المؤلفون: Ketelaers, S.H.J., van Ham, N., van Pelt, K.A.A.J., Timmers, T., Nieuwenhuijzen, G.A.P., Rutten, H.J.T., Burger, J.W.A., Bloemen, J.G.

المصدر: Ketelaers , S H J , van Ham , N , van Pelt , K A A J , Timmers , T , Nieuwenhuijzen , G A P , Rutten , H J T , Burger , J W A & Bloemen , J G 2023 , ' The development and implementation of an interactive application for new ostomy patients ' , Colorectal Disease , vol. 25 , no. 6 , pp. 1228-1237 . https://doi.org/10.1111/codi.16541Test

مصطلحات موضوعية: colorectal cancer, mobile health, ostomy, self-management, telemedicine, QUALITY-OF-LIFE, TELEPHONE FOLLOW-UP, PATIENTS RETURNING HOME, REPORTED OUTCOMES, COLORECTAL-CANCER, EDUCATION, CARE, STOMA, ONCOLOGY

الوصف: Aim: Guidance throughout the entire process of ostomy surgery is warranted to improve self-management and reduce healthcare consumption. The aim of this study was to develop an interactive application to educate patients scheduled for ostomy surgery and to evaluate patient satisfaction and implementation.Method: A literature study and a cross-sectional study among patients and nurses was performed to evaluate the relevance of different topics (e.g., ostomy materials, self-care, complications, impact) for an interactive application in ostomy surgery. The interactive application, StoManager, was developed in collaboration with patients and healthcare providers. The implementation of the application was evaluated among 30 patients scheduled for ostomy surgery to investigate usability, patient satisfaction, compliance, the need for home nursing care services, and the number of contact moments with the ostomy nurse.Results: StoManager contained all topics considered relevant by patients and healthcare providers, including information on ostomy surgery, ostomy self-care and ostomy-related complications. Patient-reported outcome measures were incorporated to monitor the patient's health status during treatment. The usability scores of StoManager were above average. Patients rated StoManager with an overall score of 7.5 (SD 1.5) out of 10. The response rate to the patient-reported outcome measures was 79.3%. At discharge, 28/30 (93.3%) patients did not need home nursing care services for ostomy care.Conclusions: An interactive application to support patients throughout the entire process of ostomy surgery is feasible. Patients were satisfied with StoManager and its usability, which might result in improved self-management and decreased healthcare consumption. A more patient-specific approach could further improve the perceived quality and value of the application.

وصف الملف: application/pdf

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/428ed4bf-6d50-4e36-9384-91aee57ff266Test

الإتاحة: https://doi.org/10.1111/codi.16541Test
https://cris.maastrichtuniversity.nl/en/publications/428ed4bf-6d50-4e36-9384-91aee57ff266Test
https://cris.maastrichtuniversity.nl/ws/files/182322222/Rutten-2023-The-development-and-implementation-of-an-interactive.pdfTest

المؤلفون: Van Zoggel, D.M.G.I., Voogt, E.L.K., Van Lijnschoten, I.G., Cnossen, J.S., Creemers, G.J., Nederend, J., Bloemen, J.G., Nieuwenhuijzen, G.A.P., Burger, P.J.W.A., Lardenoije, S.G.G.F., Rutten, H.J.T., Roef, M.J.

المصدر: Van Zoggel , D M G I , Voogt , E L K , Van Lijnschoten , I G , Cnossen , J S , Creemers , G J , Nederend , J , Bloemen , J G , Nieuwenhuijzen , G A P , Burger , P J W A , Lardenoije , S G G F , Rutten , H J T & Roef , M J 2022 , ' Metabolic positron emission tomography/CT response after induction chemotherapy and chemo(re)irradiation is associated with higher negative resection margin rate in patients with locally recurrent rectal cancer ' , ....

