المؤلفون: Muller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Brown, D, Brown, PJ, Bullock, AN, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, S, Fuchs, SM, Hall, MD, Hartung, I, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M, Scholten, C, Sharma, S, Simeonov, A, Sundstrom, M, Superti-Furga, G, Todd, MH, Tredup, C, Vedadi, M, von Delft, F, Willson, TM, Winter, GE, Workman, P, Arrowsmith, CH

المصدر: RSC medicinal chemistry. 13(1):13-21

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:148250012Test

المؤلفون: Abe, K, Akhlaq, N, Akutsu, R, Ali, A, Alonso Monsalve, S, Alt, C, Andreopoulos, C, Antonova, M, Aoki, S, Arihara, T, Asada, Y, Ashida, Y, Atkin, ET, Barbi, M, Barker, GJ, Barr, G, Barrow, D, Batkiewicz-Kwasniak, M, Bench, F, Berardi, V, Berns, L, Bhadra, S, Blanchet, A, Blondel, A, Bolognesi, S, Bonus, T, Bordoni, S, Boyd, SB, Bravar, A, Bronner, C, Bron, S, Bubak, A, Buizza Avanzini, M, Caballero, JA, Calabria, NF, Cao, S, Carabadjac, D, Carter, AJ, Cartwright, SL, Catanesi, MG, Cervera, A, Chakrani, J, Cherdack, D, Chong, PS, Christodoulou, G, Chvirova, A, Cicerchia, M, Coleman, J, Collazuol, G, Cook, L, Cudd, A, Dalmazzone, C, Daret, T, Davydov, Yu I, De Roeck, A, De Rosa, G, Dealtry, T, Delogu, CC, Densham, C, Dergacheva, A, Di Lodovico, F, Dolan, S, Douqa, D, Doyle, TA, Drapier, O, Dumarchez, J, Dunne, P, Dygnarowicz, K, Eguchi, A, Emery-Schrenk, S, Erofeev, G, Ershova, A, Eurin, G, Fedorova, D, Fedotov, S, Feltre, M, Finch, AJ, Fiorentini Aguirre, GA, Fiorillo, G, Fitton, MD, Franco Patiño, JM, Friend, M, Fujii, Y, Fukuda, Y, Fusshoeller, K, Giannessi, L, Giganti, C, Glagolev, V, Gonin, M, González Rosa, J, Goodman, EAG, Gorin, A, Grassi, M, Guigue, M, Hadley, DR, Haigh, JT, Hamacher-Baumann, P, Harris, DA, Hartz, M, Hasegawa, T

المصدر: European Physical Journal C. 83(9)

مصطلحات موضوعية: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, T2K Collaboration, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics

الوصف: The T2K experiment presents new measurements of neutrino oscillation parameters using 19.7(16.3)×1020 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional 4.7×1020 POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on sin2θ13 and the impact of priors on the δCP measurement. Both analyses prefer the normal mass ordering and upper octant of sin2θ23 with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on sin2θ13 from reactors, sin2θ23=0.561-0.032+0.021 using Feldman-Cousins corrected intervals, and Δm322=2.494-0.058+0.041×10-3eV2 using constant Δχ2 intervals. The CP-violating phase is constrained to δCP=-1.97-0.70+0.97 using Feldman-Cousins corrected intervals, and δCP=0,π is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than 2σ credible level using a flat prior in δCP, and just below 2σ using a flat prior in sinδCP. When the external constraint on sin2θ13 is removed, sin2θ13=28.0-6.5+2.8×10-3, in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/07x1s1kxTest

