المؤلفون: Small, B., Ross, D., Bhorade, S., Rosenheck, J.P.

المصدر: The Journal of Heart and Lung Transplantation ; volume 43, issue 4, page S469-S470 ; ISSN 1053-2498

مصطلحات موضوعية: Transplantation, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.healun.2024.02.623Test
https://api.elsevier.com/content/article/PII:S1053249824006661?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1053249824006661?httpAccept=text/plainTest

المؤلفون: Cantu, E, Suzuki, Y, Diamond, JM, Ellis, J, Tiwari, J, Beduhn, B, Nellen, JR, Shah, R, Meyer, NJ, Lederer, DJ, Kawut, SM, Palmer, SM, Snyder, LD, Hartwig, MG, Lama, VN, Bhorade, S, Crespo, M, Demissie, E, Wille, K, Orens, J, Shah, PD, Weinacker, A, Weill, D, Wilkes, D, Roe, D, Ware, LB, Wang, F, Feng, R, Christie, JD, Group, for the Lung Transplant Outcomes

المصدر: American Journal of Transplantation. 16(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Clinical Research, Rare Diseases, Lung, Acute Respiratory Distress Syndrome, Genetics, Human Genome, Adult, Biomarkers, Female, Follow-Up Studies, Genetic Variation, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Lung Transplantation, Male, Middle Aged, Phenotype, Plasminogen Activator Inhibitor 1, Primary Graft Dysfunction, Prognosis, Prospective Studies, Quantitative Trait Loci, translational research, science, lung transplantation, pulmonology, ischemia reperfusion injury, lung (allograft) function, dysfunction, lung disease, immune, inflammatory, Lung Transplant Outcomes Group, Medical and Health Sciences, Surgery, Clinical sciences

الوصف: The authors previously identified plasma plasminogen activator inhibitor-1 (PAI-1) level as a quantitative lung injury biomarker in primary graft dysfunction (PGD). They hypothesized that plasma levels of PAI-1 used as a quantitative trait could facilitate discovery of genetic loci important in PGD pathogenesis. A two-stage cohort study was performed. In stage 1, they tested associations of loci with PAI-1 plasma level using linear modeling. Genotyping was performed using the Illumina CVD Bead Chip v2. Loci meeting a p < 5 × 10(-4) cutoff were carried forward and tested in stage 2 for association with PGD. Two hundred ninety-seven enrollees were evaluated in stage 1. Six loci, associated with PAI-1, were carried forward to stage 2 and evaluated in 728 patients. rs3168046 (Toll interacting protein [TOLLIP]) was significantly associated with PGD (p = 0.006). The increased risk of PGD for carrying at least one copy of this variant was 11.7% (95% confidence interval 4.9-18.5%). The false-positive rate for individuals with this genotype who did not have PGD was 6.1%. Variants in the TOLLIP gene are associated with higher circulating PAI-1 plasma levels and validate for association with clinical PGD. A protein quantitative trait analysis for PGD risk prioritizes genetic variations in TOLLIP and supports a role for Toll-like receptors in PGD pathogenesis.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5352n17hTest

المؤلفون: Shah, RJ, Diamond, JM, Cantu, E, Flesch, J, Lee, JC, Lederer, DJ, Lama, VN, Orens, J, Weinacker, A, Wilkes, DS, Roe, D, Bhorade, S, Wille, KM, Ware, LB, Palmer, SM, Crespo, M, Demissie, E, Sonnet, J, Shah, A, Kawut, SM, Bellamy, SL, Localio, AR, Christie, JD

المصدر: American Journal of Transplantation. 15(8)

مصطلحات موضوعية: Patient Safety, Prevention, Lung, Rare Diseases, Organ Transplantation, Clinical Research, Transplantation, Respiratory, Adult, Female, Humans, Lung Transplantation, Male, Primary Graft Dysfunction, Risk Factors, clinical research / practice, lung (allograft) function / dysfunction, lung failure / injury, lung transplantation / pulmonology, Medical and Health Sciences, Surgery

الوصف: Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions. 211/1255 subjects in the derivation and 56/382 subjects in the validation developed PGD. We developed three prediction models, where low-risk recipients had a normal BMI (18.5-25 kg/m(2) ), chronic obstructive pulmonary disease/cystic fibrosis, and absent or mild pulmonary hypertension (mPAP

