المؤلفون: Stendardo, Giorgia, Nuccetelli, Cristina, Grande, Sveva, Palma, Alessandra, Venoso, Gennaro, Zicari, Carmine, Andenna, Claudio, Frau, Giuseppe, Bonanno, Ilaria, Landoni, Valeria, Sciuto, Rosa, Bruzzaniti, Vicente, Cassano, Bartolomeo, Iaccarino, Giuseppe, Murtas, Federica, Canzi, Cristina, Zito, Felicia, Fattibene, Paola

المصدر: Radiation Protection Dosimetry ; volume 199, issue 8-9, page 962-969 ; ISSN 0144-8420 1742-3406

الوصف: A system for internal and voluntary reporting of abnormal events in a Nuclear Medicine Therapy Unit is described. This system is based on the Internet of Things and is composed of an application for mobile devices and a wireless network of detectors. The application is addressed to healthcare professionals and is intended to be a user-friendly tool to make the reporting procedure little laborious. The network of detectors allows for a real-time measurement of the dose distribution in the patient’s room. The staff was involved in all stages, from the design of the dosimetry system and mobile application up to their final testing. Face-to-face interviews were carried out with 24 operators in different roles in the Unit (radiation protection experts, physicians, physicists, nuclear medicine technicians and nurses). The preliminary results of the interviews and the current state of development of the application and the detection network will be described.

الإتاحة: https://doi.org/10.1093/rpd/ncad098Test
https://academic.oup.com/rpd/article-pdf/199/8-9/962/50435693/ncad098.pdfTest

المؤلفون: Ciucci, Davide¹ (AUTHOR), Cassano, Bartolomeo² (AUTHOR) bartolomeo.cassano@gmail.com, Donatiello, Salvatore¹ (AUTHOR), Martire, Federica³ (AUTHOR), Napolitano, Antonio¹ (AUTHOR), Polito, Claudia¹ (AUTHOR), Solfaroli Camillocci, Elena¹ (AUTHOR), Cervino, Gianluca⁴ (AUTHOR), Pungitore, Ludovica⁴ (AUTHOR), Altini, Claudio⁵ (AUTHOR), Villani, Maria Felicia⁵ (AUTHOR), Pizzoferro, Milena⁵ (AUTHOR), Garganese, Maria Carmen⁵ (AUTHOR), Cannatà, Vittorio¹ (AUTHOR)

المصدر: EJNMMI Physics. 2/22/2024, Vol. 11 Issue 1, p1-13. 13p.

مستخلص: Background: In literature are reported different analytical methods (AM) to choose the proper fit model and to fit data of the time-activity curve (TAC). On the other hand, Machine Learning algorithms (ML) are increasingly used for both classification and regression tasks. The aim of this work was to investigate the possibility of employing ML both to classify the most appropriate fit model and to predict the area under the curve (τ). Methods: Two different ML systems have been developed for classifying the fit model and to predict the biokinetic parameters. The two systems were trained and tested with synthetic TACs simulating a whole-body Fraction Injected Activity for patients affected by metastatic Differentiated Thyroid Carcinoma, administered with [131I]I-NaI. Test performances, defined as classification accuracy (CA) and percentage difference between the actual and the estimated area under the curve (Δτ), were compared with those obtained using AM varying the number of points (N) of the TACs. A comparison between AM and ML were performed using data of 20 real patients. Results: As N varies, CA remains constant for ML (about 98%), while it improves for F-test (from 62 to 92%) and AICc (from 50 to 92%), as N increases. With AM, Δ τ can reach down to − 67%, while using ML Δ τ ranges within ± 25%. Using real TACs, there is a good agreement between τ obtained with ML system and AM. Conclusions: The employing of ML systems may be feasible, having both a better classification and a better estimation of biokinetic parameters. [ABSTRACT FROM AUTHOR]

المؤلفون: Ianiro, Anna, Infusino, Erminia, D’Andrea, Marco, Marucci, Laura, Farneti, Alessia, Sperati, Francesca, Cassano, Bartolomeo, Ungania, Sara, Soriani, Antonella

المصدر: Journal of Medical Physics; Apr-Jun2023, Vol. 48 Issue 2, p120-128, 9p

مصطلحات موضوعية: MEDICAL dosimetry, COLLIMATORS, STEREOTAXIC techniques, RADIOSURGERY, STEREOTACTIC radiosurgery, MEDIAN (Mathematics), TREATMENT duration

