المؤلفون: Fatemi, Shahab

المصدر: Lund University, Faculty of Medicine Doctoral Dissertation Series. (2024:75)

مصطلحات موضوعية: Biomarkers/blood, Atherosclerosis, peripheral arterial disease, Carotis stenosis, Abdominal aortic aneurysm (AAA), Diabetes, vascular surgery, Medicin och hälsovetenskap, Klinisk medicin, Kardiologi, Medical and Health Sciences, Clinical Medicine, Cardiac and Cardiovascular Systems

وصف الملف: electronic

الوصول الحر: https://lup.lub.lu.se/record/d3f3f519-5046-4a76-9cb7-41e101c49c21Test
https://portal.research.lu.se/files/181839381/Shahab_Kappa.pdfTest

المؤلفون: Viode, Arthur, Smolen, Kinga K, van Zalm, Patrick, Stevenson, David, Jha, Meenakshi, Parker, Kenneth, Levy, Ofer, Steen, Judith A, Steen, Hanno

المصدر: Viode , A , Smolen , K K , van Zalm , P , Stevenson , D , Jha , M , Parker , K , Levy , O , Steen , J A , Steen , H & IMPACC Network 2024 , ' Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes ' , Science advances , vol. 10 , no. 21 , 5762 . https://doi.org/10.1126/sciadv.adl5762Test

مصطلحات موضوعية: Humans, COVID-19/blood diagnosis virology, Proteomics/methods, Female, Male, SARS-CoV-2/isolation & purification, Middle Aged, Longitudinal Studies, Aged, Hospitalization, Biomarkers/blood, Proteome/analysis, Severity of Illness Index, Blood Proteins/analysis, Prognosis, Adult

الوصف: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by highly heterogeneous manifestations ranging from asymptomatic cases to death for still incompletely understood reasons. As part of the IMmunoPhenotyping Assessment in a COVID-19 Cohort study, we mapped the plasma proteomes of 1117 hospitalized patients with COVID-19 from 15 hospitals across the United States. Up to six samples were collected within ~28 days of hospitalization resulting in one of the largest COVID-19 plasma proteomics cohorts with 2934 samples. Using perchloric acid to deplete the most abundant plasma proteins allowed for detecting 2910 proteins. Our findings show that increased levels of neutrophil extracellular trap and heart damage markers are associated with fatal outcomes. Our analysis also identified prognostic biomarkers for worsening severity and death. Our comprehensive longitudinal plasma proteomics study, involving 1117 participants and 2934 samples, allowed for testing the generalizability of the findings of many previous COVID-19 plasma proteomics studies using much smaller cohorts.

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/b525d3b1-3300-4f08-8f41-3ce89de0e951Test

الإتاحة: https://doi.org/10.1126/sciadv.adl5762Test
https://cris.maastrichtuniversity.nl/en/publications/b525d3b1-3300-4f08-8f41-3ce89de0e951Test

المؤلفون: Li, Likang, Wang, Chuangshi, Ye, Zebing, Van Spall, Harriette G. C., Zhang, Jingyi, Lip, Gregory Y. H., Li, Guowei

المصدر: Li , L , Wang , C , Ye , Z , Van Spall , H G C , Zhang , J , Lip , G Y H & Li , G 2024 , ' Association Between Remnant Cholesterol and Risk of Incident Atrial Fibrillation: Population-Based Evidence From a Large-Scale Prospective Cohort Study ' , Journal of the American Heart Association , vol. 13 , no. 10 , e033840 . https://doi.org/10.1161/JAHA.123.033840Test

مصطلحات موضوعية: Humans, Atrial Fibrillation/epidemiology, Male, Female, Middle Aged, Incidence, Prospective Studies, Cholesterol/blood, Risk Factors, Aged, Risk Assessment, Biomarkers/blood