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8x64329mTest

المؤلفون: Shah, RJ, Wickersham, N, Lederer, DJ, Palmer, SM, Cantu, E, Diamond, JM, Kawut, SM, Lama, VN, Bhorade, S, Crespo, M, Demissie, E, Sonett, J, Wille, K, Orens, J, Weinacker, A, Shah, P, Arcasoy, S, Wilkes, DS, Christie, JD, Ware, LB, Group, for the Lung Transplant Outcomes

المصدر: American Journal of Transplantation. 14(2)

مصطلحات موضوعية: Lung, Organ Transplantation, Clinical Research, Rare Diseases, Transplantation, Respiratory, Adult, Aged, Biomarkers, Female, Follow-Up Studies, Humans, Lung Diseases, Lung Transplantation, Male, Middle Aged, Preoperative Care, Primary Graft Dysfunction, Prognosis, Prospective Studies, Uteroglobin, Acute lung injury, biomarkers, CC-16, lung transplantation, primary graft dysfunction, Lung Transplant Outcomes Group, Medical and Health Sciences, Surgery

الوصف: Inherent recipient factors, including pretransplant diagnosis, obesity and elevated pulmonary pressures, are established primary graft dysfunction (PGD) risks. We evaluated the relationship between preoperative lung injury biomarkers and PGD to gain further mechanistic insight in recipients. We performed a prospective cohort study of recipients in the Lung Transplant Outcomes Group enrolled between 2002 and 2010. Our primary outcome was Grade 3 PGD on Day 2 or 3. We measured preoperative plasma levels of five biomarkers (CC-16, sRAGE, ICAM-1, IL-8 and Protein C) that were previously associated with PGD when measured at the postoperative time point. We used multivariable logistic regression to adjust for potential confounders. Of 714 subjects, 130 (18%) developed PGD. Median CC-16 levels were elevated in subjects with PGD (10.1 vs. 6.0, p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7bz077n4Test

المؤلفون: Keller, M., Ross, D., Bhorade, S., Agbor-Enoh, S.

المصدر: The Journal of Heart and Lung Transplantation ; volume 42, issue 4, page S509 ; ISSN 1053-2498

مصطلحات موضوعية: Transplantation, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.healun.2023.02.1398Test
https://api.elsevier.com/content/article/PII:S1053249823014407?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1053249823014407?httpAccept=text/plainTest

المؤلفون: Poroyko, V.A., Ulanov, A., Becker, J., Latif, O., Garrity, E., Gozal, D., Bhorade, S.

المصدر: The Journal of Heart and Lung Transplantation ; volume 35, issue 4, page S170 ; ISSN 1053-2498

مصطلحات موضوعية: Transplantation, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.healun.2016.01.473Test
https://api.elsevier.com/content/article/PII:S1053249816005210?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S1053249816005210?httpAccept=text/xmlTest

المؤلفون: Rammaert B., Puyade M., Cornely O. A., Seidel D., Grossi P., Husain S., Picard C., Lass-Florl C., Manuel O., Le Pavec J., Lortholary O., Nagel C., Westall G., Morrissey O., Chambers D., Eschertzhuber S., Coussement J., Knoop C., Vos R., Dupont L., Dumonceaux M., Campos S. V., Kabbani D., Cervera C., Luong M. -L., Blanchard E., Senechal A., Pavec J. L., Brugiere O., Boussaud V., Guillemain R., Bervar J. -F., Claustre J., Haloun A., Hirschi S., Reynaud M., Kneidinger N., Gottlieb J., Roilides E., Zarrinfar H., Rosso L., Morlacchi L. C., Dell'Amore A., Loy M., Santos C. O. D., Rello J., Monforte V., Martin-Gomez M. T., Medrano F. L., Fernandez-Ruiz M., Sole A., Cifrian J. M., Neofytos D., Mueller N., Benden C., Brill A. K., Kiyan E., Gould K., Gkrania-Klotsas E., David M., Weigt S., Kwak E. J., Silveira F., Hadjiliadis D., Baddley J., Danziger-Isakov L., Bhorade S., Ison M., Wolfe C., Aslam S., Budem M., Musetti A.

