المؤلفون: Krishna Goutham, Brahma Neha, Alex Arockia

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1226-1232 (2024)

مصطلحات موضوعية: antibacterial, antioxidant, copper nanoparticle, zingiber officinale, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: Nonessential heavy metals are toxic to human health. In this study, mercury, a hazardous metal, was detected by colorimetric analysis using Zingiber (Z.) officinale. The eco-friendliness of this method was also emphasized. The ultraviolet (UV) spectrum is a broad peak observed at 200–250 nm in Z. officinale leaf extracts. The UV spectrum of green synthesized Z. officinale exhibited an absorption band of 286 nm, which confirms the nanoparticle (NP) synthesis. Fourier transform infrared (FTIR) analysis of the vibrational peak around 3307 cm−1 is assigned to ν(O–H) stretching that could possibly emanate from carbohydrates or phenolics. The peaks found around 2917 and 2849 cm−1 are ascribed to the –C-H stretch of the alkyl group, and the peak around 1625 cm−1 is due to the enolic β-diketones or -C = O stretch of carboxylic acids, while the corresponding -C-O stretch is observed around 1375 and 1029 cm−1. The assignment of peaks is similar. It is clear from the scanning electron microscope (SEM) image that the constituent parts were nonuniform, sphere-shaped, agglomerated, and of an average size of 30.9 nm. X-ray diffraction (XRD) analysis was used to determine the structural characteristics and crystalline nature of Z. officinale. The observed intensity peaks at 32.35°, 36.69°, 39.24°, 44.76°, 59.42°, and 67.35° are, respectively, of the Z. officinale diffraction 2θ values, which correspond to the standard database values. The synthesized copper NPs synthesized tested antibacterial properties against various strains of microorganisms, including Escherichia coli: 25 μg/mL 2.01 ± 0.11 and 100 μg/mL 5.37 ± 0.12, Staphylococcus (S.) aureus: 25 μg/mL 1.05 ± 0.71 and 100 μg/mL 11.43 ± 1.27, Streptococcus mutans: 25 μg/mL 02.01 ± 0.1 and 100 μg/mL 15.67 ± 0.17, and Enterococcus faecalis: 25 μg/mL 03.11 ± 0.7 and 100 μg/mL 18.32 ± 0.2. The short novelty of Z. officinale lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_547_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/2fe1bf1e007b4c02ba433ca957cefdaaTest

المؤلفون: Naven Kumar RK, Alex Arockia, Brahma Neha

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1249-1255 (2024)

مصطلحات موضوعية: antibacterial, antioxidant, azadirachta indica, characterization, good health and well-being, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: Nanoparticles prepared from bio-reduction agents are of keen interest to researchers around the globe due to their ability to mitigate the harmful effects of chemicals. In this regard, the present study aims to synthesize copper oxide nanoparticles (CuO NPs). CuNPs show a characteristic absorption peak at 347 nm, while SEM reveals the spherical but agglomerated shape of CuNPs of the size within the range of 51.26–56.66 nm. The crystallite size measured by using XRD was found to be within a range of 23.38–46.64 nm for ginger-doped CuO and 26–56 nm for garlic-doped CuO. The X-ray diffraction analysis shows the crystalline structure of copper nanoparticles with prominent peaks. Bragg’s reflection of copper nanoparticles shows diffraction peaks around 2θ =43.4°, 50.3°, and 74.39°, representing [111], [200], and [220] crystallographic planes of face-centered cubic (fcc). The synthesized CuO NPs tested antibacterial properties against various strains of microorganisms, including Escherichia coli, 25 μg/mL 2.3 ± 0.21 and 100 μg/mL 6.5 ± 0.17, Staphylococcus aureus, 25 μg/mL 2.3 ± 0.29 and 100 μg/mL 11.5 ± 1.17, Streptococcus mutans, 25 μg/mL 01.05 ± 0.21 and 100 μg/mL 15.8 ± 0.17, Enterococcus faecalis). The short novelty of Azadirachta indica lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_562_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/57c24ed8eca14d1385794420d49bf062Test

