المؤلفون: Candela M., Norbiato C., Campanini M., Brucato A. L., Simone S. D., Manfellotto D., Dentali F., Sacchetta A., Valerio A., Fontanella A., Onesta M., Marengo S., Bigliocca M., Catania E., Maggi E., Brucato A., Camma A., Pastorelli R., Di Simone S., Frediani R., Moschella A., Panigada G., Teghini L., Pierotello R., Venturini L., Rasciti L., Cipollini M. L., Sagrini E., Benvenuto A., Carella A. M., Anastasio L., Leva E., Muraca L., Ammendola L., Putorti G., Madeo C., Salerno P., Magnani L., Cavallo P., Gallia A., Corradi F., Fruttuoso S., Vendemiale L., Capurso C., Adinolfi L. E., Santoro A., Chessa E., Risicato R., Cristaldi E., Procopio L., Raco A., Pavano S., Di Natale M., Lotti P., Zanieri S., Colombo F., Carbone A., Provenzano V., Brancato D., Lo Cascio M. L., Lami F., Lucia C., Sdanganelli F., de Carli S., Bertoncelli M. C., Manfrinato C., Marvisi M., Ramponi S., Ghiringhelli P., Novati P., Poggiano M., Fioretti M., Zavarise G., Vendrame A., Guzzon S., Mazzone A., Bonardi G., Zuccoli A., Battaglia G., Ciarallo G., Salvi A., Nitti C., Favro M., Tomaselli V., Gioffre V., Catania V., Di Vita G., Anselmi P., Capoccetta G. B., Morbidoni L., Arduino S., Nasso F., Macchione R. M., Ballestri S., Puleo A.

المساهمون: M. Candela, C. Norbiato, M. Campanini, A.L. Brucato, S.D. Simone, D. Manfellotto, F. Dentali, A. Sacchetta, A. Valerio, A. Fontanella, M. Onesta, S. Marengo, M. Bigliocca, E. Catania, E. Maggi, A. Brucato, A. Camma, R. Pastorelli, S. Di Simone, R. Frediani, A. Moschella, G. Panigada, L. Teghini, R. Pierotello, L. Venturini, L. Rasciti, M.L. Cipollini, E. Sagrini, A. Benvenuto, A.M. Carella, L. Anastasio, E. Leva, L. Muraca, L. Ammendola, G. Putorti, C. Madeo, P. Salerno, L. Magnani, P. Cavallo, A. Gallia, F. Corradi, S. Fruttuoso, L. Vendemiale, C. Capurso, L.E. Adinolfi, A. Santoro, E. Chessa, R. Risicato, E. Cristaldi, L. Procopio, A. Raco, S. Pavano, M. Di Natale, P. Lotti, S. Zanieri, F. Colombo, A. Carbone, V. Provenzano, D. Brancato, M.L. Lo Cascio, F. Lami, C. Lucia, F. Sdanganelli, S. de Carli, M.C. Bertoncelli, C. Manfrinato, M. Marvisi, S. Ramponi, P. Ghiringhelli, P. Novati, M. Poggiano, M. Fioretti, G. Zavarise, A. Vendrame, S. Guzzon, A. Mazzone, G. Bonardi, A. Zuccoli, G. Battaglia, G. Ciarallo, A. Salvi, C. Nitti, M. Favro, V. Tomaselli, V. Gioffre, V. Catania, G. Di Vita, P. Anselmi, G.B. Capoccetta, L. Morbidoni, S. Arduino, F. Nasso, R.M. Macchione, S. Ballestri

مصطلحات موضوعية: Chronic obstructive pulmonary disease (COPD), GOLD cla, Hospital discharge phase, Internal Medicine, Settore MED/09 - Medicina Interna

