المؤلفون: Cosoreanu, Andrada, Rusu, Emilia, Rusu, Florin, Stanciu, Silviu, Enache, Georgiana, Radulian, Gabriela

المصدر: Cureus ; ISSN:2168-8184 ; Volume:16 ; Issue:6

مصطلحات موضوعية: caucasian patients, chronic kidney disease, risk progression to dialysis, roma population, type 2 diabetes mellitus

الوصف: Background Chronic kidney disease (CKD) poses a significant health challenge among patients, contributing to substantial morbidity and mortality outcomes. However, there remains a paucity of data within the medical literature on the Roma population, one of the most significant minority groups globally, with studies indicating that these individuals are disproportionately affected by CKD compared to the general population, with higher prevalence rates. Materials and methods We conducted an observational, cross-sectional study from October 2022 to March 2024, evaluating 735 adult patients with type 2 diabetes mellitus, of which 402 were Roma, aged 18 to 89 years, following the hospital's standard protocols for diabetes management, at the "Nicolae Malaxa" Clinical Hospital in Bucharest, Romania, a tertiary care center for diabetes. Results The prevalence of CKD was higher among the Roma patients, reaching 56.50% (n=203), in comparison with the Caucasian group (43.50%, n=156), however, with a lower mean age (55.53±10.56 years versus 63.32±10.04 years). Roma patients with CKD had a higher prevalence of cardiovascular disease compared to Caucasians, including myocardial infarction, stroke, stable angina, and heart failure. Cardiovascular risk factors, such as hypertension, obesity, and dyslipidemia, in patients with CKD, were also more prevalent among the Roma population. Taking into consideration the natural progression of CKD, the anthropometric measurements and laboratory parameters stratified by ethnicity revealed that Roma patients in the very high risk of CKD progression category had a lower mean age, and a lower median duration of diabetes (56.37±10.79 versus 59.92±7.48 years, and 4.00±2.00 versus 10.00±10.30 years, respectively), as well as a more elevated mean waist circumference (WC), body mass index (BMI), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-c) compared to Caucasians. Moreover, patients in the very high risk of CKD progression category among both groups showed the highest level of insulin resistance, measured by the triglyceride-glucose (TyG) index (mean value of 10.13±0.60 among the Roma patients, and 10.09±0.82 among Caucasians). Among the study group, weight, WC, BMI, and A Body Shape Index (ABSI) were associated with a very high risk of progression of CKD. In Caucasian patients, it was demonstrated that weight, WC, BMI, ABSI, and triglycerides (TG) have contributed to the very high risk of progression of CKD, while among the Roma patients, no association was found. Conclusion In conclusion, our findings suggested a high prevalence of CKD among both groups. There is still a need for further investigation of additional risk factors, such as genetics, limited access to health education, and appropriate treatments that could synergistically accelerate the progression of CKD among Roma patients.

العلاقة: https://doi.org/10.7759/cureus.62118Test; https://pubmed.ncbi.nlm.nih.gov/38863771Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165289Test/

الإتاحة: https://doi.org/10.7759/cureus.62118Test
https://pubmed.ncbi.nlm.nih.gov/38863771Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165289Test/

المؤلفون: Sara Bravaccini, Sara Ravaioli, Dino Amadori, Emanuela Scarpi, Maurizio Puccetti, Andrea Rocca, Maria Maddalena Tumedei, Nestory Masalu, Jackson Kahima, Akwilina Pangan, Lucas Faustine, Alberto Farolfi, Roberta Maltoni, Massimiliano Bonafè, Patrizia Serra, Giuseppe Bronte

المصدر: Frontiers in Endocrinology, Vol 9 (2018)

