المؤلفون: Chandramohan, Arun, Josien, Hubert, Yuen, Tsz Ying, Duggal, Ruchia, Spiegelberg, Diana, 1982, Yan, Lin, Juang, Yu-Chi Angela, Ge, Lan, Aronica, Pietro G., Kaan, Hung Yi Kristal, Lim, Yee Hwee, Peier, Andrea, Sherborne, Brad, Hochman, Jerome, Lin, Songnian, Biswas, Kaustav, Nestor, Marika, 1976, Verma, Chandra S., Lane, David P., Sawyer, Tomi K., Garbaccio, Robert, Henry, Brian, Kannan, Srinivasaraghavan, Brown, Christopher J., Johannes, Charles W., Partridge, Anthony W.

المصدر: Nature Communications. 15(1)

الوصف: Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflows for identifying stapled peptides against Mdm2(X) with in vivo activity and no off-target effects. Key insights include a clear correlation between lipophilicity and permeability, removal of positive charge to avoid off-target toxicities, judicious anionic residue placement to enhance solubility/behavior, optimization of C-terminal length/helicity to enhance potency, and optimization of staple type/number to avoid polypharmacology. Workflow application gives peptides with >292x improved cell proliferation potencies and no off-target cell proliferation effects ( > 3800x on-target index). Application of these ‘design rules’ to a distinct Mdm2(X) peptide series improves ( > 150x) cellular potencies and removes off-target toxicities. The outlined workflow should facilitate therapeutic impacts, especially for those targets such as Mdm2(X) that have hydrophobic interfaces and are targetable with a helical motif.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521843Test
https://doi.org/10.1038/s41467-023-43346-4Test
https://uu.diva-portal.org/smash/get/diva2:1832324/FULLTEXT01.pdfTest

المؤلفون: Brown, Christopher J.

مصطلحات موضوعية: Architecture, United States Embassy, Havana, Cuba, Embassy Design, Government Building Design, Diplomacy Architecture, Transparent Architecture

الوصف: United States embassies are essential to managing the everyday diplomatic relations with countries around the world. These buildings which are located in foreign countries are representative of the United States and provide a presence abroad. Embassies are a base of communication or a point of contact between two countries that is used to preserve diplomatic relations between the host country and the country being represented. The United States' collection of embassies has allowed the nation to develop strong relations with nearly every country. However, the emphasis of these buildings has been placed on efficiency and security in recent years. This design approach which put security first, promotes separation and isolation rather than uniting an embassy with its host country.

الإتاحة: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1584015607111365Test

المؤلفون: Bates, Amanda E., Davies, Megan A., Stuart-Smith, Rick D., Lazzari, Natali, Lefcheck, Jonathan S., Ling, Scott D., Mellin, Camille, Mouillot, David, Bernard, Anthony T.F., Bennett, Scott, Brown, Christopher J., Burrows, Michael t., Butler, Claire L., Cinner, Joshua, Clausius, Ella, Cooper, Antonia, Costello, Mark John, Denis-Roy, Lara, Edgar, Graham J., Fuchs, Yann Herrera, Johnson, Olivia J., Gordó-Vilaseca, Cesc, Hautecoeur, Cyril, Harper, Leah M., Heather, Freddie J., Jones, Tyson r., Markey, Anthony C., Oh, Elizabeth, Rose, Matthew, Ruiz-Ruiz, Paula A., Sanabria-Fernandez, Jose A., Schuster, Jasmin M., Schmid, Joanna K., Baker, Susan C.

المصدر: Bates , A E , Davies , M A , Stuart-Smith , R D , Lazzari , N , Lefcheck , J S , Ling , S D , Mellin , C , Mouillot , D , Bernard , A T F , Bennett , S , Brown , C J , Burrows , M T , Butler , C L , Cinner , J , Clausius , E , Cooper , A , Costello , M J , Denis-Roy , L , Edgar , G J , Fuchs , Y H , Johnson , O J , Gordó-Vilaseca ....