المؤلفون: Arrowsmith, CH, Audia, JE, Austin, C, Baell, J, Bennett, J, Blagg, J, Bountra, C, Brennan, PE, Brown, PJ, Bunnage, ME, Buser-Doepner, C, Campbell, RM, Carter, AJ, Cohen, P, Copeland, RA, Cravatt, B, Dahlin, JL, Dhanak, D, Edwards, AM, Frye, SV, Gray, N, Grimshaw, CE, Hepworth, D, Howe, T, Huber, KVM, Jin, J, Knapp, S, Kotz, JD, Kruger, RG, Lowe, D, Mader, MM, Marsden, B, Mueller-Fahrnow, A, Muller, S, O'Hagan, RC, Overington, JP, Owen, DR, Rosenberg, SH, Roth, B, Ross, R, Schapira, M, Schreiber, SL, Shoichet, B, Sundstrom, M, Superti-Furga, G, Taunton, J, Toledo-Sherman, L, Walpole, C, Walters, MA, Willson, TM, Workman, P, Young, RN, Zuercher, WJ

المصدر: Nature chemical biology. 11(8):536-541

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:131668584Test

المؤلفون: Pritchard, AJ, Carter, AJ, Palombit, RA

المصدر: Animal Behaviour , 198 pp. 59-72. (2023)

مصطلحات موضوعية: baboon, coping style, field experiment, individual difference, personality, primate, social dominance, social network analysis, social responsiveness, stress reactivity

الوصف: The patterning of interactions between individuals over time form the foundation for relationships, which are the basis for social group structure. The emergent social structure scaling from interactions might, therefore, be influenced by individual differences in how individuals respond to stressors and uncertainty, which are often intrinsic aspects of social dynamics. During a 17-month study of wild olive baboons, Papio anubis, in Laikipia, Kenya, we measured individual differences in coping style and stress reactivity by experimentally presenting a stressor with multiple solutions. We measured individual differences in sociality through focal animal and ad libitum sampling that recorded grooming, aggression, proximity, and social displacements. We examined whether experimental measures of coping style and stress reactivity (1) are linked to social network assortativity, (2) predict network position and (3) covary with social dominance rank. Homophily was observed for coping styles in a strong proximity network but not when weak associations were included in the analysis. Coping style scores did not predict social network strength or degree. Partner stability indices of proximity associations and social dominance rank did not covary with coping style measures. Static summative network structures may obfuscate investigative inquiries into the role of individual differences and, also, social structure may constrain or facilitate the behavioural expression of such differences. Thus, we should prioritize more fine-grain investigative approaches inclusive of variation in situation, context and consistency of group structure.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10168164/1/Pritchard%20et%20al.%20Baboon%20stress%20reactivity.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10168164Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10168164/1/Pritchard%20et%20al.%20Baboon%20stress%20reactivity.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10168164Test/

