المؤلفون: Alina Daniela Belceanu, Dumitru Branisteanu, Carmen Vulpoi, Stefana Catalina Bilha

المصدر: Minerva Endocrinology.

مصطلحات موضوعية: medicine.medical_specialty, medicine.diagnostic_test, Adiponectin, business.industry, Endocrinology, Diabetes and Metabolism, Leptin, Adipose tissue, Adipokine, Carbohydrate metabolism, Body fat percentage, Endocrinology, Internal medicine, Internal Medicine, medicine, Ghrelin, Lipid profile, business, hormones, hormone substitutes, and hormone antagonists

الوصف: BACKGROUND Besides growth acceleration, growth hormone (GH) therapy of GH deficient (GHD) children improves body composition by decreasing body fat. This effect is due to GH interaction with lipid and carbohydrate metabolism, possibly also mediated by adipokines secreted by adipose tissue, and ghrelin. This study aimed to assess the impact of oneyear GH replacement therapy on the metabolic profile, adipokines, and acylated/ unacylated ghrelin of prepubertal children with GHD. METHODS Prospective observational study of 42 non-obese, prepubertal children with GHD followed up for twelve months. Mean lipid, carbohydrate, adipokine profiles, acylated/unacylated ghrelin, and body composition data before therapy onset were compared with measurements obtained after 6 and 12 months of GH therapy. RESULTS Total body fat content and body fat percentage decreased significantly, while the lipid profile improved over the study period in the 42 GHD children with a mean age of 9.2 ±2.6 years. The levels of leptin and unacylated ghrelin decreased significantly, whereas adiponectin and acylated ghrelin values increased after GH therapy. In regression analysis models, GH treatment (reflected by increased absolute values or standard deviations of IGF1) influences the variation of leptin and adiponectin, but not ghrelin, independently of body composition - lean or fat mass. CONCLUSIONS GH replacement therapy improves body composition, lipid, and adipokine profile in GHD children. Also, GH replacement therapy directly impacts leptin and adiponectin concentrations, independently of body composition. Further research is needed to identify the molecular mechanisms and metabolic pathways by which the GH/IGF1 axis influences adipokines secretion.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e8c08c38c78d4869932a1a9bee1ccTest
https://doi.org/10.23736/s2724-6507.21.03588-0Test

المؤلفون: Carina Andrei, Luciana Carmen Nitoi, Cristina Gena Dascalu, Carmen Vulpoi, Cristian Ionita, Laura Florea, Alina Aspazia Stefan

المصدر: Revista de Chimie. 68:2573-2577

مصطلحات موضوعية: medicine.medical_specialty, biology, Process equipment, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, Serum albumin, General Chemistry, General Medicine, Chronic liver disease, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Dietary counseling, Internal medicine, Materials Chemistry, medicine, biology.protein, General Pharmacology, Toxicology and Pharmaceutics

الوصف: People on maintenance haemodialysis (MHD) are at risk of developing malnutrition, which is defined as the consequence of insufficient food intake or a suboptimal quality diet. The kidney and the liver play a central role in protein metabolism. The major aim of the study was to evaluate, for the first time in Romania, the impact of intensive dietary counseling and personalised diets on serum albumin (SA) and others nutritional parameters, but also the relationship between albumin level, inflammation and nutritional status in a cohort of haemodialysis patients which associate or not chronic liver disease (CLD). We prospectively analysed the inflammatory status and malnutrition in 162 HD patients, mean age 56�13 years, from a single dialysis centre. At baseline we evaluated: a. calorie-protein intake using patient�s diet history with the help of 72 hrs recall method;b. nutritional status by anthropometric measures- post dialysis body weight (BW), body mass index (BMI), TSF (tricipital skinfold), MAC (mid-arm circumference), MAMC (mid-arm muscle circumference);c. modified subjective global assessment score (mSGA);d. biochemical tests: pre-dialysis serum albumin, serum creatinine, alkaline reserve, Kt/V and Protein C Reactive (CRP). The patients were followed-up for 6 months.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d1fbc5eb1f7f8b301f9f4f8994d93d04Test
https://doi.org/10.37358/rc.17.11.5931Test

المؤلفون: Ioana Armasu, Carmen Vulpoi, Stefan-Adrian Strungaru, Dragomir N. Serban, Cristina Preda, Ionela Lacramioara Serban, Ioana Vasiliu, Ovidiu Bredetean, Mircea Nicoara, Bogdan Stoica, Laura Mihalache, Gabriel Plavan, Delia Ciobanu

