المؤلفون: Vásquez-Ocmín, Pedro, G, Marti, Guillaume, Gadea, Alice, Cabanac, Guillaume, Vásquez-Briones, Juan, Casavilca-Zambrano, Sandro, Ponts, Nadia, Jargeat, Patricia, Haddad, Mohamed, Bertani, Stéphane

المساهمون: Laboratoire Mixte International d'Oncologie Anthropologique Moléculaire = International Joint Laboratory of Molecular Anthropological Oncology (LOAM), Institut de Recherche pour le Développement (IRD Pérou ), MetaToul Agromix, MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Laboratoire de Recherche en Sciences Végétales (LRSV), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Recherche d’Information et Synthèse d’Information (IRIT-IRIS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Universidad Nacional Agraria La Molina (UNALM), Instituto Nacional de Enfermedades Neoplasicas Lima, Pérou (INEN), Universidad de Huánuco Huánuco, Pérou, Unité de recherche Mycologie et Sécurité des Aliments (MycSA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Evolution et Diversité Biologique (EDB), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratory MAT-IRD (Yaoundé, Cameroon), University of Yaoundé Cameroun, ANR-11-LABX-0066,SMS/SSW,Structurations des mondes sociaux(2011)

المصدر: ISSN: 0308-8146 ; EISSN: 1873-7072 ; Food Chemistry.

مصطلحات موضوعية: Pseudocereals, Mycotoxins, Food Safety, Andes, Peru, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.EE]Life Sciences [q-bio]/Ecology, environment

الوصف: International audience ; Pseudocereals are best known for three crops derived from the Andes: quinoa (Chenopodium quinoa), canihua (C. pallidicaule), and kiwicha (Amaranthus caudatus). Their grains are recognized for their nutritional benefits; however, there is a higher level of polyphenism. Meanwhile, the chemical food safety of pseudocereals remains poorly documented. Here, we applied untargeted and targeted metabolomics approaches by LC-MS to achieve both: i) a comprehensive chemical mapping of pseudocereal samples collected in the Andes; and ii) a quantification of their contents in emerging mycotoxins. An inventory of the fungal community was also realized to better know the fungi present in these grains. Metabotyping permitted to add new insights into the chemotaxonomy of pseudocereals, confirming the previously established phylotranscriptomic clades. Sixteen samples from Peru (out of 27) and one from France (out of one) were contaminated with Beauvericin, an emerging mycotoxin. Several mycotoxigenic fungi were detected, including Aspergillus sp., Penicillium sp., and Alternaria sp.

العلاقة: hal-04041003; https://hal.science/hal-04041003Test; https://hal.science/hal-04041003/documentTest; https://hal.science/hal-04041003/file/2022.06.23.497323v1.full.pdfTest; IRD: fdi:010086805; WOS: 000906307800001

الإتاحة: https://doi.org/10.1016/j.foodchem.2022.135134Test
https://hal.science/hal-04041003Test
https://hal.science/hal-04041003/documentTest
https://hal.science/hal-04041003/file/2022.06.23.497323v1.full.pdfTest

المؤلفون: Muñoz Briones , Juan Carlos, Niola Sornoza, Geovanny Genaro, Cáceres Espinoza, Evelin Jessica, Loza Balladarez, Viviana del Rocio, Camacho Garcia, Patricia Jacinta

المصدر: Ciencia Latina Revista Científica Multidisciplinar; Vol. 7 Núm. 3 (2023); 1202-1217 ; 2707-2215 ; 2707-2207 ; 10.37811/cl_rcm.v7i3

مصطلحات موضوعية: development, affectation, electronics, evasion & taxes, afectación, desarrollo, electrónica, evasión & impuestos

الوصف: This research research work was carried out with the purpose of analyzing the social impact caused by tax evasion and the implementation of electronic invoicing in Ecuador. For this work, a database was created, which was useful for the analysis, descriptive research was used because the data and information that was collected had to be described to give a correct analysis and with it a good development of the present study and documentary research, because the data was collected directly from the different web pages of the institutions and fiscal control organizations in Ecuador, based on the figures and statistics published by them, finally, for the calculation of the population-sample, a the years 2021-2022. According to the analysis carried out in the different public organizations, it has allowed us to know the importance of tax collection and the positive and negative effects that these have on taxes in Ecuador, which have an important role in the economy of our country, what is collected in the period 2022 for taxes amounts to $14,462,488, a value greater than the $13,157,515 goal established. (Thousands of dollars). While the affectation by the use of electronic invoicing shows the following results: Authorized electronic receipts 8,589,504.00; Taxpayers who are already in electronic invoicing 1,334,992.00 and Taxpayers to Enter invoicing and are in the Test Phase 12,581,000.00 which, without a doubt, will represent a greater tax collection for Ecuador in the future and will avoid the indiscriminate felling of trees, something to favor of the environment. ; Este trabajo de investigación de investigación se llevó a cabo con la finalidad de analizar el impacto social que causa la evasión de impuestos y la implementación de la facturación electrónica en el Ecuador. Para este trabajo se armó una base de datos, que fue útil para el análisis, se usó la investigación descriptiva debido a que los datos e información que se recopiló debió ser descrita para dar un correcto análisis y con ello un buen desarrollo ...