مصطلحات موضوعية: working groups, strategies, conservation, ecology, imposter syndrome, early career

الوصف: Scientific working groups bring together experts from different disciplines and perspectives to tackle the “wicked problems” facing natural systems and society. Yet participants can feel overwhelmed or inadequate in groups within academic environments, which tends to be most acute at early career stages and in people from systematically marginalized backgrounds. Such feelings can block innovation that would otherwise arise from gaining the full spectrum of unique perspectives, knowledge and skills from a group. Drawing on personal experiences and relevant literature, we identify ten contribution strategies, ranging from generating ideas, analyzing data, and producing visuals to supporting facilitation. Next, we share approaches for an inclusive and supportive process, considering the roles of both participants and leads. Generating the most productive and relevant outcomes from working groups requires engaging the full team in a constructive and supportive environment. We advocate that adopting inclusive approaches that respect the diversity of personality types and perspectives will lead to more innovative solutions to achieve conservation and sustainability goals.

وصف الملف: application/pdf

العلاقة: https://pure.uhi.ac.uk/en/publications/59f56d92-2da4-48de-9e3e-f5bca44cdeafTest

الإتاحة: https://doi.org/10.1016Test/j.biocon.2024.110566
https://pure.uhi.ac.uk/en/publications/59f56d92-2da4-48de-9e3e-f5bca44cdeafTest
https://pureadmin.uhi.ac.uk/ws/files/52613902/Overcome_imposter_syndrome_Contribute_to_working_groups_and_build_strong_networks.pdfTest
https://linkinghub.elsevier.com/retrieve/pii/S0006320724001289Test

المؤلفون: Bell-James, Justine, Foster, Rose, Shumway, Nicole, Lovelock, Catherine E, Villarreal-Rosas, Jaramar, Brown, Christopher J, Andradi-Brown, Dominic A, Saunders, Megan I, Waltham, Nathan J, Fitzsimons, James A

الوصف: With the passage of the one-year anniversary of the Kunming-Montreal Global Biodiversity Framework (GBF), substantial effort is still needed to progress Target 2 — the ‘restoration target’. The restoration target guides parties to “ensure that by 2030 at least 30 per cent of areas of degraded terrestrial, inland water, and marine and coastal ecosystems are under effective restoration, in order to enhance biodiversity and ecosystem functions and services, ecological integrity and connectivity”1. ; No Full Text

العلاقة: Nature Ecology & Evolution; Bell-James, J; Foster, R; Shumway, N; Lovelock, CE; Villarreal-Rosas, J; Brown, CJ; Andradi-Brown, DA; Saunders, MI; Waltham, NJ; Fitzsimons, JA, The Global Biodiversity Framework's ecosystem restoration target requires more clarity and careful legal interpretation, Nature Ecology & Evolution, 2024, 8, pp. 840-841; https://hdl.handle.net/10072/430529Test

الإتاحة: https://doi.org/10.1038/s41559-024-02389-6Test
https://hdl.handle.net/10072/430529Test

المؤلفون: Villarreal‐Rosas, Jaramar, Brown, Christopher J., Andradi‐Brown, Dominic A., Domínguez, Ricardo, Jacobo, Pilar, Martínez, Anuar, Mascote, Coral, Najera, Eduardo, Paiz, Yves, Vázquez Moran, Víctor Hugo, Villarreal, Jaime, Adame, María F.