الوصف: The purpose of this study was to have a nationwide snapshot of the characteristics of patients hospitalized in Internal Medicine Units (IMUs) for exacerbation of chronic obstructive pulmonary disease (COPD), and to assess applicability and contents of a specific Hospital Discharge Form for the patient with exacerbation of COPD discharged from IMUs. This was a prospective study in 44 IMUs in Italy, enrolling patients hospitalized with a diagnosis of COPD exacerbation. Information concerning clinical characteristics of patients, and treatment for COPD at discharge was collected. Specific documents for monitoring of clinical conditions and adherence to therapies as well as a form including individual indications for clinical controls, instrumental tests, etc. were provided upon discharge. Four hundred and seventy-two patients were enrolled (68% male). According to GOLD classification 2015, patients with classes A to D were 12%, 27%, 31%, and 30%, respectively. Triple therapy was prescribed in 14% of GOLD A and 51% of GOLD D patients. Around 10% of patients for each GOLD class received no specific therapy. The vast majority of patients (85%) received instructions on the correct use of inhalers, and in most cases (85%), the quality of counseling was considered optimal/adequate. Indication for performing chest X-ray, spirometry, or blood gas analysis following discharge was addressed to 29%, 59% and 52.1% of patients, respectively. The follow-up sheet for COPD used in our study was shown as applicable. This highlighted the need for greater awareness and more standardized procedures within IMUs in the post-discharge phase.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000573274600007; volume:14; issue:3; firstpage:156; lastpage:161; numberofpages:6; journal:ITALIAN JOURNAL OF MEDICINE; http://hdl.handle.net/2434/774789Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85091968945

الإتاحة: https://doi.org/10.4081/ITJM.2020.1321Test
http://hdl.handle.net/2434/774789Test

المؤلفون: Capurso C.

المساهمون: Capurso, C.

مصطلحات موضوعية: aging, carbohydrate, diet, frailty, lifespan, protein, whole grain

الوصف: Increase in the aging population is a phenomenon all over the world. Maintaining good functional ability, good mental health, and cognitive function in the absence of severe disease and physical disability define successful aging. A healthy lifestyle in middle age predisposes successful aging. Longevity is the result of a multifactorial phenomenon, which involves feeding. Diets that emphasize fruit and vegetables, whole grains rather than refined grains, low-fat dairy, lean meats, fish, legumes, and nuts are inversely associated with mortality or to a lower risk of becoming frail among elderly subjects. A regular physical activity and a regular intake of whole grain derivatives together with the optimization of the protein/carbohydrate ratio in the diet, where the ratio is significantly less than 1 such as in the Mediterranean diet and the Okinawan diet, reduces the risk of developing aging-related diseases and increases healthy life expectancy. The purpose of our review was to analyze cohort and case-control studies that investigated the effects of cereals in the diet, especially whole grains and derivatives as well as the effects of a diet with a low protein-carbohydrate ratio on the progression of aging, mortality, and lifespan.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34444699; info:eu-repo/semantics/altIdentifier/wos/WOS:000690235400001; volume:13; issue:8; firstpage:2540; lastpage:2574; numberofpages:35; journal:NUTRIENTS; https://hdl.handle.net/11369/436789Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111025802; https://www.mdpi.com/1201938Test

الإتاحة: https://doi.org/10.3390/nu13082540Test
https://hdl.handle.net/11369/436789Test
https://www.mdpi.com/1201938Test

المؤلفون: Capurso C., Bellanti F., Buglio A. L., Vendemiale G.

المساهمون: Capurso, C., Bellanti, F., Buglio, A. L., Vendemiale, G.

