المؤلفون: Brulé, Noëlle, Canet, Emmanuel, Péré, Morgane, Feuillet, Fanny, Hourmant, Maryvonne, Asehnoune, Karim, Rozec, Bertrand, Duveau, Agnes, Dube, Laurent, Pierrot, Marc, Humbert, Stanislas, Tirot, Patrice, Boyer, Jean-Marc, Martin-Lefevre, Laurent, Labadie, François, Robert, René, Benard, Thierry, Kerforne, Thomas, Thierry, Antoine, Lesieur, Olivier, Vincent, Jean-François, Lesouhaitier, Mathieu, Larmet, Raphaelle, Vigneau, Cecile, Goepp, Angelique, Bouju, Pierre, Quentin, Charlotte, Egreteau, Pierre-Yves, Huet, Olivier, Renault, Anne, Le Meur, Yannick, Venhard, Jean-Christophe, Buchler, Mathias, Michel, Olivier, Voellmy, Marie-Hélène, Herve, Fabien, Schnell, David, Courte, Anne, Glotz, Denis, Amrouche, Lucile, Hazzan, Marc, Kamar, Nassim, Moal, Valerie, Bourenne, Jeremy, Le Quintrec-Donnette, Moglie, Morelon, Emmanuel, Boulain, Thierry, Grimbert, Philippe, Heng, Anne Elisabeth, Merville, Pierre, Garin, Aude, Hiesse, Christian, Fermier, Brice, Mousson, Christiane, Guyot-Colosio, Charlotte, Bouvier, Nicolas, Rerolle, Jean-Philippe, Durrbach, Antoine, Drouin, Sarah, Caillard, Sophie, Frimat, Luc, Girerd, Sophie, Albano, Laetitia, Rostaing, Lionel, Bertrand, Dominique, Hertig, Alexandre, Westeel, Pierre-François, Montini, Florent, Delpierre, Eric, Dorez, Dider, Alamartine, Eric, Ouisse, Carole, Sebille, Veronique, Reignier, Jean

المساهمون: Université de Lille, Inserm, CHU Lille, Centre Hospitalier Universitaire de Nantes CHU Nantes, MethodS in Patients-centered outcomes and HEalth ResEarch SPHERE, Centre Hospitalier Universitaire d'Angers CHU Angers, Université d'Angers UA, Centre Hospitalier de Cholet CH Cholet, Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier de Laval CH Laval, Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon CHD Vendée, Centre hospitalier de Saint-Nazaire, Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU de Poitiers, Université de Poitiers - Faculté de Médecine et de Pharmacie, Groupe hospitalier de La Rochelle, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Université de Rennes UR, Centre Hospitalier de Lorient CH Lorient, Centre Hospitalier Mémorial France États-Unis de Saint-Lô CH Saint-Lô, CH Morlaix, Centre Hospitalier Régional Universitaire de Brest CHRU Brest, CHU Trousseau Tours, Service de néphrologie et immunologie clinique CHRU Tours, Centre Hospitalier Jacques Coeur, Centre Hospitalier d'Angoulême CH Angoulême, Centre hospitalier Saint-Brieuc, Hopital Saint-Louis AP-HP AP-HP, Hôpital Necker - Enfants Malades AP-HP, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Institut Toulousain des Maladies Infectieuses et Inflammatoires Infinity, Assistance Publique - Hôpitaux de Marseille APHM, Aix Marseille Université AMU, Centre Hospitalier Régional Universitaire Montpellier CHRU Montpellier, Université Claude Bernard Lyon 1 UCBL, Centre Hospitalier Régional d'Orléans CHRO, CHU Henri Mondor Créteil, CHU Clermont-Ferrand, CHU de Bordeaux Pellegrin Bordeaux, Centre Hospitalier Victor Jousselin Dreux, Hôpital Foch Suresnes, CHU Dijon, Université de Caen Normandie UNICAEN, Université de Limoges UNILIM, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pitié-Salpêtrière AP-HP, Centre Hospitalier Universitaire Strasbourg CHU Strasbourg, Université de Lorraine UL, Centre Hospitalier Régional Universitaire de Nancy CHRU Nancy, Centre Hospitalier Universitaire de Nice CHU Nice, Centre Hospitalier Universitaire CHU Grenoble CHUGA, Université de Rouen Normandie UNIROUEN, CHU Tenon AP-HP, CHU Amiens-Picardie, Centre Hospitalier Henri Duffaut (Avignon), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne CHU ST-E