المؤلفون: Abe K, Akhlaq N, Akutsu R, Ali A, Alonso Monsalve S, Alt C, Andreopoulos C, Antonova M, Aoki S, Arihara T, Asada Y, Ashida Y, Atkin ET, Barbi M, Barker GJ, Barr G, Barrow D, Batkiewicz-Kwasniak M, Bench F, Berardi V, Berns L, Bhadra S, Blanchet A, Blondel A, Bolognesi S, Bonus T, Bordoni S, Boyd SB, Bravar A, Bronner C, Bron S, Bubak A, Buizza Avanzini M, Caballero JA, Calabria NF, Cao S, Carabadjac D, Carter AJ, Cartwright SL, Catanesi MG, Cervera A, Chakrani J, Cherdack D, Chong PS, Christodoulou G, Chvirova A, Cicerchia M, Coleman J, Collazuol G, Cook L, Cudd A, Dalmazzone C, Daret T, Davydov YI, De Roeck A, De Rosa G, Dealtry T, Delogu CC, Densham C, Dergacheva A, Di Lodovico F, Dolan S, Douqa D, Doyle TA, Drapier O, Dumarchez J, Dunne P, Dygnarowicz K, Eguchi A, Emery-Schrenk S, Erofeev G, Ershova A, Eurin G, Fedorova D, Fedotov S, Feltre M, Finch AJ, Fiorentini Aguirre GA, Fiorillo G, Fitton MD, Franco Patiño JM, Friend M, Fujii Y, Fukuda Y, Fusshoeller K, Giannessi L, Giganti C, Glagolev V, Gonin M, González Rosa J, Goodman EAG, Gorin A, Grassi M, Guigue M, Hadley DR, Haigh JT, Hamacher-Baumann P, Harris DA, Hartz M, Hasegawa T, Hassani S, Hastings NC, Hayato Y, Henaff D, Hiramoto A, Hogan M, Holeczek J, Holin A, Holvey T, Hong Van NT, Honjo T, Iacob F, Ichikawa AK, Ikeda M, Ishida T, Ishitsuka M, Israel HT, Iwamoto K, Izmaylov A, Izumi N, Jakkapu M, Jamieson B, Jenkins SJ, Jesús-Valls C, Jiang JJ, Jonsson P, Joshi S, Jung CK, Jurj PB, Kabirnezhad M, Kaboth AC, Kajita T, Kakuno H, Kameda J, Kasetti SP, Kataoka Y, Katayama Y, Katori T, Kawaue M, Kearns E, Khabibullin M, Khotjantsev A, Kikawa T, Kikutani H, King S, Kiseeva V, Kisiel J, Kobata T, Kobayashi H, Kobayashi T, Koch L, Kodama S, Konaka A, Kormos LL, Koshio Y, Kostin A, Koto T, Kowalik K, Kudenko Y, Kudo Y, Kuribayashi S, Kurjata R, Kutter T, Kuze M, La Commara M, Labarga L, Lachner K, Lagoda J, Lakshmi SM, Lamers James M, Lamoureux M, Langella A, Laporte J, Last D, Latham N, Laveder M, Lavitola L, Lawe M, Lee Y, Lin C, Lin S, Litchfield RP, Liu SL, Li W, Longhin A, Long KR, Lopez Moreno A, Ludovici L, Lu X, Lux T, Machado LN, Magaletti L, Mahn K, Malek M, Mandal M, Manly S, Marino AD, Marti-Magro L, Martin DGR, Martini M, Martin JF, Maruyama T, Matsubara T, Matveev V, Mauger C, Mavrokoridis K, Mazzucato E, McCauley N, McElwee J, McFarland KS, McGrew C, McKean J, Mefodiev A, Megias GD, Mehta P, Mellet L, Metelko C, Mezzetto M, Miller E, Minamino A, Mineev O, Mine S, Miura M, Molina Bueno L, Moriyama S, Morrison P, Mueller TA, Munford D, Munteanu L, Nagai K, Nagai Y, Nakadaira T, Nakagiri K, Nakahata M, Nakajima Y, Nakamura A, Nakamura H, Nakamura K, Nakamura KD, Nakano Y, Nakayama S, Nakaya T, Nakayoshi K, Naseby CER, Ngoc TV, Nguyen VQ, Niewczas K, Nishimori S, Nishimura Y, Nishizaki K, Nosek T, Nova F, Novella P, Nugent JC, O’Keeffe HM, O’Sullivan L, Odagawa T, Ogawa T, Okada R, Okinaga W, Okumura K, Okusawa T, Ospina N, Owen RA, Oyama Y, Palladino V, Paolone V, Pari M, Parlone J, Parsa S, Pasternak J, Pavin M, Payne D, Penn GC, Pershey D, Pickering L, Pidcott C, Pintaudi G, Pistillo C, Popov B, Porwit K, Posiadala-Zezula M, Prabhu YS, Pupilli F, Quilain B, Radermacher T, Radicioni E, Radics B, Ramírez MA, Ratoff PN, Reh M, Riccio C, Rondio E, Roth S, Roy N, Rubbia A, Ruggeri AC, Ruggles CA, Rychter A, Sakashita K, Sánchez F, Santucci G, Schloesser CM, Scholberg K, Scott M, Seiya Y, Sekiguchi T, Sekiya H, Sgalaberna D, Shaikhiev A, Shaker F, Shaykina A, Shiozawa M, Shorrock W, Shvartsman A, Skrobova N, Skwarczynski K, Smyczek D, Smy M, Sobczyk JT, Sobel H, Soler FJP, Sonoda Y, Speers AJ, Spina R, Suslov IA, Suvorov S, Suzuki A, Suzuki SY, Suzuki Y, Sztuc AA, Tada M, Tairafune S, Takayasu S, Takeda A, Takeuchi Y, Takifuji K, Tanaka HK, Tanihara Y, Tani M, Teklu A, Tereshchenko VV, Teshima N, Thamm N, Thompson LF, Toki W, Touramanis C, Towstego T, Tsui KM, Tsukamoto T, Tzanov M, Uchida Y, Vagins M, Vargas D, Varghese M, Vasseur G, Vilela C, Villa E, Vinning WGS, Virginet U, Vladisavljevic T, Wachala T, Walsh JG, Wang Y, Wan L, Wark D, Wascko MO, Weber A, Wendell R, Wilking MJ, Wilkinson C, Wilson JR, Wood K, Wret C, Xia J, Xu Y, Yamamoto K, Yamamoto T, Yanagisawa C, Yang G, Yano T, Yasutome K, Yershov N, Yevarouskaya U, Yokoyama M, Yoshimoto Y, Yoshimura N, Yu M, Zaki R, Zalewska A, Zalipska J, Zaremba K, Zarnecki G, Zhao X, Zhu T, Ziembicki M, Zimmerman ED, Zito M, Zsoldos S