مصطلحات موضوعية: androgen receptor, breast cancer, African patients, Caucasian patients, tumor subtypes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: PurposeAndrogen receptor (AR) has been shown to have prognostic implication on breast cancer (BC). Data on the biological features of African BCs are poor. We decided for the first time to compare AR expression of Tanzanian and Italian BC patients.Patients and methodsOf the 69 consecutive patients seen at the Bugando Medical Center (Mwanza, Tanzania) from 2003 to 2010, who underwent resection of primary BC evaluable for estrogen receptor, progesterone receptor (PgR), and HER2 only 65 were evaluable for AR by immunohistochemistry. Histopathological assessment and biomolecular determinations were performed at the Cancer Institute of Romagna [Istituto Scientifico Romagnolo per lo studio e la cura dei tumori (IRST)—IRCCS, Meldola, Italy]. Caucasian BC patients were selected from an electronic database and matched (1:2 ratio) for year of diagnosis and age at diagnosis.ResultsThe median age of patients at diagnosis was 51 (range 29–83) years for Tanzanian and 53 (range 26–86) years for Italian patients. Tanzanian patients harbored tumors with lower AR expression than Italian patients according to the median percentage of immunopositive tumor cells (30% versus 80%, p

وصف الملف: electronic resource

العلاقة: http://journal.frontiersin.org/article/10.3389/fendo.2018.00137/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/52890229fa16421f9097cab0972e0e0eTest

المؤلفون: Matteo Piga, Elisabetta Chessa, Eric F Morand, Manuel F Ugarte-Gil, Maria Tektonidou, Ronald van Vollenhoven, Michelle Petri, Laurent Arnaud, Simone Appenzeller, Cynthia Aranow, Anca Askanase, Tadej Avcin, Sang-Cheol Bae, George Bertsias, Eloisa Bonfa, Ernesto Cairoli, Mario H Cardiel, Ricard Cervera, François Chasset, Carlo Chizzolini, Ann E Clarke, Fabrizio Conti, Nathalie Costedoat-Chalumeau, László Czirják, Andrea Doria, Thomas Dörner, Gerard Espinosa, Rebecca Fischer-Betz, Mercedes Garcìa, Dafna D Gladman, Luis A González, Iva Gunnarsson, Laniyati Hamijoyo, John G Hanly, Sarfaraz A Hasni, Frédéric A Houssiau, Murat Inanç, Luís S Inês, David Isenberg, Soren Jacobsen, Yeong-Jian Jan Wu, Yuko Kaneko, Yasuhiro Katsumata, Chak S Lau, Alexandra C Legge, Karoline Lerang, Maarten Limper, Worawit Louthrenoo, Shue-Fen Luo, António Marinho, Loreto Massardo, Alexis Mathian, Marta Mosca, Mandana Nikpour, José M Pego-Reigosa, Christine A Peschken, Bernardo A Pons-Estel, Guillermo J Pons-Estel, Anisur Rahman, Simona Rednic, Camillo Ribi, Guillermo Ruiz-Irastorza, Emilia I Sato, Amit Saxena, Matthias Schneider, Gian Domenico Sebastiani, Vibeke Strand, Elisabet Svenungsson, Yoshiya Tanaka, Zoubida Tazi Mezalek, Michael L Tee, Angela Tincani, Zahi Touma, Anne Troldborg, Carlos Vasconcelos, Évelyne Vinet, Edward M Vital, Alexandre E Voskuyl, Anne Voss, Daniel Wallace, Michael Ward, Leonid D Zamora

المصدر: PISCOS Investigator Group 2022, ' Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus : the PISCOS study ', The Lancet Rheumatology, vol. 4, no. 6, pp. e441-e449 . https://doi.org/10.1016/S2665-9913Test(22)00107-2
Piga, M, Chessa, E, Morand, E F, Ugarte-Gil, M F, Tektonidou, M, van Vollenhoven, R, Petri, M, Arnaud, L & PISCOS Investigator Group 2022, ' Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus : the PISCOS study ', The Lancet Rheumatology, vol. 4, no. 6, pp. e441-e449 . https://doi.org/10.1016/S2665-9913Test(22)00107-2
Piga, M, Chessa, E, Morand, E F, Ugarte-Gil, M F, Tektonidou, M, van Vollenhoven, R, Petri, M, Arnaud, L, Appenzeller, S, Aranow, C, Askanase, A, Avcin, T, Bae, S C, Bertsias, G, Bonfa, E, Cairoli, E, Cardiel, M H, Cervera, R, Chasset, F, Chizzolini, C, Clarke, A E, Conti, F, Costedoat-Chalumeau, N, Czirják, L, Doria, A, Dörner, T, Espinosa, G, Fischer-Betz, R, Garcìa, M, Gladman, D D, González, L A, Gunnarsson, I, Hamijoyo, L, Hanly, J G, Hasni, S A, Houssiau, F A, Inanç, M, Inês, L S, Isenberg, D, Jacobsen, S, Jan Wu, Y J, Kaneko, Y, Katsumata, Y, Lau, C S, Legge, A C, Lerang, K, Limper, M, Louthrenoo, W, Luo, S F, Marinho, A & PISCOS Investigator Group 2022, ' Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus : the PISCOS study ', The Lancet Rheumatology, vol. 4, no. 6, pp. e441-e449 . https://doi.org/10.1016/S2665-9913Test(22)00107-2