الوصف: 12

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العلاقة: BMJ Open; http://hdl.handle.net/20.500.12210/100856Test

الإتاحة: https://doi.org/20.500.12210/100856Test
https://hdl.handle.net/20.500.12210/100856Test

المؤلفون: Rodriguez, Maeva, Ragot, Stéphanie, Coudroy, Rémi, Quenot, Jean-Pierre, Vignon, Philippe, Forel, Jean-Marie, Demoule, Alexandre, Mira, Jean-Paul, Ricard, Jean-Damien, Nseir, Saad, Colin, Gwenhael, Pons, Bertrand, Danin, Pierre-Eric, Devaquet, Jérome, Prat, Gwenael, Merdji, Hamid, Petitpas, Franck, Vivier, Emmanuel, Mekontso-Dessap, Armand, Nay, Mai-Anh, Asfar, Pierre, Dellamonica, Jean, Argaud, Laurent, Ehrmann, Stephan, Fartoukh, Muriel, Girault, Christophe, Robert, René, Thille, Arnaud W., Frat, Jean-Pierre, Chatellier, Delphine, Boissier, Florence, Veinstein, Anne, Dahyot-Fizelier, Claire, Dargent, Auguste, Large, Audrey, Begot, Emmanuelle, Mancia, Claire, Decavele, Maxence, Dres, Martin, Lehingue, Samuel, Papazian, Laurent, Paul, Marine, Marin, Nathalie, Le Meur, Matthieu, Laissy, Mohammed, Rouzé, Anahita, Henry-Lagarrigue, Matthieu, Yehia, Aihem, Martino, Frédéric, Cerf, Charles, Bailly, Pierre, Helms, Julie, Putegnat, Jean Baptiste, Razazi, Keyvan, Boulain, Thierry, Cabasson, Séverin, Wallet, Florent, Klouche, Kada, Bellec, Frédéric

المساهمون: Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

الوصف: Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m−2) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO2/FiO2 < 300 mm Hg). The primary outcome was the occurrence of severe hypoxemia (pulse oximetry < 80%) during the intubation procedure. Results Among the 313 patients included in the original trial, 91 (29%) had obesity with a mean body mass index of 35 ± 5 kg·m−2. Patients with obesity were more likely to experience an episode of severe hypoxemia during intubation procedure than patients without obesity: 34% (31/91) vs. 22% (49/222); difference, 12%; 95% CI 1 to 23%; P = 0.03. Among patients with obesity, 40 received preoxygenation with noninvasive ventilation and 51 with high-flow nasal oxygen. Severe hypoxemia occurred in 15 patients (37%) with noninvasive ventilation and 16 patients (31%) with high-flow nasal oxygen (difference, 6%; 95% CI − 13 to 25%; P = 0.54). The lowest pulse oximetry values during intubation procedure were 87% [interquartile range, 77–93] with noninvasive ventilation and 86% [78–92] with high-flow nasal oxygen (P = 0.98). After multivariable analysis, factors independently associated with severe hypoxemia in patients with obesity were intubation difficulty scale > 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ...