مستخلص: Purpose: In our institution, stereotactic radiosurgery of multiple brain metastases is performed with the CyberKnife^® (CK) device, using fixed/Iris collimators. In this study, nineteen fixed/Iris plans were recalculated with the multileaf collimator (MLC), to assess if it is possible to produce plans with comparable dosimetric overall quality. Materials and Methods: For consistent comparisons, MLC plans were re‑optimized and re‑normalized in order to achieve the same minimum dose for the total planning target volume (PTVtot). Conformation number (CN), homogeneity index (HI) and dose gradient index (DGI) metrics were evaluated. The dose to the brain was evaluated as the volume receiving 12 Gy (V12) and as the integral dose (ID). The normal tissue complication probability (NTCP) for brain radionecrosis was calculated as a function of V12. Results: The reoptimized plans were reviewed by the radiation oncologist and were found clinically acceptable according to the The American Association of Physicists in Medicine (AAPM) Task Group‑101 protocol. However, fixed/Iris plans provided significantly higher CN (+8.6%), HI (+2.2%), and DGI (+44.0%) values, and significantly lower ID values (−35.9%). For PTVtot less than the median value of 2.58cc, fixed/Iris plans provided significantly lower NTCP values. On the other side, MLC plans provided significantly lower treatment times (−18.4%), number of monitor units (−33.3%), beams (−46.0%) and nodes (−21.3%). Conclusions: CK‑MLC plans for the stereotactic treatment of brain multi metastases could provide an important advantage in terms of treatment duration. However, to contain the increased risk for brain radionecrosis, it could be useful to calculate MLC plans only for patients with large PTVtot. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Medical Physics is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Camillocci, Elena Solfaroli, Cassano, Bartolomeo, Collamati, Francesco, Terracciano, Carlo Mancini, Mirabelli, Riccardo, Morganti, Silvio, Pacilio, Massimiliano, Soriani, Antonella, Iaccarino, Giuseppe

المصدر: Physica Medica ; volume 104, page S20 ; ISSN 1120-1797

مصطلحات موضوعية: General Physics and Astronomy, Radiology, Nuclear Medicine and imaging, General Medicine, Biophysics

الإتاحة: https://doi.org/10.1016/s1120-1797Test(22)02159-7
https://api.elsevier.com/content/article/PII:S1120179722021597?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1120179722021597?httpAccept=text/plainTest

المؤلفون: Ungania, Sara, D'Arienzo, Marco, Nocentini, Sandro, D'Andrea, Marco, Bruzzaniti, Vicente, Marconi, Raffaella, Mezzenga, Emilio, Cassano, Bartolomeo, Infusino, Erminia, Guerrisi, Antonino, Soriani, Antonella, Strigari, Lidia

المصدر: Applied Sciences (2076-3417); Oct2022, Vol. 12 Issue 19, p10022, 17p

مصطلحات موضوعية: COMPUTED tomography, SINGLE-photon emission computed tomography, RADIOEMBOLIZATION, SCINTILLATION cameras, CAMERA calibration, COLLIMATORS

الشركة/الكيان: EURATOM

مستخلص: Radioembolization (RE) with ⁹⁰Y-microspheres has gained widespread acceptance as a safe and effective technique for treating liver malignancies. Accurate quantification in RE is a key step in treatment planning optimization and is becoming a pressing issue in light of the Directive 2013/59/EURATOM. The aim of this study was to develop a SPECT/CT imaging protocol for quantitative imaging optimization in RE based on cutting edge imaging technology (Symbia IntevoTM system provided with the innovative xSPECT software) and a novel anthropomorphic 3D-printed phantom. In the present study, ^99mTc-labeled macroaggregated albumin was used as a surrogate radiopharmaceutical for treatment planning. Gamma camera calibration factors and recovery coefficients were determined performing preliminary SPECT/CT acquisitions of a point source, a cylindrical homogeneous phantom and the NEMA/IEC phantom. Data reconstruction was performed using the built-in xSPECT package, using both the Ordered Subset Expectation–Maximization (OSEM) and the Ordered Subset Conjugated Gradient (OSCG) algorithm. Specific regions of interest (ROIs) were drawn on the MIM 6.1.7 system according to the physical volume. The quantification procedure was validated using the anthropomorphic phantom provided with a fillable liver section and spheres of different diameters (20 mm, 40 mm and a 40 mm spherical shell). The measured activity concentration in all geometries is consistent within 4%, demonstrating that the xSPECT software permit an absolute quantification in anthropomorphic geometry largely within the 10% recommended from the manufacturer. Caution is advised in the presence of spherical objects with a necrotic core, as underestimations in the order of 20% were obtained. [ABSTRACT FROM AUTHOR]

: Copyright of Applied Sciences (2076-3417) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Altini, Claudio, Villani, Maria F., Di Giannatale, Angela, Cassano, Bartolomeo, Pizzoferro, Milena, Serra, Annalisa, Castellano, Aurora, Cannatà, Vittorio, Garganese, Maria C.

