المؤلفون: Deepti Naik, Sanjaya Viswamitra

المصدر: Asian Journal of Medical Sciences, Vol 15, Iss 2, Pp 257-260 (2024)

مصطلحات موضوعية: caseous necrosis, mitral annulus, calcification, intracardiac masses, Medicine

الوصف: Caseous calcification of the mitral annulus, an uncommon kind of intracardiac mass, is a form of degenerative disease that afflicts the mitral valve causing liquefactive or caseous necrosis. Caseous calcification of mitral annulus is rarely encountered in practice; however, it should be on the list of differential diagnosis of any intracardiac masses located close to the mitral annulus.

وصف الملف: electronic resource

العلاقة: https://www.nepjol.info/index.php/AJMS/article/view/59163Test; https://doaj.org/toc/2467-9100Test; https://doaj.org/toc/2091-0576Test

الوصول الحر: https://doaj.org/article/350c9f4ebf294a7887a5254d3f1b5ef3Test

المؤلفون: Yang X, Ren Y, Liu H, Ten Y, Ding Y, Fan S, Tao X, Lu W

المصدر: Clinical, Cosmetic and Investigational Dermatology, Vol Volume 16, Pp 2433-2436 (2023)

مصطلحات موضوعية: case report, cutaneous tuberculosis, scrofuloderma, caseous necrosis, Dermatology, RL1-803

الوصف: Xianhong Yang,1 Yunlin Ren,1,2 Huachu Liu,1,3 Yan Ten,1 Yang Ding,1 Shasha Fan,1 Xiaohua Tao,1 Wei Lu1 1Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, 310014, People’s Republic of China; 2Department of Dermatology and Venereology, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China; 3Department of Dermatology and Venereology, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Zhong Shan Hospital), Hangzhou, 310009, People’s Republic of ChinaCorrespondence: Xiaohua Tao; Wei Lu, Email txhtxh@sina.com; miniluwei@163.comAbstract: We report a case of 32-year-old patient who presented with painless erythematous plaque gradually ulcerated for 9 years. He had a history of pulmonary tuberculosis 12 years ago and was cured by the treatment of 2HRZE/4HR. The laboratory examination of t-spot and PPD skin test was positive. Histopathology examinations of left cervical lymph node as well as skin revealed granulomatous inflammation with caseous necrosis. A diagnosis of scrofuloderma was made. Negative sputum culture and chest CT scan results excluded pulmonary tuberculosis. The patient was treated with a standard antituberculosis therapy and recovered well after 5 months’ follow-up. Scrofuloderma is a rare manifestation of mycobacterial infection. Early diagnosis and treatment are very important.Keywords: case report, cutaneous tuberculosis, scrofuloderma, caseous necrosis

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/a-chronic-multiple-site-of-scrofuloderma-is-it-reactivation-or-treatme-peer-reviewed-fulltext-article-CCIDTest; https://doaj.org/toc/1178-7015Test

الوصول الحر: https://doaj.org/article/3f3d553aa1fe49558be0093c37376225Test

المؤلفون: Moukit, Mounir, Bougrini, Youssef, Rahmoune, Mohammed, Allilou, Ismail, Babahabib, Abdellah

المصدر: International Journal of Reproduction, Contraception, Obstetrics and Gynecology; Vol. 13 No. 4 (2024): April 2024; 1013-1019 ; 2320-1789 ; 2320-1770

مصطلحات موضوعية: Breast, Koch's Bacillus, Granuloma, Caseous necrosis, Antitubercular agents

