المؤلفون: Calonge, N (ORCID 0000-0002-2653-6001), Shekelle, Paul G., Owens, Douglas K., Teutsch, Steven, Downey, Autumn, Brown, Lisa, Noyes, Jane (ORCID 0000-0003-4238-5984)

المصدر: Research Synthesis Methods. Jan 2023 14(1):36-51.

تمت مراجعته من قبل الزملاء: Y

Page Count: 16

Sponsoring Agency: Centers for Disease Control and Prevention (CDC) (DHHS/PHS)

الواصفات: Evidence, Synthesis, Mixed Methods Research, Public Health, Emergency Programs, Intervention, Evidence Based Practice, Grading, Evaluation Methods

مستخلص: Despite research investment and a growing body of diverse evidence there has been no comprehensive review and grading of evidence for public health emergency preparedness and response practices comparable to those in medicine and other public health fields. The National Academies of Sciences, Engineering, and Medicine convened an ad hoc committee to develop and use methods for grading and synthesizing diverse types of evidence to create a single certainty of intervention-related evidence to support recommendations for Public Health Emergency Preparedness and Response Research. A 13-step consensus building method was used. Experts were first canvassed in public meetings, and a comprehensive review of existing methods was undertaken. Although aspects of existing review methodologies and evidence grading systems were relevant, none adequately covered all requirements for this specific context. Starting with a desire to synthesize diverse sources of evidence not usually included in systematic reviews and using GRADE for assessing certainty and confidence in quantitative and qualitative evidence as the foundation, we developed a mixed-methods synthesis review and grading methodology that drew on (and in some cases adapted) those elements of existing frameworks and methods that were most applicable. Four topics were selected as test cases. The process was operationalized with a suite of method-specific reviews of diverse evidence types for each topic. Further consensus building was undertaken through stakeholder engagement and feedback The NASEM committee's GRADE adaption for mixed-methods reviews will further evolve over time and has yet to be endorsed by the GRADE working group.

Abstractor: As Provided

المؤلفون: Naber, Steffie, Kundu, S, Kuntz, KM, Dotson, WD, Williams, MS, Zauber, AG, Calonge, N, Zallen, DT, Ganiats, TG, Webber, EM, Goddard, KAB, Henrikson, NB, Ballegooijen, Marjolein, Janssens, A, Lansdorp - Vogelaar, Iris

المصدر: Naber , S , Kundu , S , Kuntz , KM , Dotson , WD , Williams , MS , Zauber , AG , Calonge , N , Zallen , DT , Ganiats , TG , Webber , EM , Goddard , KAB , Henrikson , NB , Ballegooijen , M , Janssens , A & Lansdorp - Vogelaar , I 2020 , ' Cost-Effectiveness of Risk-Stratified Colorectal Cancer Screening Based on Polygenic Risk: Current Status and Future Potential ' , JNCI Cancer Spectrum , vol. 4 , no. 1 , UNSP pkz086 . https://doi.org/10.1093/jncics/pkz086Test

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1093/jncics/pkz086Test
https://pure.eur.nl/en/publications/67a2d17b-f2b1-47d6-a417-af101672e7edTest
https://pure.eur.nl/ws/files/48328520/Repub_128568_O-A.pdfTest

المؤلفون: Naber, S.K. (Steffie), Kuntz, K.M. (Karen), Henrikson, N.B. (Nora B.), Williams, M.S. (Marc S.), Calonge, N. (Ned), Goddard, K.A. (Katrina A.), Zallen, D.T. (Doris T.), Ganiats, T.G. (Theodor), Webber, E.M. (Elizabeth M.), Janssens, A.C.J.W. (A. Cecile J.W.), Ballegooijen, M. (Marjolein) van, Zauber, A.G. (Ann), Lansdorp-Vogelaar, I. (Iris)

المصدر: Gastroenterology vol. 154 no. 1, pp. 105-116.e20

مصطلحات موضوعية: Colon Cancer, Cost-Effectiveness Analysis, Genetic Risk Factor, Inherited, Relative Risk (RR)

الوصف: Background & Aims Relative risk of colorectal cancer (CRC) decreases with age among individuals with a family history of CRC. However, no screening recommendations specify less frequent screening with increasing age. We aimed to determine whether such a refinement would be cost effective. Methods We determined the relative risk for CRC for individuals based on age and number of affected first-degree relatives (FDRs) using data from publications. For each number of affected FDRs, we used the Microsimulation Screening Analysis model to estimate costs and effects of colonoscopy screening strategies with different age ranges and intervals. Screening was then optimized sequentially, starting with the youngest age group, and allowing the interval of screening to change at certain ages. Strategies with an incremental cost effectiveness ratio below $100,000 per quality-adjusted life year were considered cost effective. Results For people with 1 affected FDR (92% of those with a family history), screening every 3 years beginning at an age of 40 years is most cost effective. If no adenomas are found, the screening interval can gradually be extended to 5 and 7 years, at ages 45 and 55 years, respectively. From a cost-effectiveness perspective, individuals with more affected FDRs should start screening earlier and at shorter intervals. However, frequency can be reduced if no abnormalities are found. Conclusions Using a microsimulation model, we found that for individuals with a family history of CRC, it is cost effective to gradually increase the screening interval if several subsequent screening colonoscopies have negative results and no new cases of CRC are found in family members.

