المؤلفون: Erdogmus, E., Freedland, J., Jording, A., Kousgaard, A., Buckley, C. M.

المصدر: AEI 2013

الإتاحة: https://doi.org/10.1061/9780784412909.084Test

المؤلفون: Buckley, C. M., Madden, J., Balanda, K., Barron, S., Fahy, L., Harrington, J., Perry, I. J., M. Kearney, P.

المصدر: Diabetic Medicine ; volume 30, issue 10, page 1198-1203 ; ISSN 0742-3071 1464-5491

الوصف: Objectives Pre‐diabetes is an important indicator of future diabetes burden and many countries are reporting prevalence estimates of pre‐diabetes. To date in Ireland, estimates of the prevalence of pre‐diabetes were unavailable. Our objectives were to estimate the prevalence of pre‐diabetes in a nationally representative sample of Irish adults and to explore determinants of pre‐diabetes. Methods The Survey of Lifestyle Attitudes and Nutrition 2007 was a cross‐sectional survey on health and lifestyle in a nationally representative sample of Irish adults. Analysis was performed on a subsample of 1132 participants ≥ 45 years who provided blood samples. Determination of pre‐diabetes was based on American Diabetes Association HbA 1c cut points of 39–46 mmol/mol (5.7–6.4%). To explore determinants, we modelled pre‐diabetes prevalence as a function of a set of health system and socio‐demographic variables using logistic regression. Results The overall weighted prevalence estimate of pre‐diabetes in participants ≥ 45 years was 19.8% (95% CI 16.4–23.9). There was no significant difference between age or gender‐specific prevalence rates. Obesity was significantly associated with pre‐diabetes on univariate and multivariate analysis. Population attributable fraction estimates for excess BMI , physical inactivity and poor diet as causes of pre‐diabetes were 31.3% (95% CI –3.9 to 54.5), 10.0% (95% CI –2.7 to 21.3) and 6.1% (95% CI –4.9 to 15.9), respectively. Conclusions The high levels of pre‐diabetes detected in this study are worrying. Population level interventions to address diet and lifestyle factors are needed urgently to prevent progression to diabetes in high‐risk individuals.

الإتاحة: https://doi.org/10.1111/dme.12226Test

المؤلفون: Buckley, C M., Beekley, M D., Layton, B, Crowder, T A.

المصدر: Medicine & Science in Sports & Exercise ; volume 35, issue Supplement 1, page S89 ; ISSN 0195-9131

الإتاحة: https://doi.org/10.1097/00005768-200305001-00492Test
https://journals.lww.com/00005768-200305001-00492Test

المؤلفون: Tracey, M. L., McHugh, S. M., Buckley, C. M., Canavan, R. J., Fitzgerald, A. P., Kearney, P. M.

المصدر: Diabetic Medicine; Apr2016, Vol. 33 Issue 4, p441-445, 5p, 1 Chart

مصطلحات موضوعية: TYPE 2 diabetes diagnosis, TYPE 2 diabetes complications, AGING, BLOOD pressure measurement, CHOLESTEROL, CONFIDENCE intervals, PEOPLE with diabetes, HIGH density lipoproteins, HEALTH insurance, LOW density lipoproteins, METROPOLITAN areas, TYPE 2 diabetes, RESEARCH funding, RURAL conditions, SURVEYS, DATA analysis, BODY mass index, CROSS-sectional method, PATIENT selection, WAIST circumference

مصطلحات جغرافية: IRELAND

مستخلص: Aim To investigate the prevalence of diagnosed Type 2 diabetes and its related complications in a nationally representative sample of older adults in the Republic of Ireland. Methods Cross-sectional analysis of a population-based sample of adults aged ≥ 50 years from the first wave of The Irish Longitudinal Study on Ageing ( TILDA), (2009-2011). Diagnosed Type 2 diabetes prevalence was estimated by self-report or the use of oral hypoglycaemic agents. The prevalence of microvascular and macrovascular complications was determined by self-report. Results Diagnosed Type 2 diabetes prevalence was 8.4% [95% confidence interval ( CI): 7.8-9.0%] and was higher among men [10.3% (95% CI: 9.4-11.2%)] than women [6.6% (95% CI: 5.9-7.5%)]; P ≤ 0.001. Among participants with diagnosed Type 2 diabetes, the overall prevalence of microvascular complications was 26.0% (95% CI: 22.4-30.0%) with no evidence of gender-specific differences ( P = 0.7). The overall prevalence of macrovascular complications was 15.1% (95% CI: 12.2-18.4%) and was higher among men [17.8% (95% CI: 14.3-23.1%)] than women [11.4% (95% CI: 7.7-16.4%)]; P ≤ 0.001. Conclusions In the absence of a national diabetes register, these findings provide a robust estimate of the national prevalence of diagnosed Type 2 diabetes and level of complications among adults aged 50 years and over in Ireland. [ABSTRACT FROM AUTHOR]

