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31دورية أكاديمية
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32دورية أكاديمية
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33دورية أكاديمية
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34دورية أكاديميةAdditional file 1 of MARS: leveraging allelic heterogeneity to increase power of association testing
المؤلفون: Farhad Hormozdiari (510050), Junghyun Jung (6946745), Eleazar Eskin (108069), Jong Wha J. Joo (10732668)
مصطلحات موضوعية: Statistics, Association studies, Causal variants, Set-based association analysis
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35دورية أكاديميةAdditional file 6 of MARS: leveraging allelic heterogeneity to increase power of association testing
المؤلفون: Farhad Hormozdiari (510050), Junghyun Jung (6946745), Eleazar Eskin (108069), Jong Wha J. Joo (10732668)
مصطلحات موضوعية: Statistics, Association studies, Causal variants, Set-based association analysis
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36دورية أكاديمية
المؤلفون: R. V. Broekema, O. B. Bakker, I. H. Jonkers
المصدر: Open Biology, Vol 10, Iss 1 (2020)
مصطلحات موضوعية: genome-wide association study, fine-mapping, causal variants and genes, single-nucleotide polymorphisms, complex traits, polygenic diseases, Biology (General), QH301-705.5
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2046-2441Test
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37دورية أكاديميةGenetic variant effects on gene expression in human pancreatic islets and their implications for T2D
المؤلفون: Vinuela, Ana, Varshney, Arushi, van de Bunt, Martijn, Prasad, Rashmi B., Asplund, Olof, Bennett, Amanda, Boehnke, Michael, Brown, Andrew A., Erdos, Michael R., Fadista, Joao, Hansson, Ola, Hatem, Gad, Howald, Cedric, Iyengar, Apoorva K., Johnson, Paul, Krus, Ulrika, MacDonald, Patrick E., Mahajan, Anubha, Manning Fox, Jocelyn E., Narisu, Narisu, Nylander, Vibe, Orchard, Peter, Oskolkov, Nikolay, Panousis, Nikolaos I., Payne, Anthony, Stitzel, Michael L., Vadlamudi, Swarooparani, Welch, Ryan, Collins, Francis S., Mohlke, Karen L., Gloyn, Anna L., Scott, Laura J., Dermitzakis, Emmanouil T., Groop, Leif, Parker, Stephen C. J., McCarthy, Mark I.
المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, University Management
مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, TYPE-2 DIABETES RISK, BETA-CELL LINE, INSULIN-SECRETION, GLYCEMIC TRAITS, CAUSAL VARIANTS, OPEN CHROMATIN, MESSENGER-RNA, ARCHITECTURE, SIGNATURES, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology
وصف الملف: application/pdf
العلاقة: A.Vi. and E.T.D. were supported by EU IMI program (UE7-DIRECT-115317-1), NIH (NIH-R01-MH101814), and FNS funded project RNA1 (31003A_149984). A.Va. was supported by the American Association for University Women International Doctoral Fellowship, Barbour Doctoral Scholarship, and the University of Michigan Rackham Predoctoral Fellowship. M.v.d.B. was supported by a Novo Nordisk postdoctoral fellowship run in partnership with the University of Oxford. R.B.P. was supported by the EFSD/Novo Nordisk Programme for Diabetes Research in Europe, Diabetes Wellness (720-858-16 JDWG), angstrom ke Wiberg Foundation (M18-0216). L.G. was supported by the Swedish Research Council project grant (2015-2558) Swedish Research Council, Astra Zeneca (10033731), Strategic Research Area Exodiab, Dnr 2009-1039, Swedish Foundation for Strategic Research Dnr IRC15-0067, and the Swedish Research Council, Linnaeus grant, Dnr 349-2006-237. F.S.C., M.R.E., and N.N. were supported by NHGRI-ZIA HG000024. A.K.I., S.V., and K.L.M. were supported by NIH R01 DK072193 and NIH U01 DK105561. S.C.J.P., L.J.S., and M.B. were supported by U01DK062370. M.L.S. was supported by K99/R00DK092251. P.O. was supported by grant T32 HG00040 from the National Human Genome Research Institute of the NIH. P.E.M. was supported by a Foundation grant from the Canadian Institutes of Health Research (CIHR: 148451). S.C.J.P. was supported by National Institute of Diabetes and Digestive and Kidney Diseases grants R00 DK-099240 and R01 DK-117960, American Diabetes Association Pathway to Stop Diabetes grant 1-14-INI-7. The Alberta Diabetes Institute IsletCore was supported by the Alberta Diabetes Foundation. We thank the Human Organ Procurement and Exchange (HOPE) program and the Trillium Gift of Life Network (TGLN) for their efforts in obtaining human organs for research. A.L.G. is a Wellcome Senior Fellow in Basic