الوصف: Tuberculosis is one of the leading infectious and contagious diseases, caused by bacteria belonging to the Mycobacterium family. Breast involvement ranks last among the extrapulmonary manifestations of tuberculosis but remains an important clinical condition that may present clinical and radiological similarities with breast cancer, thus requiring a thorough diagnostic approach including histological and/or bacteriological confirmation. This is a retrospective study conducted at the department of Gynecology and Obstetrics of the Military Hospital Moulay Ismail - Meknes, over a period of 4 years. A total of 6 cases of breast tuberculosis were observed, resulting in an incidence rate of 6 cases per 7600 women-years. The mean age of patients was 39 years. Signs of tuberculosis impregnation were found in 33% of cases. The clinical forms encountered, in descending order of frequency, were: diffuse form (50% of cases), nodular form (33% of cases), and sclerotic form (16% of cases). The radiological findings were almost always suggestive of a suspicious lesion. Diagnosis was primarily based on the histopathological study of breast biopsy. All our patients received a standard regimen of anti-tubercular treatment including: 4 months of Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol followed by 2 months of Rifampicin and Isoniazid with favorable outcomes. Only one patient experienced a recurrence due to under dosing of Rifampicin, which was managed with a total of 9 months of treatment. One patient underwent additional surgical drainage. Early and thorough diagnosis of breast tuberculosis is crucial as it helps avoid mutilating surgery in often young women.

وصف الملف: application/pdf

العلاقة: https://www.ijrcog.org/index.php/ijrcog/article/view/13921/8647Test; https://www.ijrcog.org/index.php/ijrcog/article/view/13921Test

الإتاحة: https://doi.org/10.18203/2320-1770.ijrcog20240805Test
https://www.ijrcog.org/index.php/ijrcog/article/view/13921Test

المؤلفون: Шарова Наталья Михайловна, Данилова Анна Анатольевна, Хабибуллина Мария Романовна, Минаева Валерия Романовна, Кондрахина Ирина Никифоровна, Кукало Светлана Васильевна, Пивень Николай Петрович, Проценко Алексей Николаевич

مصطلحات موضوعية: туберкулез кожи, внелегочный туберкулез, диаскинтест, гранулема, казеозный некроз, клетки Пирогова–Лангханса, skin tuberculosis, extrapulmonary tuberculosis, diaskintest, granuloma, caseous necrosis, Pirogov– Langhans giant cells

الوصف: Туберкулез кожи – группа кожных заболеваний, различных по клиническим, морфологическим признакам и исходу, относится к внелегочным формам туберкулеза. Диагностика поражений кожи, вызванных микобактериями туберкулеза, является непростой задачей, поскольку специфические клинические признаки заболевания весьма разнообразны. Результаты дополнительных методов исследования могут быть неоднозначными, а туберкулез кожи не всегда ассоциирован с активным туберкулезом органов дыхания. Представленное клиническое наблюдение свидетельствует о необходимости рационального, дифференцированного подхода к диагностике данной патологии. ... : Skin tuberculosis is a group of skin diseases differing in clinical, morphological signs, and outcome. It is one of the extrapulmonary forms of tuberculosis. Diagnosis of skin lesions caused by Mycobacterium tuberculosis is not an easy task, as there are diverse specific clinical signs of the disease. The results of additional diagnostic methods may also be ambiguous, and skin tuberculosis is not always associated with active pulmonary tuberculosis. Presented clinical observation demonstrates the need for a rational and differentiated approach to the diagnosis of this pathology. ...

الإتاحة: https://doi.org/10.24412/2071-5315-2024-13093Test
https://cyberleninka.ru/article/n/problema-diagnostiki-tuberkuleza-kozhi-v-klinicheskoy-praktikeTest

المؤلفون: Runrui Wu, Shanshan Li, Yadong Liu, Hong Zhang, Dongxu Liu, Yuejiao Liu, Wen Chen, Fenghua Wang

المصدر: Frontiers in Microbiology, Vol 14 (2023)

مصطلحات موضوعية: spinal tuberculosis, pathological feature, drug resistance, gene, caseous necrosis, Microbiology, QR1-502