الوصف: BACKGROUND: Evidence for the relationship between remnant cholesterol (RC) and incident atrial fibrillation (AF) risk remains sparse and limited. METHODS AND RESULTS: Participants were enrolled between 2006 and 2010 and followed up to 2021. The multivariable Cox proportional hazards model was used to examine the relationship between RC quartiles and risk of incident AF. Subgroup analyses and sensitivity analyses were performed to explore the potential modification of the association and the robustness of the main findings. A total of 422 316 participants (mean age, 56 years; 54% women) were included for analyses. During a median follow-up of 11.9 years (first quartile-third quartile, 11.6-13.2 years), there were 24 774 AF events documented with an incidence of 4.92 events per 1000 person-years (95% CI, 4.86-4.98). Participants in higher RC quartiles had a lower risk of incident AF than those in the lowest quartile (first quartile): hazard ratio (HR)=0.96 (95% CI, 0.91-1.00) for second quartile; HR=0.92 (95% CI, 0.88-0.96) for third quartile; and HR=0.85 (95% CI, 0.81-0.89) for fourth quartile (P for trend <0.001). The association between RC quartiles and risk of incident AF was stronger in participants aged ≥65 years, in men, and in participants without history of diabetes when compared with control groups (P<0.001 for interaction). CONCLUSIONS: On the basis of data from this large-scale prospective cohort study, elevated RC was associated with a lower risk of incident AF.

وصف الملف: application/pdf

العلاقة: https://vbn.aau.dk/da/publications/f4418b4b-d3fe-43af-9104-cb06bd216b23Test

الإتاحة: https://doi.org/10.1161/JAHA.123.033840Test
https://vbn.aau.dk/da/publications/f4418b4b-d3fe-43af-9104-cb06bd216b23Test
https://vbn.aau.dk/ws/files/717350941/Li_et_al._2024_._Association_Between_Remnant_Cholesterol_and_Risk_of_Incident_Atrial_Fibrillation_Population-Based_Evidence_From_a_Large-Scale_Prospective_Cohort_Study.pdfTest

المؤلفون: Strandkjær, Nina, Jørgensen, Nicoline, Hasselbalch, Rasmus Bo, Kristensen, Jonas, Knudsen, Marie Sophie Sander, Kock, Thilde Olivia, Lange, Theis, Lindholm, Matias Greve, Bruun, Niels Eske, Holmvang, Lene, Terkelsen, Christian Juhl, Pedersen, Claus Kjær, Christensen, Martin Kirk, Lassen, Jens Flensted, Hilsted, Linda, Ladefoged, Søren, Nybo, Mads, Bor, Mustafa Vakur, Dahl, Morten, Hansen, Annebirthe Bo, Kamstrup, Pia Rørbæk, Bundgaard, Henning, Torp-Pedersen, Christian, Iversen, Kasper Karmark

المصدر: Strandkjær , N , Jørgensen , N , Hasselbalch , R B , Kristensen , J , Knudsen , M S S , Kock , T O , Lange , T , Lindholm , M G , Bruun , N E , Holmvang , L , Terkelsen , C J , Pedersen , C K , Christensen , M K , Lassen , J F , Hilsted , L , Ladefoged , S , Nybo , M , Bor , M V , Dahl , M , Hansen , A B , Kamstrup , P R , Bundgaard , ....

مصطلحات موضوعية: Biomarkers/blood, Denmark/epidemiology, Female, Humans, Male, Myocardial Infarction/blood, Predictive Value of Tests, Prospective Studies, Randomized Controlled Trials as Topic, Sex Factors, Troponin/blood, biomarkers, myocardial infarction, acute coronary syndrome, troponin

الوصف: BACKGROUND: Cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction. Although sex-specific 99th percentile thresholds of troponins are recommended in international guidelines, the clinical effect of their use is poorly investigated. The DANSPOT Study (The Danish Study of Sex- and Population-Specific 99th percentile upper reference limits of Troponin) aims to evaluate the clinical effect of a prospective implementation of population- and sex-specific diagnostic thresholds of troponins into clinical practice. METHODS: This study is a nationwide, multicenter, stepped-wedge cluster-randomized trial of the implementation of population- and sex-specific thresholds of troponins in 22 of 23 clinical centers in Denmark. We established sex-specific thresholds for 5 different troponin assays based on troponin levels in a healthy Danish reference population. Centers will sequentially cross over from current uniform manufacturer-derived thresholds to the new population- and sex-specific thresholds. The primary cohort is defined as patients with symptoms suggestive of acute coronary syndrome having at least 1 troponin measurement performed within 24 hours of arrival with a peak troponin value between the current uniform threshold and the new sex-specific female and male thresholds. The study will compare the occurrence of the primary outcome, defined as a composite of nonfatal myocardial infarction, unplanned revascularization, and all-cause mortality within 1 year, separately for men and women before and after the implementation of the new sex-specific thresholds. CONCLUSIONS: The DANSPOT Study is expected to show the clinical effects on diagnostics, treatment, and clinical outcomes in patients with myocardial infarction of implementing sex-specific diagnostic thresholds for troponin based on a national Danish reference population. REGISTRATION: URL: https://www.clinicaltrials.govTest; Unique identifier: NCT05336435.