العلاقة: urn:ISSN:1434-6052; Europ Phys J C; http://purl.org/net/epubs/series/1967Test; Science and Technology Facilities Council (2007- ); Particle Physics; Technology Department (2006- ); http://purl.org/net/epubs/work/55327528Test

الإتاحة: http://purl.org/net/epubs/work/55327528Test

المؤلفون: Abe, K, Akhlaq, N, Akutsu, R, Ali, A, Alt, C, Andreopoulos, C, Antonova, M, Aoki, S, Arihara, T, Asada, Y, Ashida, Y, Atkin, ET, Ban, S, Barbi, M, Barker, GJ, Barr, G, Barrow, D, Batkiewicz-Kwasniak, M, Bench, F, Berardi, V, Berns, L, Bhadra, S, Blanchet, A, Blondel, A, Bolognesi, S, Bonus, T, Bordoni, S, Boyd, SB, Bravar, A, Bronner, C, Bron, S, Bubak, A, Avanzini, MB, Calabria, NF, Cao, S, Carter, AJ, Cartwright, SL, Catanesi, MG, Cervera, A, Chakrani, J, Cherdack, D, Christodoulou, G, Cicerchia, M, Coleman, J, Collazuol, G, Cook, L, Cudd, A, Davydov, YI, De Roeck, A, De Rosa, G, Dealtry, T, Delogu, CC, Densham, C, Dergacheva, A, Di Lodovico, F, Dolan, S, Douqa, D, Doyle, TA, Drapier, O, Duffy, KE, Dumarchez, J, Dunne, P, Dygnarowicz, K, Eguchi, A, Emery-Schrenk, S, Ershova, A, Fedotov, S, Fernandez, P, Finch, AJ, Aguirre, GAF, Fiorillo, G, Friend, M, Fujii, Y, Fukuda, Y, Fusshoeller, K, Giganti, C, Glagolev, V, Gonin, M, Goodman, EAG, Gorin, A, Grassi, M, Guigue, M, Hadley, DR, Haigh, JT, Hamacher-Baumann, P, Harris, DA, Hartz, M, Hasegawa, T, Hassani, S, Hastings, NC, Hatzikoutelis, A, Hayato, Y, Hiramoto, A, Hogan, M, Holeczek, J, Holin, A, Holvey, TJ, Van, NTH, Honjo, T, Iacob, F, Ichikawa, AK, Ikeda, M, Ishida, T, Ishitsuka, M, Israel, HT, Ives, SJ, Iwamoto, K, Izmaylov, A, Izumi, N, Jakkapu, M, Jamieson, B, Jenkins, SJ, Jesus-Valls, C, Jiang, JJ, Jonsson, P, Jung, CK, Jurj, PB, Kabirnezhad, M, Kaboth, AC, Kajita, T, Kakuno, H, Kameda, J, Kasetti, SP, Kataoka, Y, Katayama, Y, Katori, T, Kawaue, M, Kearns, E, Khabibullin, M, Khotjantsev, A, Kikawa, T, Kikutani, H, King, S, Kisiel, J, Knight, A, Kobata, T, Kobayashi, T, Koch, L, Kogan, G, Konaka, A, Kormos, LL, Koshio, Y, Kostin, A, Kowalik, K, Kudenko, Y, Kuribayashi, S, Kurjata, R, Kutter, T, Kuze, M, La