المؤلفون: Bachour, Rafy, Sengmanivong, Nithida, Vidal, Fabien, Goumarre, Céline, Lapègue, Franck, Destombes, Louise, Gandois, Hélène Chiavassa, Gac, Yann Tanguy Le, Chantalat, Elodie, Capdet, Jérome, Blais, Donatien, Guenego, Adrien, Sans, Nicolas, Bilfeld, Marie Faruch

المصدر: Diagnostic and Interventional Imaging ; ISSN 2211-5684

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine, Radiological and Ultrasound Technology

الإتاحة: https://doi.org/10.1016/j.diii.2024.02.010Test
https://api.elsevier.com/content/article/PII:S2211568424000457?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211568424000457?httpAccept=text/plainTest

المؤلفون: Weyl, Ariane, Sevy, Virginie, Lepage, Benoît, Vidal, Fabien, Kirzin, Sylvain, Legac, Yann Tanguy, Lesourd, Florence, Gosset, Anna, Capdet, Jérome, Leguevaque, Pierre, Bournet, Barbara, Lenfant, Françoise, Brierre, Thibaut, Gornes, Hugo, Buscail, Etienne, Chantalat, Elodie

المصدر: Archives of Gynecology & Obstetrics; May2023, Vol. 307 Issue 5, p1459-1468, 10p

مصطلحات موضوعية: SURGICAL complications, ENDOMETRIOSIS, ENDOSCOPIC ultrasonography, MUCOUS membranes, PATIENT care

مستخلص: Purpose: To assess the quality of care following the establishment of a multidisciplinary care pathway for patient operated on for deep pelvic endometriosis with digestive impairment. Methods: We conducted a retrospective monocentric study of patients suffering from deep infiltrating endometriosis, treated in Gynaecological Department at Toulouse University Hospital from January 2018 to December 2020. We compared our results to those of our previous study, Gornes et al. which showed a postoperative complication occurred in 37.8% of the cases and a postoperative severe complication according to the Clavien–Dindo classification (grades 3b) rate of 18.3%. Results: 98 patients were included. Our study shows a clear decrease in postoperative complications with an overall complication rate of 19.4% and severe complications (grades 3b) of 4.1%. The rate of complication appeared to be significantly less frequent in the case of shaving in relation to other digestive procedures (p = 0.008) and in the case of a lesion of < 20 mm by MRI (p = 0.01). The use of multidisciplinary surgical care was more frequent in the case of multiple locations (66.7% vs. 41.8%, p = 0.07) and was more frequent in the case of transmural damage with echo endoscopy (and to a lesser degree in the case of damage of the muscularis or mucous membrane) (p = 0.05). Conclusions: Multidisciplinary care of endometriosis with digestive damage appears to be indispensable. The intraoperative intervention of a skilled digestive surgeon of bowel endometriosis helps create the best balance between effectiveness–complications–functional prognosis, with a reduction of severe postoperative complications. [ABSTRACT FROM AUTHOR]

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المؤلفون: Weyl, Ariane, Sevy, Virginie, Lepage, Benoît, Vidal, Fabien, Kirzin, Sylvain, Legac, Yann Tanguy, Lesourd, Florence, Gosset, Anna, Capdet, Jérome, Leguevaque, Pierre, Bournet, Barbara, Lenfant, Françoise, Brierre, Thibaut, Gornes, Hugo, Buscail, Etienne, Chantalat, Elodie

المصدر: Archives of Gynecology and Obstetrics ; volume 307, issue 5, page 1459-1468 ; ISSN 1432-0711

مصطلحات موضوعية: Obstetrics and Gynecology, General Medicine

الإتاحة: https://doi.org/10.1007/s00404-022-06899-1Test

المؤلفون: Capdet, Jérôme, Martel, Pierre, Charitansky, Hélène, Lim Timothy, Y.K., Ferron, Gwenael, Battle, Laia, Landier, Adeline, Mery, Eliane, Zerdoub, Slimane, Roche, Henri, Querleu, Denis

المساهمون: Department of Surgical Oncology, Institut Claudius Regaud, Institut Claudius Regaud. Department of pathology, Department of nuclear medecine Toulouse F-31052, Département d'oncologie médicale

المصدر: ISSN: 0748-7983 ; EJSO - European Journal of Surgical Oncology ; https://hal.archives-ouvertes.fr/hal-00556314Test ; EJSO - European Journal of Surgical Oncology, WB Saunders, 2009, 35 (12), pp.1245. ⟨10.1016/j.ejso.2009.06.002⟩.