المساهمون: Australian Research Council

المصدر: Conservation Biology ; ISSN 0888-8892 1523-1739

الوصف: Driven by the United Nations Decade on Restoration and international funding initiatives, such as the Mangrove Breakthrough, investment in mangrove restoration is expected to increase. Yet, mangrove restoration efforts frequently fail, usually because of ad hoc site‐selection processes that do not consider mangrove ecology and the socioeconomic context. Using decision analysis, we developed an approach that accounts for socioeconomic and ecological data to identify sites with the highest likelihood of mangrove restoration success. We applied our approach in the Biosphere Reserve Marismas Nacionales Nayarit, Mexico, an area that recently received funding for implementing mangrove restoration actions. We identified 468 potential restoration sites, assessed their restorability potential based on socioeconomic and ecological metrics, and ranked sites for implementation with spatial optimization. The metrics we used included favorable conditions for propagules to establish and survive under sea‐level rise, provision of ecosystem services, and community dynamics. Sites that were selected based on socioeconomic or ecological metrics alone had lower likelihood of mangrove restoration success than sites that were selected based on integrated socioeconomic and ecological metrics. For example, selecting sites based on only socioeconomic metrics captured 16% of the maximum attainable value of functioning mangroves able to provide propagules to potential restoration sites, whereas selecting sites based on ecological and socioeconomic metrics captured 46% of functioning mangroves. Our approach was developed as part of a collaboration between nongovernmental organizations, local government, and academics under rapid delivery time lines given preexisting mangrove restoration implementation commitments. The systematic decision process we used integrated socioeconomic and ecological considerations even under short delivery deadlines, and our approach can be adapted to help mangrove restoration site‐selection decisions ...

الإتاحة: https://doi.org/10.1111/cobi.14286Test

المؤلفون: Piccolo, Renee L., Brown, Christopher J., Friess, Daniel A., Lovelock, Catherine E., Brown, Benjamin M., Buelow, Christina, Saunders, Megan I.

المساهمون: Commonwealth Scientific and Industrial Research Organisation, Australian Research Council

المصدر: Ocean & Coastal Management ; volume 249, page 106977 ; ISSN 0964-5691

مصطلحات موضوعية: Management, Monitoring, Policy and Law, Aquatic Science, Oceanography

الإتاحة: https://doi.org/10.1016Test/j.ocecoaman.2023.106977
https://api.elsevier.com/content/article/PII:S0964569123005021?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0964569123005021?httpAccept=text/plainTest

المؤلفون: Turschwell, Mischa P., Connolly, Rod M., Dunic, Jillian C., Sievers, Michael, Buelow, Christina A., Pearson, Ryan M., Tulloch, Vivitskaia J. D., Côté, Isabelle M., Unsworth, Richard K. F., Collier, Catherine J., Brown, Christopher J.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2021 Nov 01. 118(45), 1-11.

الوصول الحر: https://www.jstor.org/stable/27093664Test

مستخلص: One embodiment of a fuel tank assembly includes a fuel sending unit having a float with a small thickness, which heretofore has been too thin to secure a stand-alone magnet thereon. The float may be manufactured in a complex shape or in a small size. In one embodiment the float may be manufactured of a material having magnetized particles interspersed throughout the float such that the float does not require a stand alone magnet secured thereon. The float may be manufactured of a material having a foaming agent added thereto so as to provide a finished product with air filled voids positioned throughout the float to increase the buoyancy of the finished float product.

المؤلفون: Turschwell, Mischa P., Brown, Christopher J., Lacharité, Myriam, Melbourne-Thomas, Jess, Hayes, Keith R., Bustamante, Rodrigo H., Dambacher, Jeffrey M., Evans, Karen, Fidelman, Pedro, Hatton MacDonald, Darla, Van Putten, Ingrid, Wood, Graham, Abdussamie, Nagi, Bates, Mathilda, Blackwell, Damien, D'Alessandro, Steven, Dutton, Ian, Ericson, Jessica A., Frid, Christopher LJ, McDougall, Carmel, Lea, Mary-Ann, Rissik, David, Trebilco, Rowan, Fulton, Elizabeth A.

المصدر: Turschwell , M P , Brown , C J , Lacharité , M , Melbourne-Thomas , J , Hayes , K R , Bustamante , R H , Dambacher , J M , Evans , K , Fidelman , P , Hatton MacDonald , D , Van Putten , I , Wood , G , Abdussamie , N , Bates , M , Blackwell , D , D'Alessandro , S , Dutton , I , Ericson , J A , Frid , C LJ , McDougall , C , Lea , M-A , Rissik , D , Trebilco , ....