مصطلحات موضوعية: FDG-PET, CT, histopathological response, induction chemotherapy, locally recurrent rectal cancer, NEOADJUVANT CHEMORADIOTHERAPY, PATHOLOGICAL RESPONSE, F-18-FDG PET/CT, FDG-PET/CT, CHEMORADIATION, PREDICTION, SURVIVAL, CRITERIA, RECIST, WATCH

الوصف: Aim Positron emission tomography (PET)/CT can be used to monitor the metabolic changes that occur after intensified treatment with induction chemotherapy and chemo(re)irradiation for locally recurrent rectal cancer (LRRC). This study aimed to analyse the correlation between the PET/CT response and final histopathological outcomes. Methods All LRRC patients who underwent induction chemotherapy prior to surgery between January 2010 and July 2020 and were monitored with pretreatment and post-treatment PET/CT were included. Visual qualitative analysis was performed, and patients were scored as having achieved a complete metabolic response (CMR), partial metabolic response (PMR) or no response (NR). The histopathological response was assessed according to the Mandard tumour regression (TRG) score and categorized as major (TRG 1-2), partial (TRG 3) or poor (TRG 4-5). The PET/CT and TRG categories were compared, and possible confounders were analysed. Results A total of 106 patients were eligible for analysis; 24 (23%) had a CMR, 54 (51%) had a PMR and 28 (26%) had NR. PET/CT response was a significant predictor of the negative resection margin rate, achieving 96% for CMR, 69% for PMR and 50% for NR. The overall accuracy between PET score and pathological TRG was 45%, and the positive predictive value for CMR was 63%. A longer interval between post-treatment PET/CT and surgery negatively influenced the predictive value. Conclusion Metabolic PET/CT response evaluation after neoadjuvant treatment proves to be a complementary diagnostic tool to standard MRI in assessing tumour response, and may play a role for treatment planning in LRRC patients.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1111/codi.15934Test
https://cris.maastrichtuniversity.nl/en/publications/e2683d2c-507c-4351-8d24-40abb0d32acbTest
https://cris.maastrichtuniversity.nl/ws/files/78139871/Rutten_2021_Metabolic_positron_emission_tomography_CT.pdfTest

المؤلفون: van den Berg, K.F.M., Schaap, D.P., Voogt, E.L.K., Buffart, T.E., Verheul, H.M.W., de Groot, J.W.B., Verhoef, C., Melenhorst, J., Roodhart, J.M.L., de Wilt, J.H.W., van Westreenen, H.L., Aalbers, A.G.J., van 't Veer, M., Marijnen, C.A.M., Vincent, J., Simkens, L.H.J., Peters, N.A.J.B., Berbée, M., Werter, I.M., Snaebjornsson, P., Peulen, H.M.U., van Lijnschoten, I.G., Roef, M.J., Nieuwenhuijzen, G.A.P., Bloemen, J.G., Willems, J.M.W.E., Creemers, G.J.M., Nederend, J., Rutten, H.J.T., Burger, J.W.A.

المصدر: van den Berg , K F M , Schaap , D P , Voogt , E L K , Buffart , T E , Verheul , H M W , de Groot , J W B , Verhoef , C , Melenhorst , J , Roodhart , J M L , de Wilt , J H W , van Westreenen , H L , Aalbers , A G J , van 't Veer , M , Marijnen , C A M , Vincent , J , Simkens , L H J , Peters , N A J B , ....