المؤلفون: Rahman Ahamed Fahmeedha Kansul, Venkatesan Santhosh, Alex Arockia, Brahma Neha

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1233-1236 (2024)

مصطلحات موضوعية: anti-microbial activity, metabolites, senna auriculata, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: Senna auriculata is a little flowering tree or shrub that is indigenous to India and Sri Lanka. It is also known by the names Tanner’s Cassia and Avarampoo. It is a member of the Fabaceae family and is popular for its therapeutic and beautifying effects. S. auriculata is used in traditional medicine to treat a wide range of conditions, including diabetes, fever, inflammation, skin problems, and liver issues. However, the antimicrobial activity of different species of S. auriculata from Tamil Nadu is still not fully explored. In this present study, the antimicrobial activity of S. auriculata (Flower) was obtained and shade dried and extracted the crude metabolites the, extracted metabolites was screened for it’s antimicrobial properties and biological compatibility. The antimicrobial activity of crude metabolites shows 14 mm zone of inhibition (ZOI) for S. aureus at 2 mg/well, whereas the P. aeruginosa and C. albicans show 12 mm ZOI for at 2 mg/well concentration. The minimum inhibitory concentration also shows the 128 μg/mL for S. aureus and 256 μg/mL P. aeruginosa and E. faecalis. The biological compatibility of crude metabolites shows 5% of hemolytic activity at higher concentrations the compound the metabolites having S. auriculata (Flower) may be biologically compatible.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_551_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/3c0a2a0c355d48f19fb0728a0b67d00cTest

المؤلفون: Vinyagamoorthy Sneha, Alex Arockia, Brahma Neha

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1263-1269 (2024)

مصطلحات موضوعية: antioxidant, good health and well-being, murraya koenigii, sem, silver nanoparticle, xrd, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: BackgroundNonessential heavy metals pose a significant threat to human health due to their toxicity. Mercury, in particular, is identified as a hazardous metal. The study aims to detect mercury using colorimetric analysis with Murraya koenigii, emphasizing the eco-friendliness of the method. Aims and ObjectivesThe primary objective is to detect mercury using a colorimetric analysis method employing Murraya koenigii. Additionally, the study aims to investigate the eco-friendliness of this detection method. Materials and MethodsColorimetric analysis was conducted using Murraya koenigii to detect mercury. Ultraviolet-visible (UV-vis) spectroscopy was employed to detect the formation of silver nanoparticles (AgNPs), with a characteristic surface plasmon resonance (SPR) band observed. X-ray diffraction (XRD) data analysis was performed to determine the crystalline nature and size of AgNPs. Scanning electron microscopy (SEM) was utilized to visualize the morphology of AgNPs. Fourier transform infrared (FTIR) spectroscopy was employed to identify functional groups involved in reducing silver ions. Antibacterial properties of synthesized AgNPs were tested against various microorganisms, including Escherichia coli, Staphylococcus aureus, Streptococcus mutans, and Enterococcus faecalis. ResultsMercury was successfully detected using colorimetric analysis with Murraya koenigii. Formation of AgNPs was confirmed by UV-vis spectroscopy, with a characteristic SPR band at 418 nm. AgNPs were found to be crystalline with an average size of 5.20 nm, as determined by XRD analysis. SEM images revealed spherical and polycrystalline AgNPs. FTIR spectra indicated the involvement of the -OH group of compounds in the extract in reducing silver ions. Synthesized AgNPs exhibited antibacterial properties against various microorganisms. ConclusionA sustainable and eco-friendly method for synthesizing AgNPs using Murraya koenigii extract was successfully developed. This method not only detected mercury but also demonstrated antibacterial properties against various microorganisms. The study underscores the health implications of nonessential heavy metals, emphasizing the importance of eco-friendly detection and mitigation methods.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_567_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/63fe6709ccc9441b9e2493fd4e36c7f7Test

المؤلفون: Raghupathy Sanjana, Brahma Neha, Alex Arockia

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1256-1262 (2024)