الوصف: The special blood circulation, anatomy, and tissue structure of the spine may lead to significant differences in pathological features and drug resistance between spinal tuberculosis and pulmonary tuberculosis. Here, we collected 168 spinal tuberculosis cases and 207 pulmonary tuberculosis cases, and compared their clinical and pathological features as well as drug resistance. From the anatomical location, the highest incidence was of lumbar tuberculosis, followed by thoracic tuberculosis. PET-CT scans showed increased FDG uptake in the diseased vertebrae, discernible peripheral soft tissue shadow, visible internal capsular shadow, and an abnormal increase in FDG uptake. MRI showed infectious lesions in the diseased vertebral body, formation of paravertebral and bilateral psoas muscle abscess, and edema of surrounding soft tissues. As with control tuberculosis, the typical pathological features of spinal tuberculosis were chronic granulomatous inflammation with caseous necrosis. The incidence of granulomas was not statistically different between the groups. However, the proportions of caseous necrosis, acute inflammation, abscess, exudation, and granulation tissue formation in the spinal tuberculosis group were all significantly increased relative to the control tuberculosis group. Compared to the control tuberculosis group, the incidences of resistance to rifampicin (RFP) + isoniazid (INH) + streptomycin (STR) and INH + ethambutol (EMB) were lower in the spinal tuberculosis group, while the incidences of resistance to RFP + INH + EMB and RFP + EMB were higher. Moreover, we also found some differences in drug-resistance gene mutations. In conclusion, there are noticeable differences between spinal Mycobacterium tuberculosis and pulmonary tuberculosis in pathological characteristics, drug resistance, and drug resistance gene mutations.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1230572/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/0a456884583f45779d7631c1b85e6f66Test

المؤلفون: Chahrazed Benrabah

المصدر: Journal de la Faculté de Médecine d'Oran, Vol 6, Iss 2, Pp 815-818 (2022)

مصطلحات موضوعية: cerebral tuberculosis, surgical cure, caseous necrosis, anti-tuberculosis treatment, Medicine (General), R5-920

الوصف: Abstract Tuberculosis is one of the most widespread infectious diseases in the world. It constitutes a major public health problem, especially in developing countries, including Algeria. Globally and among all tuberculosis cases, WHO reports 14% extra-pulmonary tuberculosis (EPT) without concomitant pulmonary involvement. In our country and in recent years, an upsurge in extrapulmonary tuberculosis has been observed. The objective of this article was to present an atypical case of cerebral tuberculosis whose diagnosis was late, made by anatomopathological examination with a review of the literature. We report the case of a young patient hospitalized in emergency for an intracranial hypertension syndrome with neurological disorders. Cerebral computed tomography revealed multiple brain locations with active hydrocephalus. The extension assessment was without anomaly.The patient underwent a surgical intervention, the operative consequences were favorable. The pathological examination was in favor of a specific inflammatory granulomatous lesion made up of large areas of caseous necrosis. The patient was cured under anti-tuberculosis treatment. The diagnostic problem and the results will be discussed with a review of the literature. Cerebral tuberculosis is a rare form of extrapulmonary tuberculosis. The clinic as well as the neuroimaging (CT, MRI) are atypical. The diagnosis is postoperative, based on the pathological examination. The prognosis depends on the early diagnosis, the site of the lesion and the response to anti-tuberculosis treatment. Résumé La tuberculose est une des maladies infectieuses les plus répandues dans le monde .Elle représente un problème de santé publique majeur dans les pays en voie de développement, y compris l’Algérie . À l’échelle mondiale et parmi tous les cas de tuberculose, l’OMS rapporte 14 % de tuberculose extra-pulmonaire (TEP) sans atteinte pulmonaire concomitante. Dans notre pays et durant ces dernières années, une recrudescence de la tuberculose extrapulmonaire a été observée. L’objectif de cet article était de présenter un cas atypique de tuberculose cérébrale dont le diagnostic a été tardif, posé par l’examen anatomopathologique avec une revue de la littérature. C’est le cas d’une jeune patiente hospitalisée dans le cadre de l’urgence pour un syndrome d’hypertension intracrânienne avec troubles neurologiques. La tomodensitométrie cérébrale a objectivé de multiples localisations cérébrales avec une hydrocéphalie active. Le bilan d’extension était sans anomalie. La patiente avait bénéficié d’une intervention chirurgicale, les suites opératoires ont été favorables. L’examen anatomo-pathologique était en faveur d’une lésion inflammatoire spécifique granulomateuse faite de larges plages de nécrose caséeuse. La patiente a répondu au traitement antituberculeux. Le problème diagnosticque et les résultats seront discutés avec une revue de la littérature. La tuberculose cérébrale est une forme rare de la tuberculose extra-pulmonaire. Le tableau clinique ainsi que la neuro-imagerie (TDM, IRM) sont atypiques. Le diagnostic était postopératoire, reposant sur l’examen anatomopathologique. Le pronostic dépend de la précocité du diagnostic, du siège de la lésion et de la réponse au traitement antituberculeux.

