المؤلفون: Bikfalvi, A., Da Costa, C. A., Avril, T., Barnier, J. V., Bauchet, L., Brisson, L., Cartron, P. F., Castel, H., Chevet, E., Chneiweiss, H., Clavreul, A., Constantin, B., Coronas, V., Daubon, T., Dontenwill, M., Ducray, F., Enz-Werle, N., Figarella-Branger, D., FOURNIER, Isabelle, Frenel, J. S., Gabut, M., Galli, T., Gavard, J., Huberfeld, G., Hugnot, J. P., Idbaih, A., Junier, M. P., Mathivet, T., Menei, P., Meyronet, D., Mirjolet, C., Morin, F., Mosser, J., Moyal, E. C., Rousseau, V., Salzet, Michel, Sanson, M., Seano, G., Tabouret, E., Tchoghandjian, A., Turchi, L., Vallette, F. M., Vats, S., Verreault, M., Virolle, T.

المساهمون: Université de Lille, Inserm, CHU Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

الوصف: Glioblastoma (GBM) is the most deadJy type of malignant brain tumor, despite extensive molecular ana y ses of GBM cens. ln recent years, the tumor microenvirc;inment (TME} has been ,recognized as an important player and therapeutic target ln GBM. However, there is a need for a full and Integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. ln this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and ttierapy in France. We propose a holistic view of the subject by delineating the specifio features of the GBM TME at the cellular, molecul·ar, and therapeutic levels.

وصف الملف: application/octet-stream

العلاقة: Trends in Cancer; Trends Cancer; http://hdl.handle.net/20.500.12210/92582Test

الإتاحة: https://doi.org/20.500.12210/92582Test
https://hdl.handle.net/20.500.12210/92582Test

المؤلفون: Frenel, J-S., Cartron, P-F., Gourmelon, C., Campion, L., Aumont, M., Augereau, P., Ducray, F., Loussouarn, D., Lallier, L., Robert, M., Campone, M.

المصدر: Annals of Oncology ; volume 31, page S400 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1016/j.annonc.2020.08.479Test
https://api.elsevier.com/content/article/PII:S0923753420404752?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753420404752?httpAccept=text/plainTest

المؤلفون: Asgarova, A., Asgarov, K., Godet, Y., Peixoto, P., Nadaradjane, A., Boyer-Guittaut, M., Galaine, J., Guenat, D., Mougey, V., Perrard, J., Pallandre, J. R., Bouard, A., Balland, J., Tirole, C., Adotevi, O., Hendrick, E., Herfs, M., Cartron, P. F., Borg, C., Hervouet, E.

المساهمون: Ligue Contre le Cancer, ANR

المصدر: OncoImmunology ; volume 7, issue 5, page e1423170 ; ISSN 2162-402X

الإتاحة: https://doi.org/10.1080/2162402x.2017.1423170Test

المؤلفون: Morfouace, M, Lalier, L, Oliver, L, Cheray, M, Pecqueur, C, Cartron, P-F, Vallette, F M

المصدر: Cell Death & Disease ; volume 5, issue 1, page e1036-e1036 ; ISSN 2041-4889

مصطلحات موضوعية: Cancer Research, Cell Biology, Cellular and Molecular Neuroscience, Immunology

الوصف: Glioma stem cells are highly resistant to cell death and as such are supposed to contribute to tumor recurrence by eluding anticancer treatments. Here, we show that spheroids that contain rat neural stem cells (NSCs) or rat glioma stem cells (cancer stem cells, CSCs) express isoforms 1 and 2 of pyruvate kinase (PKM1 and PKM2); however, the expression of PKM2 is considerably higher in glioma spheroids. Silencing of PKM2 enhances both apoptosis and differentiation of rat and human glioma spheroids. We establish that PKM2 was implicated in glioma spheroid differentiation through its interaction with Oct4, a major regulator of self-renewal and differentiation in stem cells. The small molecule Dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, increases the amount of PKM2/Oct4 complexes and thus inhibited Oct4-dependent gene expression. Taken together, our results highlight a new molecular pathway through which PKM2 can manage gliomagenesis via the control of glioma stemness by Oct4.

الإتاحة: https://doi.org/10.1038/cddis.2013.561Test
http://www.nature.com/articles/cddis2013561.pdfTest
http://www.nature.com/articles/cddis2013561Test
https://www.nature.com/articles/cddis2013561.pdfTest

المؤلفون: Cartron, P.-F., Nadaradjane, A., LePape, F., Lalier, L., Gardie, B., Vallette, F. M.

المصدر: Genes & Cancer ; volume 4, issue 5-6, page 235-241 ; ISSN 1947-6019 1947-6027

مصطلحات موضوعية: Cancer Research, Genetics

الإتاحة: https://doi.org/10.1177/1947601913489020Test

المؤلفون: Cartron, P F, Loussouarn, D, Campone, M, Martin, S A, Vallette, F M

المصدر: Cell Death & Disease ; volume 3, issue 11, page e421-e421 ; ISSN 2041-4889

مصطلحات موضوعية: Cancer Research, Cell Biology, Cellular and Molecular Neuroscience, Immunology

الإتاحة: https://doi.org/10.1038/cddis.2012.150Test
http://www.nature.com/articles/cddis2012150.pdfTest
http://www.nature.com/articles/cddis2012150Test
https://www.nature.com/articles/cddis2012150.pdfTest

المؤلفون: Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.

المصدر: Molecular and Cellular Biology ; volume 31, issue 4, page 832-844 ; ISSN 1098-5549

الإتاحة: https://doi.org/10.1128/mcb.00161-10Test

المؤلفون: Lalier, L, Cartron, P-F, Olivier, C, Logé, C, Bougras, G, Robert, J-M, Oliver, L, Vallette, F M

المصدر: Cell Death & Differentiation ; volume 18, issue 3, page 528-537 ; ISSN 1350-9047 1476-5403

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1038/cdd.2010.128Test
http://www.nature.com/articles/cdd2010128.pdfTest
http://www.nature.com/articles/cdd2010128Test

المؤلفون: Hervouet, E, Vallette, F M, Cartron, P-F

المصدر: Cell Death & Disease ; volume 1, issue 1, page e8-e8 ; ISSN 2041-4889

مصطلحات موضوعية: Cancer Research, Cell Biology, Cellular and Molecular Neuroscience, Immunology

الإتاحة: https://doi.org/10.1038/cddis.2009.7Test
http://www.nature.com/articles/cddis20097.pdfTest
http://www.nature.com/articles/cddis20097Test
https://www.nature.com/articles/cddis20097.pdfTest

المؤلفون: Lalier, L, Cartron, P-F, Pedelaborde, F, Olivier, C, Loussouarn, D, Martin, S A, Meflah, K, Menanteau, J, Vallette, F M

المصدر: Oncogene ; volume 26, issue 34, page 4999-5009 ; ISSN 0950-9232 1476-5594

مصطلحات موضوعية: Cancer Research, Genetics, Molecular Biology

الإتاحة: https://doi.org/10.1038/sj.onc.1210303Test
https://www.nature.com/articles/1210303.pdfTest
https://www.nature.com/articles/1210303Test