وصف الملف: application/pdf; text/html

العلاقة: https://ciencialatina.org/index.php/cienciala/article/view/6267/9526Test; https://ciencialatina.org/index.php/cienciala/article/view/6267/9528Test; https://ciencialatina.org/index.php/cienciala/article/view/6267Test

الإتاحة: https://doi.org/10.37811/cl_rcm.v7i3.6267Test
https://doi.org/10.37811/cl_rcm.v7i3Test
https://ciencialatina.org/index.php/cienciala/article/view/6267Test

المؤلفون: Salinas, Maria Paz, Sepúlveda, Javiera, Hidalgo, Leonel, Peirano, Dominga, Morel, Macarena, Uribe, Pablo, Rotemberg, Veronica, Briones, Juan, Mery, Domingo, Navarrete-Dechent, Cristian

المصدر: NPJ Digital Medicine; 5/14/2024, Vol. 7 Issue 1, p1-23, 23p

مصطلحات موضوعية: MEDICAL information storage & retrieval systems, SKIN tumors, RECEIVER operating characteristic curves, DIAGNOSTIC imaging, RESEARCH funding, ARTIFICIAL intelligence, META-analysis, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, HOSPITAL medical staff, ODDS ratio, COMPUTER-aided diagnosis, MEDICAL databases, DERMOSCOPY, HISTOLOGICAL techniques, ONLINE information services, DATA analysis software, DERMATOLOGISTS, CONFIDENCE intervals, MACHINE learning, ALGORITHMS, SENSITIVITY & specificity (Statistics), EVALUATION

مستخلص: Scientific research of artificial intelligence (AI) in dermatology has increased exponentially. The objective of this study was to perform a systematic review and meta-analysis to evaluate the performance of AI algorithms for skin cancer classification in comparison to clinicians with different levels of expertise. Based on PRISMA guidelines, 3 electronic databases (PubMed, Embase, and Cochrane Library) were screened for relevant articles up to August 2022. The quality of the studies was assessed using QUADAS-2. A meta-analysis of sensitivity and specificity was performed for the accuracy of AI and clinicians. Fifty-three studies were included in the systematic review, and 19 met the inclusion criteria for the meta-analysis. Considering all studies and all subgroups of clinicians, we found a sensitivity (Sn) and specificity (Sp) of 87.0% and 77.1% for AI algorithms, respectively, and a Sn of 79.78% and Sp of 73.6% for all clinicians (overall); differences were statistically significant for both Sn and Sp. The difference between AI performance (Sn 92.5%, Sp 66.5%) vs. generalists (Sn 64.6%, Sp 72.8%), was greater, when compared with expert clinicians. Performance between AI algorithms (Sn 86.3%, Sp 78.4%) vs expert dermatologists (Sn 84.2%, Sp 74.4%) was clinically comparable. Limitations of AI algorithms in clinical practice should be considered, and future studies should focus on real-world settings, and towards AI-assistance. [ABSTRACT FROM AUTHOR]

: Copyright of NPJ Digital Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Lercari, M, GONZALEZ BRIONES, JUAN SEBASTIAN, Espinoza, C, Longo, G, Antonacci, F, Sarti, A

المساهمون: Lercari, M, GONZALEZ BRIONES, JUAN SEBASTIAN, Espinoza, C, Longo, G, Antonacci, F, Sarti, A

مصطلحات موضوعية: musical instruments, modal analysis, finite element modelling, new materials for musical instruments

