المؤلفون: Richard A. Oram, Stefan Bilz, Eleonora Seelig, Timothy J. McDonald, Marc Y. Donath, Katharina Timper, R. Stoeckli, C. Falconnier

المصدر: Diabetesmetabolism. 42(6)

مصطلحات موضوعية: 0301 basic medicine, Adult, Blood Glucose, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Interleukin-1beta, 030209 endocrinology & metabolism, Antibodies, Monoclonal, Humanized, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Randomized controlled trial, law, Diabetes mellitus, Internal medicine, Insulin-Secreting Cells, Internal Medicine, medicine, Humans, Young adult, Glycated Hemoglobin, Type 1 diabetes, biology, C-Peptide, business.industry, Interleukin, General Medicine, Middle Aged, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 1, Monoclonal, Chronic Disease, biology.protein, Antibody, business, Antagonism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9844e4d3471d316f81661ca9dd42ceaTest
https://pubmed.ncbi.nlm.nih.gov/27720360Test

المؤلفون: A. Gessler, Juan Ruiz, C. Schindler, C. Falconnier Bendik, Natascha Moriconi, Ulrich Keller, Henryk Zulewski, Jardena J. Puder

المصدر: Diabetes Research and Clinical Practice. 83:327-333

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Hospitals, University, Endocrinology, Patient Education as Topic, Quality of life, Surveys and Questionnaires, Diabetes mellitus, Internal medicine, Outpatients, Internal Medicine, Humans, Insulin, Medicine, Outpatient clinic, Prospective Studies, education, Internal-External Control, Glycated Hemoglobin, Type 1 diabetes, education.field_of_study, Informed Consent, business.industry, Standard treatment, General Medicine, medicine.disease, Hypoglycemia, Self Care, Diabetes Mellitus, Type 1, Knowledge, Metabolic control analysis, Quality of Life, Physical therapy, business, Switzerland

الوصف: Intensified insulin therapy has evolved to be the standard treatment of type 1 diabetes. However, it has been reported to increase significantly the risk of hypoglycaemia. We studied the effect of structured group teaching courses in flexible insulin therapy (FIT) on psychological and metabolic parameters in patients with type 1 diabetes.We prospectively followed 45 type 1 diabetic patients of our outpatient clinic participating in 5 consecutive FIT teaching courses at the University Hospital of Basel. These courses consist of 7 weekly ambulatory evening group sessions. Patients were studied before and 1, 6, and 18 months after the course. Main outcome measures were glycated haemoglobin (HbA1c), severe hypoglycaemic events, quality of life (DQoL), diabetes self-control (IPC-9) and diabetes knowledge (DWT).Quality of life, self-control and diabetes knowledge improved after the FIT courses (all p0.001). The frequency of severe hypoglycaemic events decreased ten-fold from 0.33 episodes/6 months at baseline to 0.03 episodes/6 months after 18 months (p0.05). Baseline HbA1c was 7.2+/-1.1% and decreased in the subgroup with HbA1cor = 8% from 8.4% to 7.8% (p0.05).In an unselected, but relatively well-controlled population of type 1 diabetes, a structured, but not very time consuming FIT teaching programme in the outpatient setting improves psychological well-being and metabolic parameters.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e037078d84ad50d3a422db1f89a70dTest
https://doi.org/10.1016/j.diabres.2008.11.034Test

المؤلفون: Ch. R. Meier, C. Falconnier Bendik

المصدر: Praxis. 92:241-243

مصطلحات موضوعية: General Medicine

الوصف: Ein Vitamin D-Mangel ist keine Seltenheit und kommt auch in Mitteleuropa häufig vor. Ursachen einer Vitamin D bedingten Stoffwechselstörung mit konsekutivem sekundären Hyperparathyreoidismus sind neben der ungenügenden Sonnenexposition eine Malnutrition, eine intestinale Malabsorption oder eine Niereninsuffizienz. McKenny [6] schätzte sogar, dass 40% der Erwachsenen während der Wintermonate ein entsprechendes Defizit aufweisen. Da aus verschiedenen Gründen eine intensivere Sonnenlicht-Exposition nicht empfohlen werden kann (z.B. wegen der Gefahr von Hauttumoren oder aus religiösen Gründen) muss auf eine genügende orale Vitamin D Aufnahme geachtet werden, wahrscheinlich im Bereich von 600–800 IU täglich, was in Risikogruppen (z.B. ältere Personen) oft nur mittels Supplementierung erreicht werden kann.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3a1bc00677d2f3019804f79db2e71db4Test
https://doi.org/10.1024/0369-8394.92.6.241Test

المؤلفون: Bendik, C. Falconnier, Keller, U., Moriconi, N., Gessler, A., Schindler, Ch, Zulewski, H., Ruiz, J., Puder, J. J.

