that it can be practically used as active materials beyond as a simple sacrificial layer. In this perspective review article, after a brief introduction to the synthesis and properties of the a-C thin films, their potential practical applications are proposed, including hardmasks, extreme ultraviolet (EUV) pellicles, diffusion barriers, deformable electrodes and interconnects, sensors, active layers, electrodes for energy, micro-supercapacitors, batteries, nanogenerators, electromagnetic interference (EMI) shielding, and nanomembranes. The article ends with a discussion on the technological challenges in a-C thin films.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0120f8fad1c3d9c5121a012a654720Test
https://pubmed.ncbi.nlm.nih.gov/36408886Test

المؤلفون: Chang-Seok Lee, Cheol-Sang Hwang, Dasom Kim

المصدر: Molecules and Cells. 45:109-111

مصطلحات موضوعية: Cell Biology, General Medicine, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d09a75e6d446d3eb0b65a428eb22bcbaTest
https://doi.org/10.14348/molcells.2021.5040Test