الوصف: Featured Application The use of mechanical metamaterials in musical instruments could be an excellent way to engineer the wood of the instrument to obtain a particular sound. It has recently been shown that the mechanical properties of thin, rectangular wooden plates can be tuned by carving them with specific patterns of perforations, effectively realising a 2D wooden mechanical metamaterial. Such a material is of great interest for the construction of musical instruments, as it could allow a new degree of creative control for makers. Furthermore, issues with the shrinking supplies of tone-woods could be alleviated as wood samples that don not meet the desired requirements could simply be altered, instead of being discarded. In this work, we study the effect of the use of these metamaterials in the soundboards of classical guitars. By way of simulations, we evaluate their impact on the modal behaviour and on the sound pressure level of the instrument, as well as on its ability to sustain the load exerted by the strings. Our results show that the metamaterials can tune the instrument's response without compromising its structural integrity. We thus conclude that the use of wooden mechanical metamaterials in the soundboards of classical guitars is feasible and, in many ways, beneficial, not the least since it opens the door to using non-traditional woods with bespoke density and stiffness.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000850947200001; volume:12; issue:17; firstpage:8619; lastpage:8628; numberofpages:10; journal:APPLIED SCIENCES; https://hdl.handle.net/11311/1233977Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85137788038

الإتاحة: https://doi.org/10.3390/app12178619Test
https://hdl.handle.net/11311/1233977Test

المؤلفون: Pizarro, Gonzalo, Pinto, Mauricio P., Muñoz-Medel, Matías, Cordova-Delgado, Miguel, Bravo, M. Loreto, Nervi, Bruno, Sánchez, César, Ibañez, Carolina, Peña, José, Walbaum, Benjamín, Madrid, Jorge, Briones, Juan, Koch, Erica, Valbuena, Jose, Gonzalez, Sergio, Gejman, Roger, Acevedo, Francisco, Mondaca, Sebastian, Garrido, Marcelo, Vines, Eugenio, Galindo, Hector

مصطلحات موضوعية: Checkpoint inhibitors, Lung cancer, Radiation therapy, Somatic copy number alterations, Next-generation sequencing, Medicina y salud

الوقت: 610

العلاقة: http://dx.doi.org/10.1016/j.cllc.2020.01.012Test; https://repositorio.uc.cl/handle/11534/80808Test

الإتاحة: https://doi.org/10.1016/j.cllc.2020.01.012Test
https://repositorio.uc.cl/handle/11534/80808Test

المؤلفون: Muñoz Briones , Juan Carlos, Jiménez Hidalgo , Gary Fernando, Aguirre Valverde, M.Sc. Dennis Guillermo, Angamarca Izquierdo, M.Sc Guillermo Remigio

المصدر: Ciencia Latina Revista Científica Multidisciplinar; Vol. 6 Núm. 4 (2022); 3071-3084 ; 2707-2215 ; 2707-2207 ; 10.37811/cl_rcm.v6i4

مصطلحات موضوعية: gap, compliance, tax, collection & value added, brecha, cumplimiento, impuesto, recaudación & valor agregado

الوصف: The intention to carry out the present investigation was to have a clear idea about the breaches of compliance and truthfulness of the collection by way of the 2% increase in Value Added Tax (VAT) from 12% to 14%. For this work a database was assembled, which was useful for the analysis, descriptive research was used because the data and information that was collected had to be described to give a correct analysis and with it a good development of the present study. documentary research, because the data was collected directly from the different websites of the institutions and agencies of fiscal control in Ecuador, based on the figures and statistics published by these, finally for the calculation of the population-sample was used to total number of months to be evaluated in the investigation in this case a period corresponds to 12 months. Although the collection goal proposed by the Internal Revenue Service (SRI) was not fully met, it is clear that the breach of truth at 1.8% is not significant, so the Internal Revenue Service must Establish policies that allow you to collect taxes according to the levels planned. ; La intención de llevar a cabo la presente investigación consistió en tener una idea clara sobre las brechas de cumplimiento y veracidad de la recaudación por concepto del aumento de 2% de Impuesto al Valor Agregado (IVA) del 12% al 14%. Para este trabajo se armó una base de datos, que fue útil para el análisis, se usó la investigación descriptiva debido a que los datos e información que se recopiló debió ser descrita para dar un correcto análisis y con ello un buen desarrollo del presente estudio e investigación documental, porque los datos fueron recogidos directamente desde las diferentes páginas webs de las instituciones y organismos de control fiscal en el Ecuador, en base a las cifras y estadísticas publicadas por estas, por último para el cálculo de la población-muestra se utilizó al número total de meses a ser evaluados en la investigación en este caso un período corresponde a 12 meses. A ...