المصدر: Revista de Chimie. 68:1617-1621

مصطلحات موضوعية: endocrine system, Antioxidant, endocrine system diseases, Process equipment, Materials Science (miscellaneous), Process Chemistry and Technology, medicine.medical_treatment, General Engineering, chemistry.chemical_element, General Chemistry, General Medicine, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Thyroiditis, chemistry, Petrochemistry, Environmental chemistry, Materials Chemistry, medicine, General Pharmacology, Toxicology and Pharmaceutics, Selenium

الوصف: To evaluate the effect of Selenium (Se) supplementation on: thyroid stimulating hormone (TSH), antiperoxidase antibodies (TPOAb) and glutathione peroxidise 1 (GPx1) in euthyroid subjects with autoimmune thyroiditis. 100 euthyroid women with autoimmune thyroiditis, from the same region, were randomized to receive daily 100 mg selenomethionine (n=50) or placebo (n=50) for 3 months. Serum concentrations of Se, TPOAb and TSH were performed in all patients at baseline and after 3 months. GPx1 activity was measured only in the interventional group before and after Se supplementation. At 3 months TSH presented a significant increase both in treated (2.49 vs. 2.09 UI/mL; p=0.001) and untreated groups (2.38 vs. 1.91 UI/mL; p=0.008). TPOAb decreased by 15.2% in patients treated with Se (p=0.002) and were not modified in untreated patients. At the end of the study Se and TPOAb were in direct insignificant correlation (r=+0.267, p=0.105). GPx1 did not show significant changes after Se supplementation. After 3 months of Se supplementation results showed a mild decrease of TPOAb and a weak negative correlation of these antibodies with Se levels. This suggests that Se treatment may improve the course of thyroid autoimmunity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::02e084c65954558b4d085e842f74d633Test
https://doi.org/10.37358/rc.17.7.5729Test

المؤلفون: J. Guigay, Catherine Cardot-Bauters, Patricia Niccoli, H. Du Boullay, B. Delemer, M. Le Bras, Catherine Lombard-Bohas, Olivier Chabre, Pierre B. A. Lecomte, Jean-Yves Scoazec, Christine Binquet, Ph. Caron, P. Chanson, Marc Klein, Carmen Vulpoi, Pierre Goudet, F. Borson-Chazot, T. Aparicio, Vincent Rohmer, E. Cosson, Albert Beckers, I. Guilhem, Eric Baudin, Bruno Vergès, A. Tabarin

المساهمون: Equipe EPICAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Médecine nucléaire, Département d'imagerie médicale [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Service d'Endocrinologie - Diabète - Nutrition [Reims], Université de Reims Champagne-Ardenne (URCA)-Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Gastro-entérologie [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie, diabétologie et nutrition, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Cité (USPC)-Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Institut des Sciences de la Terre (ISTerre), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pontchaillou [Rennes], Service d'Endocrinologie (ANGERS - Endocrino), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Pathologie morphologique, Département de biologie et pathologie médicales [Gustave Roussy], Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon), Eq 4, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Groupement Hospitalier Lyon-Est (GHE), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre de médecine nucléaire, Fédération d'endocrinologie-Groupement hospitalier Lyon-Est-Fédération d'endocrinologie-Groupement hospitalier Lyon-Est, Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF)-Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13), Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Groupement Hospitalier Lyon-Est (GHE), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris 13 (UP13)-Hôpital Avicenne, Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF)-Hôpital Jean Verdier [Bondy], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers (INSU - CNRS)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université Joseph Fourier - Grenoble 1 (UJF), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques ( CIC-EC ), Université de Bourgogne ( UB ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Groupement Hospitalier Lyon-Est ( GHE ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ) -Centre de médecine nucléaire, Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Institut Gustave Roussy ( IGR ) -Institut Gustave Roussy ( IGR ), Université de Reims Champagne-Ardenne ( URCA ) -Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims ( CHU Reims ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Université Paris 13 ( UP13 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle ( CRESS - U1153 ), Université Paris 13 ( UP13 ) -Institut National de la Recherche Agronomique ( INRA ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris 13 ( UP13 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Université Sorbonne Paris Cité ( USPC ) -Hôpital Jean Verdier-Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Institut des Sciences de la Terre ( ISTerre ), Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers ( INSU - CNRS ) -Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux ( IFSTTAR ) -Université Joseph Fourier - Grenoble 1 ( UJF ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service d'Endocrinologie ( ANGERS - Endocrino ), CHU Angers