مصطلحات موضوعية: Sustainability, Equity, Seafood production, Renewable energy, Ocean multi-use

الوصف: A multi-sectoral assessment of risks can support the management and investment decisions necessary for emerging blue economy industries to succeed. Traditional risk assessment methods will be challenged when applied to the complex socio-ecological systems that characterise offshore environments, and when data available to support management are lacking. Therefore, there is a need for assessments that account for multiple sectors. Here we describe the development of an efficient method for an integrated hazard analysis that is a precursor to full risk assessments. Our approach combines diverse disciplinary expertise, expert elicitation and multi-criteria analysis to rank hazards, so it encompasses all types of hazards including human-caused, natural and technological. We demonstrate our approach for two sectors that are predicted to grow rapidly in Australia: offshore aquaculture and marine renewable energy. Experts ranked Climate Change as the hazard with the highest overall concern, but hazards including Altered Ecosystem Function, Biosecurity, Cumulative Effects, Structural Failure and Social Licence were also highly ranked. We show here how outputs from this approach (multi-criteria scores and ranks) could be used to identify hazards that; i) could be safely retired, ii) should be progressed to more quantitative risk assessments or iii) require ongoing information collection. The approach can encompass all types of hazards, which enables it to holistically consider priorities. The expert-based multi-criteria approach outlined here represents a pragmatic way to solve some of the challenges of applying risk assessments to emerging industries by using a method that can be applied across multiple blue economy sectors.

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/codesigning-a-multicriteria-approach-to-ranking-hazards-to-and-from-australias-emerging-offshore-blue-economyTest(9a11d563-1a10-456d-899a-a32fca0f31d6).html

الإتاحة: https://doi.org/10.1016Test/j.envsci.2023.06.008
https://research-portal.st-andrews.ac.uk/en/researchoutput/codesigning-a-multicriteria-approach-to-ranking-hazards-to-and-from-australias-emerging-offshore-blue-economyTest(9a11d563-1a10-456d-899a-a32fca0f31d6).html

المؤلفون: Griffiths, Laura L, Williams, Joel, Buelow, Christina A, Tulloch, Vivitskaia J, Turschwell, Mischa P, Campbell, Max D, Harasti, David, Connolly, Rod M, Brown, Christopher J

مصطلحات موضوعية: Ecology, Zoology, Environmental management, New South Wales, coastal management, fishing pressure, impact maps, multiple threats

الوصف: The coastal environment is not managed in a way that considers the impact of cumulative threats, despite being subject to threats from all realms (marine, land and atmosphere). Relationships between threats and species are often non-linear, thus current (linear) approaches to estimating the impact of threats may be misleading. We developed a data-driven approach to assessing cumulative impacts on ecosystems and apply it to explore non-linear relationships between threats and a temperate reef fish community. We use data on water quality, commercial fishing, climate change, and indicators of recreational fishing and urbanisation to build a cumulative threat map of the Northern Region in New South Wales, Australia. Using statistical models of fish abundance, we quantified associations among threats and biophysical covariates and predicted where cumulative impacts are likely to have the greatest impact on fish. We also assessed the performance of no-take zones, to protect fish from cumulative threats across two marine protected area networks (marine parks). We found that fishing has a greater impact on fish than water quality threats (i.e., percent increase above the mean for invertivores was 337% when fishing was removed c.f. 11% when water quality was removed inside no-take zones), and that fishing outside of no-take zones affects fish abundances inside no-take zones. Quantifying the spatial influence of multiple threats enables managers to understand the multitude of management actions required to address threats. This article is protected by copyright. All rights reserved. ; Full Text

العلاقة: Conservation Biology; Griffiths, LL; Williams, J; Buelow, CA; Tulloch, VJ; Turschwell, MP; Campbell, MD; Harasti, D; Connolly, RM; Brown, CJ, A data driven approach to multiple stressor impact assessment for a marine protected area, Conservation Biology, 2023; http://hdl.handle.net/10072/425239Test

الإتاحة: https://doi.org/10.1111/cobi.14177Test
http://hdl.handle.net/10072/425239Test