وصف الملف: application/pdf

العلاقة: https://ciencialatina.org/index.php/cienciala/article/view/2813/4236Test; https://ciencialatina.org/index.php/cienciala/article/view/2813Test

الإتاحة: https://doi.org/10.37811/cl_rcm.v6i4.2813Test
https://doi.org/10.37811/cl_rcm.v6i4Test
https://ciencialatina.org/index.php/cienciala/article/view/2813Test

المؤلفون: Nikolay, Milev, Takashi Kiyota, Briones Juan, Briones Othon, Ozer, Cinicioglu, Seda, Torisu

المصدر: Archives for Technical Sciences / Arhiv za Tehnicke Nauke; 2024, Issue 30, p79-96, 18p

مصطلحات موضوعية: KAHRAMANMARAS Earthquake, Turkey & Syria, 2023, CITIES & towns, SOIL liquefaction, SHEAR waves, SPECIFIC gravity

مصطلحات جغرافية: TURKEY

مستخلص: On February 6th 2023 two major earthquakes struck southeast Turkey, M7.7 Kahramanmaras and M7.6 Elbistan, respectively. Unfortunately, due to the impact of these catastrophic events more than 50 000 casualties and 35 000 collapsed buildings have been reported since then. The aim of the study is to demonstrate preliminary site response analysis and assessment of re-liquefaction potential of sites which have been affected by the earthquakes - especially the cities of Iskenderun and Golbasi. Both site-specific areas have clear evidences of liquefaction and lateral spreading events which imply the focus of the presented paper. A series of geophysical MASW and microtremor tests have been performed in order to determine shear wave velocities up to depth of 30 m as well as the fundamental natural frequency of the soil deposits. Moreover, samples have been collected from sand and silt ejecta in order to evaluate some basic physical properties - grain-size curves, specific gravity and plasticity parameters. On the basis of the obtained data seismic classification of the investigated sites according to current design codes has been made and in-depth distance to relatively stiff layer has been assumed. For the sake of evaluating risk of re-liquefaction the widely-used simplified stress-based approach to triggering assessment has been adopted considering some rules of the thumb (e.g., sieve analysis and plasticity properties evaluation). Lastly, post-liquefaction reconsolidation settlement and lateral displacement have been determined in terms of future earthquakes. [ABSTRACT FROM AUTHOR]

: Copyright of Archives for Technical Sciences / Arhiv za Tehnicke Nauke is the property of Archives for Technical Science / Arhiv za tehnicke nauke and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Briones, Juan, Khan, Maira, Sidhu, Amanjot K., Zhang, Liying, Smoragiewicz, Martin, Emmenegger, Urban

المصدر: Frontiers in Oncology ; volume 11 ; ISSN 2234-943X

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Background Both Docetaxel (DOC) and Abiraterone (ABI) improve the survival of men with metastatic, castration sensitive prostate cancer (mCSPC). However, the outcome among mCSPC patients is highly variable, while there is a lack of predictive markers of therapeutic benefit. Furthermore, there is limited data on the comparative real-world effectiveness of adding DOC or ABI to androgen deprivation therapy (ADT). Methods We conducted a retrospective analysis of 121 mCSPC patients treated at Odette Cancer Centre (Toronto, ON, Canada) between Dec 2014 and Mar 2021 (DOC n = 79, ABI n = 42). The primary endpoint studied was progression free survival (PFS), defined as the interval from start of ADT to either (i) biochemical, radiological, or symptomatic progression, (ii) start of first-line systemic therapy for castration-resistant prostate cancer (CRPC), or (iii) death, whichever occurred first. To identify independent predictive factors for PFS in the entire cohort, a Cox proportional hazard model (stepwise selection) was applied. Overall survival (OS) was among secondary endpoints. Results After a median follow-up of 39.6 and 25.1 months in the DOC and ABI cohorts, respectively, 79.7% of men in the DOC and 40.5% in the ABI group experienced a progression event. PFS favored the ABI cohort (p = 0.0038, log-rank test), with 78.0% (95%CI 66.4–91.8%) of ABI versus 67.1% (57.5–78.3%) of DOC patients being free of progression at 12 months. In univariate analysis superior PFS was significantly related to older age at diagnosis of mCSPC, metachronous metastatic presentation, low-volume (CHAARTED), and low-risk (LATITUDE) disease, ≥90% PSA decrease at 3 months (PSA90), and PSA nadir ≤0.2 at 6 months. Age (HR = 0.955), PSA90 (HR = 0.462), and LATITUDE risk stratification (HR = 1.965) remained significantly associated with PFS in multivariable analysis. OS at 12 months was 98.7% (96.3–100%) and 92.7% (85.0–100%) in the DOC and ABI groups (p = 0.97), respectively. Conclusions In this real-world group of men undergoing treatment ...