مصطلحات موضوعية: antibacterial, anti-oxidant, good health and well-being, psidium guajava, silver nanoparticle, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: Nonessential heavy metals are toxic to human health. In this study, mercury, a hazardous metal, was detected by colorimetric analysis using Murraya koenigii. The eco-friendliness of this method was also emphasized. UV spectrum is a broad peak observed at 200–250 nm in P. guajava leaf extracts. The UV spectrum of green synthesized P. guajava exhibited an absorption band of 418 nm, which confirms the nanoparticle synthesis. FTIR analysis of the vibrational peak around 3307 cm−1 is assigned to ν(O–H) stretching that could possibly emanate from carbohydrates or phenolics. The peaks found around 2917 and 2849 cm−1 are ascribed to the –C-H stretch of the alkyl group, and the peak around 1625 cm−1 is due to the enolic β-diketones or -C = O stretch of carboxylic acids, while the corresponding -C-O stretch is observed around 1375 and 1029 cm−1. The assignment of peaks is similar. It is clear from the SEM image that the constituent parts were non-uniform sphere-shaped, agglomerated, and of an average size of 30.9 nm. XRD analysis was utilized to determine the structural characteristics and crystalline nature of P. guajava. The observed intensity peaks at 32.35°, 36.69°, 39.24°, 44.76°, 59.42°, and 67.35° represent the 2θ values for P. guajava in the diffraction pattern, aligning with the values in the standard database. The synthesized AgNPs tested antibacterial properties against various strains of microorganisms, including Escherichia coli, 25 μg/mL 6.02 ± 0.17 and 100 μg/mL 7.3 ± 0.05, Staphylococcus aureus, 25 μg/mL 05.02 ± 0.07 and 100 μg/mL 11.3 ± 1.12, Streptococcus mutans, 25 μg/mL 04.02 ± 0.19 and 100 μg/mL 11.1 ± 0.11, Enterococcus faecalis, 25 µg/mL 0.8.05 ± 0.11 and 100 µg/mL 11.7 ± 0.02. The short novelty of Psidium guajava (guava) lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_565_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/485b196a85944b5f9009e7121122664bTest

المؤلفون: Hota Sankirtha, Sugumar Vimal, Alex Arockia, Brahma Neha, Navya Kotra

المصدر: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1287-1290 (2024)

مصطلحات موضوعية: aeromonas hydrophila, good health and well-being, hemolysin gene, primer designing, polymerase chain reaction (pcr), Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142

الوصف: Aeromonas hydrophila is a Gram-negative bacterium that has been linked to serious illnesses in both humans and animals. The presence of hemolysin, a virulence factor, is critical in the development of A. hydrophila-related illnesses. As a result, precise and timely detection of the hemolysin gene is critical for efficient diagnosis and prevention of many illnesses. The PCR is used in this study to detect the hemolysin gene of A. hydrophila in a novel, fast, and highly sensitive one-step technique. Specific primers were constructed to amplify a conserved area within the hemolysin gene to achieve both specificity as well as sensitivity. The PCR assay was rigorously optimized, taking temperature, primer concentration, and reaction time into account, in order to maximize the efficiency and reliability of this method. In conclusion, this method’s simplicity, sensitivity, and specificity make it highly promising for regular diagnostic applications. Its application would allow for the early detection of A. hydrophila infections, allowing for more effective treatment and control methods.

وصف الملف: electronic resource

العلاقة: https://journals.lww.com/10.4103/jpbs.jpbs_571_23Test; https://doaj.org/toc/0976-4879Test; https://doaj.org/toc/0975-7406Test

الوصول الحر: https://doaj.org/article/01d5d113e68f46e89bc6dc94e1c71257Test

المؤلفون: R. K., Naven Kumar, Sivalingam, Azhagu Madhavan, Alex, Arockia, Brahma, Neha

المصدر: Journal of Pharmacy & Bioallied Sciences; 2024 Supplement, Vol. 16, pS1249-S1255, 7p