: Copyright of Diabetic Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Buckley, Jonathan D., Pendergrass, Thomas W., Buckley, Constance M., Pritchard, Douglas J., Nesbit, Mark E., Provisor, Arthur J., Robison, Leslie L., Buckley, J D, Pendergrass, T W, Buckley, C M, Pritchard, D J, Nesbit, M E, Provisor, A J, Robison, L L

المصدر: Cancer (0008543X); Oct1998, Vol. 83 Issue 7, p1440-1448, 9p

المؤلفون: Martínez-Mier, E. A., Soto-Rojas, A. E., Buckley, C. M., Margineda, J., Zero, D. T.

المصدر: Community Dental Health; Dec2009, Vol. 26 Issue 4, p204-210, 7p, 3 Charts

مستخلص: Objective: The aim of this study was to assess methods currently used for analyzing fluoridated salt in order to identify the most useful method for this type of analysis. Basic research design: Seventy-five fluoridated salt samples were obtained. Samples were analyzed for fluoride content, with and without pretreatment, using direct and diffusion methods. Element analysis was also conducted in selected samples. Fluoride was added to ultra pure NaCl and non-fluoridated commercial salt samples and Ca and Mg were added to fluoride samples in order to assess fluoride recoveries using modifications to the methods. Results: Larger amounts of fluoride were found and recovered using diffusion than direct methods (96%-100% for diffusion vs. 67%-90% for direct). Statistically significant differences were obtained between direct and diffusion methods using different ion strength adjusters. Pretreatment methods reduced the amount of recovered fluoride. Determination of fluoride content was influenced both by the presence of NaCl and other ions in the salt. Conclusion: Direct and diffusion techniques for analysis of fluoridated salt are suitable methods for fluoride analysis. The choice of method should depend on the purpose of the analysis. [ABSTRACT FROM AUTHOR]

: Copyright of Community Dental Health is the property of Dennis BarberJournals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Buckley, C. M.

المصدر: Social Science Quarterly, 1968 Sep 01. 49(2), 380-381.

العلاقة: Churches and States: The Religious Institution and Modernization Kalman S. Silvert

الوصول الحر: https://www.jstor.org/stable/42858374Test

المؤلفون: Buckley, C. M., Day, R.

المصدر: Technical Innovation and British Economic Performance ; page 252-266 ; ISBN 9780333333815 9781349063819

الإتاحة: https://doi.org/10.1007/978-1-349-06381-9_14Test

المؤلفون: Surrey, A. J., Buckley, C. M., Robson, M. J.

المصدر: Technical Innovation and British Economic Performance ; page 235-251 ; ISBN 9780333333815 9781349063819

الإتاحة: https://doi.org/10.1007/978-1-349-06381-9_13Test

المؤلفون: Buckley, N J, Bonner, T I, Buckley, C M, Brann, M R

المصدر: Molecular Pharmacology; April 1989, Vol. 35 Issue: 4 p469-476, 8p

مستخلص: A family of five cholinergic muscarinic receptor genes (m1, m2, m3, m4, and m5) has recently been identified and cloned. In order to investigate the pharmacological properties of the individual muscarinic receptors, we have transfected each of these genes into Chinese hamster ovary cells (CHO-K1) and have established stable cell lines expressing each receptor. In the present study we have examined the antagonist binding properties of each muscarinic receptor. Antagonists were chosen that had previously been proposed to be selective for muscarinic receptor subtypes and included pirenzepine, AF-DX 116, methoctramine, dicyclomine, hexohydrodifenidol, hexahydrosiladifenidol, hexocyclium, and silahexocyclium. m1, m2, and m3 receptors express binding properties similar to those expected of high affinity pirenzepine-type receptors of cerebral cortex ("M1"), low affinity pirenzepine-type receptors of atria ("M2 cardiac type"), and the intermediate affinity pirenzepine-type receptors found in exocrine glands ("M2 glandular type"), respectively. The M1/M2 schema cannot readily accommodate the binding properties of the m4 and m5 receptors. Pirenzepine, methoctramine, and hexahydrosiladifenidol were the most selective agents for the m1, m2, and m3 receptors, respectively. None of the antagonists used in this study were uniquely selective for either the m4 or m5 receptors. The diverse binding profiles of individual cloned receptors and the widespread distribution of m1-m4 mRNAs indicate that radioligand binding studies performed on primary tissues may actually be assessing the composite properties of a heterogeneous mixture of muscarinic receptor subtypes.