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العلاقة: Annals of Intensive Care; Ann. Intensive Care; http://hdl.handle.net/20.500.12210/107894Test

الإتاحة: https://doi.org/20.500.12210/107894Test
https://hdl.handle.net/20.500.12210/107894Test

المؤلفون: Condé, Mohamed, Lespessailles, Eric, Wanneveich, Mathilde, Allemandou, Delphine, Boulain, Thierry, Dimitrov, Georges

المساهمون: University Hospital Centre of Orléans

المصدر: BMJ Open ; volume 14, issue 4, page e080235 ; ISSN 2044-6055 2044-6055

مصطلحات موضوعية: General Medicine

الوصف: Introduction Children with sickle cell disease show a significant decrease in bone mineral density, an increase in resting energy expenditure of more than 15%, a decrease in fat and lean mass as well as a significant increase in protein turnover, particularly in bone tissue. This study aims to evaluate the effectiveness of an increase in food intake on bone mineral density and the clinical and biological complications of paediatric sickle cell disease. Methods and analysis The study is designed as an open-label randomised controlled clinical trial conducted in the Paediatrics Unit of the Orléans University Hospital Centre. Participants aged 3–16 years will be randomly divided into two groups: the intervention group will receive oral nutritional supplements (pharmacological nutritional hypercaloric products) while the control group will receive age-appropriate and gender-appropriate nutritional intake during 12 months. Total body less head bone mineral density will be measured at the beginning and the end of the trial. A rigorous nutritional follow-up by weekly 24 hours recall dietary assessment and planned contacts every 6 weeks will be carried out throughout the study. A school absenteeism questionnaire, intended to reflect the patient’s school productivity, will be completed by participants and parents every 3 months. Blood samples of each patient of both groups will be stocked at the beginning and at the end of the trial, for future biological trial. Clinical and biological complications will be regularly monitored. Ethics and dissemination The protocol has been approved by the French ethics committee (Comité de Protection des Personnes Sud-Ouest et Outre-Mer 2, Toulouse; approval no: 2-20-092 id9534). Children and their parents will give informed consent to participate in the study before taking part. Results will be disseminated through peer-reviewed journals or international academic conferences. Trial registration number NCT04754711 .

الإتاحة: https://doi.org/10.1136/bmjopen-2023-080235Test

المؤلفون: Lakhal, Karim, Dauvergne, Jérôme E., Messet-Charriere, Hélène, Nay, Mai-Anh, Kamel, Toufik, Muller, Grégoire, Robert-Edan, Vincent, Rozec, Bertrand, Ehrmann, Stephan, Jacquier, Sophie, Boulain, Thierry

المصدر: Anaesthesia Critical Care & Pain Medicine ; volume 43, issue 2, page 101333 ; ISSN 2352-5568

مصطلحات موضوعية: Anesthesiology and Pain Medicine, Critical Care and Intensive Care Medicine, General Medicine

الإتاحة: https://doi.org/10.1016/j.accpm.2023.101333Test
https://api.elsevier.com/content/article/PII:S2352556823001418?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352556823001418?httpAccept=text/plainTest