Commara, M, Labarga, L, Lachner, K, Lagoda, J, Lakshmi, SM, James, ML, Lamont, I, Lamoureux, M, Last, D, Latham, N, Laveder, M, Lawe, M, Lee, Y, Lin, C, Lindner, T, Lin, SK, Litchfield, RP, Liu, SL, Longhin, A, Long, KR, Ludovici, L, Lu, X, Lux, T, Machado, LN, Magaletti, L, Mahn, K, Malek, M, Mandal, M, Manly, S, Marino, AD, Marti-Magro, L, Martin, DGR, Martini, M, Martin, JF, Maruyama, T, Matsubara, T, Matveev, V, Mauger, C, Mavrokoridis, K, Mazzucato, E, McCauley, N, McElwee, J, McFarland, KS, McGrew, C, Mefodiev, A, Megias, GD, Mellet, L, Metelko, C, Mezzetto, M, Minamino, A, Mineev, O, Mine, S, Miura, M, Bueno, LM, Moriyama, S, Mueller, TA, Munford, D, Munteanu, L, Nagai, K, Nagai, Y, Nakadaira, T, Nakagiri, K, Nakahata, M, Nakajima, Y, Nakamura, A, Nakamura, H, Nakamura, K, Nakano, Y, Nakayama, S, Nakaya, T, Nakayoshi, K, Naseby, CER, Ngoc, TV, Nguyen, VQ, Niewczas, K, Nishimura, Y, Nishizaki, K, Nova, F, Novella, P, Nugent, JC, Odagawa, T, Ogawa, T, Okada, R, Okumura, K, Okusawa, T, Owen, RA, Oyama, Y, Palladino, V, Paolone, V, Pari, M, Parlone, J, Parsa, S, Pasternak, J, Pavin, M, Payne, D, Penn, GC, Perkin, JD, Pershey, D, Pickering, L, Pidcott, C, Pintaudi, G, Pistillo, C, Popov, B, Porwit, K, Posiadala-Zezula, M, Prabhu, YS, Quilain, B, Radermacher, T, Radicioni, E, Radics, B, Ratoff, PN, Reh, M, Riccio, C, Rondio, E, Roth, S, Rubbia, A, Ruggeri, AC, Ruggles, CA, Rychter, A, Sakashita, K, Sanchez, F, Santucci, G, Schloesser, CM, Scholberg, K, Scott, M, Seiya, Y, Sekiguchi, T, Sekiya, H, Sgalaberna, D, Shaikhiev, A, Shaykina, A, Shiozawa, M, Shorrock, W, Shvartsman, A, Skwarczynski, K, Smy, M, Sobczyk, JT, Sobel, H, Soler, FJP, Sonoda, Y, Spina, R, Su, H, Suslov, IA, Suvorov, S, Suzuki, A, Suzuki, SY, Suzuki, Y, Sztuc, AA, Tada, M, Takayasu, S, Takeda, A, Takeuchi, Y, Tanaka, HK, Tanihara, Y, Tani, M, Tereshchenko, VV, Teshima, N, Thamm, N, Thompson, LF, Toki, W, Touramanis, C, Towstego, T, Tsui, KM, Tsukamoto, T, Tzanov, M, Uchida, Y, Vacheret, A, Vagins, M, Vallari, Z, Vargas, D, Vasseur, G, Vilela, C, Vinning, WGS, Vladisavljevic, T, Wachala, T, Waldron, AV, Walsh, JG, Wang, Y, Wan, L, Wark, D, Wascko, MO, Weber, A, Wendell, R, Wilking, MJ, Wilkinson, C, Wilson, JR, Wood, K, Wret, C, Xia, J, Xu, YH, Yamamoto, K, Yanagisawa, C, Yang, G, Yano, T, Yasutome, K, Yershov, N, Yevarouskaya, U, Yokoyama, M, Yoshimoto, Y, Yu, M, Zaki, R, Zalewska, A, Zalipska, J, Zaremba, K, Zarnecki, G, Zhao, X, Zhu, T, Ziembicki, M, Zimmerman, ED, Zito, M, Zsoldos, S