مصطلحات موضوعية: DISEASE-ACTIVITY STATE, Rheumatology, ACTIVITY INDEX, Immunology, CAUCASIAN PATIENTS, SLE, Immunology and Allergy, FLARE, IMPACT TRACKER, REMISSION, DOUBLE-STRANDED DNA, MONOCENTRIC COHORT, ASSESSMENT PGA

الوصف: The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were rated, using a 0 (strongly disagree) to 10 (strongly agree) numerical rating scale. Statements with agreement of 75% or greater were selected and further validated by the expert panel. Consensus was reached on 27 statements, grouped in 14 recommendations, for the use of the PGA in SLE, design of the PGA scale, practical considerations for PGA scoring, and the relationship between PGA values and levels of disease activity. Among these recommendations, the expert panel agreed that the PGA should consist of a 0–3 visual analogue scale for measuring disease activity in patients with SLE in the preceding month. The PGA is intended to rate the overall disease activity, taking into account the severity of active manifestations and clinical laboratory results, but excluding organ damage, serology, and subjective findings unrelated to disease activity. The PGA scale ranges from “no disease activity” (0) to the “most severe disease activity” (3) and incorporates the values 1 and 2 as inner markers to categorise disease activity as mild (≥0·5 to 1), moderate (>1 and ≤2) and severe (>2 to 3). Only experienced physicians can rate the PGA, and it should be preferably scored by the same rater at each visit. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7f28a6249779d8eb25c8c72e590f03Test
https://research.vumc.nl/en/publications/8c7a10fe-b283-490a-a924-30561949034aTest

المؤلفون: Lightstone, L, Doria, A, Wilson, H, Ward, FL, Larosa, M, Bargman, JM

المساهمون: Arthritis Research UK

المصدر: 10 ; 4

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Immunology, Corticosteroids, Lupus nephritis, Management, Adverse events, MYCOPHENOLATE-MOFETIL, INTRAVENOUS CYCLOPHOSPHAMIDE, PULSE METHYLPREDNISOLONE, CONTROLLED-TRIAL, ACCELERATED ATHEROSCLEROSIS, RENAL-TRANSPLANTATION, MAINTENANCE THERAPY, CAUCASIAN PATIENTS, ORGAN DAMAGE, DOUBLE-BLIND, Adrenal Cortex Hormones, Humans, Immunosuppressive Agents, 1107 Immunology

الوصف: The outcome of lupus nephritis (LN) has changed since the introduction of glucocorticoids (GCs), which dramatically reduced the mortality related to one of the most severe complications of systemic lupus erythematosus (SLE). Since the 1950's, other immunosuppressants, including biologic drugs (i.e. rituximab) have aided in maintaining remission, preserving kidney function, but not preventing treatment-related toxicity. GCs still remain the cornerstone in the treatment of SLE, including LN, and they are widely used in clinical practice. However, GC administration represents a double-edged sword. Indeed, from one side they allow a fast and effective control of disease activity by dampening inflammation; from the other side, they have many and severe side effects leading to organ damage. In this paper, we will discuss pros and cons of the chronic use of GCs, especially focusing on LN.

