المؤلفون: Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: Marek’s disease virus, T cell proliferation, COX2 = cyclooxygenase 2, PGE2, immunosuppression, Immunologic diseases. Allergy, RC581-607

الوصف: Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2021.801781/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/8ef9b155eae1450fb46c81651de219eeTest

المؤلفون: Kamble, Nitin, Gurung, Angila, Kaufer, Benedikt B., Pathan, Ansar Ahmed, Behboudi, Shahriar

مصطلحات موضوعية: Marek’s disease virus, T cell proliferation, COX2 = cyclooxygenase 2, PGE2, immunosuppression, ddc:630

الوصف: Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens.

وصف الملف: 16 Seiten; application/pdf

العلاقة: https://refubium.fu-berlin.de/handle/fub188/33907Test; http://dx.doi.org/10.17169/refubium-33626Test

الإتاحة: https://doi.org/10.17169/refubium-33626Test
https://doi.org/10.3389/fimmu.2021.801781Test
https://refubium.fu-berlin.de/handle/fub188/33907Test

المؤلفون: Dutta, Somit, Mukherjee, Amartya, Nongthomba, Upendra

المصدر: Cytokine & Growth Factor Reviews

مصطلحات موضوعية: viruses, TLR, toll like receptor, Endocrinology, Diabetes and Metabolism, DAMP, damage associated molecular pattern, Apoptosis, Cytokine storm, SOCS, Suppressor Of Cytokine Signalling, TNF-α, tumour necrosis factor α, LPC, lysophosphatidylcholines, DC, dendritic cell, COVID-19, coronavirus disease of 2019, Autoimmune disease, Immunology and Allergy, skin and connective tissue diseases, Efferocytosis, Diabetes, TUNNEL, Terminal deoxynucleotidyl transferase dUTP nick end labelling, Macrophage, Macrophages, cAMP, cyclic adenosine monophosphate, HIV, human immunodeficiency virus, Rac-GEF, Rac guanine nucleotide exchange factor, MERTK, proto-oncogene tyrosine-protein kinase MER, TIM, T cell immunoglobulin mucin receptor, PS, Phosphatidyl serine, Cytokine Release Syndrome, HCoV229E, human coronavirus 229E, RAGE, receptor for advanced glycation end products, ATP, adenosine triphosphate, MFG-E8, milk fat globule-EGF factor 8 protein, HMGB1, High mobility group box 1 protein, GAS-6, Growth arrest specific gene 6, SARS-CoV, severe acute respiratory syndrome coronavirus, Immunology, ACE2, angiotensin-converting enzyme, COPD, Chronic obstructive pulmonary disease, Article, WHO, World health organization, General Biochemistry, Genetics and Molecular Biology, Phagocytosis, TGF-β, transforming growth factor beta, Humans, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2-AC, Severe acute respiratory syndrome coronavirus 2 infected apoptotic cell, Pandemics, ARDS, acute respiratory distress syndrome, S1P, sphingosine-1-phosphate, CXCL, chemokine (C-X-C motif) ligand, Inflammation, BAI1, brain angiogenesis inhibitor 1, SARS-CoV-2, Macrophages, fungi, COX2, cyclooxygenase 2, COVID-19, respiratory tract diseases, IL, interleukin, body regions, FDA, food and drug administration, AMP, adenosine monophosphate, LC3, microtubule-associated protein 1 A/1B-light chain 3, TMPRSS2, transmembrane serine protease 2, ARDS, MARS-CoV, middle east respiratory syndrome-related coronavirus