مصطلحات موضوعية: Sentinel node, early breast cancer, T1 tumor, axillary lymphadenectomy

الوصف: International audience ; To determine the factors associated with the metastatic involvement of sentinel lymph node (SLN) biopsy in patients with early breast cancer.

العلاقة: hal-00556314; https://hal.archives-ouvertes.fr/hal-00556314Test; https://hal.archives-ouvertes.fr/hal-00556314/documentTest; https://hal.archives-ouvertes.fr/hal-00556314/file/PEER_stage2_10.1016%252Fj.ejso.2009.06.002.pdfTest

الإتاحة: https://doi.org/10.1016/j.ejso.2009.06.002Test
https://hal.archives-ouvertes.fr/hal-00556314Test
https://hal.archives-ouvertes.fr/hal-00556314/documentTest
https://hal.archives-ouvertes.fr/hal-00556314/file/PEER_stage2_10.1016%252Fj.ejso.2009.06.002.pdfTest

المؤلفون: Rafii, Arash, Mirshahi, Pejman, Poupot, Mary, Faussat, Anne-Marie, Simon, Anne, Ducros, Elodie, Mery, Eliane, Couderc, Bettina, Lis, Raphael, Capdet, Jérôme, Bergalet, Julie, Querleu, Denis, Dagonnet, Francoise, Fournié, Jean-Jacques, Marie, Jean-Pierre, Pujade-Lauraine, Eric, Favre, Gilles, Soria, Jeanine, Mirshahi, Massoud

المساهمون: Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IFR 31 Louis Bugnard (IFR 31), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Physiopathologie de Toulouse-Purpan (INSERM U563 - CNRS UMR1037), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut Claudius Regaud-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de lutte contre le cancer (CLCC)-Centre National de la Recherche Scientifique (CNRS), Faculté des Sciences Pharmaceutiques, Université de Toulouse (UT)-Université de Toulouse (UT)

المصدر: ISSN: 1932-6203.

مصطلحات موضوعية: [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology

الوصف: International audience ; BACKGROUND:The microenvironment plays a major role in the onset and progression of metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity where interactions within the microenvironment might lead to chemoresistance. Mesothelial cells are important actors of the peritoneal homeostasis; we determined their role in the acquisition of chemoresistance of ovarian tumours.METHODOLOGY/PRINCIPAL FINDINGS:We isolated an original type of stromal cells, referred to as "Hospicells" from ascitis of patients with ovarian carcinosis using limiting dilution. We studied their ability to confer chemoresistance through heterocellular interactions. These stromal cells displayed a new phenotype with positive immunostaining for CD9, CD10, CD29, CD146, CD166 and Multi drug resistance protein. They preferentially interacted with epithelial ovarian cancer cells. This interaction induced chemoresistance to platin and taxans with the implication of multi-drug resistance proteins. This contact enabled EOC cells to capture patches of the Hospicells membrane through oncologic trogocytosis, therefore acquiring their functional P-gp proteins and thus developing chemoresistance. Presence of Hospicells on ovarian cancer tissue micro-array from patients with neo-adjuvant chemotherapy was also significantly associated to chemoresistance.CONCLUSIONS/SIGNIFICANCE:This is the first report of trogocytosis occurring between a cancer cell and an original type of stromal cell. This interaction induced autonomous acquisition of chemoresistance. The presence of stromal cells within patient's tumour might be predictive of chemoresistance. The specific interaction between cancer cells and stromal cells might be targeted during chemotherapy.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/19079610; inserm-02472253; https://inserm.hal.science/inserm-02472253Test; https://inserm.hal.science/inserm-02472253/documentTest; https://inserm.hal.science/inserm-02472253/file/journal.pone.0003894.PDFTest; PUBMED: 19079610; PUBMEDCENTRAL: PMC2597737

الإتاحة: https://doi.org/10.1371/journal.pone.0003894Test
https://inserm.hal.science/inserm-02472253Test
https://inserm.hal.science/inserm-02472253/documentTest
https://inserm.hal.science/inserm-02472253/file/journal.pone.0003894.PDFTest

المؤلفون: Parant, Olivier, Capdet, Jérôme, Kessler, Sylvie, Aziza, Jacqueline, Berrebi, Alain

المصدر: European Journal of Obstetrics & Gynecology and Reproductive Biology ; volume 143, issue 1, page 9-13 ; ISSN 0301-2115

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.ejogrb.2008.06.012Test
https://api.elsevier.com/content/article/PII:S0301211508004181?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0301211508004181?httpAccept=text/plainTest