المؤلفون: Fleuriet, Jérôme, Heming, Nicholas, Meziani, Ferhat, Reignier, Jean, Declerq, Pierre-Louis, Mercier, Emmanuelle, Muller, Grégoire, Colin, Gwenhaël, Monnet, Xavier, Robine, Adrien, Siami, Shidasp, Uhel, Fabrice, Quenot, Jean-Pierre, Plantefeve, Gaetan, Badie, Julio, Schneider, Francis, Cerf, Charles, Troché, Gilles, Monchi, Mehran, Mira, Jean-Paul, Francois, Bruno, Lamiae, Grimaldi, Chevret, Sylvie, Annane, Djillali, RECORDS consortium, CRICS TRIGGERSEP network, Antigoni, Alexandrou, Djillali, Annane, Birte, Arlt, Julio, Badie, Sarah, Benghanem, Fernando, Berdaguer Ferrari, Charles, Cerf, Zaineb, Chelly Dagdia, Sylvie, Chevret, Gwenhaël, Colin, Christel, Daniel, Pierre-Louis, Declercq, Agathe, Delbove, Philippe, Devillier, Jérome, Fleuriet, Bruno, Francois, Henri-Jean, Garchon, Véronique, Godot, Stanislas, Grassin-Delyle, Mathieu, Grisolia, Christophe, Guitton, Julie, Helms, Nicholas, Heming, Marielle, Herzog, Toufik, Kamel, Zoubida, Kedad, Philippe, Lassalle, Guillaume, Lhermite, Bruno, Megarbane, Armand, Mekontso Dessap, Emmanuelle, Mercier, Ferhat, Meziani, Jean-Paul, Mira, Mehran, Monchi, Xavier, Monnet, Grégoire, Muller, Jean-Pierre, Quenot, Jean, Reignier, Adrien, Robine, Martin, Rottman, Anne-Laure, Roux, Francis, Schneider, Shidasp, Siami, Pierre, Tissieres, Gilles, Troché, Fabrice, Uhel, Karine, Zeitouni, Gaëtan, Plantefève, Nawal, Derridj, Bodet-Contentin, Laetitia, Darwiche, Walid, Ehrmann, Stephan, Garot, Denis, Guillon, Antoine, Jouan, Youenn, Legras, Annick, Mankikian, Julie, Morisseau, Marlene, Perez, Yonatan, Rouve, Emmanuelle, Salmon-Gandonniere, Charlotte, Helms, Julie, Rahmani, Hassene, Monnier, Alexandra, Merdji, Hamid, Clere-Jehl, Raphael, Stiel, Laure, Studer, Antoine, Andreu, Pascal, Roudaut, Jean-Baptiste, Labruyere, Marie, Jacquier, Marine, Barbier, Francois, Benzekri, Dalila, Boulain, Thierry, Jacquier, Sophie, Mathonnet, Armelle, Muller, Gregoire, Nai, Mai-Anh, Runge, Isabelle, Tollec, Sophie, Roux, Damien, Messika, Jonathan, Vuillard, Constance, Dumont, Louis-Marie, Federici, Laura, Zucman, Noemie, Amouretti, Marc, Moine, Pierre, Meng, Paris, Bounab, Rania, Fartoukh, Muriel-Sarah, Djibre, Michel, Elabbadi, Alexandre, Azais, Marie-Ange, Bachoumas, Konstantinos, Bailly, Arthur, Bernardon, Remi, Blonz, Gauthier, Desmedt, Luc, Emonet, Brian, Fiancette, Maud, Henry, Matthieu, Lacherade, Jean-Claude, Lascarrou, Jean-Baptiste, Lebert, Christine, Lorber, Julien, Martin-Lefevre, Laurent, Pouplet, Caroline, Vinatier, Isabelle, Yehia, Aihem, Benghanem, Sarah, Charpentier, Julien, Vigneron, Clara, Pichon, Nicolas, Fedou, Anne-Laure, Mancia, Claire, Begot, Emmanuelle, Daix, Thomas, Vignon, Philippe, Galy, Antoine, Gonzalez, Celine, Goudelin, Marine, Evrard, Bruno, Desachy, Arnaud, Vaidie, Julien, Gilbert, Guillaume, Darreau, Cedric, Derrien, Benoit, Saint-Martin, Marjorie, Tirot, Patrice, Landais, Mickael, Chudeau, Nicolas, Callahan, Jean Christophe, Vivier, Dominique, Moal, Charlene Le, Olivier, Pierre-Yves, Marnai, Remy, Sedillot, Nicolas, Tchenio, Xavier, Poncelin, Yves, Bruyere, Remi

