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61دورية أكاديمية
المؤلفون: Çetin, Meriç
مصطلحات موضوعية: Epileptic seizure, Cortex model, Observer-based stabilization, PID control, Takagi–Sugeno fuzzy modeling, Uncertain dynamics, Article, biofeedback, brain cortex, brain function, computer model, fuzzy system, human, membrane potential, nonhuman, nonlinear system, seizure, sensory analysis
الوصف: Uncontrolled seizures may lead to irreversible damages in the brain and various limitations in the patient’s life. There exist experimental studies to stabilize the patient seizures. However, the experimental setups have many sensory devices to measure the dynamics of the brain cortex. These equipments prevent to produce small portable stabilizers for patients in everyday life. Recently, a comprehensive cortex model is introduced to apply model-based observers and controllers. However, this cortex model can be uncertain and have time-varying parameters. Therefore, in this paper, a robust Takagi–Sugeno (TS) controller and observer are designed to suppress the epileptic seizures without sensory measurements. The unavailable sensory measurements are provided by the designed nonlinear observer. The exponential convergence of the observer and controller is satisfied by the feedback parameter design using linear matrix inequalities. In addition, TS fuzzy observer–controller design has been compared with the conventional PID method in terms of control performance and design problem. The numerical computations show that the epileptic seizures are more effectively suppressed by the TS fuzzy observer-based controller under uncertain membrane potential dynamics. © 2019, Springer Nature B.V.
العلاقة: Cognitive Neurodynamics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37249Test; https://doi.org/10.1007/s11571-019-09555-8Test; 14; 51; 67; 2-s2.0-85073963508; WOS:000512014600003
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62دورية أكاديمية
المؤلفون: Demirkapu, Mahluga Jafarova, Yananlı, Hasan Raci, Akşahin, E., Karabiber, C., Günay, P., Kekilli, A., Topkara, B.
مصطلحات موضوعية: epilepsy, glutamate, hippocampus, kindling, drinking water, glutamate sodium, ketamine, neurotransmitter, animal experiment, animal tissue, Article, body weight, comparative study, electroencephalogram, electroencephalography, electrostimulation, epileptogenesis, infant, nonhuman, priority journal, rat, animal, brain cortex, disease model, drug effect, electrocorticography, female, male, pathophysiology, Wistar rat
الوصف: Aim: Glutamate is an excitatory neurotransmitter that is widely distributed throughout the brain. An increase in glutamate concentration or sensitivity of glutamate receptors triggers neurodegenerative diseases, epilepsy in particular. Monosodium glutamate is a substance added to foods to enhance flavour. We investigated the effect of monosodium glutamate on epileptogenesis, as well asheight and weight, in rats that were just weaned. Methods: Twenty-four male and female 21-day-old Wistar Albino rats were divided into two groups: one with monosodium glutamate added to the drinking water, and a control in which NaCl was added to the drinking water. The electrical stimulation threshold values were determined in animals to which the hippocampal kindling process was applied, and the stimulations at these threshold values were invariably applied to the animals until they were kindled. Results: The electrical stimulation threshold values of the monosodium glutamate group did not statistically change, whereas the number of required stimulations for kindled rats was significantly lower compared with the control group. Conclusion: These results reveal that long-term oral administration of glutamate salts causes an increase in excitability in the central nervous system during ontogenetic development. © 2020 Epileptic Disorders
العلاقة: Epileptic Disorders; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1684/epd.2020.1156Test; https://hdl.handle.net/20.500.11776/4909Test; 22; 195; 201; WOS:000530695900007; 2-s2.0-85084271535
الإتاحة: https://doi.org/20.500.11776/4909Test
https://doi.org/10.1684/epd.2020.1156Test
https://hdl.handle.net/20.500.11776/4909Test -
63دورية أكاديمية
المؤلفون: Kullanda K.M., Sorokina T.S.
