المؤلفون: Englert, Kimberly, Ruedy, Katrina, Coffey, Julie, Caswell, Kimberly, Steffen, Amy, Levandoski, Lucy, Tsalikian, Eva, Tansey, Michael J., Cabbage, Joanne, Salamati, Sara, Mauras, Nelly, Fox, Larry A., Permuy, Joe, Sikes, Kaitlin, Buckingham, Bruce A., Wilson, Darrell M., Clinton, Paula, Weinzimer, Stuart A., Tamborlane, William V., Sherr, Jennifer, Weyman, Kate, Zgorski, Melinda, Tichy, Eileen, White, Neil H., Arbelaez, Ana Maria, Starnes, Angie, Beck, Roy W., Ruedy, Katrina J., Kollman, Craig, Xing, Dongyuan, Hall, Callyn, Stevens, Beth, Grave, Gilman D., Winer, Karen K., Leschek, Ellen, Becker, Dorothy M., Cleary, Patricia, Greenbaum, Carla, Moran, Antoinette, Steffes, Michael W., Bucksa, Jean M., Nowicki, Maren L., Makky, Vicky

المصدر: Journal of Diabetes Science and Technology ; volume 8, issue 4, page 745-751 ; ISSN 1932-2968 1932-2968

الوصف: Background: The purpose of this article is to describe challenges associated with successful use of continuous glucose monitoring (CGM) by young children with type 1 diabetes (T1D) and to detail the techniques and products used to improve the duration of sensor wear. Methods: The DirecNet Study Group conducted 2 studies in 169 children with T1D between the ages of 1 and 9 years who were instructed to wear a CGM device daily. Problems related to skin irritation and sensor adhesiveness in these young children presented challenges to daily use of the CGM. Study coordinators instituted a variety of techniques using commercially available products to attempt to overcome these problems. Results: Three primary factors that contributed to reduced CGM use were identified: the limited body surface area in smaller children, ambient temperature and humidity, as well as the type and duration of physical activity. Using supplemental products to minimize the impact of these factors resulted in improved adherence and reduced skin irritation. Conclusion: Achieving satisfactory adhesion of the CGM sensor and transmitter may involve finding the right supplemental product or combination of products through trial and error. Optimizing adhesion and minimizing skin irritation can significantly improve duration of use and tolerability of CGM devices by young children.

الإتاحة: https://doi.org/10.1177/1932296814529893Test

المؤلفون: Jacobs, Ellis, Tolnai, Judit, Joynes, Judy Ostrom, Bucksa, Jean M., Idzorek, Julie, Tideman, Ann M.

المصدر: Laboratory Medicine ; volume 30, issue 3, page 203-206 ; ISSN 0007-5027 1943-7730

مصطلحات موضوعية: Biochemistry (medical), Clinical Biochemistry

الإتاحة: https://doi.org/10.1093/labmed/30.3.203Test
http://academic.oup.com/labmed/article-pdf/30/3/203/7618262/labmed30-0203.pdfTest

المؤلفون: Al-Kateb, Hussam, Boright, Andrew P, Mirea, Lucia, Xie, Xinlei, Sutradhar, Rinku, Mowjoodi, Alireza, Bharaj, Bhupinder, Liu, Michelle, Bucksa, Jean M, Arends, Valerie L, Steffes, Michael W, Cleary, Patricia A, Sun, Wanjie, Lachin, John M, Thorner, Paul S, Ho, Michael, McKnight, Amy Jayne, Maxwell, A Peter, Savage, David A, Kidd, Kenneth K, Kidd, Judith R, Speed, William C, Orchard, Trevor J, Miller, Rachel G, Sun, Lei, Bull, Shelley B, Paterson, Andrew D, Maxwell, Alexander

المصدر: Al-Kateb , H , Boright , A P , Mirea , L , Xie , X , Sutradhar , R , Mowjoodi , A , Bharaj , B , Liu , M , Bucksa , J M , Arends , V L , Steffes , M W , Cleary , P A , Sun , W , Lachin , J M , Thorner , P S , Ho , M , McKnight , A J , Maxwell , A P , Savage , D A , Kidd , K K , Kidd , J R , Speed , W ....