مصطلحات موضوعية: Intensive care

الوصف: Introduction Corticosteroids affect variably survival in sepsis trials, suggesting heterogeneity in patients’ response to corticosteroids. The RECORDS (Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis) trial aimed at defining endotypes associated with adults with sepsis responsiveness to corticosteroids. Methods and analysis RECORDS, a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial, will randomly assign to a biomarker stratum 1800 adults with community-acquired pneumonia, vasopressor-dependent sepsis, septic shock or acute respiratory distress syndrome. In each stratum, patients will be randomly assigned to receive a 7-day course of hydrocortisone and fludrocortisone or their placebos. Patients with COVID-19 will be treated with a 10-day standard course of dexamethasone and randomised to fludrocortisone or its placebo. Primary outcome will be 90-day death or persistent organ dysfunction. Large simulation study will be performed across a range of plausible scenarios to foresee power to detect a 5%–10% absolute difference with corticosteroids. We will assess subset-by-treatment interaction by estimating in a Bayesian framework two quantities: (1) measure of influence, relying on the value of the estimation of corticosteroids’ effect in each subset, and (2) measure of interaction. Ethics and dissemination The protocol was approved by the Ethics Committee ( Comit e ´ de Protection des Personnes, Dijon, France), on 6 April 2020. Trial results will be disseminated at scientific conferences and results will be published in peer-reviewed journals. Trial registration number ClinicalTrials.gov Registry ( NCT04280497 ).

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العلاقة: http://bmjopen.bmj.com/cgi/content/short/13/3/e066496Test; http://dx.doi.org/10.1136/bmjopen-2022-066496Test

الإتاحة: https://doi.org/10.1136/bmjopen-2022-066496Test
http://bmjopen.bmj.com/cgi/content/short/13/3/e066496Test

المؤلفون: Nay, Mai-Anh, Hindre, Raphaël, Perrin, Christophe, Clément, Jérémy, Plantier, Laurent, Sève, Aymeric, Druelle, Sylvie, Morrier, Marine, Lainé, Jean-Baptiste, Colombain, Léa, Corvaisier, Grégory, Bizien, Nicolas, Pouget-Abadie, Xavier, Bigot, Adrien, Jamard, Simon, Nyamankolly, Elsa, Planquette, Benjamin, Fossat, Guillaume, Boulain, Thierry

المصدر: Critical Care ; volume 27, issue 1 ; ISSN 1364-8535

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background Benefit of early awake prone positioning for COVID-19 patients hospitalised in medical wards and who need oxygen therapy remains to be demonstrated. The question was considered at the time of COVID-19 pandemic to avoid overloading the intensive care units. We aimed to determine whether prone position plus usual care could reduce the rate of non-invasive ventilation (NIV) or intubation or death as compared to usual care alone. Methods In this multicentre randomised clinical trial, 268 patients were randomly assigned to awake prone position plus usual care ( N = 135) or usual care alone ( N = 132). The primary outcome was the proportion of patients who underwent NIV or intubation or died within 28 days. Main secondary outcomes included the rates of NIV, of intubation or death, within 28 days. Results Median time spent each day in the prone position within 72 h of randomisation was 90 min (IQR 30–133). The proportion of NIV or intubation or death within 28 days was 14.1% (19/135) in the prone position group and 12.9% (17/132) in the usual care group [odds ratio adjusted for stratification (aOR) 0.43; 95% confidence interval (CI) 0.14–1.35]. The probability of intubation, or intubation or death (secondary outcomes) was lower in the prone position group than in the usual care group (aOR 0.11; 95% CI 0.01–0.89 and aOR 0.09; 95% CI 0.01–0.76, respectively) in the whole study population and in the prespecified subgroup of patients with SpO 2 ≥ 95% on inclusion (aOR 0.11; 95% CI 0.01–0.90, and aOR 0.09; 95% CI 0.03–0.27, respectively). Conclusions Awake prone position plus usual care in COVID-19 patients in medical wards did not decrease the composite outcome of need for NIV or intubation or death. Trial registration ClinicalTrials.gov Identifier: NCT04363463 . Registered 27 April 2020.