المساهمون: Abe, K, Akhlaq, N, Akutsu, R, Ali, A, Alt, C, Andreopoulos, C, Antonova, M, Aoki, S, Arihara, T, Asada, Y, Ashida, Y, Atkin, Et, Ban, S, Barbi, M, Barker, Gj, Barr, G, Barrow, D, Batkiewicz-Kwasniak, M, Bench, F, Berardi, V, Berns, L, Bhadra, S, Blanchet, A, Blondel, A, Bolognesi, S, Bonus, T, Bordoni, S, Boyd, Sb, Bravar, A, Bronner, C, Bron, S, Bubak, A, Avanzini, Mb, Calabria, Nf, Cao, S, Carter, Aj, Cartwright, Sl, Catanesi, Mg, Cervera, A, Chakrani, J, Cherdack, D, Christodoulou, G, Cicerchia, M, Coleman, J, Collazuol, G, Cook, L, Cudd, A, Davydov, Yi, De Roeck, A, De Rosa, G, Dealtry, T, Delogu, Cc, Densham, C, Dergacheva, A, Di Lodovico, F, Dolan, S, Douqa, D, Doyle, Ta, Drapier, O, Duffy, Ke, Dumarchez, J, Dunne, P, Dygnarowicz, K, Eguchi, A, Emery-Schrenk, S, Ershova, A, Fedotov, S, Fernandez, P, Finch, Aj, Aguirre, Gaf, Fiorillo, G, Friend, M, Fujii, Y, Fukuda, Y, Fusshoeller, K, Giganti, C, Glagolev, V, Gonin, M, Goodman, Eag, Gorin, A, Grassi, M, Guigue, M, Hadley, Dr, Haigh, Jt, Hamacher-Baumann, P, Harris, Da, Hartz, M, Hasegawa, T, Hassani, S, Hastings, Nc, Hatzikoutelis, A, Hayato, Y, Hiramoto, A, Hogan, M, Holeczek, J, Holin, A, Holvey, Tj, Van, Nth, Honjo, T, Iacob, F

مصطلحات موضوعية: Gamma detectors (scintillators, CZT, HPGe, HgI etc), Neutrino detectors, Performance of High Energy Physics Detectors, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators)

الوصف: The T2K experiment widely uses plastic scintillator as a target for neutrino interactions and an active medium for the measurement of charged particles produced in neutrino interactions at its near detector complex. Over 10 years of operation the measured light yield recorded by the scintillator based subsystems has been observed to degrade by 0.9-2.2% per year. Extrapolation of the degradation rate through to 2040 indicates the recorded light yield should remain above the lower threshold used by the current reconstruction algorithms for all subsystems. This will allow the near detectors to continue contributing to important physics measurements during the T2K-II and Hyper-Kamiokande eras. Additionally, work to disentangle the degradation of the plastic scintillator and wavelength shifting fibres shows that the reduction in light yield can be attributed to the ageing of the plastic scintillator. The long component of the attenuation length of the wavelength shifting fibres was observed to degrade by 1.3-5.4% per year, while the short component of the attenuation length did not show any conclusive degradation.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000898723700007; volume:17; issue:10; numberofpages:35; journal:JOURNAL OF INSTRUMENTATION; https://hdl.handle.net/11589/251001Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85141098028; https://iopscience.iop.org/article/10.1088/1748-0221/17/10/P10028Test