الوصف: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding the immunological routes underlying the clinical manifestations of COVID-19 is important for developing effective therapeutic interventions. The clearance of SARS-CoV-2-infected apoptotic cells by professional efferocytes, through a process termed as 'efferocytosis', is essential for maintaining tissue homeostasis, and reducing the chances of health complications caused by SARS-CoV-2 infection. In this review, we focus on the cellular events leading to engagement of the SARS-CoV-2 with type 2 alveolar cells, and how SARS-COV-2 infection impairs the macrophage anti-inflammatory programming. We also discuss accounts of impaired efferocytosis, and the “cytokine storm” which occur concomitantly with the SARS-CoV-2 infection. Finally, we propose how targeting impaired efferocytosis, due to the SARS-CoV-2 infection, may be a beneficial therapeutic strategy to combat COVID-19, and its complications.
Graphical Abstract ga1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5990459f79223696772bfb7610dedbTest
https://doi.org/10.1016/j.cytogfr.2022.01.002Test

المؤلفون: Zengli Liu, Tianli Chen, Rongqi Sun, Yunfei Xu, Bo Qiu, Xiaoming Zhang, Zongli Zhang, Zhipeng Li

المصدر: EBioMedicine

مصطلحات موضوعية: Oncology, Male, Research paper, TCF4, Transcription factor 4, RUNX2, Runt related transcription factor 2, CD44, Cluster of differentiation 44, 0302 clinical medicine, Transcription (biology), MMP26, Matrix metalloproteinase 26, Medicine, IHCC, Intrahepatic cholangiocarcinoma, CCA, Cholangiocarcinoma, education.field_of_study, qRT-PCR, Quantitative real-time PCR, GJA1, Gap junction alpha-1, PBS, Phosphate buffer saline, General Medicine, TCF4, SOX2, SRY-box 2, Prognosis, SOX9, SRY-box 9, Reverse transcription polymerase chain reaction, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, CCND1, Cyclin D1, Immunohistochemistry, PPAR, Peroxisome proliferating activation receptor, GJB6, Gap junction beta-6, CDH1, Cadherin 1, SALL4, Spalt like transcription factor 4, medicine.medical_specialty, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Transcription factor 7, SALL4, Secreted frizzled-related protein 1, SDS-PAGE, Sodium dodecyl sulfate polyacrylamide gel electrophoresis, PVDF, Polyvinylidene fluoride, Humans, FOSL1, FOS-like antigen 1, education, Aged, FGF3, Fibroblast growth factor 3, CD44, HATH1, Human atonal homolog 1, FOS-like antigen 1, FOSL1, CDX4, Caudal type homeobox 4, 030104 developmental biology, Bile Ducts, Intrahepatic, Perihilar cholangiocarcinoma, 0301 basic medicine, IHC, Immunohistochemistry, CCK-8, Cell counting kit-8, MAPK, Mitogen-activated protein kinase, TCF7, Transcription factor 7, COX2, Cyclooxygenase 2, ID2, Inhibitor of DNA binding 2, FGF9, Fibroblast growth factor 9, AJCC/UICC, American joint committee on cancer/Union for International Cancer Control, SFRP1, Secreted frizzled related protein 1, BIRC5, Baculoviral IAP repeat containing 5, T Cell Transcription Factor 1, PTTG1, Pituitary tumor-transforming 1, Perihilar Cholangiocarcinoma, TWIST1, TWIST family BHLH transcription factor 1, Tissue microarray, biology, Progression, ERK, Extracellular regulated protein kinases, FOXN1, Forkhead box N1, Middle Aged, Real-time polymerase chain reaction, TMA, Tissue microarray, FGF4, Fibroblast growth factor 4, Female, Proto-Oncogene Proteins c-fos, Poor prognosis, IRX3, Iroquois Homeobox 3, KRAS, Kirsten rat sarcoma viral oncogene, DCC, Distal cholangiocarcinoma, Internal medicine, Cell Line, Tumor, CDX1, Caudal type homeobox 1, Biomarkers, Tumor, C-Myc, CCN1, Cysteine rich 61, In patient, MMP7, Matrix metalloproteinase 7, business.industry, Transcription Factor 7, AXIN2, Axis inhibition protein 2, AP-1, Activating protein-1, biology.protein, Cancer research, FBS, Fetal bovine serum, PHCC, Perihilar cholangiocarcinoma, business, OS, Overall survival rate, Klatskin Tumor