الإتاحة: https://doi.org/10.1186/s13054-023-04529-zTest

المؤلفون: Szychowiak, Piotr, Boulain, Thierry, Timsit, Jean-François, Elabaddi, Alexandre, Argaud, Laurent, Ehrmann, Stephan, Issa, Nahema, Canet, Emmanuel, Martino, Frédéric, Bruneel, Fabrice, Quenot, Jean-Pierre, Wallet, Florent, Azoulay, Élie, Barbier, François

المصدر: Annals of Intensive Care ; volume 13, issue 1 ; ISSN 2110-5820

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background Both AIDS-defining and non-AIDS-defining cancers (ADC/NADC) predispose people living with HIV (PLHIV) to critical illnesses. The objective of this multicentre study was to investigate the prognostic impact of ADC and NADC in PLHIV admitted to the intensive care unit (ICU). Methods All PLHIV admitted over the 2015–2020 period in 12 university-affiliated ICUs in France were included in the study cohort. The effect of ADC and NADC on in-hospital mortality (primary study endpoint) was measured through logistic regression with augmented backward elimination of potential independent variables. The association between ADC/NADC and treatment limitation decision (TLD) during the ICU stay (secondary study endpoint) was analysed. One-year mortality in patients discharged alive from the index hospital admission (exploratory study endpoint) was compared between those with ADC, NADC or no cancer. Results Amongst the 939 included PLHIV (median age, 52 [43–59] years; combination antiretroviral therapy, 74.4%), 97 (10.3%) and 106 (11.3%) presented with an active NADC (mostly lung and intestinal neoplasms) and an active ADC (predominantly AIDS-defining non-Hodgkin lymphoma), respectively. Inaugural admissions were common. Bacterial sepsis and non-infectious neoplasm-related complications accounted for most of admissions in these subgroups. Hospital mortality was 12.4% in patients without cancer, 30.2% in ADC patients and 45.4% in NADC patients ( P < 0.0001). NADC (adjusted odds ratio [aOR], 7.00; 95% confidence interval [CI], 4.07–12.05) and ADC (aOR, 3.11; 95% CI 1.76–5.51) were independently associated with in-hospital death after adjustment on severity and frailty markers. The prevalence of TLD was 8.0% in patients without cancer, 17.9% in ADC patients and 33.0% in NADC patients ( P < 0.0001)—organ failures and non-neoplastic comorbidities were less often considered in patients with cancer. One-year mortality in survivors of the index hospital admission was 7.8% in patients without cancer, 17.0% in ...

الإتاحة: https://doi.org/10.1186/s13613-023-01171-4Test

المؤلفون: Desgrouas, Maxime, Demiselle, Julien, Stiel, Laure, Brunot, Vincent, Marnai, Rémy, Sarfati, Sacha, Fiancette, Maud, Lambiotte, Fabien, Thille, Arnaud W., Leloup, Maxime, Clerc, Sébastien, Beuret, Pascal, Bourion, Anne-Astrid, Daum, Johan, Malhomme, Rémi, Ravan, Ramin, Sauneuf, Bertrand, Rigaud, Jean-Philippe, Dequin, Pierre-François, Boulain, Thierry