وصف الملف: application/pdf

العلاقة: https://vbn.aau.dk/da/publications/1eec25e9-8023-402e-8a82-d7fd4cab558aTest

الإتاحة: https://doi.org/10.1161/JAHA.123.033493Test
https://vbn.aau.dk/da/publications/1eec25e9-8023-402e-8a82-d7fd4cab558aTest
https://vbn.aau.dk/ws/files/712435785/Strandkj_r_et_al._2024_._DANSPOT_A_Multicenter_Stepped-Wedge_Cluster-Randomized_Trial_of_the_Reclassification_of_Acute_Myocardial_Infarction_Rationale_and_Study_Design.pdfTest
http://www.scopus.com/inward/record.url?scp=85192428242&partnerID=8YFLogxKTest

المؤلفون: Colantoni, Alessandra, Bucci, Tommaso, Cocomello, Nicholas, Angelico, Francesco, Ettorre, Evaristo, Pastori, Daniele, Lip, Gregory Y. H., Del Ben, Maria, Baratta, Francesco

المصدر: Colantoni , A , Bucci , T , Cocomello , N , Angelico , F , Ettorre , E , Pastori , D , Lip , G Y H , Del Ben , M & Baratta , F 2024 , ' Lipid-based insulin-resistance markers predict cardiovascular events in metabolic dysfunction associated steatotic liver disease ' , Cardiovascular Diabetology , vol. 23 , 175 . https://doi.org/10.1186/s12933-024-02263-6Test

مصطلحات موضوعية: Humans, Insulin Resistance, Male, Middle Aged, Female, Biomarkers/blood, Prospective Studies, Aged, Risk Assessment, Cardiovascular Diseases/diagnosis, Predictive Value of Tests, Prognosis, Adult, Lipid Accumulation Product, Non-alcoholic Fatty Liver Disease/blood, Triglycerides/blood, Blood Glucose/metabolism, Risk Factors, Insulin/blood, Heart Disease Risk Factors, Time Factors

الوصف: BACKGROUND: Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being the key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing the predictive values of different markers of insulin resistance (IR) in identifying the presence of MASLD and the associated risk of cardiovascular events (CVEs). METHODS: Post hoc analysis of the prospective Plinio Study, involving dysmetabolic patients evaluated for the presence of MASLD. The IR markers considered were Homeostatic Model Assessment for IR (HOMA-IR), Triglycerides-Glycemia (TyG) index, Triglycerides to High-Density Lipoprotein Cholesterol ratio (TG/HDL-C), Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI). Receiver operative characteristic (ROC) analyses were performed to find the optimal cut-offs of each IR marker for detecting MASLD and predicting CVEs in MASLD patients. Logistic and Cox multivariable regression analyses were performed, after dichotomizing the IR markers based on the optimal cut-offs, to assess the factors independently associated with MASLD and the risk of CVEs. RESULTS: The study included 772 patients (age 55.6 ± 12.1 years, 39.4% women), of whom 82.8% had MASLD. VAI (Area Under the Curve [AUC] 0.731), TyG Index (AUC 0.723), and TG/HDL-C ratio (AUC: 0.721) predicted MASLD but was greater with HOMA-IR (AUC: 0.792) and LAP (AUC: 0.787). After a median follow-up of 48.7 (25.4-75.8) months, 53 MASLD patients experienced CVEs (1.8%/year). TyG index (AUC: 0.630), LAP (AUC: 0.626), TG/HDL-C (AUC: 0.614), and VAI (AUC: 0.590) demonstrated comparable, modest predictive values in assessing the CVEs risk in MASLD patients. CONCLUSION: In dysmetabolic patients HOMA-IR and LAP showed the best accuracy in detecting MASLD. The possible use of lipid-based IR markers in stratifying the CV risk in patients with MASLD needs further validation in larger cohorts.

