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1دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Rubin, Katrine Hass, Nymark, Tine, Schmal, Hagen, Lindberg-Larsen, Martin
المصدر: Acta orthopaedica. - 95 (2024) , 86-91, ISSN: 1745-3682
الوصف: Background and purpose: Re-amputation after lower extremity amputation is frequent. The primary aim of our study was to investigate cumulative re-amputation risk after transtibial amputation (TTA), knee disarticulation (KD), and transfemoral amputation (TFA) and secondarily to investigate time to re-amputation, and risk factors. Methods: This observational cohort study was based on data from the Danish Nationwide Health registers. The population included first-time major lower extremity amputations (MLEA) performed in patients ≥ 50 years between 2010 and 2021. Both left and right sided MLEA from the same patient were included as index procedures. Results: 11,743 index MLEAs on 10,052 patients were included. The overall cumulative risks for re-amputation were 29% (95% confidence interval [CI] 27–30), 30% (CI 26–35), and 11% (CI 10–12) for TTA, KD, and TFA, respectively. 58% of re-amputations were performed within 30 days after index MLEA. Risk factors for re-amputation within 30 days were dyslipidemia (hazard ratio [HR] 1.2, CI 1.0–1.3), renal insufficiency (HR 1.2, CI 1.1–1.4), and prior vascular surgery (HR 1.3, CI 1.2–1.5). Conclusion: The risk of re-amputation was more than twice as high after TTA (29%) and KD (30%) compared with TFA (11%). Most re-amputations were conducted within 30 days of the index MLEA. Dyslipidemia, renal insufficiency, and prior vascular surgery were associated with higher risk of re-amputation.
وصف الملف: pdf
الإتاحة: https://doi.org/10.2340/17453674.2024.39963Test
https://freidok.uni-freiburg.de/data/246701Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2467017Test
https://freidok.uni-freiburg.de/dnb/download/246701Test -
2دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Rubin, Katrine Hass, Nymark, Tine, Schmal, Hagen, Lindberg-Larsen, Martin
المصدر: Acta Orthopaedica. - 95 (2024) , 358-363, ISSN: 1745-3682
الإتاحة: https://doi.org/10.2340/17453674.2024.40996Test
https://freidok.uni-freiburg.de/data/253583Test -
3دورية أكاديمية
المصدر: BMC musculoskeletal disorders. - 23, 1 (2022) , 1088, ISSN: 1471-2474
الوصف: Background Lower extremity amputation patients represent a frail group with extensive comorbidity. Transfemoral amputation is a high-risk procedure with 37–50% risk of mortality in the first year. Substantial blood loss during surgery increases the risk of anemic complications and death for these already weakened patients. The use of tourniquet during surgery may reduce blood loss, the need for blood transfusions, the related complications as well as the length of the surgery. However the use of tourniquet may be related to impaired wound healing and hence the use should be investigated in a randomized controlled trial. The primary aim of this study is to investigate the total blood loss and secondary to investigate differences in complications after transfemoral amputation between patients operated with or without tourniquet. Methods The total blood loss is calculated using Nadlers approach. Based on data from a pilot series, the sample size was calculated to 124, allocated 1:1 in two groups of 62 participants to ensure detection of at least 200 mL difference in the total blood loss. The primary outcome is the total blood loss. Secondary outcomes are blood transfusions, duration of surgery, length of hospital stay and risk of complications within 90 days (re-admissions, re-operations and mortality). Explorative outcomes are 1 year mortality and re-operation risk. Further explorative outcomes are postoperative quality of life (questionnaire EQ-5D-5L) and evaluation of number of prosthesis users including evaluation of prosthesis-specific function measured 3, 6, and 12 months postoperatively. Discussion The possibility to enhance patient safety is highly relevant and this trial will provide data for evidence based recommendations of best practice in amputation surgery.
وصف الملف: pdf
الإتاحة: https://doi.org/10.1186/s12891-022-06000-6Test
https://freidok.uni-freiburg.de/data/232411Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2324111Test
https://freidok.uni-freiburg.de/dnb/download/232411Test -
4دورية أكاديمية
المصدر: Brix , A T H , Tørring , P M & Bygum , A 2022 , ' Capillary Malformation-arteriovenous Malformation Type 2 : A Case Report and Review ' , Acta Dermato-Venereologica , vol. 102 , adv00662 . https://doi.org/10.2340/actadv.v102.1126Test
الوصف: Capillary malformation-arteriovenous malformation syndrome is a rare genodermatosis with cutaneous capillary malformations and a risk of associated fast-flow malformations. We describe here a four-generation family with a novel heterozygous pathogenic variant in the EPHB4 gene (NM_004444.5 (EPHB4): c.2224G>C, p.(Ala742Pro)). A review of the literature retrieved 127 patients with capillary malformation-arteriovenous malformation syndrome and confirmed variants in EPHB4. Multiple capillary malformations were present in 114 (89.76%) patients, and 12 (9.44%) patients had a solitary capillary malformation. Arteriovenous malformations/fistulas were present in 23 (18.1%) patients, and were located within the central nervous system in 5 (3.9%) patients. Not all papers included description of epistaxis. Telangiectasias were reported in 28 (22%) patients, and Bier spots were described in 20 (15.7%) patients. The clinical characteristics of capillary malformation-arteriovenous malformation syndrome are diverse and often discrete, which can make it difficult to distinguish capillary malformation-arteriovenous malformation syndrome from hereditary haemorrhagic telangiectasia.