الوصف: AIM: Intensified insulin therapy has evolved to be the standard treatment of type 1 diabetes. However, it has been reported to increase significantly the risk of hypoglycaemia. We studied the effect of structured group teaching courses in flexible insulin therapy (FIT) on psychological and metabolic parameters in patients with type 1 diabetes. METHODS: We prospectively followed 45 type 1 diabetic patients of our outpatient clinic participating in 5 consecutive FIT teaching courses at the University Hospital of Basel. These courses consist of 7 weekly ambulatory evening group sessions. Patients were studied before and 1, 6, and 18 months after the course. Main outcome measures were glycated haemoglobin (HbA1c), severe hypoglycaemic events, quality of life (DQoL), diabetes self-control (IPC-9) and diabetes knowledge (DWT). RESULTS: Quality of life, self-control and diabetes knowledge improved after the FIT courses (all p or = 8% from 8.4% to 7.8% (p>0.05). CONCLUSIONS: In an unselected, but relatively well-controlled population of type 1 diabetes, a structured, but not very time consuming FIT teaching programme in the outpatient setting improves psychological well-being and metabolic parameters

العلاقة: Bendik, C. Falconnier and Keller, U. and Moriconi, N. and Gessler, A. and Schindler, Ch and Zulewski, H. and Ruiz, J. and Puder, J. J. (2009) Training in flexible intensive insulin therapy improves quality of life, decreases the risk of hypoglycaemia and ameliorates poor metabolic control in patients with type 1 diabetes. Diabetes research and clinical practice : affiliated with the International Diabetes Federation and published in collaboration with the Western Pacific Region of IDF, Vol. 83, H. 3. pp. 327-333.; info:pmid/19128852; urn:ISSN:0168-8227

الإتاحة: https://doi.org/10.1016/j.diabres.2008.11.034Test
http://edoc.unibas.ch/dok/A5843363Test
https://edoc.unibas.ch/19521Test/

المؤلفون: C Falconnier, Bendik, Ch, Meier

المصدر: Praxis. 92(6)

مصطلحات موضوعية: Lumbar Vertebrae, Time Factors, Pain, Middle Aged, Vitamin D Deficiency, Clothing, Diagnosis, Differential, Thigh, Osteomalacia, Sunlight, Humans, Calcium, Female, Hyperparathyroidism, Secondary, Vitamin D, Spondylitis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::f1e07e8c53ff7f2027ad3e4540a8bb7dTest
https://pubmed.ncbi.nlm.nih.gov/12645387Test

المؤلفون: C, Falconnier, A, Kress

المصدر: Europe PubMed Central

مصطلحات موضوعية: Organelles, Microscopy, Electron, Biometry, Time Factors, Ovarian Follicle, Oocytes, Animals, Golgi Apparatus, Female, Opossums, Endoplasmic Reticulum, Mitochondria, Research Article

الوصف: The growth of the opossum Monodelphis oocyte does not correspond to the strict biphasic pattern so far described in eutherians and marsupials. The oocyte increases appreciably in size during the last stage of antral follicle development. During the primordial and primary follicle stage Balbiani bodies or paranuclear complexes are not detectable in Monodelphis oocytes. Organelles are randomly distributed. In addition to the nucleolus, perichromatin and ribonucleoprotein particles are other intranuclear structures which occur as regular components in the early Monodelphis oocyte. Clusters of particles are mostly seen in close association with the nuclear envelope. Similar material has been encountered in the cytoplasm as a type of freely-existing 'nuage' material but never as mitochondria-associated 'nuage' or 'cement'. Both types of particles, intranuclear and cytoplasmic, disappear by the time antral follicle formation begins. Mitochondria are at first of the typical transformed shape seen in most mammalian oocytes. They are large, round or oval in outline with a few, often arched, cristae and a light matrix. During the primary follicle stage, mitochondrial size and complexity decrease and the matrix becomes electron dense. A close relationship between mitochondria and endoplasmic reticulum appears early in the primordial and later in the primary follicle oocyte. Regularly detected structures in the ooplasm of preantrum oocytes are paired or 'confronting' cisternae of endoplasmic reticulum, which are lamellar complexes comprised of 2 or more parallel cisternae with intervening electron-dense material. The most conspicuous inclusions in the Monodelphis oocytes of the tertiary and graafian follicles are vesicles. All other organelles are confined to the peripheral zone of the oocyte. Golgi and endoplasmic vesicles both take part in the formation of multivesicular bodies which seems to be the starting point for the vesicle accumulation. Further increase in size involves the incorporation of endocytotic vesicles and the coalescence of larger vesicles. Ordinary fixation procedure leave the vesicles empty. Cortical granules are found only in small numbers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a82c414b575f72590f431bd09a435ce6Test
http://europepmc.org/abstract/med/1304586Test