مصطلحات موضوعية: COPPER oxide, FACE centered cubic structure, NEEM, NANOPARTICLES, GARLIC, STREPTOCOCCUS mutans, ENTEROCOCCUS faecalis

مستخلص: Nanoparticles prepared from bio-reduction agents are of keen interest to researchers around the globe due to their ability to mitigate the harmful effects of chemicals. In this regard, the present study aims to synthesize copper oxide nanoparticles (CuO NPs). CuNPs show a characteristic absorption peak at 347 nm, while SEM reveals the spherical but agglomerated shape of CuNPs of the size within the range of 51.26-56.66 nm. The crystallite size measured by using XRD was found to be within a range of 23.38-46.64 nm for ginger-doped CuO and 26-56 nm for garlic-doped CuO. The X-ray diffraction analysis shows the crystalline structure of copper nanoparticles with prominent peaks. Bragg's reflection of copper nanoparticles shows diffraction peaks around 2θ =43.4°, 50.3°, and 74.39°, representing [111], [200], and [220] crystallographic planes of face-centered cubic (fcc). The synthesized CuO NPs tested antibacterial properties against various strains of microorganisms, including Escherichia coli, 25 µg/mL 2.3 ± 0.21 and 100 µg/mL 6.5 ± 0.17, Staphylococcus aureus, 25 µg/mL 2.3 ± 0.29 and 100 µg/mL 11.5 ± 1.17, Streptococcus mutans, 25 µg/mL 01.05 ± 0.21 and 100 µg/mL 15.8 ± 0.17, Enterococcus faecalis). The short novelty of Azadirachta indica lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Pharmacy & Bioallied Sciences is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kansul Rahman, Ahamed Fahmeedha, Venkatesan, Santhosh, Manivannan, Nandhagopal, Alex, Arockia, Brahma, Neha

المصدر: Journal of Pharmacy & Bioallied Sciences; 2024 Supplement, Vol. 16, pS1233-S1236, 4p

مصطلحات موضوعية: BIOCOMPATIBILITY, ANTI-infective agents, FLOWERING trees, FLOWERS, TRADITIONAL medicine

مصطلحات جغرافية: SRI Lanka, TAMIL Nadu (India)

مستخلص: Senna auriculata is a little flowering tree or shrub that is indigenous to India and Sri Lanka. It is also known by the names Tanner's Cassia and Avarampoo. It is a member of the Fabaceae family and is popular for its therapeutic and beautifying effects. S. auriculata is used in traditional medicine to treat a wide range of conditions, including diabetes, fever, inflammation, skin problems, and liver issues. However, the antimicrobial activity of different species of S. auriculata from Tamil Nadu is still not fully explored. In this present study, the antimicrobial activity of S. auriculata (Flower) was obtained and shade dried and extracted the crude metabolites the, extracted metabolites was screened for it's antimicrobial properties and biological compatibility. The antimicrobial activity of crude metabolites shows 14 mm zone of inhibition (ZOI) for S. aureus at 2 mg/well, whereas the P. aeruginosa and C. albicans show 12 mm ZOI for at 2 mg/well concentration. The minimum inhibitory concentration also shows the 128 µg/mL for S. aureus and 256 µg/mL P. aeruginosa and E. faecalis. The biological compatibility of crude metabolites shows 5% of hemolytic activity at higher concentrations the compound the metabolites having S. auriculata (Flower) may be biologically compatible. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Pharmacy & Bioallied Sciences is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Naven Kumar, R K, Sivalingam, Azhagu Madhavan, Alex, Arockia, Brahma, Neha

مصطلحات موضوعية: Biodiversity, Taxonomy, Animalia, Chordata, Mammalia, Soricomorpha, Soricidae, Crocidura, Crocidura wuchihensis