مصطلحات موضوعية: Antineoplastic Combined Chemotherapy Protocols/adverse effects, Camptothecin/analogs & derivatives, Chemoradiotherapy/methods, Clinical Trials, Phase II as Topic, Fluorouracil/therapeutic use, Humans, Leucovorin, Multicenter Studies as Topic, Neoadjuvant Therapy/methods, Neoplasm Staging, Neoplasms, Second Primary/pathology, Organoplatinum Compounds, Quality of Life, Rectal Neoplasms/pathology, Treatment Outcome, Neoadjuvant chemotherapy, Induction chemotherapy, Locally advanced rectal cancer, Pathological complete response, Complete response, Neoadjuvant treatment, Clinical complete response, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: BACKGROUND: The presence of mesorectal fascia (MRF) invasion, grade 4 extramural venous invasion (EMVI), tumour deposits (TD) or extensive or bilateral extramesorectal (lateral) lymph nodes (LLN) on MRI has been suggested to identify patients with indisputable, extensive locally advanced rectal cancer (LARC), at high risk of treatment failure. The aim of this study is to evaluate whether or not intensified chemotherapy prior to neoadjuvant chemoradiotherapy improves the complete response (CR) rate in these patients. METHODS: This multicentre, single-arm, open-label, phase II trial will include 128 patients with non-metastatic high-risk LARC (hr-LARC), fit for triplet chemotherapy. To ensure a study population with indisputable, unfavourable prognostic characteristics, hr-LARC is defined as LARC with on baseline MRI at least one of the following characteristics; MRF invasion, EMVI grade 4, enlarged bilateral or extensive LLN at high risk of an incomplete resection, or TD. Exclusion criteria are the presence of a homozygous DPD deficiency, distant metastases, any chemotherapy within the past 6 months, previous radiotherapy within the pelvic area precluding standard chemoradiotherapy, and any contraindication for the planned treatment. All patients will be planned for six two-weekly cycles of FOLFOXIRI (5-fluorouracil, leucovorin, oxaliplatin and irinotecan) prior to chemoradiotherapy (25 × 2 Gy or 28 × 1.8 Gy with concomitant capecitabine). A resection will be performed following radiological confirmation of resectable disease after the completion of chemoradiotherapy. A watch and wait strategy is allowed in case of a clinical complete response. The primary endpoint is the CR rate, described as a pathological CR or a sustained clinical CR one year after chemoradiotherapy. The main secondary objectives are long-term oncological outcomes, radiological and pathological response, the number of resections with clear margins, treatment-related toxicity, perioperative complications, health-related costs, and quality of ...

وصف الملف: application/pdf

العلاقة: https://research.tue.nl/en/publications/93a6abe3-bb54-40fd-87d7-5499b4fcd39aTest

الإتاحة: https://doi.org/10.1186/s12885-022-09947-wTest
https://research.tue.nl/en/publications/93a6abe3-bb54-40fd-87d7-5499b4fcd39aTest
https://pure.tue.nl/ws/files/274769094/s12885_022_09947_w.pdfTest
http://www.scopus.com/inward/record.url?scp=85137313555&partnerID=8YFLogxKTest

المؤلفون: Voogt, E.L.K., Schaap, D.P., van den Berg, K., Nieuwenhuijzen, G.A.P., Bloemen, J.G., Creemers, G.J., Willems, J., Cnossen, J.S., Peulen, H.M.U., Nederend, J., van Lijnschoten, G., Burger, J.W.A., Rutten, H.J.T.

المصدر: Voogt , E L K , Schaap , D P , van den Berg , K , Nieuwenhuijzen , G A P , Bloemen , J G , Creemers , G J , Willems , J , Cnossen , J S , Peulen , H M U , Nederend , J , van Lijnschoten , G , Burger , J W A & Rutten , H J T 2021 , ' Reply to: Use of induction chemotherapy in locally advanced rectal cancers to increase the response rates: Is it actually helping? ' , European Journal of Surgical Oncology , ....

مصطلحات موضوعية: Locally advanced rectal cancer, Induction chemotherapy, Chemoradiotherapy, Total neoadjuvant therapy, Pathological complete response, Clinical complete response

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.ejso.2021.06.021Test
https://cris.maastrichtuniversity.nl/en/publications/ca65cd5f-dcdc-470e-bc8d-10e0e977fcc5Test
https://cris.maastrichtuniversity.nl/ws/files/78140772/Rutten_2021_Reply_to_use_of_induction.pdfTest

المؤلفون: Koelfat, K.V.K., van Mierlo, K.M.C., Lodewick, T.M., Bloemen, J.G., van der Kroft, G., Amygdalos, I., Neumann, U.P., Dejong, C.H.C., Jansen, P.L.M., Damink, S.W.M.O., Schaap, F.G.