الإتاحة: https://doi.org/10.3389/fonc.2021.658331Test

المؤلفون: Sidhu, Amanjot, Khan, Nabeeha, Phillips, Cameron, Briones, Juan, Kapoor, Anil, Zalewski, Pawel, Fleshner, Neil E., Chow, Edward, Emmenegger, Urban

المصدر: Journal of Clinical Medicine; Sep2023, Vol. 12 Issue 17, p5604, 12p

مصطلحات موضوعية: CASTRATION-resistant prostate cancer, PROSTATE-specific antigen, PROGNOSIS, BIOMARKERS

مصطلحات جغرافية: ONTARIO, CANADA

مستخلص: Radium-223 (Ra233) prolongs the survival of men with symptomatic bone-predominant metastatic castration-resistant prostate cancer (mCRPC). However, prostate-specific antigen (PSA) response patterns are not closely associated with Ra223 therapy outcomes. Herein, we sought to analyze the impact of Ra223-induced PSA flares on patient outcome. Using a retrospective cohort study of Ra223 treatment in four Ontario/Canada cancer centres, we identified 134 patients grouped into sub-cohorts according to distinct PSA response patterns: (i) initial PSA flare followed by eventual PSA decline; (ii) PSA response (≥30% PSA decrease within 12 weeks of treatment); and (iii) PSA non-response. We analyzed patient characteristics and outcome measures, including overall survival (OS), using the Kaplan-Meier method and log-rank testing. PSA flares were observed in 27 (20.2%), PSA responses in 11 (8.2%), and PSA non-responses in 96 (71.6%) patients. Amongst PSA flare patients, 12 presented with post-flare PSA decreases below baseline and 15 with PSA decreases below the flare peak but above baseline. Although only six flare patients achieved ≥30% PSA decreases below baseline, the median OS of all flare patients (16.8 months, 95% CI 14.9–18.7) was comparable to that of PSA responders and non-responders (p = 0.349). In summary, around 20% of mCRPC patients experience Ra223-induced PSA flares, whose outcome is similar to that of men with or without PSA responses. Further studies are needed regarding suitable biochemical surrogate markers of response to Ra223. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Clinical Medicine is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Khan, Maira, Parshad, Shruti, Naimi, Mahdi F., Sidhu, Amanjot K., Lyons, Frank, Hardisty, Michael R., Whyne, Cari M., Smoragiewicz, Martin, Phillips, Cameron M., Briones, Juan, Emmenegger, Urban

المصدر: Clinical Genitourinary Cancer; Aug2023, Vol. 21 Issue 4, pe228-e235, 9p

مصطلحات موضوعية: CASTRATION-resistant prostate cancer, PROSTATE cancer treatment, RADIUMTHERAPY, DENOSUMAB, COMPUTED tomography

مستخلص: There are complex interactions between bone and skeletal muscle. However, the prevention and treatment of treatment-induced osteosarcopenia in men with metastatic castration-resistant prostate cancer focuses predominantly on bone health. In a single-center cohort of 52 patients we demonstrate that bone-targeted Radium-223 therapy does not accelerate sarcopenia, but baseline sarcopenia is associated with poor survival in such patients. Introduction: Osteosarcopenia is the progressive loss of musculoskeletal structure and functionality, contributing to disability and mortality. Despite complex interactions between bone and muscle, osteosarcopenia prevention and treatment in men with metastatic castration-resistant prostate cancer (mCRPC) focuses predominantly on bone health. It is unknown whether Radium-223 (Ra-223) therapy affects sarcopenia. Methods: We identified 52 patients with mCRPC who had received Ra-223 and had a baseline plus =1 follow-up abdominopelvic CT scan. The total contour area (TCA) and averaged Hounsfield units (HU) of the left and right psoas muscles were obtained at the inferior L3 endplate, and the psoas muscle index (PMI) was calculated there from. Intrapatient musculoskeletal changes were analyzed across various time points. Results: TCA and PMI gradually declined over the study period (P = .002, P = .003, respectively), but Ra-223 therapy did not accelerate sarcopenia, nor the decline of HU compared to the pre-Ra-223 period. The median overall survival of patients with baseline sarcopenia was numerically worse (14.93 vs. 23.23 months, HR 0.612, P = .198). Conclusions: Ra-223 does not accelerate sarcopenia. Thus, worsening muscle parameters in men with mCRPC undergoing Ra-223 therapy are attributable to other factors. Further research is needed to determine whether baseline sarcopenia predicts poor overall survival in such patients. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Genitourinary Cancer is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)