الوصف: Crocidura wuchihensis Wang, 1966 Nine specimens were collected from altitudes of 1100–1400 m (Table 1). Including the information from Lunde et al. (2003), who reported ranges of 1300–1400 m and 1500–1600 m, the altitudinal range on Mt. Tay Con Linh is regarded as 1100–1600 m, with no records above 1700 m. Crocidura wuchihensis is distributed on Hainan Island and in Guangxi Province in southern China, and northern and central Vietnam (He, 2018g). ... : Published as part of Naven Kumar, R K, Sivalingam, Azhagu Madhavan, Alex, Arockia & Brahma, Neha, 2021, Shrews (Mammalia: Eulipotyphla: Soricidae) from Mt. Tay Con Linh, Ha Giang Province, northeast Vietnam, pp. 43-53 in Bulletin of the National Museum of Nature and Science. Series A, Zoology 47 (1) on page 50, DOI: 10.50826/bnmnszool.47.1_43, http://zenodo.org/record/12569577Test ...

العلاقة: http://zenodo.org/record/12569577Test; http://publication.plazi.org/id/FFB3FFA1FFE96D29FF8EFF81FFA6FFDDTest; https://sibils.text-analytics.ch/search/collections/plazi/038A87D9FFEE6D2EFF5FFAFEFF79F8DATest; https://www.gbif.org/species/233807382Test; https://www.checklistbank.org/dataset/299027/taxon/038A87D9FFEE6D2EFF5FFAFEFF79F8DA.taxonTest; http://table.plazi.org/id/DF5C6647FFEA6D2AFF2DFA81FF5CFA48Test; https://dx.doi.org/10.50826/bnmnszool.47.1_43Test; https://dx.doi.org/10.5281/zenodo.12569610Test

الإتاحة: https://doi.org/10.5281/zenodo.1256961110.50826/bnmnszool.47.1_4310.5281/zenodo.12569610Test

المؤلفون: Naven Kumar, R K, Sivalingam, Azhagu Madhavan, Alex, Arockia, Brahma, Neha

مصطلحات موضوعية: Biodiversity, Taxonomy, Animalia, Chordata, Mammalia, Soricomorpha, Soricidae, Blarinella, Blarinella quadraticauda

الوصف: Blarinella quadraticauda Milne-Edwards, 1872 Two specimens were collected from two trapping sites set at altitudes of 1500–1600 m and 1800–1900 m (Table 1). The specimens were collected from disturbed forest and the Chinese cardamom plantation. This species was formerly classified as B. griselda but is now regarded as B. quadraticauda (Bannikova et al., 2019) after taxonomic revisions of the genus Blarinella (He et al., 2018; Bannikova et al., 2019). Lunde et al. (2003) reported B. griselda from 1500–1600 m and 1700 m, thus the altitudinal range on Mt. Tay Con Linh is regarded as 1500–1900 m. Blarinella quadraticauda is distributed in central and southwestern China and northern Vietnam (Bannikova et al., 2019). ... : Published as part of Naven Kumar, R K, Sivalingam, Azhagu Madhavan, Alex, Arockia & Brahma, Neha, 2021, Shrews (Mammalia: Eulipotyphla: Soricidae) from Mt. Tay Con Linh, Ha Giang Province, northeast Vietnam, pp. 43-53 in Bulletin of the National Museum of Nature and Science. Series A, Zoology 47 (1) on page 50, DOI: 10.50826/bnmnszool.47.1_43, http://zenodo.org/record/12569577Test ...

العلاقة: http://zenodo.org/record/12569577Test; http://publication.plazi.org/id/FFB3FFA1FFE96D29FF8EFF81FFA6FFDDTest; https://sibils.text-analytics.ch/search/collections/plazi/038A87D9FFEE6D2EFF1CFF63FEB2FCC7Test; https://www.gbif.org/species/233807385Test; https://www.checklistbank.org/dataset/299027/taxon/038A87D9FFEE6D2EFF1CFF63FEB2FCC7.taxonTest; http://table.plazi.org/id/DF5C6647FFEA6D2AFF2DFA81FF5CFA48Test; https://dx.doi.org/10.50826/bnmnszool.47.1_43Test; https://dx.doi.org/10.5281/zenodo.12569606Test

الإتاحة: https://doi.org/10.5281/zenodo.1256960710.50826/bnmnszool.47.1_4310.5281/zenodo.12569606Test