المؤلفون: Pambet, Mathilde, Sirodot, Fanny, Pereira, Bruno, Cahierc, Romain, Delabaere, Amélie, Comptour, Aurélie, Rouzaire, Marion, Sapin, Vincent, Gallot, Denis

المساهمون: Centre d'Investigation Clinique CHU Clermont-Ferrand (CIC 1405), Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Biostatistiques CHU Clermont-Ferrand, Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Service Obstétrique CHU Clermont-Ferrand, CHU Estaing Clermont-Ferrand, Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Service de Biochimie et Génétique Moléculaire CHU Clermont-Ferrand, CHU Gabriel Montpied Clermont-Ferrand, CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing Clermont-Ferrand, CHU Clermont-Ferrand

المصدر: ISSN: 2077-0383 ; Journal of Clinical Medicine ; https://hal.science/hal-04350517Test ; Journal of Clinical Medicine, 2023, 12 (17), pp.5707. ⟨10.3390/jcm12175707⟩.

مصطلحات موضوعية: preterm labor, IGFBP-1, IL-6, fibronectin, vaginal biomarkers, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity

الوصف: International audience ; We conducted a prospective double-blind study to compare two vaginal diagnostic methods in singleton pregnancies with threatened preterm labor (TPL) at the University Hospital of Clermont-Ferrand (France) from August 2018 to December 2020. Our main objective was to compare the diagnostic capacity at admission, in terms of positive predictive value (PPV) and negative predictive value (NPV), of Premaquick® (combined detection of IL-6/total IGFBP-1/native IGFBP-1) and QuikCheck fFN™ (fetal fibronectin) for delivery within 7 days in cases of TPL. We included 193 patients. Premaquick® had a sensitivity close to 89%, equivalent to QuikCheck fFN™, but a higher statistical specificity of 49.5% against 38.6% for QuikCheck fFN™. We found no superiority of Premaquick® over QuickCheck fFN™ in terms of PPV (6.6% vs. 7.9%), with NPV being equivalent in predicting childbirth within 7 days in cases of TPL (98.6% vs. 98.9%). Nevertheless, the combination of positive native and total IGFBP-1 and the combination of all three positive markers were associated with a higher PPV. Our results, though non-significant, support this combined multiple-biomarker approach to improve testing in terms of predictive values.

العلاقة: hal-04350517; https://hal.science/hal-04350517Test; https://hal.science/hal-04350517/documentTest; https://hal.science/hal-04350517/file/jcm-12-05707-v2.pdfTest

الإتاحة: https://doi.org/10.3390/jcm12175707Test
https://hal.science/hal-04350517Test
https://hal.science/hal-04350517/documentTest
https://hal.science/hal-04350517/file/jcm-12-05707-v2.pdfTest

المؤلفون: Delabaere, Amélie, Guerard, Maeva, Cahierc, Romain, Bouvier, Damien, Pereira, Bruno, Gallot, Denis

المصدر: The Journal of Maternal-Fetal & Neonatal Medicine ; volume 36, issue 2 ; ISSN 1476-7058 1476-4954

الإتاحة: https://doi.org/10.1080/14767058.2023.2266092Test

المؤلفون: Cahierc, Romain, Debost-Legrand, Anne, Lane, Sophie, Rouzaire, Marion, Bonnin, Martine, Delabaere, Amélie, Gallot, Denis

المصدر: Gynécologie Obstétrique Fertilité & Sénologie ; volume 51, issue 10, page 448-454 ; ISSN 2468-7189

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.gofs.2023.08.001Test
https://api.elsevier.com/content/article/PII:S2468718923001629?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2468718923001629?httpAccept=text/plainTest

المؤلفون: Reitz, Aurélie, Rouzaire, Marion, Cahierc, Romain, Pereira, Bruno, Lemal, Richard, Garrouste, Cyril, Gallot, Denis

المصدر: Gynécologie Obstétrique Fertilité & Sénologie ; ISSN 2468-7189

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.gofs.2024.01.011Test
https://api.elsevier.com/content/article/PII:S2468718924000345?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2468718924000345?httpAccept=text/plainTest

المؤلفون: Pambet, Mathilde, Sirodot, Fanny, Pereira, Bruno, Cahierc, Romain, Delabaere, Amélie, Comptour, Aurélie, Rouzaire, Marion, Sapin, Vincent, Gallot, Denis

المصدر: Journal of Clinical Medicine; Sep2023, Vol. 12 Issue 17, p5707, 11p

مصطلحات موضوعية: PREMATURE labor, CHILDBIRTH, UNIVERSITY hospitals, FIBRONECTINS, LONGITUDINAL method

مصطلحات جغرافية: CLERMONT-Ferrand (France)

مستخلص: We conducted a prospective double-blind study to compare two vaginal diagnostic methods in singleton pregnancies with threatened preterm labor (TPL) at the University Hospital of Clermont-Ferrand (France) from August 2018 to December 2020. Our main objective was to compare the diagnostic capacity at admission, in terms of positive predictive value (PPV) and negative predictive value (NPV), of Premaquick^® (combined detection of IL-6/total IGFBP-1/native IGFBP-1) and QuikCheck fFN™ (fetal fibronectin) for delivery within 7 days in cases of TPL. We included 193 patients. Premaquick^® had a sensitivity close to 89%, equivalent to QuikCheck fFN™, but a higher statistical specificity of 49.5% against 38.6% for QuikCheck fFN™. We found no superiority of Premaquick^® over QuickCheck fFN™ in terms of PPV (6.6% vs. 7.9%), with NPV being equivalent in predicting childbirth within 7 days in cases of TPL (98.6% vs. 98.9%). Nevertheless, the combination of positive native and total IGFBP-1 and the combination of all three positive markers were associated with a higher PPV. Our results, though non-significant, support this combined multiple-biomarker approach to improve testing in terms of predictive values. [ABSTRACT FROM AUTHOR]

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