المساهمون: Rammaert, B., Puyade, M., Cornely, O. A., Seidel, D., Grossi, P., Husain, S., Picard, C., Lass-Florl, C., Manuel, O., Le Pavec, J., Lortholary, O., Nagel, C., Westall, G., Morrissey, O., Chambers, D., Eschertzhuber, S., Coussement, J., Knoop, C., Vos, R., Dupont, L., Dumonceaux, M., Campos, S. V., Kabbani, D., Cervera, C., Luong, M. -L., Blanchard, E., Senechal, A., Pavec, J. L., Brugiere, O., Boussaud, V., Guillemain, R., Bervar, J. -F., Claustre, J., Haloun, A., Hirschi, S., Reynaud, M., Kneidinger, N., Gottlieb, J., Roilides, E., Zarrinfar, H., Rosso, L., Morlacchi, L. C., Dell'Amore, A., Loy, M., Santos, C. O. D., Rello, J., Monforte, V., Martin-Gomez, M. T., Medrano, F. L., Fernandez-Ruiz, M., Sole, A., Cifrian, J. M., Neofytos, D., Mueller, N., Benden, C., Brill, A. K., Kiyan, E., Gould, K., Gkrania-Klotsas, E., David, M., Weigt, S., Kwak, E. J., Silveira, F., Hadjiliadis, D., Baddley, J., Danziger-Isakov, L., Bhorade, S., Ison, M., Wolfe, C., Aslam, S., Budem, M., Musetti, A.

مصطلحات موضوعية: invasive fungal disease, lomentosporiosi, scedosporiosi, solid organ transplantation, Ascomycota, Human, Internationality, Lung Transplantation, Mycose, Prospective Studie, Respiratory Tract Infection, Scedosporium, Surveys and Questionnaire, Disease Management, Immunocompromised Host

الوصف: Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31283872; info:eu-repo/semantics/altIdentifier/wos/WOS:000477404300001; volume:21; issue:5; firstpage:e13141; journal:TRANSPLANT INFECTIOUS DISEASE; http://hdl.handle.net/11577/3360321Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85069887016

الإتاحة: https://doi.org/10.1111/tid.13141Test
http://hdl.handle.net/11577/3360321Test

المؤلفون: University of Chicago, Chicago, IL ( host institution ), Ghassemieh, B.J. ( author ), Charbeneau, J. ( author ), Ahya, V.N. ( author ), Baz, M.A. ( author ), Valentine, V.G. ( author ), Arcasoy, S.M. ( author ), Love, R.B. ( author ), Seethamraju, H. ( author ), Alex, C.G. ( author ), Bag, R. ( author ), DeOliveira, N.C. ( author ), Husain, A. ( author ), Vigneswaran, W.T. ( author ), Krishnan, J.A. ( author ), Durazo-Arvizu, R. ( author ), Norwick, L. ( author ), Garrity, E. ( author ), Bhorade, S. ( author )

الوصف: Journal of Heart and Lung Transplantation 30 (2011) S181-S182. doi:10.1016/j.healun.2011.01.551 ; 2016-03-04T18:48:28Z

وصف الملف: Pages S181-S182

العلاقة: Journal of Heart and Lung Transplantation; S1053-2498(11)00553-5; http://ufdc.ufl.edu/LS00524767/00001Test

الإتاحة: https://doi.org/10.1016/j.healun.2011.01.551Test
http://ufdc.ufl.edu/LS00524767/00001Test

المؤلفون: Diamond, J.M., Lederer, D.J., Kawut, S.M., Lee, J., Ahya, V.N., Bellamy, S., Palmer, S.M., Lama, V.N., Bhorade, S., Crespo, M., Demissie, E., Sonett, J., Wille, K., Orens, J., Shah, P.D., Weinacker, A., Weill, D., Kohl, B.A., Deutschman, C.C., Arcasoy, S., Shah, A.S., Belperio, J.A., Wilkes, D., Reynolds, J.M., Ware, L.B., Christie, J.D.

المصدر: American Journal of Transplantation ; volume 11, issue 11, page 2517-2522 ; ISSN 1600-6135

مصطلحات موضوعية: Pharmacology (medical), Transplantation, Immunology and Allergy

الإتاحة: https://doi.org/10.1111/j.1600-6143.2011.03702.xTest
https://api.elsevier.com/content/article/PII:S1600613522281696?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1600613522281696?httpAccept=text/plainTest

المؤلفون: Diamond, J.M., Kawut, S.M., Lederer, D.J., Ahya, V.N., Kohl, B., Sonett, J., Palmer, S.M., Crespo, M., Wille, K., Lama, V.N., Shah, P.D., Orens, J., Bhorade, S., Weinacker, A., Demissie, E., Bellamy, S., Christie, J.D., Ware, L.B.

المصدر: American Journal of Transplantation ; volume 11, issue 3, page 561-567 ; ISSN 1600-6135

مصطلحات موضوعية: Pharmacology (medical), Transplantation, Immunology and Allergy

الإتاحة: https://doi.org/10.1111/j.1600-6143.2010.03431.xTest
https://api.elsevier.com/content/article/PII:S1600613522278599?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1600613522278599?httpAccept=text/plainTest