الوصف: Background: Perihilar cholangiocarcinoma (PHCC) is the most common type of cholangiocarcinoma with the worst prognosis. Radical resection of PHCC is difficult; thus, few effective biomarkers or useful molecular profiles for PHCC have been reported in recent years. Methods: In this study, we screened potential biomarkers for PHCC using exon and transcriptome sequencing with PHCC tissues and paired normal tissues, and confirmed that transcription factor 7(TCF7) was upregulated in PHCC using qRT-PCR, western blotting and immunohistochemistry. The correlations between TCF7 and clinicopathological factors were analyzed with Chi-square test, and the prognostic significance of TCF7 was evaluated with univariate and multivariate analysis in two independent cohorts. Moreover, the functions of TCF7 and its main effectors in PHCC cells proliferation, invasion, and migration were investigated with in vitro and in vivo experiments. Findings: TCF7 expression was upregulated in PHCC and it was an unfavorable prognostic biomarker. c-Myc was a main effector of TCF7 in PHCC cells and responsible for TCF7-induced proliferation, invasion, and migration of PHCC cells. With qRT-PCR screening, FOSL1 was also identified as a downstream target gene of TCF7 and was required in TCF7-induced PHCC proliferation. Triple-positive expression of TCF7, c-Myc, and FOSL1 predicted a much worse prognosis in patients with PHCC than TCF7 expression alone. Interpretation: TCF7 correlated with poor prognosis of PHCC by promoting proliferation, invasion, and migration of PHCC, which required the participation of its target gene c-Myc and FOSL1. Triple-positive expression of TCF7, c-Myc, and FOSL1 was a more sensitive factor to predict prognosis than TCF7 expression alone in patients with PHCC. These results suggested that postoperative detection of TCF7, c-Myc, and FOSL1 may be useful for stratifying patients with a high risk of unfavorable prognosis and that suppressing TCF7 or its downstream effectors may be a promising strategy for the treatment of PHCC. Funding: Our study was supported by National Natural Science Foundation of China (Grant no. 81601668), Shandong Province Major Research and Design Program (Grant No. 2018GSF118169), Jinan City Science and Technology Development Program (Grant No. 201805017, 201805013), and Hengrui Hepatobiliary and Pancreatic Foundation (Grant No.Y-2017-144). Declaration of Interest: We declare no conflicts of interest. Ethical Approval: This study was approved by the Qilu Hospital of Shandong Univeristy. The Laboratory Animal Care and Use Committees of the hospital approved all experimental procedures. Written informed consents were received from all patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155cb7697f054b98040d94d0bc60a157Test
https://pubmed.ncbi.nlm.nih.gov/31248836Test

