المؤلفون: Cella, D., Vallow, S., Bermann, G., McDonald, J., Ngerano, G., Linton, S., Arenson, E., Maitra, S., Lamoureux, R., Dickie, G.

المصدر: Value in Health ; volume 26, issue 12, page S454 ; ISSN 1098-3015

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الإتاحة: https://doi.org/10.1016/j.jval.2023.09.2470Test
https://api.elsevier.com/content/article/PII:S1098301523056000?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1098301523056000?httpAccept=text/plainTest

المؤلفون: Basch, E., Schrag, D., Jansen, J., Ginos, B., Spears, P.A., Jonsson, M., Carr, P., Deal, A.M., Thanarajasingam, G., Reeve, B.B., Snyder, C., Bruner, D., Cella, D., Blinder, V., Kottschade, L., Perlmutter, J., Geoghegan, C., Mazza, G.L., Weiss, A., Dueck, A.C.

المصدر: Annals of Oncology ; volume 34, page S1078 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2023.09.813Test
https://api.elsevier.com/content/article/PII:S0923753423016496?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753423016496?httpAccept=text/plainTest

المؤلفون: Brennan, Patricia A., Nozadi, Sara S., McGrath, Monica, Churchill, Marie L., Dunlop, Anne L., Elliott, Amy J., MacKenzie, Debra, Margolis, Amy E., Ghassabian, Akhgar, McEvoy, Cindy T., Fry, Rebecca C., Bekelman, Traci A., Ganiban, Jody M., Williams, Lue, Wilson, Constance L., Lewis, Johnnye, Smith, P.B., Newby, K.L., Johns, Hopkins, Jacobson, L.P., Catellier, D.J., Gershon, R., Cella, D., Trasande, L., Gatzke-Kopp, L., Swingler, M., Dabelea, D., Koinis Mitchell, D., Deoni, S., D’Sa, V., Karr, C., Tylavsky, F., Mason, A., Zhao, Q., Sathyanarayana, S., Bush, N., LeWinn, K.Z., Leve, L., Neiderhiser, J., Tepper, R., O’Shea, M., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Singh, R., Msall, M., Frazier, J.

المصدر: Journal of the American Academy of Child & Adolescent Psychiatry ; ISSN 0890-8567

مصطلحات موضوعية: Psychiatry and Mental health, Developmental and Educational Psychology

الإتاحة: https://doi.org/10.1016/j.jaac.2023.07.996Test
https://api.elsevier.com/content/article/PII:S0890856723014259?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0890856723014259?httpAccept=text/plainTest

المؤلفون: Grady, K., Burns, J., Teuteberg, J., Allen, L., Beiser, D., Lindenfeld, J., Yancy, C., Cella, D., Kirklin, J., Denfeld, Q., Ruo, B., McIlvennan, C., Walsh, M., Adler, E., Klein, L., Murks, C., Pham, D., Rich, J., Stehlik, J., Kiernan, M., Hahn, E.

المصدر: The Journal of Heart and Lung Transplantation ; volume 42, issue 4, page S157-S158 ; ISSN 1053-2498

مصطلحات موضوعية: Transplantation, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.healun.2023.02.1635Test
https://api.elsevier.com/content/article/PII:S1053249823017023?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1053249823017023?httpAccept=text/plainTest

المؤلفون: Cottone, F, Deliu, N, Collins, G, Anota, A, Bonnetain, F, Van Steen, K, Cella, D, Efficace, F

الوصف: Purpose The inclusion of patient-reported outcome (PRO) questionnaires in prognostic factor analyses in oncology has substantially increased in recent years. We performed a simulation study to compare the performances of four different modeling strategies in estimating the prognostic impact of multiple collinear scales from PRO questionnaires. Methods We generated multiple scenarios describing survival data with different sample sizes, event rates and degrees of multicollinearity among five PRO scales. We used the Cox proportional hazards (PH) model to estimate the hazard ratios (HR) using automatic selection procedures, which were based on either the likelihood ratio-test (Cox-PV) or the Akaike Information Criterion (Cox-AIC). We also used Cox PH models which included all variables and were either penalized using the Ridge regression (Cox-R) or were estimated as usual (Cox-Full). For each scenario, we simulated 1000 independent datasets and compared the average outcomes of all methods. Results The Cox-R showed similar or better performances with respect to the other methods, particularly in scenarios with medium–high multicollinearity (ρ = 0.4 to ρ = 0.8) and small sample sizes (n = 100). Overall, the Cox-PV and Cox-AIC performed worse, for example they did not select one or more prognostic collinear PRO scales in some scenarios. Compared with the Cox-Full, the Cox-R provided HR estimates with similar bias patterns but smaller root-mean-squared errors, particularly in higher multicollinearity scenarios. Conclusions Our findings suggest that the Cox-R is the best approach when performing prognostic factor analyses with multiple and collinear PRO scales, particularly in situations of high multicollinearity, small sample sizes and low event rates.