المصدر: World Journal of Surgery
World Journal of Surgery, Springer Verlag, 2018, 42 (1), pp.143-152. ⟨10.1007/s00268-017-4135-z⟩
World Journal of Surgery, Springer Verlag, 2018, 42 (1), pp.143-152. 〈https://link.springer.com/article/10.1007%2Fs00268-017-4135-z#enumerationTest〉. 〈10.1007/s00268-017-4135-z〉

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pathology, Neuroendocrine tumors, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Gastroenterology, Metastasis, Cohort Studies, br-NETs, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, Internal medicine, Biopsy, Multiple Endocrine Neoplasia Type 1, Humans, Medicine, Survival analysis, Aged, Cause of death, medicine.diagnostic_test, business.industry, Large cell, Bronchial Neoplasms, Middle Aged, medicine.disease, Survival Analysis, 3. Good health, Neuroendocrine Tumors, 030104 developmental biology, survival in MEN1 patients, 030220 oncology & carcinogenesis, Cohort, Female, Surgery, business, [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Follow-Up Studies, Cohort study

الوصف: IF 2.673; International audience; ObjectiveTo evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death.Summary background databr-NETs frequency ranges from 3 to 13% and may reach 32% depending on the number of patients evaluated and on the criteria required for diagnosis.MethodsThe 1023-patient series of symptomatic MEN1 patients followed up in a median of 48.7 [35.5–59.6] years by the Groupe d’étude des Tumeurs Endocrines was analyzed using time-to-event techniques.Resultsbr-NETs were found in 51 patients (4.8%, [95% CI 3.6–6.2%]) and were discovered by imaging in 86% of cases (CT scan, Octreoscan, Chest X-ray, MRI). Median age at diagnosis was 45 years [28–66]. Histological examination showed 27 (53%) typical carcinoids (TC), 16 (31%) atypical carcinoids (AC), 2 (4%) large cell neuroendocrine carcinomas (LCNEC), 3(6%) small cell neuroendocrine carcinomas (SCLC), 3(6%) TC associated with AC. Overall survival was not different from the rest of the cohort (HR 0.29, [95% CI 0.02–5.14]). AC tended to have a worse prognosis than TC (p = 0.08). Seven deaths were directly related to br-NETs (three AC, three SCLC and one LCNEC). Patients who underwent surgery survived longer (p = 10−4) and were metastasis free, while 8 of 14 non-operated patients were metastatic. There were no operative deaths.ConclusionsAround 5% of MEN1 patients develop br-NETs. br-NETs do not decrease overall survival in MEN1 patients, but poorly differentiated and aggressive br-NETs can cause death. br-NETs must be screened carefully. A biopsy is essential to operate on patients in time.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98736ccd83e87b8902168191cb719acTest
https://doi.org/10.1007/s00268-017-4135-zTest

المؤلفون: Carmen Vulpoi, Gatu A, Cristina Preda, Dumitru Branisteanu, Mogoş, Simona Mogos, Muntean, Radu Danila, Cristian Velicescu, Alexandru Grigorovici

المصدر: Acta Endocrinologica (Bucharest). 13:441-446

مصطلحات موضوعية: Medical unit, medicine.medical_specialty, Adenoma, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, Urology, chemistry.chemical_element, Calcium, medicine.disease, vitamin D deficiency, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, chemistry, 030220 oncology & carcinogenesis, medicine, Vitamin D and neurology, 030223 otorhinolaryngology, business, hormones, hormone substitutes, and hormone antagonists, Primary hyperparathyroidism, Hormone, Parathyroid adenoma

الوصف: Purpose To correlate the volume of parathyroid adenomas with the hormonal and metabolic profile at patients diagnosed with primary hyperparathyroidism (pHPTH). Patients and Methods Cross-sectional multicentric study, enrolling 52 patients with pHPTH from two medical institutions. Serum calcium and PTH were evaluated in all patients before surgery, whereas 25OHD3 was measured only in the 33 patients recruited form one medical unit. The volume of parathyroid adenoma was measured by using the formula of a rotating ellipsoid. Results We observed a significant correlation of the volume of parathyroid adenomas with PTH at patients from the two units and in the whole group (p < 0.0001), but not with serum calcium (p = 0.494). Twenty-five out of the 33 patients at whom 25OHD3 was measured had levels in the range of deficiency. 25OHD3 was not correlated with PTH or calcium levels, but was negatively correlated to the adenoma volume and positively to the PTH/volume ratio (p = 0.041 and p = 0.048, respectively). Conclusions The volume of parathyroid adenoma seems to be related to preoperative PTH and 25OHD3, but not to calcium level. Vitamin D deficiency is frequently found at patients with pHPTH and may contribute to particular disease profiles, including larger parathyroid adenomas.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8b8ca6b1334adbb43370f61b14d300Test
https://doi.org/10.4183/aeb.2017.441Test