العلاقة: http://repub.eur.nl/pub/103615Test; urn:hdl:1765/103615

الإتاحة: https://doi.org/10.1053/j.gastro.2017.09.021Test
http://repub.eur.nl/pub/103615Test

المؤلفون: Calonge, N.

المصدر: JNCI Journal of the National Cancer Institute ; volume 102, issue 22, page 1742-1743 ; ISSN 0027-8874 1460-2105

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1093/jnci/djq398Test
http://academic.oup.com/jnci/article-pdf/102/22/1742/7671683/djq398.pdfTest

المؤلفون: Naber, S.K. (Steffie), Kundu, S. (Suman), Kuntz, K.M. (Karen), Dotson, W.D. (David), Williams, MS, Zauber, A.G., Calonge, N, Zallen, DT, Ganiats, TG, Webber, EM, Goddard, K.A.B., Henrikson, NB, Ballegooijen, M. (Marjolein) van, Janssens, A.C.J.W. (Cécile), Lansdorp-Vogelaar, I. (Iris)

المصدر: Jnci Cancer Spectrum vol. 4 no. 1

الوصف: Background: Although uniform colonoscopy screening reduces colorectal cancer (CRC) mortality, risk-based screening may be more efficient. We investigated whether CRC screening based on polygenic risk is a cost-effective alternative to current uniform screening, and if not, under what conditions it would be. Methods: The MISCAN-Colon model was used to simulate a hypothetical cohort of US 40-year-olds. Uniform screening was modeled as colonoscopy screening at ages 50, 60, and 70 years. For risk-stratified screening, individuals underwent polygenic testing with current and potential future discriminatory performance (area under the receiveroperating curve [AUC] of 0.60 and 0.65–0.80, respectively). Polygenic testing results were used to create risk groups, for which colonoscopy screening was optimized by varying the start age (40–60 years), end age (70–85 years), and interval (1–20 years). Results: With current discriminatory performance, optimal screening ranged from once-only colonoscopy at age 60 years for the lowest-risk group to six colonoscopies at ages 40–80 years for the highest-risk group. While maintaining the same health benefits, risk-stratified screening increased costs by $59 per person. Risk-stratified screening could become cost-effective if the AUC value would increase beyond 0.65, the price per polygenic test would drop to less than $141, or risk-stratified screening would lead to a 5% increase in screening participation. Conclusions: Currently, CRC screening based on polygenic risk is unlikely to be cost-effective compared with uniform screening. This is expected to change with a greater than 0.05 increase in AUC value, a greater than 30% reduction in polygenic testing costs, or a greater than 5% increase in adherence with screening.

وصف الملف: application/pdf

العلاقة: https://repub.eur.nl/pub/128568Test; urn:hdl:1765/128568

الإتاحة: https://doi.org/10.1093/jncics/pkz086Test
https://repub.eur.nl/pub/128568Test

المؤلفون: Ramos, EM, Din-Lovinescu, C, Berg, JS, Brooks, LD, Duncanson, A, Dunn, M, Good, P, Hubbard, TJP, Jarvik, GP, O'Donnell, C, Sherry, ST, Aronson, N, Biesecker, LG, Blumberg, B, Calonge, N, Colhoun, HM, Epstein, RS, Flicek, P, Gordon, ES, Green, ED, Green, RC, Hurles, M, Kawamoto, K, Knaus, W, Ledbetter, DH, Levy, HP, Lyon, E, Maglott, D, McLeod, HL, Rahman, N, Randhawa, G, Wicklund, C, Manolio, TA, Chisholm, RL, Williams, MS

المساهمون: Rahman, Sabera

مصطلحات موضوعية: Humans, Information Dissemination, Phenotype, Education, Medical Informatics, United States, National Human Genome Research Institute (U.S.), Genetic Variation, Precision Medicine

الوصف: Genome-wide association studies, DNA sequencing studies, and other genomic studies are finding an increasing number of genetic variants associated with clinical phenotypes that may be useful in developing diagnostic, preventive, and treatment strategies for individual patients. However, few variants have been integrated into routine clinical practice. The reasons for this are several, but two of the most significant are limited evidence about the clinical implications of the variants and a lack of a comprehensive knowledge base that captures genetic variants, their phenotypic associations, and other pertinent phenotypic information that is openly accessible to clinical groups attempting to interpret sequencing data. As the field of medicine begins to incorporate genome-scale analysis into clinical care, approaches need to be developed for collecting and characterizing data on the clinical implications of variants, developing consensus on their actionability, and making this information available for clinical use. The National Human Genome Research Institute (NHGRI) and the Wellcome Trust thus convened a workshop to consider the processes and resources needed to: (1) identify clinically valid genetic variants; (2) decide whether they are actionable and what the action should be; and (3) provide this information for clinical use. This commentary outlines the key discussion points and recommendations from the workshop.