المصدر: Fiziologicheskii Zhurnal SSSR Imeni I.M. Sechenova
مصطلحات موضوعية: brain cortex, electroencephalography, hyperpolarization, in vitro study, theoretical study, animal, article, cat, drug effect, electrode, electrostimulation, evoked response, peripheral nerve, physiology, somatosensory cortex, 4 aminobutyric acid, strychnine, Cats, Cerebral Cortex, Electric Stimulation, Electrodes, English Abstract, Evoked Potentials, gamma-Aminobutyric Acid, In Vitro, Peripheral Nerves
الوصف: [No abstract available]
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64دورية أكاديمية
المؤلفون: Pavlova I.G., Medvedev D.I.
المصدر: Zhurnal Nevropatologii i Psikhiatrii Imeni S.S.Korsakova
مصطلحات موضوعية: animal experiment, brain cortex, central nervous system, electron microscopy, malnutrition, mouse, animal, article, cell granule, cell nucleus, dendrite, endoplasmic reticulum, intracellular membrane, lysosome, mouse strain, pathology, protein calorie malnutrition, ribosome, synapse, time, ultrastructure, Cerebral Cortex, Cytoplasmic Granules, Dendrites, English Abstract, Intracellular Membranes, Lysosomes, Mice, Inbred CBA, Microscopy
الوصف: [No abstract available]
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65دورية أكاديمية
المؤلفون: Agadzhanian N.A., Torshin V.I.
المصدر: Byulleten Eksperimentalnoi Biologii i Meditsiny
مصطلحات موضوعية: penicillin G, strychnine, animal experiment, brain cortex, central nervous system, drug tolerance, electroencephalography, epileptic discharge, epileptic focus, hypoxia, nonhuman, rat, Animalia, Strychnos toxifera
الوصف: It has been shown in experiments on white random-bred rats that there is a correlation between tolerance of hypoxia and resistance to the action of convulsants. Animals with a high individual tolerance of hypoxia needed higher concentrations of penicillin for creating an epileptic focus in the brain cortex than those with a lower tolerance. During application of equal concentrations of penicillin, the degree of bioelectrical epileptic activity of the brain was less pronounced in animals with high hypoxia tolerance than in those with lower tolerance. In the former group of animals the latent period of epileptic discharges was considerably longer and convulsive attacks occurred less frequently. Intraperitoneal injection of the same doses of strychnine exerted a lesser convulsant action on animals with a higher hypoxia tolerance. In these animals epileptic seizures developed less slowly, were less lasting and were tolerated better than in those with a lower tolerance. The conclusion is made about certain aspects of CNS activity in animals with varying tolerance of hypoxia.
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66دورية أكاديمية
المؤلفون: Agadzhanyan N.A., Torshin V.I.
المصدر: Byulleten Eksperimentalnoi Biologii i Meditsiny
مصطلحات موضوعية: penicillin G, penicillin derivative, adaptation, animal experiment, brain cortex, central nervous system, drug mechanism, epileptogenesis, hypoxia, intoxication, nervous system, neurotoxicity, nonhuman, rat, air quality control, animal, anoxia, article, comparative study, disease predisposition, electroencephalography, focal epilepsy, iatrogenic disease, male, pathophysiology, time, Animalia, Physiological, Atmosphere Exposure Chambers, Disease Susceptibility
الوصف: [No abstract available]
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67دورية أكاديمية
المؤلفون: Babichenko I.I., Medvedev D.I., D Yachkova L.N.
المصدر: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian
مصطلحات موضوعية: animal cell, anterior horn cell, brain, brain cortex, cat, cerebellum, hypothalamus, mouse, neocortex, nervous system development, nonhuman, paleocortex, rat, sympathetic ganglion, synaptogenesis, ultrastructure
الوصف: [No abstract available]
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68دورية أكاديمية
المؤلفون: Korkina M.V., Korchak G.M., Medvedev D.I.