الإتاحة: https://doi.org/10.1088/1748-0221/17/10/P10028Test
https://hdl.handle.net/11589/251001Test

المؤلفون: Mueller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Bullock, AN, Brown, D, Brown, PJ, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, SV, Fuchs, SM, Hall, MD, Hartung, IV, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M

الوصف: Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new knowledge from genomics into new medicines is that proteins, and not genes, are the primary executers of biological function. Therefore, much of how biology works in health and disease must be understood through the lens of protein function. Accordingly, a subset of human proteins has been at the heart of research interests of scientists over the centuries, and we have accumulated varying degrees of knowledge about approximately 65% of the human proteome. Nevertheless, a large proportion of proteins in the human proteome (∼35%) remains uncharacterized, and less than 5% of the human proteome has been successfully targeted for drug discovery. This highlights the profound disconnect between our abilities to obtain genetic information and subsequent development of effective medicines. Target 2035 is an international federation of biomedical scientists from the public and private sectors, which aims to address this gap by developing and applying new technologies to create by year 2035 chemogenomic libraries, chemical probes, and/or biological probes for the entire human proteome.

العلاقة: https://ora.ox.ac.uk/objects/uuid:60f0d024-e9cc-4c87-b222-d00b73a47532Test; https://doi.org/10.1039/d1md00228gTest

الإتاحة: https://doi.org/10.1039/d1md00228gTest
https://ora.ox.ac.uk/objects/uuid:60f0d024-e9cc-4c87-b222-d00b73a47532Test

المؤلفون: Mueller, S, Ackloo, S, Al Chawaf, A, Al-Lazikani, B, Antolin, A, Baell, JB, Beck, H, Beedie, S, Betz, UAK, Bezerra, GA, Brennan, PE, Brown, D, Brown, PJ, Bullock, AN, Carter, AJ, Chaikuad, A, Chaineau, M, Ciulli, A, Collins, I, Dreher, J, Drewry, D, Edfeldt, K, Edwards, AM, Egner, U, Frye, S, Fuchs, SM, Hall, MD, Hartung, I, Hillisch, A, Hitchcock, SH, Homan, E, Kannan, N, Kiefer, JR, Knapp, S, Kostic, M, Kubicek, S, Leach, AR, Lindemann, S, Marsden, BD, Matsui, H, Meier, JL, Merk, D, Michel, M, Morgan, MR, Mueller-Fahrnow, A, Owen, DR, Perry, BG, Rosenberg, SH, Saikatendu, KS, Schapira, M, Scholten, C, Sharma, S, Simeonov, A, Sundstrom, M, Superti-Furga, G, Todd, MH, Tredup, C, Vedadi, M, von Delft, F, Willson, TM, Winter, GE, Workman, P, Arrowsmith, CH

المصدر: RSC Medicinal Chemistry (2021)

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Chemistry, Medicinal, Pharmacology & Pharmacy, DRUG DISCOVERY