المصدر: Annals of Intensive Care ; volume 13, issue 1 ; ISSN 2110-5820

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background Hyperglycaemia is common in critically ill patients, but blood glucose and insulin management may differ widely among intensive care units (ICUs). We aimed to describe insulin use practices and the resulting glycaemic control in French ICUs. We conducted a multicentre 1-day observational study on November 23, 2021, in 69 French ICUs. Adult patients hospitalized for an acute organ failure, severe infection or post-operative care were included. Data were recorded from midnight to 11:59 p.m. the day of the study by 4-h periods. Results Two ICUs declared to have no insulin protocol. There was a wide disparity in blood glucose targets between ICUs with 35 different target ranges recorded. In 893 included patients we collected 4823 blood glucose values whose distribution varied significantly across ICUs ( P < 0.0001). We observed 1135 hyperglycaemias (> 1.8 g/L) in 402 (45.0%) patients, 35 hypoglycaemias (≤ 0.7 g/L) in 26 (2.9%) patients, and one instance of severe hypoglycaemia (≤ 0.4 g/L). Four hundred eight (45.7%) patients received either IV insulin (255 [62.5%]), subcutaneous (SC) insulin (126 [30.9%]), or both (27 [6.6%]). Among patients under protocolized intravenous (IV) insulin, 767/1681 (45.6%) of glycaemias were above the target range. Among patients receiving insulin, short- and long-acting SC insulin use were associated with higher counts of hyperglycaemias as assessed by multivariable negative binomial regression adjusted for the propensity to receive SC insulin: incidence rate ratio of 3.45 (95% confidence interval [CI] 2.97–4.00) ( P < 0.0001) and 3.58 (95% CI 2.84–4.52) ( P < 0.0001), respectively. Conclusions Practices regarding blood glucose management varied widely among French ICUs. Administration of short or long-acting SC insulin was not unusual and associated with more frequent hyperglycaemia. The protocolized insulin algorithms used failed to prevent hyperglycaemic events. Graphical Abstract

الإتاحة: https://doi.org/10.1186/s13613-023-01142-9Test

المؤلفون: Kamel, Toufik, Sauvage, Brice, Lakhal, Karim, Ottavy, Grégoire, Janssen-Langenstein, Ralf, Jacquier, Marine, Larrat, Charlotte, Jacq, Gwenaëlle, Dauvergne, Jérôme E., Maugars, Diane, Labruyere, Marie, Simeon, Véronique, Cugnart, Cécile, Girault, Christophe, Boulain, Thierry

المصدر: Australian Critical Care ; volume 36, issue 6, page 948-954 ; ISSN 1036-7314

مصطلحات موضوعية: Critical Care Nursing, Emergency Nursing

الإتاحة: https://doi.org/10.1016/j.aucc.2023.01.002Test
https://api.elsevier.com/content/article/PII:S1036731423000061?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1036731423000061?httpAccept=text/plainTest

المؤلفون: Boulain, Thierry, Nay, Mai-Anh, Dequin, Pierre-François, Lascarrou, Jean-Baptiste, Vignon, Philippe, Kamel, Toufik, Muller, Grégoire, Ehrmann, Stephan, Baudin, Olivier, Calvat, Sylvie, Cracco, Christophe, Desachy, Arnault, Lafon, Charles, Boitrou, Emmanuelle, Follin, Arnaud, Mentec, Hervé, Pajot, Olivier, Plantefève, Gaëtan, Thirion, Marina, Bruyère, Rémi, Quenot, Jean-Pierre, Bachoumas, Konstantinos, Fiancette, Maud, Lacherade, Jean Claude, Lebert, Christine, Martin-Lefèvre, Laurent, Reignier, Jean, Vinatier, Isabelle, Yehia, Aihem, Begot, Emmanuelle, Bellier, Remy, Clavel, Marc, François, Bruno, Galy, Antoine, Pichon, Nicolas, Bardou, Patrick, Bellec, Frédéric, Bonnivard, Michel, Marco, Anne, Roustan, Jérôme, Vimeux, Sylvie, Bretagnol, Anne, Mathonnet, Armelle, Bercault, Nicolas, Réminiac, François, Runge, Isabelle, Skarzynski, Marie, Chatellier, Delphine

المصدر: Australian Critical Care ; volume 36, issue 3, page 307-312 ; ISSN 1036-7314

مصطلحات موضوعية: Critical Care Nursing, Emergency Nursing

الإتاحة: https://doi.org/10.1016/j.aucc.2022.03.010Test
https://api.elsevier.com/content/article/PII:S103673142200042X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S103673142200042X?httpAccept=text/plainTest