المؤلفون: Jihye Lee, Hee-Seop Lee, Seong-Ho Lee, Dmitriy Smolensky

المصدر: International Immunopharmacology

مصطلحات موضوعية: ERK, Extracellular signal-Regulated Kinase, HPU, Helicobactor Pylori Urease, IR, Ischemia/reperfusion, iNOS, Inducible Nitric Oxide Synthase, PERK, Protein kinase R-like Endoplasmic Reticulum Kinase, Alcohol, C/EBPα, CCAT/enhancer Binding Protein α, RIP3, Receptor Interacting Serine/Threonine- Protein kinase3, CXCL11, C-X-C Motif Chemokine 11, IBD, Inflammatory Bowel Disease, DCNB, 2,4-Dinitro-chlorobenzene, IRE1, Inositol-requiring Enzyme 1, 0302 clinical medicine, ACE2, Angiotensin Converting Enzyme 2, Medicine, 4E-BP1, Eukaryotic Translation Initiation Factor 4E Binding Protein 1, SOD, Superoxide Dismutase, 5-HT, 5-Hydroxytryptamine, LPS, Lipopolysaccharide, TLR2, Toll-like Receptor 2, media_common, ER, Estrogen Receptor, IFNγ, Interferon γ, Nrf2, Nuclear Factor Erythroid 2-Related Factor 2, NF-κB, Nuclear Factor κ-light-chain-enhancer of activated B cells, VDCC, Voltage-Dependent Ca2+ Channel, Pogostemon, SYN1, Synapsin-1, PXR, Pregnane X Receptor, 030220 oncology & carcinogenesis, IP3R, Inositol Triphosphate Receptor, Sesquiterpenes, PSD-95, Postsynaptic Density Protein 95, TPH1, Tryptophan Hydroxylase 1, Drug, media_common.quotation_subject, Immunology, CUMS, Chronic Unpredictable Mild Stress, ZO-1, Zonula Occludens-1, Article, WHO, World Health Organization, 03 medical and health sciences, food, ICAM-1, Intracellular Adhesion Molecule-1, Humans, VLDL, Very Low Density Lipoprotein, Pharmacology, IDO-1, Indoleamine 2,3-dioxygenease-1, TNFα, Tumor Necrosis Factor α, MAPK, Mitogen-Activated Protein Kinase, NO, Nitric Oxide, CAT, Catalase, 030104 developmental biology, Patchouli alcohol, mTOR, Mammalian Target of Rapamycin, chemistry, PI3K, Phosphoinositol-3 Kinase, RdRp, RNA-Dependent RNA Polymerase, 0301 basic medicine, CXCL10, C-X-C Motif Chemokine 10, PLpro, Papain-like Protease, Anti-Inflammatory Agents, 3CLpro, 3C-Like Protease, PGE2, Prostaglandin E2, Health benefits, COX2, Cyclooxygenase 2, MLKL, Mixed Lineage Kinase Domain-Like Pseudokinase, chemistry.chemical_compound, 5-FU, 5-Fluorouracil, Immunology and Allergy, CXCL9, C-X-C Motif Chemokine 9, eNOS, Endothelial Nitric Oxide Synthase, biology, Traditional medicine, respiratory system, 5-HTP, 5-Hydroxytryptophan, VCAM-1, Vascular Cell Adhesion Molecule 1, NLRP3, NOD-, LRR- and Pyrin Domain-containing Protein 3, Immunosuppressive Agents, food.ingredient, ATF6, Activating Transcription Factor 6, DSS, Dextran Sulfate Sodium, TXNIP, Thioredoxin Interacting Protein, ROCCs, Receptor-operated Ca2+ Channels, Functional food, PA, Patchouli Alcohol, SCFA, Short Chain Fatty Acid, MDA, Malondialdehyde, Biological mechanisms, RyRs, Ryanodine Receptors, Lung protection, business.industry, PHE, Phenylephrine, GSH-px, Glutathione Peroxidase, MMP9, Matrix Metalloproteinase 9, biology.organism_classification, Antineoplastic Agents, Phytogenic, DTH, Delayed Type Hypersensitivity, PPARγ, Peroxisome Proliferator Activated Receptor γ, HO-1, Heme Oxidase-1, Molecular targets, EGFR, Epidermal Growth Factor Receptor, Kyn, L-Kynurenine, MCP-1, Monocyte Chemoattractant Protein-1, Patchouli, business, human activities, ROS, Reactive Oxygen Species