المصدر: Koelfat , K V K , van Mierlo , K M C , Lodewick , T M , Bloemen , J G , van der Kroft , G , Amygdalos , I , Neumann , U P , Dejong , C H C , Jansen , P L M , Damink , S W M O & Schaap , F G 2021 , ' Bile Salt and FGF19 Signaling in the Early Phase of Human Liver Regeneration ' , Hepatology communications , vol. 5 , no. 8 , pp. 1400-1411 . https://doi.org/10.1002/hep4.1728Test

الوصف: The involvement of bile salt-fibroblast growth factor 19 (FGF19) signaling in human liver regeneration (LR) is not well studied. Therefore, we studied aspects of bile salt-FGF19 signaling shortly after liver resection in patients. We compared plasma bile salt and FGF19 levels in arterial, portal and hepatic venous blood, calculated venous-arterial differences (Delta VA), and determined hepatic transcript levels on two intra-operative time points: before (< 1 hour) and immediately after (> 2-3 hours) liver resection (i.e., following surgery). Postoperative bile salt and FGF19 levels were assessed on days 1, 2, and 3. LR was studied by computed tomography (CT)-liver volumetry. Following surgery, the liver, arterial, and portal bile salt levels were elevated (P < 0.05). Furthermore, an increased amount of bile salts was released in portal blood and extracted by the remnant liver (P < 0.05). Postoperatively, bile salt levels were elevated from day 1 onward (P < 0.001). For FGF19, intra-operative or postoperative changes of Delta VA or plasma levels were not observed. The bile salt-homeostatic regulator farnesoid X receptor (FXR) was markedly up-regulated following surgery (P < 0.001). Cell-cycle re-entry priming factors (interleukin 6 [IL-6], signal transducer and activator of transcription 3 [STAT3], and cJUN) were up-regulated following surgery and were positively correlated with FXR expression (P < 0.05). Postoperative hyperbilirubinemia was preceded by postsurgery low FXR and high Na+/Taurocholate cotransporting polypeptide (NTCP) expression in the remnant liver coupled with higher liver bile salt content (P < 0.05). Finally, bile salt levels on postoperative day 1 were an independent predictor of LR (P < 0.05). Conclusion: Systemic, portal, and liver bile salt levels are rapidly elevated after liver resection. Postoperative bile salts were positively associated with liver volume gain. In the studied time frame, FGF19 levels remained unaltered, suggesting that FGF19 plays a minor role ...

الإتاحة: https://doi.org/10.1002/hep4.1728Test
https://cris.maastrichtuniversity.nl/en/publications/8b280c58-350a-4b73-8298-a2cf6bf1af50Test

المؤلفون: Ketelaers, S.H.J., Voogt, E.L.K., Simkens, G.A., Bloemen, J.G., Nieuwenhuijzen, G.A.P., de Hingh, I.H.J., Rutten, H.J.T., Burger, J.W.A., Orsini, R.G.

المصدر: Ketelaers , S H J , Voogt , E L K , Simkens , G A , Bloemen , J G , Nieuwenhuijzen , G A P , de Hingh , I H J , Rutten , H J T , Burger , J W A & Orsini , R G 2021 , ' Age-related differences in morbidity and mortality after surgery for primary clinical T4 and locally recurrent rectal cancer ' , Colorectal Disease , vol. 23 , no. 5 , pp. 1141-1152 . https://doi.org/10.1111/codi.15542Test

مصطلحات موضوعية: rectal cancer, locally advanced, locally recurrent, surgery, elderly, survival