وصف الملف: application/pdf

العلاقة: https://vbn.aau.dk/da/publications/056897b4-4475-4ca7-ae69-40484608e974Test

الإتاحة: https://doi.org/10.1186/s12933-024-02263-6Test
https://vbn.aau.dk/da/publications/056897b4-4475-4ca7-ae69-40484608e974Test
https://vbn.aau.dk/ws/files/717211607/Colantoni_et_al._2024_._Lipid-based_insulin-resistance_markers_predict_cardiovascular_events_in_metabolic_dysfunction_associated_steatotic_liver_disease.pdfTest

المؤلفون: Fidanza, Mario, Hibbert, Julie, Acton, Erica, Harbeson, Danny, Schoeman, Elizna, Skut, Patrycja, Woodman, Tabitha, Eynaud, Adrien, Hartnell, Lucy, Brook, Byron, Cai, Bing, Lo, Mandy, Falsafi, Reza, Hancock, Robert E W, Chiume-Kayuni, Msandeni, Lufesi, Norman, Popescu, Constantin R, Lavoie, Pascal M, Strunk, Tobias, Kollmann, Tobias R, Currie, Andrew J, Amenyogbe, Nelly, Lee, Amy H

مصطلحات موضوعية: Angiogenesis, Angiopoietin-1 - blood, Angiopoietin-1 - metabolism, Animals, Newborn, Arachidonic Acid - blood, Arachidonic Acid - metabolism, Arginine - blood, Arginine - metabolism, Biomarkers - blood, Disease Models, Animal, Female, Humans, Infant, Male, Mice, Neonatal Sepsis, Neovascularization, Pathologic - metabolism, Nitric Oxide - blood, Nitric Oxide - metabolism, Nitric Oxide Synthase Type III - metabolism, Reactive Oxygen Species - metabolism, Signal Transduction

الوصف: Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism. We here provide the mechanistic evidence in support of the relevance for these observations. Angiopoetin-1 (Ang-1), which promotes vascular integrity, was decreased in blood plasma of human and murine septic newborns. In preclinical models, administration of Ang-1 provided prophylactic protection from septic death. Arachidonic acid metabolism appears to be functionally connected to Ang-1 via reactive oxygen species (ROS) with a direct role of nitric oxide (NO). Strengthening this intersection via oral administration of arachidonic acid and/or the NO donor L-arginine provided prophylactic as well as therapeutic protection from septic death while also increasing plasma Ang-1 levels among septic newborns. Our data highlight that targeting angiogenesis-associated pathways with interventions that increase Ang-1 activity directly or indirectly through ROS/eNOS provide promising avenues to prevent and/or treat severe neonatal sepsis.

وصف الملف: pdf

العلاقة: ispartof: Scientific reports vol 14; 991005666667607891; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Angiogenesis-associated-pathways-play-critical-roles-in/991005666667607891Test; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12162685070007891/13162685060007891Test; alma:61MUN_INST/bibs/991005666667607891

الإتاحة: https://doi.org/10.1038/s41598-024-62195-9Test
https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Angiogenesis-associated-pathways-play-critical-roles-in/991005666667607891Test
https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12162685070007891/13162685060007891Test

المؤلفون: Ahmadi, Matthew N., Blodgett, Joanna M., Atkin, Andrew J., Chan, Hsiu Wen, del Pozo Cruz, Borja, Suorsa, Kristin, Bakker, Esmee A., Pulsford, Richard M., Mielke, Gregore I., Johansson, Peter J., Hettiarachchi, Pasan, Thijssen, Dick H.J., Stenholm, Sari, Mishra, Gita D., Teixeira-Pinot, Armando, Rangul, Vegar, Sherar, Lauren B., Ekelund, Ulf, Hughes, Alun D., Lee, I. Min, Holtermann, Andreas, Koster, Annemarie, Hamer, Mark, Stamatakis, Emmanuel

المصدر: Ahmadi , M N , Blodgett , J M , Atkin , A J , Chan , H W , del Pozo Cruz , B , Suorsa , K , Bakker , E A , Pulsford , R M , Mielke , G I , Johansson , P J , Hettiarachchi , P , Thijssen , D H J , Stenholm , S , Mishra , G D , Teixeira-Pinot , A , Rangul , V , Sherar , L B , Ekelund , U , Hughes , A D , Lee , I M , ProPASS collaboration , ....