الوصف: Highlights • Patchouli alcohol (PA) is a bioactive component in essential oil extracted from Pogostemon cablin. • The present review provides the scientific mechanisms for health beneficial activities of PA in diverse disease models. • PA possesses diverse health beneficial activities.
Patchouli alcohol (PA), a tricyclic sesquiterpene, is a dominant bioactive component in oil extracted from the aerial parts of Pogostemon cablin (patchouli). Diverse beneficial activities have been reported, including anti-influenza virus, anti-depressant, anti-nociceptive, vasorelaxation, lung protection, brain protection, anti-ulcerogenic, anti-colitis, pre-biotic-like, anti-inflammatory, anti-cancer and protective activities against metabolic diseases. However, detailed mechanistic studies are required to explore the possibility of developing PA as a functional food material or promising drug for the prevention and treatment of human diseases. This review highlights multiple molecular targets and working mechanisms by which PA mediates health benefits.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0bef40b542aa0945c4a6b4a7afa05Test
https://doi.org/10.1016/j.intimp.2020.107056Test

المؤلفون: Xiangming Guan

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 402-418 (2015)

مصطلحات موضوعية: CA15-3, Pathology, HA, hyaluronan, JAK, the Janus kinases, Detachment, medicine.medical_treatment, Review, PDGF, platelet-derived growth factor, Metastasis, DISC, death-inducing signaling complex, Invasion, General Pharmacology, Toxicology and Pharmaceutics, FAs, focal adhesions, IKK, IκB kinase, VN, vitronectin, Migration, Cancer, TGF-β, transforming growth factor β, biology, TME, tumor microenvironment, PI3K, phosphatidylinositol 3-kinase, VCAMs, vascular cell adhesion molecules, VEGF, vascular endothelial growth factor, Primary tumor, ECM, extracellular matrix, CAT, collective amoeboid transition, CSF-1, chemokine colonystimulating factor–1, FAK, focal adhesion kinase, EGFR, EGF receptor, Adhesion, STATs, signal transducers and activators of transcription, EMT, epithelial–mesenchymal transition, Platelet-derived growth factor receptor, LN, laminin, medicine.medical_specialty, MAT, mesenchymal to amoeboid transition, MET, mesenchymal–epithelial transition, CTGF, connective tissue growth factor, Cancer stem cell, HIFs, hypoxia-inducible factors, TAMs, tumor-associated macrophages, medicine, CCR3, chemokine receptor 3, FN, fibronectin, EGF, epidermal growth factor, Tumor microenvironment, business.industry, lcsh:RM1-950, COX2, cyclooxygenase 2, CXCR2, chemokine receptor type 2, medicine.disease, Col, collagen, FGF, fibroblast growth factor, Radiation therapy, lcsh:Therapeutics. Pharmacology, BM, basement membrane, Cancer research, biology.protein, HGF, hepatocyte growth factor, MMPs, matrix metalloproteinases, CAMs, cell adhesion molecules, business, MAPK, mitogen-activated protein kinase, CAFs, cancer-associated fibroblasts, CCL2, chemokine (C–C motif) ligand 2

الوصف: Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Although cancer survival rate has been significantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition. Limited progress has been made in the treatment of cancer metastasis due to various factors. Current treatments for cancer metastasis are mainly chemotherapy and radiotherapy, though the new generation anti-cancer drugs (predominantly neutralizing antibodies for growth factors and small molecule kinase inhibitors) do have the effects on cancer metastasis in addition to their effects on cancer growth. Cancer metastasis begins with detachment of metastatic cells from the primary tumor, travel of the cells to different sites through blood/lymphatic vessels, settlement and growth of the cells at a distal site. During the process, metastatic cells go through detachment, migration, invasion and adhesion. These four essential, metastatic steps are inter-related and affected by multi-biochemical events and parameters. Additionally, it is known that tumor microenvironment (such as extracellular matrix structure, growth factors, chemokines, matrix metalloproteinases) plays a significant role in cancer metastasis. The biochemical events and parameters involved in the metastatic process and tumor microenvironment have been targeted or can be potential targets for metastasis prevention and inhibition. This review provides an overview of these metastasis essential steps, related biochemical factors, and targets for intervention.
Graphical abstract Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Limited progress has been made in the treatment of cancer metastasis due to various factors. This review is aimed to provide an overview of the metastasis process and targets for intervention with a focus on cancer cell detachment, migration, invasion and adhesion. It is hoped that this review can serve as a lead for readers who are interested in cancer metastasis and intervention.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f6f06ec2fa7a03c41137b4a13ce17Test
https://doi.org/10.1016/j.apsb.2015.07.005Test