مصطلحات موضوعية: Aging, Frailty, Mediterranean diet, Sarcopenia

الوصف: The aging population is rapidly increasing all over the world. This results in significant implications for the planning and provision of health and social care. Aging is physiologically characterized by a decrease in lean mass, bone mineral density and, to a lesser extent, fat mass. The onset of sarcopenia leads to weakness and a further decrease in physical activity. An insufficient protein intake, which we often observe in patients of advanced age, certainly accelerates the progression of sarcopenia. In addition, many other factors (e.g., insulin resistance, impaired protein digestion and absorption of amino acids) reduce the stimulation of muscle protein synthesis in the elderly, even if the protein intake is adequate. Inadequate intake of foods can also cause micronutrient deficiencies that contribute to the development of frailty. We know that a healthy eating style in middle age predisposes to so-called “healthy and successful” aging, which is the condition of the absence of serious chronic diseases or of an important decline in cognitive or physical functions, or mental health. The Mediterranean diet is recognized to be a “healthy food” dietary pattern; high adherence to this dietary pattern is associated with a lower incidence of chronic diseases and lower physical impairment in old age. The aim of our review was to analyze observational studies (cohort and case–control studies) that investigated the effects of following a healthy diet, and especially the effect of adherence to a Mediterranean diet (MD), on the progression of aging and on onset of frailty.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000516825500035; volume:12; issue:1; firstpage:35; lastpage:68; numberofpages:34; journal:NUTRIENTS; http://hdl.handle.net/11369/388922Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077205795

الإتاحة: https://doi.org/10.3390/nu12010035Test
http://hdl.handle.net/11369/388922Test

المؤلفون: Capurso A, Crepaldi G, Capurso C.

المساهمون: Capurso, A, Crepaldi, G, Capurso, C.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30859461; info:eu-repo/semantics/altIdentifier/wos/WOS:000553577400026; volume:32; issue:6; firstpage:1187; lastpage:1188; numberofpages:2; journal:AGING CLINICAL AND EXPERIMENTAL RESEARCH; http://hdl.handle.net/11369/376573Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071225345

الإتاحة: https://doi.org/10.1007/s40520-019-01160-3Test
http://hdl.handle.net/11369/376573Test

المؤلفون: Capurso C.

المساهمون: Capurso, C.

مصطلحات موضوعية: Systemic inflammation, intestinal chronic inflammation, diet, Mediterranean diet, cancer

الوصف: Idiopathic intestinal inflammatory diseases (IID) include two types of chronic intestinal disorders: Crohn’s disease and ulcerative rectocolitis. Evidence suggests that the IID is derived from the loss of immune tolerance in normal enteric bacteria diners in a genetically susceptible host. In humans, the initial intestinal immune response to intestinal microbiota is closely regulated; this regulation determines if there is a condition of immune tolerance or an inflammatory defensive response. The alteration of the balance of this immune response can lead to IID. In healthy people, the intestinal lamina contains a complex population of cells of the immune system that secrete cytokines with the function of modulating the immune response, both in the anti-inflammatory direction that reduces immune response transforming growth factor β (TGF-β) and Interleukin-10 and pro-inflammatory direction. All these mediators are produced by innate and adaptive immune cells, which limit the excessive entry of intestinal microbiota and defend themselves from pathogens. The balance of the immune response is maintained between regulatory T cells and effector T cells (Th1, Th2, and Th17). In IID, innate cells increase the production of tumor necrosis factor-alpha (TNF-α), interleukin-1β, interleukin-6, interleukin-12, interleukin-23, and chemokines. There is a marked increase in the thickness of the lamina propria, with an increase in the number of CD4+ T cells, in particular proinflammatory subgroups of T cells, which also produce cytokines and chemokines in high quantities. This increase in the production of cytokines determines the recruitment of further leukocytes, thus determining a vicious circle that maintains the state of inflammation.

وصف الملف: ELETTRONICO

العلاقة: volume:4; issue:21; numberofpages:4; journal:AME Medical Journal; https://hdl.handle.net/11369/447423Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85150053810; https://amj.amegroups.org/article/view/4910/htmlTest

الإتاحة: https://doi.org/10.21037/amj.2019.03.03Test
https://hdl.handle.net/11369/447423Test
https://amj.amegroups.org/article/view/4910/htmlTest

المؤلفون: Panza, F., Capurso, C., D'Introno, A., Colacicco, A.M., Frisardi, V., Santamato, A., Ranieri, M., Fiore, P., Vendemiale, G., Seripa, D., Pilotto, A., Capurso, A., Solfrizzi, V.