العلاقة: Autoimmunity Reviews; http://hdl.handle.net/10044/1/61678Test; https://dx.doi.org/10.1016/j.autrev.2017.11.002Test; 20108

الإتاحة: https://doi.org/10.1016/j.autrev.2017.11.002Test
http://hdl.handle.net/10044/1/61678Test

المؤلفون: Piga, Matteo, Chessa, Elisabetta, Morand, Eric F., Ugarte-Gil, Manuel F., Tektonidou, Maria, van Vollenhoven, Ronald, Petri, Michelle, Arnaud, Laurent

المصدر: Piga , M , Chessa , E , Morand , E F , Ugarte-Gil , M F , Tektonidou , M , van Vollenhoven , R , Petri , M , Arnaud , L & PISCOS Investigator Group 2022 , ' Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus : the PISCOS study ' , The Lancet Rheumatology , vol. 4 , no. 6 , pp. e441-e449 . https://doi.org/10.1016/S2665-9913Test(22)00107-2

مصطلحات موضوعية: ACTIVITY INDEX, ASSESSMENT PGA, CAUCASIAN PATIENTS, DISEASE-ACTIVITY STATE, DOUBLE-STRANDED DNA, FLARE, IMPACT TRACKER, MONOCENTRIC COHORT, REMISSION, SLE

الوصف: The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were rated, using a 0 (strongly disagree) to 10 (strongly agree) numerical rating scale. Statements with agreement of 75% or greater were selected and further validated by the expert panel. Consensus was reached on 27 statements, grouped in 14 recommendations, for the use of the PGA in SLE, design of the PGA scale, practical considerations for PGA scoring, and the relationship between PGA values and levels of disease activity. Among these recommendations, the expert panel agreed that the PGA should consist of a 0–3 visual analogue scale for measuring disease activity in patients with SLE in the preceding month. The PGA is intended to rate the overall disease activity, taking into account the severity of active manifestations and clinical laboratory results, but excluding organ damage, serology, and subjective findings unrelated to disease activity. The PGA scale ranges from “no disease activity” (0) to the “most severe disease activity” (3) and incorporates the values 1 and 2 as inner markers to categorise disease activity as mild (≥0·5 to 1), moderate (>1 and ≤2) and severe (>2 to 3). Only experienced physicians can rate the PGA, and it should be preferably scored by the same rater at each visit. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials.

العلاقة: https://pure.au.dk/portal/en/publications/df44306a-5716-41fc-abdc-9ca15d376ebeTest

الإتاحة: https://doi.org/10.1016/S2665-9913Test(22)00107-2
https://pure.au.dk/portal/en/publications/df44306a-5716-41fc-abdc-9ca15d376ebeTest
http://www.scopus.com/inward/record.url?scp=85134577300&partnerID=8YFLogxKTest

المؤلفون: Seer, C, Lange, F, Georgiev, D, Jahanshahi, M, Kopp, B

المصدر: Neuroscience & Biobehavioral Reviews , 71 pp. 691-714. (2016)

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Behavioral Sciences, Neurosciences, Neurosciences & Neurology, Parkinson's disease, Cognition, Dementia, Executive function, Basal ganglia, Dopamine, Event-related potentials (ERPs), P3, P3a, P3b, MMN, NoGo-P3, N2, N-e/ERN, PROGRESSIVE SUPRANUCLEAR PALSY, MULTIPLE SYSTEM ATROPHY, VISUAL WORKING-MEMORY, AMYOTROPHIC-LATERAL-SCLEROSIS, AUDITORY SELECTIVE ATTENTION, MOVEMENT-RELATED POTENTIALS, FRONTAL-LOBE DYSFUNCTION, ERROR-RELATED NEGATIVITY, NON-CAUCASIAN PATIENTS, CHOICE-REACTION TASKS