مصطلحات موضوعية: Cardiometabolic health, Individual participant meta-analysis, Physical activity type, Posture, Running, Sitting, Stair climbing, Standing, Walking, Wearables, Waist Circumference/physiology, Prospective Studies, Cardiovascular Diseases/prevention & control, Humans, Middle Aged, Male, Posture/physiology, Sleep/physiology, Standing Position, Walking/physiology, Female, Adult, Biomarkers/blood, Stair Climbing/physiology, Body Mass Index, Cross-Sectional Studies, Exercise/physiology, Sitting Position, Cholesterol, HDL/blood

الوصف: AIMS/HYPOTHESIS: The aim of this study was to examine the dose-response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health. METHODS: We conducted an individual participant harmonised meta-analysis of 12,095 adults (mean ± SD age 54.5±9.6 years; female participants 54.8%) from six cohorts with thigh-worn accelerometry data from the Prospective Physical Activity, Sitting and Sleep (ProPASS) Consortium. Associations of daily walking, stair climbing, running, standing and sitting time with a composite cardiometabolic health score (based on standardised z scores) and individual cardiometabolic markers (BMI, waist circumference, triglycerides, HDL-cholesterol, HbA 1c and total cholesterol) were examined cross-sectionally using generalised linear modelling and cubic splines. RESULTS: We observed more favourable composite cardiometabolic health (i.e. z score <0) with approximately 64 min/day walking (z score [95% CI] -0.14 [-0.25, -0.02]) and 5 min/day stair climbing (-0.14 [-0.24, -0.03]). We observed an equivalent magnitude of association at 2.6 h/day standing. Any amount of running was associated with better composite cardiometabolic health. We did not observe an upper limit to the magnitude of the dose-response associations for any activity type or standing. There was an inverse dose-response association between sitting time and composite cardiometabolic health that became markedly less favourable when daily durations exceeded 12.1 h/day. Associations for sitting time were no longer significant after excluding participants with prevalent CVD or medication use. The dose-response pattern was generally consistent between activity and posture types and individual cardiometabolic health markers. CONCLUSIONS/INTERPRETATION: In this first activity type-specific analysis of device-based physical activity, ~64 min/day of walking and ~5.0 min/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious ...

وصف الملف: application/pdf

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/02684ac3-e426-4cc8-8863-fa9b72c57a83Test

الإتاحة: https://doi.org/10.1007/s00125-024-06090-yTest
https://portal.findresearcher.sdu.dk/da/publications/02684ac3-e426-4cc8-8863-fa9b72c57a83Test
https://findresearcher.sdu.dk/ws/files/259713223/s00125-024-06090-y.pdfTest

المؤلفون: Garcia-Moreno, Hector, Prudencio, Mercedes, Thomas-Black, Gilbert, Solanky, Nita, Jansen-West, Karen R, Hanna Al-Shaikh, Rana, Heslegrave, Amanda, Zetterberg, Henrik, Santana, Magda M, Pereira de Almeida, Luis, Vasconcelos-Ferreira, Ana, Januário, Cristina, Infante, Jon, Faber, Jennifer, Klockgether, Thomas, Reetz, Kathrin, Raposo, Mafalda, Ferreira, Ana F, Lima, Manuela, Schöls, Ludger, Synofzik, Matthis, Hübener-Schmid, Jeannette, Puschmann, Andreas, Gorcenco, Sorina, Wszolek, Zbigniew K, Petrucelli, Leonard, Giunti, Paola

المصدر: European Journal of Neurology MultiPark: Multidisciplinary research focused on Parkinson´s disease. 29(8):2439-2452

مصطلحات موضوعية: Animals, Biomarkers/blood, Cerebellum/chemistry, Heterozygote, Humans, Machado-Joseph Disease/blood, Mice, Transgenic, Neurofilament Proteins/blood, tau Proteins/blood, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Neurovetenskaper, Medical and Health Sciences, Basic Medicine, Neurosciences