المصدر: The Journal of nutrition, health and aging ; volume 12, issue 6, page 376-381 ; ISSN 1279-7707

مصطلحات موضوعية: Geriatrics and Gerontology, Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1007/bf02982669Test
https://api.elsevier.com/content/article/PII:S1279770723020110?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1279770723020110?httpAccept=text/plainTest

المؤلفون: Di Lorenzo A., Castriotta V., Gargano A., Capurso C., Bellanti F., Serviddio G., Vendemiale G.

المساهمون: Di Lorenzo A., Castriotta V., Gargano A., Capurso C., Bellanti F., Serviddio G., Vendemiale G., Di Lorenzo, A., Castriotta, V., Gargano, A., Capurso, C., Bellanti, F., Serviddio, G., Vendemiale, G.

الوصف: L’invecchiamento si accompagna ad importanti cambiamenti nella composizione corporea, che includono una progressiva perdita della massa, della forza e della qualità muscolare – definita come sarcopenia – così come un aumento della massa grassa. Condizioni croniche quali il diabete mellito tipo 2 possono contribuire alla perdita muscolare e determinare importanti alterazioni nella composizione corporea. Studiare la composizione corporea in pazienti anziani affetti da diabete mellito tipo 2. Sono stati arruolati 115 pazienti (50 M e 65 F); tra questi, abbiamo confrontato un gruppo di diabetici (n=44) versus i non diabetici (n=71). I pazienti sono stati sottoposti a prelievo ematico per dosaggio di glicemia, emoglobina glicata e assetto lipidico, nonché ad esame densitometrico con apparecchio Lunar i-DEXA per lo studio della composizione corporea e per la diagnosi di sarcopenia (RSMI < 5.67 nelle F; RSMI < 7.25 nei M). La sarcopenia è stata diagnosticata in 36 pazienti non diabetici ed in 11 pazienti diabetici. Nel gruppo dei pazienti non diabetici, i sarcopenici risultavano più anziani rispetto ai non sarcopenici (età 79.6 ± 5.6 anni vs 74.7 ± 7.7 anni, p < 0.005), mentre non si registrava nessuna differenza nel gruppo dei pazienti diabetici (73.4 ± 5.3 anni vs 74.1 ± 6.1 anni, p = n.s.). Considerando il gruppo dei diabetici, il controllo glicemico era simile tra i soggetti sarcopenici e quelli non sarcopenici, ma il primo sottogruppo mostrava livelli sierici di trigliceridemia e di colesterolemia HDL rispetto al sottogruppo dei non sarcopenici. Nonostante non ci fossero differenze di BMI e di prevalenza dell’obesità in entrambi i gruppi, la massa grassa e l’adiposità viscerale risultavano più basse nel gruppo dei sarcopenici rispetto a quello dei non sarcopenici. È interessante notare che, anche se la massa magra in valore assoluto era inferiore nei sarcopenici rispetto ai non sarcopenici, il valore in percentuale era maggiore nei non diabetici con sarcopenia rispetto ai diabetici con ...

وصف الملف: STAMPA

العلاقة: ispartofbook:Giornale di Gerontologia; 60° Congresso Nazionale Società Italiana di Gerontologia e Geriatria -SIGG; volume:63 (4) Suppl. 2; firstpage:225; lastpage:225; numberofpages:1; journal:GIORNALE DI GERONTOLOGIA; http://hdl.handle.net/11369/371559Test

الإتاحة: http://hdl.handle.net/11369/371559Test

المؤلفون: Castriotta V., Gargano A., Di Lorenzo A., Capurso C., Bellanti F., Serviddio G., Vendemiale G.

المساهمون: Castriotta V., Gargano A., Di Lorenzo A., Capurso C., Bellanti F., Serviddio G., Vendemiale G, Castriotta, V., Gargano, A., Di Lorenzo, A., Capurso, C., Bellanti, F., Serviddio, G., Vendemiale, G.