مصطلحات موضوعية: /dk/atira/pure/subjectarea/asjc/2700/2712, name=Endocrinology, Diabetes and Metabolism, /dk/atira/pure/subjectarea/asjc/2700/2724, name=Internal Medicine, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes.

العلاقة: https://pure.qub.ac.uk/en/publications/01acc6c0-a26a-477a-bc34-56f3a0a5b304Test

الإتاحة: https://doi.org/10.2337/db07-1059Test
https://pure.qub.ac.uk/en/publications/01acc6c0-a26a-477a-bc34-56f3a0a5b304Test

المؤلفون: Wallace, Jane F., Pugia, Michael J., Lott, John A., Luke, Karl E., Shihabi, Zak K., Sheehan, Michael, Bucksa, Jean M.

المصدر: Journal of Clinical Laboratory Analysis ; volume 15, issue 5, page 231-235 ; ISSN 0887-8013 1098-2825

الوصف: The goal of our study was to perform a multisite evaluation of a new urine dipstick called Multistix PRO™ (Bayer, Elkhart, IN), which has reagent pads for the simultaneous assay of urinary albumin, protein, and creatinine. Patients’ urine specimens were assayed at four sites with these dipsticks and with the familiar Bayer Multistix® 10SG dipsticks for protein. The new dipstick pads for albumin are impregnated with bis (3′,3″‐diiodo‐4′,4″‐dihydroxy‐5′,5″‐dinitrophenyl)‐3,4,5,6‐tetrabromo‐sulfonephthalein (DIDNTB) dye. These dipsticks also have a novel pad that estimates urinary creatinine using the peroxidase activity of the copper‐creatinine complex. We determined the interlaboratory agreement of these dipsticks by comparing dipstick results to values obtained by quantitative analytical methods. We found that dividing the dipsticks’ albumin or protein results by the creatinine concentration reduced the number of false‐positive albumin or protein values observed in concentrated urines, and reduced the number of false negatives in dilute urines. The ratio of albumin to creatinine, or protein to creatinine gives a better measure of albumin or protein excretion. Compared to reading by eye, the dipstick results agreed better with the quantitative assays when they were read by a reflectometer (Bayer Clinitek). J. Clin. Lab. Anal. 15:231–235, 2001. © 2001 Wiley‐Liss, Inc.

الإتاحة: https://doi.org/10.1002/jcla.1032Test

المؤلفون: Pugia, Michael J., Wallace, Jane F., Lott, John A., Sommer, Ronald, Luke, Karl E., Shihabi, Zak K., Sheehan, Michael, Bucksa, Jean M.

المصدر: Journal of Clinical Laboratory Analysis ; volume 15, issue 5, page 295-300 ; ISSN 0887-8013 1098-2825

الوصف: We tested patients’ urines for albumin, protein, and creatinine by quantitative and dipstick methods. The concentrations of these analytes were established by quantitative, cuvet‐based chemistry methods that we assumed gave the “correct” values. There was good to excellent agreement of the dipstick results with the quantitative methods for the above three analytes. We found many patients who excreted pathological amounts of albumin and/or protein who did not have a diagnosis of kidney disease or other likely causes of proteinuria, suggesting that albuminuria and/or proteinuria were underdiagnosed in our group of patients. Those with cardiovascular disease, kidney disease, or diabetes showed the greatest predictive value of a positive test for albumin or protein by dipstick. Dipstick testing for albumin, protein, and creatinine had good or excellent agreement with quantitative methods. The dipstick tests were easy to use, simple, and low in cost, and can serve well for point‐of‐care testing. J. Clin. Lab. Anal. 15:295–300, 2001. © 2001 Wiley‐Liss, Inc.