الوصف: Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD), but the nature of cognitive changes varies considerably between individuals. According to the dual-syndrome hypothesis, one cluster of patients is characterized by deficits in executive function that may be related to fronto-striatal dysfunction. Other patients primarily show non-frontal cognitive impairments that progress rapidly to PD dementia (PDD). We provide a comprehensive review of event-related potential (ERP) studies to identify ERP measures substantiating the heterogeneity of cognitive impairment in PD. Our review revealed evidence for P3b and mismatch-negativity alterations in PDD, but not in non-demented PD, indicating that alterations of these ERPs constitute electrophysiological markers for PDD. In contrast, ERP correlates of executive functions, such as NoGo-P3, N2, and error(-related) negativity (Ne/ERN), appear to be attenuated in non-demented PD patients in a dopamine-dependent manner. Hence, ERP measures confirm and yield distinct electrophysiological markers for the heterogeneity of cognitive impairment in PD. We discuss limitations and open questions of the ERP approach and provide directions and predictions for future ERP research.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/1511980/1/Jahanshahi_ACCEPTED_Seer,%20Lange%20et%20al.%20%28in%20press%29%20Neurosci%20Biobehav%20Rev_afterProofreading20160906.pdfTest; https://discovery.ucl.ac.uk/id/eprint/1511980Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/1511980/1/Jahanshahi_ACCEPTED_Seer,%20Lange%20et%20al.%20%28in%20press%29%20Neurosci%20Biobehav%20Rev_afterProofreading20160906.pdfTest
https://discovery.ucl.ac.uk/id/eprint/1511980Test/

المؤلفون: Gijsberts, Crystel M., Seneviratna, Aruni, de Carvalho, Leonardo P., den Ruijter, Hester M., Vidanapthirana, Puwalani, Sorokin, Vitaly, Stella, Pieter, Agostoni, Pierfrancesco, Asselbergs, Folkert W., Richards, A. Mark, Low, Adrian F., Lee, Chi-Hang, Tan, Huay Cheem, Hoefer, Imo E., Pasterkamp, Gerard, de Kleijn, Dominique P. V., Chan, Mark Y.

المساهمون: Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Cardiologie, CDL Staf Research, CDL Arcadia, CDL Cluster Onderzoek en Onderwijs

مصطلحات موضوعية: ACUTE MYOCARDIAL-INFARCTION, SOUTH ASIANS, ARTERY-DISEASE, HEART-DISEASE, CAUCASIAN PATIENTS, UNITED-KINGDOM, MORTALITY, INTERVENTION, CHINESE, ATHEROSCLEROSIS, General Agricultural and Biological Sciences, General Biochemistry,Genetics and Molecular Biology, General Medicine

الوصف: Background In 2020 the largest number of patients with coronary artery disease (CAD) will be found in Asia. Published epidemiological and clinical reports are overwhelmingly derived from western (White) cohorts and data from Asia are scant. We compared CAD severity and all-cause mortality among 4 of the world's most populous ethnicities: Whites, Chinese, Indians and Malays. Methods The UNIted CORoNary cohort (UNICORN) simultaneously enrolled parallel populations of consecutive patients undergoing coronary angiography or intervention for suspected CAD in the Netherlands and Singapore. Using multivariable ordinal regression, we investigated the independent association of ethnicity with CAD severity and interactions between risk factors and ethnicity on CAD severity. Also, we compared all-cause mortality among the ethnic groups using multivariable Cox regression analysis. Results We included 1,759 White, 685 Chinese, 201 Indian and 224 Malay patients undergoing coronary angiography. We found distinct inter-ethnic differences in cardiovascular risk factors. Furthermore, the associations of gender and diabetes with severity of CAD were significantly stronger in Chinese than Whites. Chinese (OR 1.3 [1.1-1.7], p = 0.008) and Malay (OR 1.9 [1.4-2.6], p Conclusion In this population of individuals undergoing coronary angiography, ethnicity is independently associated with the severity of CAD and modifies the strength of association between certain risk factors and CAD severity. Furthermore, mortality differs among ethnic groups. Our data provide insight in inter-ethnic differences in CAD risk factors, CAD severity and mortality.