وصف الملف: electronic resource

العلاقة: https://confajol3.ajol.info/index.php/jmfo/article/view/999Test; https://doaj.org/toc/2571-9874Test; https://doaj.org/toc/2602-6511Test

الوصول الحر: https://doaj.org/article/028e30a64d8541d49616d36401814773Test

المؤلفون: Kamal AF, Oktari PR, Kurniawan A, Kodrat E, Mumpuni NA

المصدر: Orthopedic Research and Reviews, Vol Volume 14, Pp 351-363 (2022)

مصطلحات موضوعية: osteoarticular tb, tuberculosis, extrapulmonary tb, caseous necrosis, jakarta, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

الوصف: Achmad Fauzi Kamal,1 Prima Rizky Oktari,1 Aryadi Kurniawan,1 Evelina Kodrat,2 Nadia Asmirtania Mumpuni3 1Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 2Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 3Pelni General Hospital, Jakarta, IndonesiaCorrespondence: Prima Rizky Oktari, Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jl Diponegoro No. 71, Central of Jakarta, Jakarta, Indonesia, Email primarizkyoktari@gmail.comPurpose: The lack of knowledge regarding osteoarticular tuberculosis (TB) cases in Indonesia leads to delayed and chronic conditions. This study aims to evaluate clinical outcomes of patients with osteoarticular TB.Materials and Methods: Thirty osteoarticular cases were retrospectively analyzed, with a focus on non-immunocompromised patients without spine involvement. Chemotherapy length, operative treatment method, and infection recurrence were evaluated.Results: The majority (60%) of patients were aged between 19 to 49 years. The most common complaint was painful swelling, particularly during physical activity. Weight-bearing joints, such as the hips, knees, and ankles, were the most affected. Laboratory results showed over half of the patients had anemia, 96% had elevated erythrocyte sedimentation rate (ESR), and 76% had elevated C-reactive protein (CRP) levels. Radiological findings varied, with lytic lesions, abscesses, and joint destruction observed. All patients presented with pathognomonic histological tubercle appearances, with caseous necrosis, lymphocytes, and Langhans giant cells present. Twenty-nine cases were treated with anti-TB drugs for 12 months, while one recurrent case received the drugs for 24 months. All patients underwent surgery to gain local infection control.Conclusion: Osteoarticular TB is a common manifestation of extrapulmonary TB and must not be overlooked. Early detection of osteoarticular TB may prevent limb morbidity. Although anti-TB drugs are the primary treatment for osteoarticular TB, in some cases, surgery is required to establish a diagnosis and gain local infection control.Keywords: osteoarticular TB, tuberculosis, extrapulmonary TB, caseous necrosis, Jakarta

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/clinical-outcomes-of-delayed-osteoarticular-tuberculosis-a-review-of-3-peer-reviewed-fulltext-article-ORRTest; https://doaj.org/toc/1179-1462Test

الوصول الحر: https://doaj.org/article/cca1b4ff4315456caadbeb8a50557ea3Test

المؤلفون: Najib Bouhabba, Imane Meziane, Mohammed Tarchouli, Sidi Driss El Jaouhari and Karim Filali

مصطلحات موضوعية: Miliary Tuberculosis Epithelia Gigantocellular Granuloma With Caseous Necrosis Ileo-Caecal Biopsy Bilateral Kidney Hypertrophy

الوصف: Acute surgical abdomen is a diagnostic and therapeutic emergency, manifested by a generalized contracture of the abdominal muscles following a peritoneal irritation. In the majority of cases, acute peritonitis is the most common etiology requiring urgent surgical intervention. Nevertheless, some medical pathologies, notably acute adrenal deficiency and inflammatory colitis, can mimic this surgical situation, leading to an aberrant surgical intervention. Through a clinical case, we report the diagnostic and therapeutic modalities of a multifocal tuberculosis initially admitted for an acute surgical abdomen.