الوصف: Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new knowledge from genomics into new medicines is that proteins, and not genes, are the primary executers of biological function. Therefore, much of how biology works in health and disease must be understood through the lens of protein function. Accordingly, a subset of human proteins has been at the heart of research interests of scientists over the centuries, and we have accumulated varying degrees of knowledge about approximately 65% of the human proteome. Nevertheless, a large proportion of proteins in the human proteome (∼35%) remains uncharacterized, and less than 5% of the human proteome has been successfully targeted for drug discovery. This highlights the profound disconnect between our abilities to obtain genetic information and subsequent development of effective medicines. Target 2035 is an international federation of biomedical scientists from the public and private sectors, which aims to address this gap by developing and applying new technologies to create by year 2035 chemogenomic libraries, chemical probes, and/or biological probes for the entire human proteome.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10140551/1/d1md00228g.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10140551Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10140551/1/d1md00228g.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10140551Test/

المؤلفون: Fernández-Fueyo, E, Sugiyama, Y, Matsui, T, Carter, AJ

المصدر: Proceedings of the Royal Society B: Biological Sciences , 288 (1959) , Article 20210590. (2021)

مصطلحات موضوعية: Death detection, emotion, infant corpse carrying, maternal behaviour, primates’ responses to death, thanatology

الوصف: Non-human primates respond to the death of a conspecific in diverse ways, some of which may present phylogenetic continuity with human thanatological responses. Of these responses, infant corpse carrying by mothers (ICC) is the most frequently reported. Despite its prevalence, quantitative analyses of this behaviour are scarce and inconclusive. We compiled a database of 409 published cases across 50 different primate species of mothers' responses to their infants' deaths and used Bayesian phylogenetic regressions with an information-theoretic approach to test hypotheses proposed to explain between- and within-species variation in ICC. We found that ICC was more likely when the infant's death was non-traumatic (e.g. illness) versus traumatic (e.g. infanticide), and when the mother was younger. These results support the death detection hypothesis, which proposes that ICC occurs when there are fewer contextual or sensory cues indicating death. Such an interpretation suggests that primates are able to attain an awareness of death. In addition, when carried, infant age affected ICC duration, with longer ICC observed for younger infants. This result suggests that ICC is a by-product of strong selection on maternal behaviour. The findings are discussed in the context of the evolution of emotion, and implications for evolutionary thanatology are proposed.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10134556/1/Ferna%CC%81ndez-Fueyo_et%20al_2021_submitted_with%20figures.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10134556Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10134556/1/Ferna%CC%81ndez-Fueyo_et%20al_2021_submitted_with%20figures.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10134556Test/

المؤلفون: Dezeure, J, Dagorrette, J, Baniel, A, Carter, AJ, Cowlishaw, G, Marshall, HH, Martina, C, Raby, CL, Huchard, E

المصدر: American Journal of Physical Anthropology , 174 (1) , Article e24118. (2021)

مصطلحات موضوعية: aging method, development, food availability, interindividual variation, natal coat, primate

الوصف: OBJECTIVES: In many primates, one of the most noticeable morphological developmental traits is the transition from natal fur and skin color to adult coloration. Studying the chronology and average age at such color transitions can be an easy and noninvasive method to (a) estimate the age of infants whose dates of birth were not observed, and (b) detect interindividual differences in the pace of development for infants with known birth dates. MATERIALS AND METHODS: Using a combination of photographs and field observations from 73 infant chacma baboons (Papio ursinus) of known ages, we (a) scored the skin color of six different body parts from pink to gray, as well as the color of the fur from black to gray; (b) validated our method of age estimation using photographic and field observations on an independent subset of 22 infants with known date of birth; and (c) investigated ecological, social, and individual determinants of age-related variation in skin and fur color. RESULTS: Our results show that transitions in skin color can be used to age infant chacma baboons less than 7 months old with accuracy (median number of days between actual and estimated age = 10, range = 0-86). We also reveal that food availability during the mother's pregnancy, but not during lactation, affects infant color-for-age and therefore acts as a predictor of developmental pace. DISCUSSION: This study highlights the potential of monitoring within- and between-infant variation in color to estimate age when age is unknown, and developmental pace when age is known.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10109107/1/Dezeure%20et%20al%202020%20AJPA%20ms.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10109107Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10109107/1/Dezeure%20et%20al%202020%20AJPA%20ms.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10109107Test/