الوصف: Aim Outcomes in elderly patients (>= 75 years) with non-advanced colorectal cancer have improved. It is unclear whether this is also true for elderly patients with clinical T4 rectal cancer (cT4RC) or locally recurrent rectal cancer (LRRC). We aimed to compare age-related differences in morbidity and mortality after curative treatment for cT4RC and LRRC.Methods All cT4RC and LRRC patients without distant metastasis who underwent curative surgery between 2005 and 2017 in the Catharina Hospital (Eindhoven, The Netherlands) were included. Morbidity and mortality were evaluated based on age (<75 and >= 75 years) and date of surgery (2005-2011 and 2012-2017).Results Overall, 72 of 474 (15.2%) cT4RC and 53 of 293 (18.1%) LRRC patients were >= 75 years. No significant differences in the incidence of Clavien-Dindo I-IV complications were observed between age groups. However, in elderly cT4RC patients, cerebrovascular accidents occurred more frequently (4.2% vs. 0.5%, P = 0.03). Between 2005-2011 and 2012-2017, 30-day mortality improved from 7.5% to 3.1% and from 10.0% to 0.0% in elderly cT4RC and LRRC patients, respectively. The 1-year mortality during 2012-2017 was worse in elderly than in younger patients (28.1% vs. 6.2%, P = 0.001 for cT4RC and 27.3% vs. 13.8%, P = 0.06 for LRRC). In elderly cT4RC and LRRC patients, 44.4% and 46.2% died due to non-cancer-related causes, while only 27.8% and 23.1% died due to disease recurrence, respectively.Conclusion Although the 30-day mortality in elderly cT4RC and LRRC patients improved after curative treatment, the 1-year mortality in elderly patients continued to be high, which requires more awareness for the elderly after hospitalization.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1111/codi.15542Test
https://cris.maastrichtuniversity.nl/en/publications/a94d2164-91cb-4fef-b1fc-e4871fc4a7e1Test
https://cris.maastrichtuniversity.nl/ws/files/78139962/Rutten_2021_Age_related_differences_in_morbidity_and.pdfTest

المؤلفون: van Riet, Y.E., Schipper, R.J., van Merrienboer, F., Orsini, R.G., Bloemen, J.G., Jansen, F.H., Nieuwenhuijzen, G.A.P.

المصدر: van Riet , Y E , Schipper , R J , van Merrienboer , F , Orsini , R G , Bloemen , J G , Jansen , F H & Nieuwenhuijzen , G A P 2021 , ' Is specimen radiography still necessary in patients with non-palpable breast cancer undergoing breast-conserving surgery using radioactive I-125 seed localization? ' , Clinical Imaging , vol. 69 , pp. 311-317 . https://doi.org/10.1016/j.clinimag.2020.10.004Test

مصطلحات موضوعية: biopsy, breast cancer, breast-conserving surgery, carcinoma in-situ, excision, intraoperative margin assessment, mammography, margin assessment, radioactive seed localization, recurrence, reexcision, specimen radiography, surgical-treatment, wire localization

الوصف: Aim: To evaluate the diagnostic performance for margin assessment of specimen radiography (SR) in breast conserving surgery (BCS) using radioactive I-125-seed localization (RSL).Methods: The clinical, radiographic and histopathological data of women who underwent BCS after pre-operative RSL with intraoperative SR during nine consecutive years were analyzed. The histological margin and radiographic margin outcomes on SR were compared and results of intraoperative re-excisions were investigated.Results: A consecutive series of 448 women with invasive carcinoma (n = 211), ductal carcinoma in situ (DCIS) (n = 79) and a combination of DCIS and invasive carcinoma (n = 158) were included. The median minimal margins for the radiological masses and microcalcifications measured on SR were 14 mm and 11 mm, respectively. Based on a radiological cut-off SR margin value of 1 mm, the overall sensitivity, specificity, and positive and negative predictive values (PPV and NPV) were 21.0%, 95.0%, 26.0%, and 94.0%, respectively. The area under the receiver-operating curve was 0.73. Intraoperative re-excisions based on SR were performed in 31 (6.9%) patients; histopathological examination of the additional excised tissue revealed DCIS or invasive carcinoma in 6 (19.4%) patients. Hence, SR was beneficial for 6/448 patients (1.3%), and unnecessary intraoperative re-excisions were performed in 20/448 patients (4.5%). The number need to treat is 75; this implies that per 75-SR one resection with involved margins is prevented.Conclusion: SR has a moderate diagnostic performance for margin involvement using RSL. A more accurate intraoperative margin assessment tool is warranted.