الوصف: BACKGROUND AND PURPOSE: Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures.METHODS: To evaluate total tau (t-tau), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and neurofilament light-chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers (n = 143) and controls (n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD-1 platform. Eleven ATXN3 mutation carrier cerebrospinal fluid samples were analysed for t-tau and phosphorylated tau (p-tau181 ). A transgenic SCA3 mouse model (MJDTg) was used to measure cerebellar t-tau levels.RESULTS: Plasma t-tau levels were higher in mutation carriers below the age of 50 compared to controls, and the Inventory of Non-Ataxia Signs was associated with t-tau in ataxic patients (p = 0.004). Pre-ataxic carriers showed higher cerebrospinal fluid t-tau and p-tau181 concentrations compared to ataxic patients (p = 0.025 and p = 0.014, respectively). Cerebellar t-tau was elevated in MJDTg mice compared to wild-type (p = 0.033) only in the early stages of the disease. GFAP and UCHL1 did not show higher levels in mutation carriers compared to controls. Plasma NfL concentrations were higher in mutation carriers compared to controls, and differences were greater for younger carriers. The Scale for the Assessment and Rating of Ataxia was the strongest predictor of NfL in ataxic patients (p < 0.001).CONCLUSION: Our results suggest that tau might be a marker of early disease stages in SCA3. NfL can discriminate mutation carriers from controls and is associated with different clinical variables. Longitudinal studies are required to confirm their potential role as biomarkers in clinical trials.

الوصول الحر: https://lup.lub.lu.se/record/0d803d65-f2a3-4bc6-b38a-4ca82ae24b95Test
http://dx.doi.org/10.1111/ene.15373Test

المؤلفون: Timpka, Simon, Melander, Olle, Engström, Gunnar, Elmståhl, Sölve, Nilsson, Peter M, Lind, Lars, Pihlsgård, Mats, Enhörning, Sofia

المصدر: EBioMedicine EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health MultiPark: Multidisciplinary research focused on Parkinson´s disease. 95

مصطلحات موضوعية: Adolescent, Adult, Aged, 80 and over, Female, Humans, Male, Middle Aged, Young Adult, Biomarkers/blood, Glycopeptides/blood, Temperature, Vasopressins/blood, Seasons, Hot Temperature, Cold Temperature, Medicin och hälsovetenskap, Hälsovetenskap, Näringslära, Medical and Health Sciences, Health Sciences, Nutrition and Dietetics

الوصف: BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.

الوصول الحر: https://lup.lub.lu.se/record/2f6ede7b-49b9-40d0-9b73-06b527a81819Test
http://dx.doi.org/10.1016/j.ebiom.2023.104750Test

المؤلفون: Lindsay, Karen L, Buss, Claudia, Wadhwa, Pathik D, Entringer, Sonja

المصدر: Nutrients. 10(9)

مصطلحات موضوعية: Adult, Biomarkers: blood, Diet: adverse effects, Female, Humans, Inflammation: blood, diagnosis, immunology, Inflammation Mediators: blood, Longitudinal Studies, Maternal Nutritional Physiological Phenomena, Nutritional Status, Pregnancy, Pregnancy Complications: blood, diagnosis, immunology, Prospective Studies, Risk Factors, Stress, Psychological: blood, diagnosis, immunology, Tumor Necrosis Factor-alpha: blood, Young Adult

الوصف: Maternal inflammation during pregnancy is known to adversely impact fetal development, birth outcomes, and offspring physical and mental health. Diet and stress have been identified as important determinants of inflammation, yet their combined effects have not been examined in the context of pregnancy. The aim of this study was to examine the relationship between maternal diet with inflammatory potential and psychological stress, and to determine their interaction effect on concentrations of tumor necrosis factor (TNF)-α across pregnancy. We conducted a prospective longitudinal study of n = 202 women with three assessments during pregnancy, which included: ecological momentary assessment (EMA) of maternal stress using the perceived stress scale (PSS) short version; 24-h dietary recalls from which the dietary inflammatory index (DII) was computed; and serum measurements of TNF-α. Across pregnancy, higher perceived stress was associated with consumption of a more pro-inflammatory diet (r = 0.137; p < 0.05). In a linear regression model adjusted for covariates, DII was positively associated with TNF-α (B = 0.093, p = 0.010). The effect of the pro-inflammatory diet on concentrations of TNF-α was more pronounced in women reporting higher levels of stress (B = 0.134, p = 0.018 for DII*PSS interaction). These results highlight the need to consider nutrition and stress concurrently in the context of inflammation during pregnancy.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/78s5f7nvTest