المؤلفون: Mircea Onofriescu, I Crumpei Tanasa, Irina Dumitrascu, Carmen Vulpoi, R D Matasariu, Alexandra Mihaila, M Iacob

المصدر: Acta Endocrinologica (Bucharest). 13:334-339

مصطلحات موضوعية: Infertility, 030219 obstetrics & reproductive medicine, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Social anxiety, Beck Depression Inventory, Endometriosis, Fertility, medicine.disease, Irritability, 03 medical and health sciences, Distress, Editorial, 0302 clinical medicine, Endocrinology, Quality of life, 030220 oncology & carcinogenesis, medicine, medicine.symptom, business, Clinical psychology, media_common

الوصف: Objectives The objective of this study was to assess the impact of endometriosis on the quality of life. Patients and methods Study group of 205 women, aged between 18-45 years old, hospitalized in the "Cuza-Voda" Hospital of Iasi, between 2013-2015. We used the Fertility Problem Inventory, the Endometriosis Health Profile and the Beck Depression Inventory. Results We first realized a descriptive analyses of patients' health related quality of life - 60% of women reported higher infertility distress associated with relationship issues caused by difficulties to conceive. The descriptive analysis over the quality of life in patients with endometriosis suggests that the high level of stress related factors, are: the loss over the control of the symptoms, dyspareunia and altered emotional status. Regarding the sexual aspect of life, almost a quarter of the women complained about an altered sexual status, due to both fear of failing in conceiving and dyspareunia caused by the endometriosis. The descriptive analysis over the infertility related stress suggests that the factors associated with a high level of stress are: sadness, pessimism, feeling of failure, irritability, lack of confidence, self-hatred and fatigue. Conclusions Patients with endometriosis are dealing daily with a large spectrum of symptoms, including pain, dyspareunia, emotional instability and high levels of stress, which have a negative impact upon the quality of life, by lowering it on different levels. Also, within the present study we showed a significant presence of high infertility stress in patients of all ages that lead to depression and social anxiety.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de990a6627968886fc5233498f5706f0Test
https://doi.org/10.4183/aeb.2017.334Test

المؤلفون: C. Dumitrescu, Ionela Pascanu, C Procopiuc, Otilia Marginean, I Gherlan, Carmen Barbu, Carmen Vulpoi, Michael Hermanussen, Cristina Preda, Raluca-Monica Pop

المصدر: Acta endocrinologica (Bucharest, Romania : 2005). 12(3)

مصطلحات موضوعية: education.field_of_study, Endocrine and Autonomic Systems, business.industry, Endocrine Care, Endocrinology, Diabetes and Metabolism, Romanian, Growth data, Population, 030209 endocrinology & metabolism, Short stature, language.human_language, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine, language, 030212 general & internal medicine, medicine.symptom, business, education, Body mass index, Demography

الوصف: There are no new national growth references for the Romanian population and the current recommendations for short stature evaluation is the use of the Swiss growth charts developed based on a longitudinal study. The aim of the present paper is to present the new synthetic growth references for Romanian children. MATERIAL AND METHODS: We used local Romanian data from 9 studies with information on height and weight obtained between 1999 and 2016. Based on their plausibility and methodology six studies were selected for generating the National Synthetic Growth References for Romanian Children based on the specific methodology described previously. The selected studies included 8407 subjects measured in schools/kindergartens. Age is reported in years covering a range from 3-18 years. Height and weight were measured at a precision of 0.1 cm and 0.1 kg. All children were measured at normal temperature, in light clothes, without footwear. RESULTS: We present the charts and tables with the common centiles for height, weight and body mass index for boys and girls. CONCLUSION: We suggest synthetic growth references based upon recent growth data from 6 different Romanian regions as new National Growth Charts for Romanian children.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b52483270481a62863b4f6125e2c51Test
https://pubmed.ncbi.nlm.nih.gov/31149106Test

المؤلفون: Irina Dumitrascu, Gabriel Costachescu, Carmen Vulpoi, Daniela Constantinescu, Elena Mihalceanu, Daniela Roxana Albu, Alina Pangal, Luciana Carmen Nitoi, Mircea Onofriescu, Alexandra Mihaila

المصدر: Scopus-Elsevier

مصطلحات موضوعية: biology, business.industry, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, Endometriosis, General Chemistry, General Medicine, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Materials Chemistry, medicine, Cancer research, biology.protein, Biomarker (medicine), Osteopontin, General Pharmacology, Toxicology and Pharmaceutics, business