الإتاحة: https://doi.org/10.1016/j.clinimag.2020.10.004Test
https://cris.maastrichtuniversity.nl/en/publications/3c6ca731-7c94-4164-932b-96a787e9cd4aTest

المؤلفون: Nordkamp, S., Piqeur, F., Berg, K. van den, Tolenaar, J.L., Hellemond, I.E.G. van, Creemers, G.J., Roef, M., Lijnschoten, G. van, Cnossen, J.S., Nieuwenhuijzen, G.A.P., Bloemen, J.G., Coolen, L., Nederend, J., Peulen, H.M.U., Rutten, H.J.T., Burger, J.W.A.

المصدر: British Journal of Surgery

الوصف: Background: For patients with locally recurrent rectal cancer, it is an ongoing pursuit to establish factors predicting or improving oncological outcomes. In locally advanced rectal cancer, a pCR appears to be associated with improved outcomes. The aim of this retrospective cohort study was to compare the oncological outcomes of patients with locally recurrent rectal cancer with and without a pCR. Methods: Patients who underwent neoadjuvant treatment and surgery for locally recurrent rectal cancer with curative intent between January 2004 and June 2020 at a tertiary referral hospital were analysed. Primary outcomes included overall survival, disease-free survival, metastasis-free survival, and local re-recurrence-free survival, stratified according to whether the patient had a pCR. Results: Of a total of 345 patients, 51 (14.8 per cent) had a pCR. Median follow-up was 36 (i.q.r. 16-60) months. The 3-year overall survival rate was 77 per cent for patients with a pCR and 51.1 per cent for those without (P < 0.001). The 3-year disease-free survival rate was 56 per cent for patients with a pCR and 26.1 per cent for those without (P < 0.001). The 3-year local re-recurrence-free survival rate was 82 and 44 per cent respectively (P < 0.001). Surgical procedures (for example soft tissue, sacrum, and urogenital organ resections) and postoperative complications were comparable between patients with and without a pCR. Conclusion: This study showed that patients with a pCR have superior oncological outcomes to those without a pCR. It may therefore be safe to consider a watch-and-wait approach in highly selected patients, potentially improving quality of life by omitting extensive surgical procedures without compromising oncological outcomes.

وصف الملف: application/pdf

العلاقة: https://academic.oup.com/bjs/article-abstract/110/8/950/7181206Test; lumc-id: 183880300; https://hdl.handle.net/1887/3763560Test

الإتاحة: https://doi.org/10.1093/bjs/znad094Test
https://hdl.handle.net/1887/3763560Test
https://academic.oup.com/bjs/article-abstract/110/8/950/7181206Test

المؤلفون: Ketelaers, S.H.J., Orsini, R.G., Nieuwenhuijzen, G.A.P., Rutten, H.J.T., Burger, J.W.A., Bloemen, J.G.

المصدر: European Journal of Surgical Oncology ; volume 48, issue 6, page 1414-1420 ; ISSN 0748-7983

مصطلحات موضوعية: Oncology, General Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.ejso.2021.12.020Test
https://api.elsevier.com/content/article/PII:S0748798321009902?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0748798321009902?httpAccept=text/plainTest

المؤلفون: Koelfat, K.V.K., Schaap, F.G., Bloemen, J.G., Groen, A.K., Jansen, P.L.M., Dejong, C.H.C., Olde Damink, S.W.M.

المصدر: HPB ; volume 18, page e163 ; ISSN 1365-182X

مصطلحات موضوعية: Gastroenterology, Hepatology

الإتاحة: https://doi.org/10.1016/j.hpb.2016.02.387Test
https://api.elsevier.com/content/article/PII:S1365182X1630404X?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S1365182X1630404X?httpAccept=text/xmlTest