العلاقة: https://ora.ox.ac.uk/objects/uuid:9f4d1da2-4218-4b97-9c54-9f2cb8edfb7aTest; https://doi.org/10.1007/s11136-018-02097-2Test

الإتاحة: https://doi.org/10.1007/s11136-018-02097-2Test
https://ora.ox.ac.uk/objects/uuid:9f4d1da2-4218-4b97-9c54-9f2cb8edfb7aTest

المؤلفون: Xie, GL, Chen, LD, Yang, SL, Tao, J, Chan, CCH, Heinemann, AW, Cella, D, Lai, JS, Correia, H, Wong, AWK

المساهمون: Department of Rehabilitation Sciences

مصطلحات موضوعية: Neuro-QoL, Translation, Item Bank, Cross-cultural validation

الوصف: 201901 bcrc ; Version of Record ; Published ; CC

العلاقة: http://hdl.handle.net/10397/80295Test; 18; WOS:000448796200004; 2-s2.0-85055650764; 825; OA_IR/PIRA

الإتاحة: https://doi.org/10.1186/s12913-018-3631-7Test
http://hdl.handle.net/10397/80295Test

المؤلفون: Tykodi, SS, Schadendorf, D, Cella, D, Reck, M, Harrington, K, Wagner, S, Shaw, JW

المساهمون: Harrington, Kevin

مصطلحات موضوعية: Humans, Neoplasms, Antineoplastic Agents, Antibodies, Monoclonal, Quality of Life, Patient Reported Outcome Measures

الوصف: Patients with recurrent or metastatic cancer commonly suffer from debilitating toxicity associated with conventional treatment modalities, as well as disease-related symptoms, often with a concomitant negative impact on health-related quality of life (HRQoL). Patient-reported outcomes (PROs) provide important insights into the patient experience in clinical trials. Nivolumab is a programmed death-1 receptor inhibitor that extends survival in patients with recurrent or metastatic disease in multiple tumor types. In this review, we summarize published PRO analyses from eight phase II-IV clinical trials with nivolumab for the treatment of melanoma, non-small cell lung cancer, renal cell carcinoma (RCC), and squamous cell carcinoma of the head and neck (SCCHN). Symptom burden, physical functioning, and HRQoL were measured using generic, cancer-specific, and tumor type-specific validated PRO instruments. Nivolumab showed sustained stabilization across all tumor types and, in some cases, clinically meaningful improvement in HRQoL, whereas standard of care therapies often led to deteriorations. Exploratory analyses found a positive correlation between baseline HRQoL scores and overall survival in RCC, and between baseline HRQoL scores and healthcare resource utilization in SCCHN, suggesting that patient-reported symptoms at treatment initiation may have clinical value. In the era of value-based oncology care, stakeholders are increasingly interested in PRO findings to guide clinical, regulatory, and reimbursement decisions. However, missing data remain a significant challenge in PRO analyses, including in nivolumab trials. Future clinical trials in immuno-oncology should incorporate PRO data collection, including beyond treatment discontinuation or trial completion to assess the long-term effects of treatment on HRQoL.

وصف الملف: Print-Electronic; 87; application/pdf

العلاقة: Cancer treatment reviews, 2018, 70 pp. 75 - 87; https://repository.icr.ac.uk/handle/internal/3027Test

الإتاحة: https://doi.org/10.1016/j.ctrv.2018.08.001Test
https://repository.icr.ac.uk/handle/internal/3027Test

المؤلفون: Cella, D., Escudier, B., Ivanescu, C., Mauer, M., Lord-Bessen, J., Gooden, K.

المصدر: Annals of Oncology ; volume 30, page v383-v384 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdz249.047Test
https://api.elsevier.com/content/article/PII:S0923753419591645?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753419591645?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/Supplement_5/mdz249.047/30086448/mdz249.047.pdfTest

المؤلفون: Coleman, R.L., Fleming, G.F., Brady, M.F., Swisher, E., Steffensen, K.D., Friedlander, M., Okamoto, A., Moore, K., Ben-Baruch, N., Werner, T.L., Oaknin, A., Nam, J.-H., Leath, C.A., Nicum, S., Cella, D., Sullivan, D.M., Ansell, P.J., Dinh, M., Aghajanian, C., Bookman, M.A.

المصدر: Annals of Oncology ; volume 30, page v895-v896 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdz394.054Test
https://api.elsevier.com/content/article/PII:S092375341960414X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092375341960414X?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/Supplement_5/mdz394.054/30083479/mdz394.054.pdfTest

المؤلفون: Hansen, A.R., Ala-leppilampi, K., McKillop, C., Siu, L.L., Bedard, P., Razak, A R Abdul, Spreafico, A., Sridhar, S., Leighl, N.B., Butler, M.O., Hogg, D., Sacher, A., Oza, A.M., Nisenbaum, R., Webster, K.A., Cella, D., Parsons, J.

المصدر: Annals of Oncology ; volume 30, page v519 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdz253.101Test
https://api.elsevier.com/content/article/PII:S092375341959487X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S092375341959487X?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/Supplement_5/mdz253.101/30082450/mdz253.101.pdfTest