وصف الملف: application/pdf
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/a303950a-5616-415c-96a1-18dbd4b0e7bcTest
الإتاحة: https://doi.org/10.2340/actadv.v102.1126Test
https://portal.findresearcher.sdu.dk/da/publications/a303950a-5616-415c-96a1-18dbd4b0e7bcTest
https://findresearcher.sdu.dk/ws/files/200292062/1126.pdfTest -
5دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Boysen, Henrik Balle, Weller, Karsten, Caballero, Teresa, Bygum, Anette
المصدر: Brix , A T H , Boysen , H B , Weller , K , Caballero , T & Bygum , A 2021 , ' Patient-reported Outcome Measures for Angioedema : A Literature Review ' , Acta Dermato-Venereologica , vol. 101 , no. 5 , adv00456 . https://doi.org/10.2340/00015555-3807Test
مصطلحات موضوعية: angioedema, hereditary angioedema, patient-reported outcome measure
الوصف: Angioedema and hereditary angioedema are characterized by swelling of the subcutaneous and/or submucosal tissue, resulting in localized oedema. The rarity, but also the diverse clinical presentation, of these conditions can be challenging regarding diagnosis, treatment, and management. Patient-reported outcome measures (PROMs) are data received directly from the patient, providing the patient’s perspective on various subjects regarding health and well-being. PROMs can be helpful tools to optimize treatment and long-term management of conditions. A major challenge regarding the consistent use of PROMs in clinical settings in Scandinavia is language availability; many of the validated PROMs for hereditary angioedema and angioedema lack translations into the Nordic languages. The litterature search yielded 9 different PROM tools for angioedema and hereditary angioedema. Five were found suitable for use in clinical practice in Europe. Even though several PROMs exist they are not used consistent. Accessible electronic PROMs and careful planning is required to implement PROMs optimally in routine care processes.
وصف الملف: application/pdf
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/b3de7bf4-e1ba-4b75-9c06-2490d6f6e65eTest
الإتاحة: https://doi.org/10.2340/00015555-3807Test
https://portal.findresearcher.sdu.dk/da/publications/b3de7bf4-e1ba-4b75-9c06-2490d6f6e65eTest
https://findresearcher.sdu.dk/ws/files/183127089/6051.pdfTest -
6دورية أكاديمية
المصدر: Brix , A T H , Svensson , T M , Sandberg , M & Bygum , A 2020 , ' Hereditary angioedema : The challenges of cross-border family investigation and treatment ' , BMJ Case Reports , vol. 13 , no. 4 , 231906 . https://doi.org/10.1136/bcr-2019-231906Test
مصطلحات موضوعية: dermatology, ethics, ethnic studies
الوصف: Hereditary angioedema (HAE) is a rare genetic disorder characterised by recurrent swellings involving subcutaneous and submucosal tissue that can be potentially life threatening in cases involving the upper airway. In this case report, we present a Syrian refugee family with HAE who have lived in Denmark since 2014. The index patient is an 8-year-old girl diagnosed with HAE after being hospitalised in Denmark with an angioedema attack. Her younger sister and father were diagnosed later, following investigation of the family. Exploring the family history, deaths due to suffocation were described in previous generations and other family members based in Sweden, Germany, Turkey, Saudi Arabia, USA and Syria could also potentially be affected. This highlights the need for a cross-border effort to diagnose and treat this inherited disorder.