المؤلفون: Toos Daemen, Joyce M Lubbers, Hans W. Nijman, Oana Draghiciu

المصدر: Oncoimmunology

مصطلحات موضوعية: CD62L, L-selectin, TUMOR-BEARING MICE, MDSCs, myeloid-derived suppressor cells, STAT3, signal transducer and activator of transcription 3, medicine.medical_treatment, ARG1, arginase-1, ATRA, all-trans retinoic acid, PDE-5, phosphodiesterase type 5, Review, IMCs, immature myeloid cells, HNSCC, head and neck squamous cell carcinoma, law.invention, APCs, antigen presenting cells, CARCINOMA PATIENTS, iNOS2, inducible nitric oxid synthase 2, law, GM-CSF/CSF2, granulocyte monocyte colony stimulating factor, ANTITUMOR IMMUNITY, GSH, glutathione, TGFβ, transforming growth factor β, Immunology and Allergy, Cytotoxic T cell, JAK2, Janus kinase 2, IN-VIVO, TCR, T cell receptor, gemcitabine, IL-1β, interleukin 1 β, NSAID, nonsteroidal anti-inflammatory drugs, c-kit, Mast/stem cell growth factor receptor, all-trans retinoic acid, TNFα, tumor necrosis factor α, IL-6, interleukin 6, mRCC, metastatic renal cell carcinoma, CCL2, chemokine (C-C motif) ligand 2, Oncology, VEGFR, vascular endothelial growth factor receptor, Tregs, regulatory T cells, CDDO-Me, bardoxolone methyl, ESTABLISHED TUMORS, DCs, dendritic cells, WITHANIA-SOMNIFERA, medicine.drug, MMPs, metalloproteinases (e.g., MMP9), CTLs, cytotoxic T lymphocytes, ERK1/2, extracellular signal-regulated kinases, FoxP3, forkhead box P3, 5-Fluorouracil, Immunology, sunitinib therapeutic vaccination, IFNγ, interferon γ, CANCER-PATIENTS, CD8(+) T-CELLS, Biology, ODN, oligodeoxynucleotides, RNS, reactive nitrogen species, ROS, reactive oxygen species, In vivo, IL-4, interleukin 4, TAMs, tumor-associated macrophages, medicine, PGE2, prostaglandin E2, WA, withaferin A, GITR, anti-glucocorticoid tumor necrosis factor receptor, bisphosphonates, CXCL15, chemokine (C-X-C motif) ligand 15, Flt3, Fms-like tyrosine kinase 3, WRE, Withaferin somnifera, NO, nitric oxide, immune suppressive mechanisms, HLA, human leukocyte antigen, SCF, stem cell factor, IMMUNOSUPPRESSIVE ACTIVITY, HSCs, hematopoietic stem cells, Cancer, COX2, cyclooxygenase 2, Immunotherapy, NADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cells, medicine.disease, myeloid-derived suppressor cells, HPV-16, human papillomavirus 16, ADAM17, metalloproteinase domain-containing protein 17, Gemcitabine, Blockade, TRANS-RETINOIC ACID, NOHA, N-hydroxy-L-Arginine, NAC, N-acetyl cysteine, Myeloid-derived Suppressor Cell, Suppressor, CXCL12, chemokine (C-X-C motif) ligand 12, 5-FU, 5-fluorouracil, HIF-1α, hypoxia inducible factor 1α, IL-10, interleukin 10, Myd88, myeloid differentiation primary response protein 88, ICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavone, IL-13, interleukin 13

الوصف: Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono- or multimodal-therapies that target MDSCs for the benefit of cancer treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d066a21e4c242e158360b8a1aa115a0Test
https://pubmed.ncbi.nlm.nih.gov/25949858Test

المؤلفون: Chong, Parkson L.