Biomedical Science. This work was funded in Oxford by the Wellcome Trust (095101, 200837, 106130, 203141, Medical Research Council (MR/L020149/1), European Union Horizon 2020 Programme (T2D Systems), NIH (U01-DK105535; U01-DK085545) and by the EU IMI program (UE7-DIRECT-115317-1). M.I.Mc.C was a Wellcome Senior Investigator and an NIHR Senior Investigator. He was supported by the Wellcome Trust (grants nos. 090532, 106130, 098381, 203141, and 212259); Medical Research Council grant no. MR/L020149/1; NIDDK (U01-DK105535, R01-MH101814, and R01-MH090941); NIHR (NF-SI-0617-10090). This work was also supported by the Oxford NIHR Biomedical Research Centre. The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.; Vinuela , A , Varshney , A , van de Bunt , M , Prasad , R B , Asplund , O , Bennett , A , Boehnke , M , Brown , A A , Erdos , M R , Fadista , J , Hansson , O , Hatem , G , Howald , C , Iyengar , A K , Johnson , P , Krus , U , MacDonald , P E , Mahajan , A , Manning Fox , J E , Narisu , N , Nylander , V , Orchard , P , Oskolkov , N , Panousis , N I , Payne , A , Stitzel , M L , Vadlamudi , S , Welch , R , Collins , F S , Mohlke , K L , Gloyn , A L , Scott , L J , Dermitzakis , E T , Groop , L , Parker , S C J & McCarthy , M I 2020 , ' Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D ' , Nature Communications , vol. 11 , no. 1 , 4912 . https://doi.org/10.1038/s41467-020-18581-8Test; a072aa55-8617-4927-8f78-76786b1b1cd8; http://hdl.handle.net/10138/321023Test; 000577276800002
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38دورية أكاديمية
المؤلفون: Broekema, R. V., Bakker, O. B., Jonkers, I. H.
المصدر: Broekema , R V , Bakker , O B & Jonkers , I H 2020 , ' A practical view of fine-mapping and gene prioritization in the post-genome-wide association era ' , Open Biology , vol. 10 , no. 1 , 190221 . https://doi.org/10.1098/rsob.190221Test
مصطلحات موضوعية: genome-wide association study, fine-mapping, causal variants and genes, single-nucleotide polymorphisms, complex traits, polygenic diseases, TRANSCRIPTIONAL VARIATION, RISK PREDICTION, SINGLE-CELL, EXPRESSION, VARIANTS, DISEASE, IDENTIFICATION, RESPONSES, SNPS, GWAS
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1098/rsob.190221Test
https://hdl.handle.net/11370/8ab815ac-4d8c-4218-adc5-bda3b0b379a4Test
https://research.rug.nl/en/publications/8ab815ac-4d8c-4218-adc5-bda3b0b379a4Test
https://pure.rug.nl/ws/files/132894838/rsob.190221.pdfTest -
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المؤلفون: Wenmin Zhang, Hamed Najafabadi, Yue Li
مصطلحات موضوعية: Genetics, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, widespread linkage disequilibrium, underlying genetic architecture, summarizing posterior probabilities, reduced computation time, propose effective strategies, level causal configurations, high computational cost, multiple causal variants, identifying causal variants, five functional biomarkers, clinically relevant phenotypes, thus improve fine, integrating summary statistics, incorporate functional annotations, genome may help, div >< p, wide association studies, mapping methods conducting, functional annotations, prioritize variants, functional follow, biologically relevant, art methods, wide utility
الإتاحة: https://doi.org/10.1371/journal.pgen.1011104.s004Test
https://figshare.com/articles/dataset/Annotation_enrichment_weights_and_G-test_p-values_from_SparsePro_in_locus_simulations_/24914768Test -
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المؤلفون: Wenmin Zhang, Hamed Najafabadi, Yue Li
مصطلحات موضوعية: Genetics, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Information Systems not elsewhere classified, widespread linkage disequilibrium, underlying genetic architecture, summarizing posterior probabilities, reduced computation time, propose effective strategies, level causal configurations, high computational cost, multiple causal variants, identifying causal variants, five functional biomarkers, clinically relevant phenotypes, thus improve fine, integrating summary statistics, incorporate functional annotations, genome may help, div >< p, wide association studies, mapping methods conducting, functional annotations, prioritize variants, functional follow, biologically relevant, art methods, wide utility
الإتاحة: https://doi.org/10.1371/journal.pgen.1011104.s003Test
https://figshare.com/articles/dataset/Summary_of_AUPRC_in_locus_simulations_/24914765Test
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