الإتاحة: https://doi.org/10.1002/jcla.1040Test

المؤلفون: Al-Kateb, Hussam, Boright, Andrew P., Mirea, Lucia, Xie, Xinlei, Sutradhar, Rinku, Mowjoodi, Alireza, Bharaj, Bhupinder, Liu, Michelle, Bucksa, Jean M., Arends, Valerie L., Steffes, Michael W., Cleary, Patricia A., Sun, Wanjie, Lachin, John M., Thorner, Paul S., Ho, Michael, McKnight, Amy Jayne, Maxwell, A. Peter, Savage, David A., Kidd, Kenneth K.

المصدر: Diabetes; Jan2008, Vol. 57 Issue 1, p218-228, 11p, 1 Color Photograph, 5 Charts, 2 Graphs

مصطلحات موضوعية: GENES, DIABETIC nephropathies, SUPEROXIDE dismutase, SERINE, ALANINE

مستخلص: BACKGROUND--Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes. RESEARCH DESIGN AND METHODS--We performed an individual-based genetic association study with time to renal and retinal outcomes in 1,362 white probands with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Specifically, we genotyped 1,411 SNPs that capture common variations in 212 candidate genes for long-term complications and analyzed them for association with the time from DCCT baseline to event for renal and retinal outcomes using multivariate Cox proportion hazards models. To address multiple testing and assist interpretation of the results, false discovery rate q values were calculated separately for each outcome. RESULTS--We observed association between rs17880135 in the 3′ region of superoxide dismutase 1 (SOD1) and the incidence of both severe nephropathy (hazard ratio [HR] 2.62 [95% CI 1.64-4.18], P = 5.6 x 10^-5, q = 0.06) and persistent microalbuminuria (1.82 [1.29-2.57], P = 6.4 x 10^-4, q = 0.46). Sequencing and fine-mapping identified additional SOD1 variants, including rs202446, rs9974610, and rs204732, which were also associated (P < 10^-3) with persistent microalbuminuria, whereas rs17880135 and rs17881180 were similarly associated with the development of severe nephropathy. Attempts to replicate the findings in three cross-sectional case-control studies produced equivocal results. We observed no striking differences between risk genotypes in serum SOD activity, serum SOD1 mass, or SOD1 mRNA expression in lymphoblastoid cell lines. CONCLUSIONS--Multiple variations in SOD1 are significantly associated with persistent microalbuminuria and severe nephropathy in the DCCT/EDIC study. Diabetes 57:218-228, 2008 [ABSTRACT FROM AUTHOR]

: Copyright of Diabetes is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Buckingham, Bruce A., Wilson, Darrell M., Bucksa, Jean M., Kunselman, Elizabeth L., Tamborlane, William V., Doyle, Elizabeth A.

المصدر: Diabetes Care; Mar2004, Vol. 27 Issue 3, p722-726, 5p, 2 Charts

مصطلحات موضوعية: MEDICAL equipment, GLUCOSE, HYPOGLYCEMIA, DIABETES, TEENAGERS

مستخلص: The goal of this study was to assess the accuracy of the GlucoWatch G Biographer (GW2B) and the continuous glucose monitoring system (CGMS) during hypoglyce mia m children and adolescents with type 1 diabetes. During hypoglycemia, the median absolute difference between the 192 GW2 reference glucose pairs was 26 mg/dl and between the 401 CGMS reference glucose pairs was mg/dl with 31 and 42%, respectively, of the sensor values within 15 mg/dl of the reference glucose. Sensitivity to detect hypoglycemia when the GW2B alarm level was set to 60 mg/dl was 23 % with a false false-rate of 51%. Analyses suggested that modified CGMS sensors that became available in November 2002 might be more accurate than the original CGMS sensors (media absolute difference 15 vs. 20 mg/dl). These data show that the GW2B and the CGMS do not reliably detect hypoglycemia. Both of these devices perform better at higher glucose levels, suggesting they may be more useful in reducing HbA1c levels than in detecting hypoglycemia. [ABSTRACT FROM AUTHOR]

: Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)