المساهمون: TEMPLE UNIV PHILADELPHIA PA

المصدر: DTIC

مصطلحات موضوعية: Biochemistry, Medicine and Medical Research, RESISTANCE(BIOLOGY), BREAST CANCER, GROWTH(PHYSIOLOGY), ANGIOGENESIS, CELLS(BIOLOGY), FATTY ACIDS, METASTASIS, CHOLESTEROL, PENETRATION, NEOPLASMS, TISSUES(BIOLOGY), CYCLOOXYGENASE, CANCER INVASION, MCF-7 CELLS, CELLULAR SIGNALING, COX2(CYCLOOXYGENASE 2), CYCLOOXYGENASE 2, AA(ARACHIDONIC ACID)

الوصف: Cyclooxygenase-2 (COX-2) and its product PGE2 are known to promote tumor growth and to enhance the penetration of cancer cells into adjacent tissues. Thus, knowing how the activity of COX2 is regulated at the cellular level has implications for breast cancer therapeutic strategies. The goal is to unravel a new molecular mechanism for regulating the activity of COX-2. In plasma membranes, arachidonic acid (AA) is released by phospholipase A2 (PLA2). COX then converts AA to prostaglandins. The activity of PLA2 is known to vary with cholesterol content in an alternating manner, showing a local minimum at critical sterol mole fractions for maximal superlattice formation. In this study, the cholesterol content in MCF-7 human breast cancer cells was depleted by using methyl-beta-cyclodextrin. A biphasic change in COX-2 activity was observed at certain cell cholesterol content Cr. The cholesterol content near Cr could serve as a fine-tuning mechanism to regulate COX-2 activity and PGE2 production, and consequently, cancer cell growth and metastasis. ; The original document contains color images.

وصف الملف: text/html

العلاقة: http://www.dtic.mil/docs/citations/ADA493736Test

الإتاحة: http://www.dtic.mil/docs/citations/ADA493736Test
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA493736Test

المصدر: DTIC

مستخلص: Cyclooxygenase-2 (COX-2) and its product PGE2 are known to promote tumor growth and to enhance the penetration of cancer cells into adjacent tissues. Thus, knowing how the activity of COX2 is regulated at the cellular level has implications for breast cancer therapeutic strategies. The goal is to unravel a new molecular mechanism for regulating the activity of COX-2. In plasma membranes, arachidonic acid (AA) is released by phospholipase A2 (PLA2). COX then converts AA to prostaglandins. The activity of PLA2 is known to vary with cholesterol content in an alternating manner, showing a local minimum at critical sterol mole fractions for maximal superlattice formation. In this study, the cholesterol content in MCF-7 human breast cancer cells was depleted by using methyl-beta-cyclodextrin. A biphasic change in COX-2 activity was observed at certain cell cholesterol content Cr. The cholesterol content near Cr could serve as a fine-tuning mechanism to regulate COX-2 activity and PGE2 production, and consequently, cancer cell growth and metastasis.
The original document contains color images.

مصطلحات الفهرس: Biochemistry, Medicine and Medical Research, RESISTANCE(BIOLOGY), BREAST CANCER, GROWTH(PHYSIOLOGY), ANGIOGENESIS, CELLS(BIOLOGY), FATTY ACIDS, METASTASIS, CHOLESTEROL, PENETRATION, NEOPLASMS, TISSUES(BIOLOGY), CYCLOOXYGENASE, CANCER INVASION, MCF-7 CELLS, CELLULAR SIGNALING, COX2(CYCLOOXYGENASE 2), CYCLOOXYGENASE 2, AA(ARACHIDONIC ACID), Text

URL: https://apps.dtic.mil/docs/citations/ADA493736Test