الوصف: Endometriosis is a multifactorial disease that is manifested by infertility and pelvic pain. The purpose of the study was to evaluate the effect of progesterone treatment on the serum level of osteopontin, a multipotent cytokine, in patients with endometriosis. The study was prospective and we evaluated osteopontin levels that were measured in the serum of 40 patients with endometriosis and 12 healthy women using a standardized Enzyme-Linked Immunosorbent Assay (ELISA) kit. Osteopontin seric levels were lower in endometriosis patients and increased after progesterone treatment. Because of the large dispersion of data even in the control group, we find the association between osteopontin and endometriosis questionable.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1079476a14f9935a748c9d421dea43Test
https://doi.org/10.37358/rc.17.9.5840Test

المؤلفون: Luciana Carmen, Nitoi, Alina, Aspazia Stefan, C, Ionita, Carina, Andrei, Carmen, Vulpoi

المصدر: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 120(4)

مصطلحات موضوعية: Psychiatric Status Rating Scales, Nutritional Status, Serum Albumin, Human, Cross-Sectional Studies, Social Class, Renal Dialysis, Risk Factors, Creatinine, Surveys and Questionnaires, Quality of Life, Humans, Kidney Failure, Chronic, Peritoneal Dialysis, Biomarkers

الوصف: This cross-sectional study aimed to determine the relationship between socio-economic status and laboratory values with mental and physical components of QoL (quality of life) in chronic dialysis patients.254 patients were included in the study and divided into two groups: 243 hemodialysis (HD) patients and 11 peritoneal dialysis (PD) patients. QoL was measured by the Short Form 36(SF-36). Scores for all dimensions are expressed on a 0-100 scale. Higher score indicates better health status. Two more questions related to monthly food expenditure and the presence/or lack of family support were added. Laboratory investigations included the following nutritional parameters: serum albumin and creatinine.Our study results showed that compared to PD group in HD patients QoL was compromised in all SF-36 subscale except physical functioning, role limitations due to physical functioning and role limitations due to emotional functioning. Also, the presence of supportive family members/ caregivers showed a significant improvement of all QoL scores. HD patients who spend at least 90 euros monthly on groceries/food had higher values of SF-36 items. Better QoL is associated with high pre-dialysis serum creatinine and serum albumin levels.Future work should incorporate larger and more balanced sample sizes and patient recruitment from multiple dialysis centers to truly capture the variability in patient characteristics.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::be7eb65ae360b839fc32b094b2ac44c3Test
https://pubmed.ncbi.nlm.nih.gov/30137952Test

المؤلفون: Cristina Preda, Carmen Vulpoi, Ioana Armasu, Ioana Vasiliu, Cipriana Ștefănescu, Delia Ciobanu, Radu Danila, Iulia Crumpei

المصدر: Archive of Clinical Cases. :157-163

مصطلحات موضوعية: endocrine system, medicine.medical_specialty, endocrine system diseases, Materials Science (miscellaneous), Osteoporosis, Scintigraphy, Gastroenterology, Industrial and Manufacturing Engineering, Lesion, Autoimmune thyroiditis, Internal medicine, medicine, Vitamin D and neurology, Business and International Management, medicine.diagnostic_test, business.industry, Thyroid, medicine.disease, General Business, Management and Accounting, Endocrinology, medicine.anatomical_structure, Concomitant, medicine.symptom, General Agricultural and Biological Sciences, business, Primary hyperparathyroidism

الوصف: Autoimmune thyroiditis and primary hyperparathyroidism are frequent diseases, mainly affecting postmenopausal women. The association between the two pathologies has been described in the literature but the underlying mechanism is not yet elucidated. We present two female patients with autoimmune thyroiditis who developed primary hyperparathyroidism. Both had normal thyroid function, high antithyroid antibodies, and high PTH and calcium values. Thyroid ultrasonography and 99mTc-MIBI scintigraphy localized the lesion but only one patient underwent surgery. Vitamin D and selenium values were normal or slightly reduced. Both patients had osteoporosis, treated with bisphosphonates. Their evolution is, till now, satisfactory. More theories are trying to explain the correlation between autoimmune thyroiditis and primary hyperparathyroidism: the inflammatory process, the high TSH or PTH values, high calcium, low vitamin D. The possible selenium intervention would correlate environmental and genetic factors. However, all these theories are controversial and not yet proved by experimental or randomized clinical studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f5fa5454541cd2804d173f81164d24bfTest
https://doi.org/10.22551/2015.07.0203.10049Test