المصدر: Zhurnal Nevropatologii i Psikhiatrii Imeni S.S.Korsakova
مصطلحات موضوعية: carnitine, cobamamide, cyanocobalamin, adult, anorexia nervosa, body weight, brain cortex, clinical article, fatigue, histology, human, starvation, ultrastructure, animal, article, comparative study, disease model, drug combination, drug effect, drug potentiation, drug screening, electron microscopy, mouse, mouse strain, organ weight, pathology, Cerebral Cortex, Disease Models, Drug Evaluation, Preclinical
الوصف: [No abstract available]
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69دورية أكاديمية
المؤلفون: Tsekhmistrenko T.A., Vasil'eva V.A., Shumeǐko N.S., Vologirov A.S.
المصدر: Morfologiia (Saint Petersburg, Russia)
مصطلحات موضوعية: aging, article, brain cortex, child, growth, development and aging, histology, human, image processing, infant, nerve fiber, newborn, physiology, preschool child, ultrastructure, Cerebral Cortex, Preschool, Humans, Computer-Assisted, Nerve Fibers
الوصف: The peculiarities of fibroarchitectonics in topographically and functionally distinct cortical zones (including temporo-parieto-occipital subarea, occipital, pre-, postcentral, and frontal areas) were studied in the brain specimens of 74 children of different ages (from birth to 12 years) taken with yearly intervals, while those in the first year of life--with monthly intervals. Frontal sections stained with Nissl, Peters and Golgi methods were studied using computer analysis of optical images. The data were obtained on the increment rates of radial fiber fascicles' thickness, distances between fascicles and age dynamics of ratios of volume densities of neurons and fibers in areas 3, 4p, 6op, 17, 19, 37ac, 44 and 32/10. It was shown that age-related transformations of fibroarchitectonics in the areas of sensomotor, somatosensory, occipital, temporo-parieto-occipital and frontal cortex were heterochronic and took place with different intensity; most pronounced changes were found to occur during the first 2-3 years, while less intensive ones were observed up to the age of 9-12 years.
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70دورية أكاديمية
المؤلفون: Reznikov K.Y.
المصدر: Advances in anatomy, embryology, and cell biology
مصطلحات موضوعية: animal, article, brain cortex, brain mapping, cell death, cell division, cytology, electron microscopy, embryology, female, hippocampus, male, mouse, physiology, rat, Cerebral Cortex, Mice, Microscopy, Electron, Rats
الوصف: In the present work, processes of cell proliferation, cell death, neurogenesis, and gliogenesis in the mouse hippocampus were studied. The mapping of distribution of hippocampal mitoses and counting of their number allowed a more precise definition of the data concerning the disposition and age reduction of proliferative sites in Ammon's horn and the dentate gyrus in the mouse. As a result, the following generalized scheme of development and age reduction of the germinal zones in the mouse hippocampus has been suggested. 1. Ammon's horn a) The ventricular zone, from the beginning of formation of the hippocampus (E11) until E20 b) The suprafimbrial zone, from E16 until P7 2. Dentate gyrus a) The prime germinal zone ("the anlage of the dentate gyrus" of Stanfield and Cowan1979b), from E15 until P3 b) The proliferative zone of the hilus, from P3 until P14 c) The subgranular zone, from P3 until adult age The adduced scheme needs some comments: 1. In the hippocampus (as well as in other formations of the developing brain), primary precursors of all types of cells of neuroectodermal origin are represented by cells of the ventricular zone. They give rise to cells of secondary germinal zones in the dentate gyrus and Ammon's horn and are direct precursors of the majority (if not of all) neuronal cells in Ammon's horn, the earliest originating generations of neurons in the dentate gyrus, hippocampal radial glial cells, and, evidently, of a considerable part of astroblasts and oligodendroblasts in Ammon's horn. 2. In contrast to the subiculum, Ammon's horn in the mouse lacks a subventricular (subependymal) zone. These data differ from the results obtained in the rat, where the subventricular zone is described both in the subiculum and Ammon's horn (Bayer 1980b) and from the study in the monkey, where the subiculum and Ammon's horn lack the subventricular zone (Nowakowski and Rakic 1981). Thus, in the case of the mouse, the subventricular zone can serve as a cytoarchitectural characteristic allowing detection of a border ...
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