العلاقة: https://zenodo.org/record/7932780Test; https://doi.org/10.5281/zenodo.7932780Test; oai:zenodo.org:7932780

الإتاحة: https://doi.org/10.5281/zenodo.7932780Test
https://doi.org/10.5281/zenodo.7932779Test
https://zenodo.org/record/7932780Test

المؤلفون: Haifa, Rafa Nabila, Lubis, Humairah Medina Liza

المصدر: Buletin Farmatera; Vol 8, No 1 (2023); 64-72 ; 2528-410X ; 10.30596/bf.v8i1

مصطلحات موضوعية: Central caseous necrosis, Lymphocyte density, Tuberculous lymphadenitis

الوصف: Tuberculosis lymphadenitis (TBLN) is the most common extra pulmonary TB (EPTB) case in the world with a range of 30-40% of all EPTB cases. When the body's immune system cannot kill the pathogen, the body will try to contain the pathogen (granuloma). The outer portion of the granuloma becomes calcified and the cells in the center undergo necrosis. The formation of central necrosis is associated with the emergence of cellular hypersensitivity with the features of local accumulation of macrophages and lymphocytes. The current study aimed to determine the relationship between the microscopic features of central caseous necrosis with lymphocyte density in patients with tuberculous lymphadenitis. Thirty histopathological slides of TBLN patients were observed under a microscope to see the features of central caseous necrosis and assess the lymphocyte density with the results assessed based on the cutoff point of the median of all lymphocyte mean values. Based on the microscopic examination, 25 samples of central caseous necrosis were found and the other 5 samples were not found to have caseous necrosis. Twenty-six patients had low lymphocyte density, and 4 patients had high lymphocyte density. The results of the Fisher Exact test obtained p = 0.009. There is a significant relationship between the features of central caseous necrosis and lymphocyte density in patients with TBLN.

وصف الملف: application/pdf

العلاقة: https://jurnal.umsu.ac.id/index.php/buletin_farmatera/article/view/12282/8960Test; https://jurnal.umsu.ac.id/index.php/buletin_farmatera/article/view/12282Test

الإتاحة: https://doi.org/10.30596/bf.v8i1.12282Test
https://doi.org/10.30596/bf.v8i1Test
https://jurnal.umsu.ac.id/index.php/buletin_farmatera/article/view/12282Test

المؤلفون: Hind Bouyabla, Ibtissam Bellajdel, Fatima Zahra Bouabdellaoui, Samia Malki, Amal Bennani, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni

المصدر: International Journal of Reproduction, Contraception, Obstetrics and Gynecology; Vol. 12 No. 5 (2023): May 2023; 1465-1467 ; 2320-1789 ; 2320-1770

مصطلحات موضوعية: Mammary tuberculosis, Anti-bacillary polychemotherapy, Caseous necrosis

الوصف: Mammary tuberculosis is a rare disease that affects young women during the genital period, usually between the ages of 20 and 40 years, and remains rare in postmenopausal women. Its risk factors are multiparity, breastfeeding, breast trauma and chronic mastitis. Depending on the mode of contamination, there are 2 forms of mammary tuberculosis: primary or secondary. On ultrasound, breast tuberculosis often appears as a heterogeneous hypoechoic image, poorly limited with minimal posterior enhancement. It may also appear as a hypoechoic, homogeneous or heterogeneous image, well limited with posterior enhancement and some calcifications. Histological criteria suggestive of breast tuberculosis are the presence of epithelioid follicles and Langhans-type giant cells, which may or may not be associated with caseous necrosis. A certain number of diagnoses must be eliminated before the diagnosis of breast tuberculosis can be made, in particular breast cancer; it should be noted that the literature describes forms associating cancer and breast tuberculosis, hence the need for a histological study of the breast tissue in order to eliminate an associated carcinoma. It poses diagnostic and therapeutic problems. Current treatment is based on antituberculosis chemotherapy sometimes associated with surgery. The evolution of the disease is usually favourable with a well conducted treatment.

وصف الملف: application/pdf

العلاقة: https://www.ijrcog.org/index.php/ijrcog/article/view/12856/7984Test; https://www.ijrcog.org/index.php/ijrcog/article/view/12856Test

الإتاحة: https://doi.org/10.18203/2320-1770.ijrcog20231243Test
https://www.ijrcog.org/index.php/ijrcog/article/view/12856Test