وصف الملف: image/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/332112Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/332112Test

المؤلفون: Parth A. Patel (11517744), Tae Jin Lee (11517747), Sai Karthik Kodeboyina (6398240), Garrett Jones (11517750), Kathryn Bollinger (5945738), Lane Ulrich (11517753), David Bogorad (11517756), Amy Estes (11517759), Wenbo Zhi (482439), Shruti Sharma (308114), Ashok Sharma (11517762)

مصطلحات موضوعية: Biochemistry, Medicine, peptide spectrum matches, human aqueous humor, heidelberg retinal tomography, specific alterations may, glaucomatous caucasian patients, low protein concentration, african american population, race revealed demographic, glaucoma incisional surgery, male poag patients, female poag patients, relative protein levels, apolipoprotein levels highlights, methods ah samples, apolipoprotein levels, specific variations, population variation, population differences, apolipoprotein family, ah ’, ah ), without poag, poag ), apoh levels, small volume, sample collection, race ), quantitative measure

الوصف: Additional file 1.

العلاقة: https://figshare.com/articles/dataset/Additional_file_1_of_Intra-population_differences_of_apolipoproteins_in_the_aqueous_humor/16727646Test

الإتاحة: https://doi.org/10.6084/m9.figshare.16727646.v1Test

المؤلفون: Krikelis, Dimitrios, Bobos, Mattheos, Karayannopoulou, Georgia, Resiga, Liliana, Chrysafi, Sofia, Samantas, Epaminontas, Andreopoulos, Dimitrios, Vasiliou, Vassilios, Ciuleanu, Elisabeta, Fountzilas, George

مصطلحات موضوعية: Nasopharyngeal carcinoma, Caucasian patients, Immunohistochemistry, Protein-expression profiling

الوصف: Background Since scarce data exist on the pathogenesis of nasopharyngeal carcinoma in Caucasian patients, we attempted to elucidate the responsible molecular pathways in this patient population. Methods Formalin-fixed paraffin-embedded tumor tissue samples from 107 patients, diagnosed with locally-advanced nasopharyngeal carcinoma and treated with chemotherapy or chemo-radiotherapy, were analyzed by immunohistochemistry for the expression of the following proteins: E-cadherin, P-cadherin, Fascin-1, Cyclin D1, COX-2, EGFR, VEGF-A, VEGF-C, VEGFR-2, VEGFR-3, ERCC1, p53, p63, Ki67, MAPT, phospho-p44/42MAPK, PTEN, phospho-AKT, phospho-mTOR, and phospho-GSK-3β. EBER status was assessed by in situ hybridization. The majority of the cases were included in tissue microarray. All stains were performed and assessed centrally by two pathologists. The median follow-up time was 76.8 (42.3 – 99.2) months. Results Biomolecules expressed in >90% of cases were: p53, COX-2, P-cadherin, EBER, phospho-GSK-3β, and Fascin-1. WHO II+III tumors were more frequently EBER & PTEN positive and VEGF-A negative. Advanced age was significantly associated with positive phospho-GSK-3β and ERCC1 expression; male gender with positive phospho-AKT and phospho-p44/42MAPK; and worse performance status (1 or 2) with negative Ki67, ERCC1, PTEN, and phospho-mTOR expression. Earlier disease stage was closely associated with p63, MAPT, PTEN, and Cyclin D1 positivity. Univariate Cox regression analysis highlighted Cyclin D1 as a negative prognostic factor for disease-free survival (p=0.034) and EBER as a positive one for overall survival (p=0.048). In multivariate analysis, advanced age and stage, poor performance status, and positive ERCC1 emerged as predictors of worse disease-free and overall survival, as opposed to positive phospho-mTOR. Clustering analysis defined two protein-expression groups being predictive of better overall survival (p=0.043). Conclusions Our study is the first to examine the activation and interaction of ...

العلاقة: http://www.biomedcentral.com/1472-6890/13/1Test

الإتاحة: http://www.biomedcentral.com/1472-6890/13/1Test

المؤلفون: N. L. Polissar, T. S. Hatsukami, C. Yuan

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://atvb.ahajournals.org/content/25/3/611.full.pdfTest.

مصطلحات موضوعية: Caucasian Patients

الوصف: The online version of this article, along with updated information and services, is located on the

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.582.5530Test; http://atvb.ahajournals.org/content/25/3/611.full.pdfTest

الإتاحة: http://atvb.ahajournals.org/content/25/3/611.full.pdfTest