المصدر: Nuclear Medicine Communications ; volume 43, issue 2, page 129-144 ; ISSN 0143-3636

الوصف: Objective 131 I-meta-iodobenzylguanidine (131I-MIBG) combined with myeloablative chemotherapy represents an effective treatment in children affected by relapsed/refractory neuroblastoma (NBL) for disease palliation and in improving progression-free survival. The aim of our study is to evaluate the feasibility, safety and efficacy of tandem 131I-MIBG followed by high-dose chemotherapy with Melphalan. Methods Thirteen patients (age range: 3–17 years) affected by relapsed/refractory NB, previously treated according to standard procedures, were included in the study. Each treatment cycle included two administrations of 131I-MIBG (with a dosimetric approach) followed by a single dose of Melphalan with peripheral blood stem cell rescue. Results At the end of the treatment, ten patients experienced grade 4 neutropenia, two grade 3 and one patient grade 2, three patients presented febrile neutropenia and all needed RBC and platelets transfusions; one patient presented grade 4 mucositis, four grade 3 and one patient grade 2 mucositis. One patient showed progressive disease, eight patients showed stable disease and four patients showed partial response. Conclusion High-dose 131I-MIBG therapy combined with chemotherapy represent a well-tolerated and effective modality of treatment in heavily pretreated patients affected by relapsed/refractory NBL. However, further studies, including a wider cohort of patients, are needed.

الإتاحة: https://doi.org/10.1097/mnm.0000000000001496Test

المؤلفون: Pizzoferro, Milena, Cassano, Bartolomeo, Altini, Claudio, Cacchione, Antonella, Cefalo, Maria Giuseppina, Cannatà, Vittorio, Garganese, Maria Carmen

المصدر: European Journal of Nuclear Medicine and Molecular Imaging ; volume 48, issue 3, page 937-939 ; ISSN 1619-7070 1619-7089

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine

الإتاحة: https://doi.org/10.1007/s00259-020-04966-wTest

المؤلفون: Altini, Claudio, Villani, Maria F., Di Giannatale, Angela, Cassano, Bartolomeo, Pizzoferro, Milena, Serra, Annalisa, Castellano, Aurora, Cannatà, Vittorio, Garganese, Maria C.

المصدر: Nuclear Medicine Communications; Feb2022, Vol. 43 Issue 2, p129-144, 16p

المؤلفون: Longo, Mariaconcetta, Genovese, Elisabetta, Donatiello, Salvatore, Cassano, Bartolomeo, Insero, Teresa, Campoleoni, Mauro, Del Vecchio, Antonella, Magistrelli, Andrea, Tomà, Paolo, Cannatà, Vittorio

المساهمون: Longo, Mariaconcetta, Genovese, Elisabetta, Donatiello, Salvatore, Cassano, Bartolomeo, Insero, Teresa, Campoleoni, Mauro, Del Vecchio, Antonella, Magistrelli, Andrea, Tomà, Paolo, Cannatà, Vittorio

مصطلحات موضوعية: infant, neonatal intensive care unit, neonate, patient dose, radiation protection, radiation protection device, scatter radiation, pediatric, perinatology and child health, radiology, nuclear medicine and imaging

الوصف: Background In a neonatal intensive care unit (NICU), preterm infants are often exposed to a large number of radiographic examinations, which could cause adjacent neonates, family caregivers and staff members to be exposed to a dose amount due to scatter radiation. Objective To provide information on scatter radiation exposure levels in a NICU, to compare these values with the effective dose limits established by the European Union and to evaluate the effectiveness of radiation protection devices in this setting. Materials and methods Radiation exposure levels due to scatter radiation were estimated by passive detectors (thermoluminescent dosimeters) and direct dosimetric measurements (with a dose rate meter); in the latter case, an angular map of the scatter dose distribution was achieved. Results The dose due to scatter radiation to staff in our setting is approximately 160 μSv/year, which is markedly lower than the effective dose limit for workers established by the European Union (20 mSv/year). The doses range between 0.012 and 0.095 μSv/radiograph. Considering a mean hospitalization period of 3 months and our NICU workload, the corresponding scatter radiation dose to an adjacent patient and/or his/her caregiver is at most 40 μSv. Conclusion For distances greater than 1 m from the irradiation field, both scatter dose absorbed by a staff member during a year and that by an adjacent patient and/or his/her caregiver during hospitalization is less than 1 mSv, which is the exposure limit for public members in a year.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29442153; info:eu-repo/semantics/altIdentifier/wos/WOS:000429802500017; volume:48; issue:5; firstpage:715; lastpage:721; numberofpages:7; journal:PEDIATRIC RADIOLOGY; http://hdl.handle.net/11573/1071836Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85041908859; link.springer.de/link/service/journals/00247/index.htm

الإتاحة: https://doi.org/10.1007/s00247-018-4081-4Test
http://hdl.handle.net/11573/1071836Test

المؤلفون: Pacilio, Massimiliano, Verdolino, Elisabetta, Cassano, Bartolomeo, De Vincentis, Giuseppe

المصدر: Clinical Applications of Nuclear Medicine Targeted Therapy ; page 393-403 ; ISBN 9783319630663 9783319630670

الإتاحة: https://doi.org/10.1007/978-3-319-63067-0_29Test