وصف الملف: Print-Electronic; 104; application/pdf

العلاقة: American journal of medical genetics. Part C, Seminars in medical genetics, 2014, 166C (1), pp. 93 - 104; https://repository.icr.ac.uk/handle/internal/1851Test

الإتاحة: https://doi.org/10.1002/ajmg.c.31386Test
https://repository.icr.ac.uk/handle/internal/1851Test

المؤلفون: Henrikson, NB, Webber, EM, Goddard, KA, Scrol, A, Piper, M, Williams, MS, Zallen, DT, Calonge, N, Ganiats, TG, Janssens, A, Zauber, A, Lansdorp - Vogelaar, Iris, Ballegooijen, Marjolein, Whitlock, EP

المصدر: Henrikson , NB , Webber , EM , Goddard , KA , Scrol , A , Piper , M , Williams , MS , Zallen , DT , Calonge , N , Ganiats , TG , Janssens , A , Zauber , A , Lansdorp - Vogelaar , I , Ballegooijen , M & Whitlock , EP 2015 , ' Family history and the natural history of colorectal cancer: systematic review ' , Genetics in Medicine , vol. 17 , no. 9 , pp. 702-712 . https://doi.org/10.1038/gim.2014.188Test

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, SDG 3 - Good Health and Well-being

الوصف: Purpose: Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks. Methods: We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening. Results: We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC. Conclusion: Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family historybased approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.

الإتاحة: https://doi.org/10.1038/gim.2014.188Test
https://pure.eur.nl/en/publications/956c502e-ad98-42d3-a57f-d5a9c5833f12Test
http://hdl.handle.net/1765/81356Test

المؤلفون: Schully, S.D., Lam, T.K., Dotson, W.D., Chang, C.Q., Aronson, N., Birkeland, M.L., Brewster, S.J., Boccia, S., Buchanan, A.H., Calonge, N., Calzone, K., Djulbegovic, B., Goddard, K.A.B., Klein, R.D., Klein, T.E., Lau, J., Long, R., Lyman, G.H., Morgan, R.L., Palmer, C.G.S., Ling, M.V.R., Rubinstein, W.S., Swen, J.J., Terry, S.F., Williams, M.S., Khoury, M.J.

المصدر: Genetics in Medicine

مصطلحات موضوعية: evidence synthesis, genomic medicine, guideline development

الوصف: Personalised Therapeutics

العلاقة: lumc-id: 4299110; https://hdl.handle.net/1887/107424Test

الإتاحة: https://doi.org/10.1038/gim.2014.69Test
https://hdl.handle.net/1887/107424Test

المؤلفون: Calonge, N.

المصدر: JNCI Journal of the National Cancer Institute ; volume 102, issue 10, page 668-669 ; ISSN 0027-8874 1460-2105

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1093/jnci/djq137Test
http://academic.oup.com/jnci/article-pdf/102/10/668/18614502/djq137.pdfTest

المؤلفون: Baier M, Calonge N, Gary Cutter, McClatchey M, Schoentgen S, Hines S, Marcus A, Ahnen D

المصدر: Europe PubMed Central

مصطلحات موضوعية: Adult, Male, Data Collection, Health Behavior, Reproducibility of Results, Colonoscopy, Middle Aged, Truth Disclosure, Sensitivity and Specificity, Telephone, Occult Blood, Humans, Mass Screening, Patient Compliance, Female, Colorectal Neoplasms, Sigmoidoscopy, Aged

الوصف: End points for trials promoting cancer screening are often based on self-reported screening behavior. This study was designed to evaluate and optimize the reliability of a computer-assisted telephone interview for collecting self-reported colorectal cancer screening behavior. Cases who had received a fecal occult blood test (FOBT), flexible sigmoidoscopy, and/or colonoscopy, and controls who had no record of colorectal screening were identified among 40-75-year-old members of the Denver Kaiser Permanente Health Care Program and were contacted by telephone. Sensitivities and specificities of self-reported screening were calculated by comparison of subjects' recall with Kaiser Permanente records. The questionnaire was revised based upon results of the pilot phase of the study. Using the revised questionnaire, the sensitivity of self-reported screening was 96.2% for the FOBT, 94.9% for flexible sigmoidoscopy, 88.7% for colonoscopy, and 96.2% for either endoscopic screening test. The specificity of self-reported screening was 85.9% for the FOBT, 92.2% for flexible sigmoidoscopy, 96.8% for colonoscopy, and 92.0% for either endoscopic screening test. No marked differences in the accuracy of the self-reports were detected as a function of gender, age, ethnicity, or family history of colorectal cancer of the participants. Self-reports of colon cancer screening behavior can be reliably used as end points for intervention trials when carefully phrased questions are used.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::79b36704a681e41dbaef80255ff76e49Test
https://pubmed.ncbi.nlm.nih.gov/10698488Test