الوصف: I cambiamenti nella composizione corporea associati all’invecchiamento sono caratterizzati da una riduzione della massa muscolare scheletrica e da un aumento della massa grassa. Anche la distribuzione del tessuto adiposo subisce importanti variazioni legate all’età, in quanto si riducono i depositi sottocutanei ed aumenta il grasso viscerale, contribuendo all’insulino-resistenza, al diabete mellito tipo 2 ed alle dislipidemie. La sarcopenia e l’aumento della massa grassa sono frequentemente associati tra loro, caratterizzando l’obesità sarcopenica. Poiché manca ancora una definizione univoca di obesità sarcopenica, non sono stati condotti finora studi clinici di associazione tra questa condizione e le malattie cardiovascolari. Definire l’impatto della sarcopenia e dell’obesità sarcopenica sul rischio cardiovascolare (RCV). Sono stati arruolati 115 pazienti di età ≥ 65 anni, caratterizzati dal punto di vista antropometrico e biochimico. L’obesità è stata definita da un indice di massa corporea (BMI) ≥ 30 kg/m2. La composizione corporea è stata misurata mediante la DEXA (Dual X-ray Absorptiometry), e la sarcopenia è stata definita con un valore di RSMI (Relative Skeletal Muscle Index) inferiore a 7.25 kg/m2 nei maschi e inferiore a 5.67 kg/m2 nelle femmine. La sarcopenia è stata riscontrata in 47 (41%) soggetti, mentre 52 (45.2%) erano obesi. L’obesità sarcopenica, definita dalla compresenza delle due condizioni, si riscontrava in 24 (21%) soggetti. I soggetti sarcopenici mostravano un punteggio di RCV simile a quello dei non sarcopenici. Tuttavia, il gruppo degli obesi sarcopenici presentava un punteggio di RCV maggiore rispetto ai sarcopenici non obesi ed agli obesi non sarcopenici. Il punteggio di RCV mostrava una correlazione positiva con il BMI (coeff. di Pearson = 0.377, p < 0.0001) ma non con la circonferenza addominale. Nel gruppo dei sarcopenici, si evidenziava una correlazione significativa tra RCV e massa grassa (coeff. di Pearson = 0.667, p < 0.0001), nonché tra RCV e massa magra ...

وصف الملف: STAMPA

العلاقة: ispartofbook:Giornale di Gerontologia; 60° Congresso Nazionale Società Italiana di Gerontologia e Geriatria -SIGG; volume:63 (4) Suppl. 2; firstpage:225; lastpage:225; numberofpages:1; journal:GIORNALE DI GERONTOLOGIA; http://hdl.handle.net/11369/371557Test

الإتاحة: http://hdl.handle.net/11369/371557Test

المؤلفون: Capurso, C., Solfrizzi, V., D'Introno, A., Colacicco, A. M., Capurso, S. A., Mastroianni, F., Liaci, M., Vendemiale, G., Capurso, A., Panza, F.

المصدر: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ; volume 60, issue 8, page 991-996 ; ISSN 1079-5006 1758-535X

مصطلحات موضوعية: Geriatrics and Gerontology, Aging

الإتاحة: https://doi.org/10.1093/gerona/60.8.991Test
http://academic.oup.com/biomedgerontology/article-pdf/60/8/991/9733040/991.pdfTest

المؤلفون: D'Introno, A., Solfrizzi, V., Colacicco, A. M., Capurso, C., Torres, F., Capurso, S. A., Capurso, A., Panza, F.

المصدر: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ; volume 60, issue 3, page 280-284 ; ISSN 1079-5006 1758-535X

مصطلحات موضوعية: Geriatrics and Gerontology, Aging

الإتاحة: https://doi.org/10.1093/gerona/60.3.280Test
http://academic.oup.com/biomedgerontology/article-pdf/60/3/280/1756938/280.pdfTest