وصف الملف: application/pdf
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/38dbdfff-bfb2-4f8a-b560-51cd4477c98dTest
الإتاحة: https://doi.org/10.1136/bcr-2019-231906Test
https://portal.findresearcher.sdu.dk/da/publications/38dbdfff-bfb2-4f8a-b560-51cd4477c98dTest
https://findresearcher.sdu.dk/ws/files/170115379/Hereditary_angioedema2.pdfTest -
7دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Tørring, Pernille M, Kjeldsen, Anette Drøhse, Bygum, Anette, Schuster, Annette, Nielsen, Troels Halfeld
المصدر: Brix , A T H , Tørring , P M , Kjeldsen , A D , Bygum , A , Schuster , A & Nielsen , T H 2022 , ' Kutane kapillære malformationer med cerebral involvering ' , Ugeskrift for Læger , bind 184 , nr. 21 , V03210220 . < https://ugeskriftet.dk/videnskab/kutanekapillaeremalformationer-med-cerebral-involveringTest >
الوصف: Capillary malformations – arteriovenous malformation, hereditary hemorrhagic telangiectasia and Sturge-Weber syndrome – are rare diseases in which cutaneous capillary malformations (CM) may be associated with cerebral vascular malformations. The clinical presentation of each disease is described with focus on how to distinguish them in the clinic and differential diagnoses are listed. This review finds that upon thorough and careful examination of patients, cutaneous CM might be a diagnostic hallmark for underlying disease and therefore a significant clinical observation.
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/fb90be42-8b61-42ab-a710-40be9771666dTest
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8دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Tørring, Pernille M, Kamaleswaran, Shailajah, Kjeldsen, Anette Drøhse, Kjærskov, Mette Wanscher, Bygum, Anette
المصدر: Brix , A T H , Tørring , P M , Kamaleswaran , S , Kjeldsen , A D , Kjærskov , M W & Bygum , A 2019 , ' Glomuvenøse malformationer ' , Ugeskrift for Læger , bind 181 , nr. 22 , V10180740 . < http://ugeskriftet.dk/videnskab/glomuvenose-malformationerTest >
الوصف: In this review, the importance of correct diagnosis of glomuvenous malformations (GVM) is emphasised, and different treatment modalities are discussed. GVM are simple venous malformations located in the skin and subcutis, and GVM has a characteristic blue to reddish cobblestone-like appearance with not fully compressible elements, which can be associated with pain on palpation. Clinically, GVM differ from blue rubber bleb naevus syndrome and common/familial cutaneo-mucosal venous malformations in appearance, compressibility and in having a normal D-dimer concentration.
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/8864dd95-5205-43f1-8b4d-8a844845c860Test
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9دورية أكاديمية
المؤلفون: Brix, Anna Trier Heiberg, Tørring, Pernille Mathiesen, Kamaleswaran, Shailajah, Gad, Dorte, Bygum, Anette
المصدر: Brix , A T H , Tørring , P M , Kamaleswaran , S , Gad , D & Bygum , A 2019 , ' Glomuvenøse malformationer kan være meget smertefulde og medføre diagnostiske vanskeligheder ' , Ugeskrift for Læger , bind 181 , nr. 22 , V10180735 . < http://ugeskriftet.dk/videnskab/glomuvenose-malformationer-kan-vaere-meget-smertefulde-og-medfore-diagnostiskeTest >
الوصف: This case report describes three different cases of glomuvenous malformations, which is a rare, autosomal dominant inherited cutaneous venous disease. There is a broad variation in the clinical appearance of these lesions, from flat blue elements to raised purple element with cobblestone appearance. One of the patients in this report experienced intense pain in her lesions, but after surgical resection the pain resolved. All diagnoses were confirmed with biopsy. If in doubt of the diagnosis, biopsy of vascular lesions is important.
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/3bf1f9b5-70c9-4178-ad4c-3ca7e8b1f6e2Test
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10
المؤلفون: Brix, Anna Trier Heiberg, Tørring, Pernille M, Kamaleswaran, Shailajah, Kjeldsen, Anette Drøhse, Kjærskov, Mette Wanscher, Bygum, Anette
المصدر: Brix, A T H, Tørring, P M, Kamaleswaran, S, Kjeldsen, A D, Kjærskov, M W & Bygum, A 2019, ' Glomuvenøse malformationer ', Ugeskrift for Laeger, bind 181, nr. 22, V10180740 . < http://ugeskriftet.dk/videnskab/glomuvenose-malformationerTest >
مصطلحات موضوعية: genetic structures
الوصف: In this review, the importance of correct diagnosis of glomuvenous malformations (GVM) is emphasised, and different treatment modalities are discussed. GVM are simple venous malformations located in the skin and subcutis, and GVM has a characteristic blue to reddish cobblestone-like appearance with not fully compressible elements, which can be associated with pain on palpation. Clinically, GVM differ from blue rubber bleb naevus syndrome and common/familial cutaneo-mucosal venous malformations in appearance, compressibility and in having a normal D-dimer concentration.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3062::ab5badf570f3e58708505d8b4f773ae3Test
http://ugeskriftet.dk/videnskab/glomuvenose-malformationerTest
