المؤلفون: De Almeida, Sergio M, Rotta, Indianara, Tang, Bin, Umlauf, Anya, Vaida, Florin, Cherner, Mariana, Franklin, Donald, Letendre, Scott, Ellis, Ronald J, Group, the HNRC

المصدر: JAIDS Journal of Acquired Immune Deficiency Syndromes. 90(1)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Neurosciences, Clinical Research, Brain Disorders, Mental Health, Infectious Diseases, HIV/AIDS, Infection, AIDS Dementia Complex, Biomarkers, Case-Control Studies, Chemokine CXCL10, HIV Infections, HIV-1, Humans, Memory Disorders, Neopterin, Receptors, Urokinase Plasminogen Activator, subtypes, HIV-associated neurocognitive disorders, cerebrospinal fluid, suPAR, IP-10, neopterin, beta(2) microglobulin, HNRC Group, Clinical Sciences, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health

الوصف: BackgroundWe hypothesized that the induction of monocyte activation biomarkers, especially soluble urokinase-type plasminogen activator receptor (suPAR) and interferon γ-inducible protein 10 (IP-10), is lower in HIV-1C than HIV-1B, owing to a defective Tat cysteine dimotif (C30S).MethodsA total of 68 paired cerebrospinal fluid (CSF) and blood samples from people with HIV (PWH), free of CNS opportunistic infections, from a Southern Brazil outpatient HIV clinic were evaluated such as HIV-1B subtype (n = 27), HIV-1C (n = 26), other (n = 15), and 19 HIV-negative controls. The levels of suPAR, IP-10, neopterin, and β2 microglobulin (β2m) in the CSF and serum were quantified using different immunoassays.ResultsOverall, in PWH, increases in CSF suPAR, CSF/serum suPAR, and CSF/serum β2m correlated with worse working memory deficits (r = 0.303, 0.353, and 0.289, respectively, all P < 0.05). The medians of IP-10, suPAR, neopterin, and β2m in CSF and serum and the CSF/serum ratio and suPAR index were comparable between the HIV-1B and HIV-1C subtypes. CSF IP-10 and neopterin and serum IP-10 and suPAR levels were higher in PWH than the HIV-negative controls (P = 0.015, P = 0.001, P < 0.0001, and P < 0.001, respectively). The serum β2m level was higher in HIV-associated dementia than neuropsychologically normal or asymptomatic (P = 0.024).DiscussionWe observed that higher levels of CSF suPAR and the suPAR quotient correlated with worse working memory deficit. Elevated levels of monocyte activation were similar in both HIV-1 B and C subtypes, providing no evidence of reduced neuropathogenicity of HIV-1 subtype C Tat compared with subtype B.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2c98z3jtTest
https://escholarship.org/content/qt2c98z3jt/qt2c98z3jt.pdfTest

المؤلفون: Contardi, Cecilia, Rubes, Davide, Serra, Massimo, Dorati, Rossella, Dattilo, Marco, Mavliutova, Liliia, Patrini, Maddalena, Guglielmann, Raffaella, Sellergren, Börje, De Lorenzi, Ersilia

المصدر: Analytical Chemistry. 96(7):3017-3024

مصطلحات موضوعية: polymer nanoparticles, sialic-acid, expression, beta(2)-microglobulin, glycosylation, adsorption, isotherm, gold

الوصف: In this work, an innovative and accurate affinity capillary electrophoresis (ACE) method was set up to monitor the complexation of aqueous MIP nanogels (NGs) with model cancer-related antigens. Using α2,6′- and α2,3′-sialyllactose as oversimplified cancer biomarker-mimicking templates, NGs were synthesized and characterized in terms of size, polydispersity, and overall charge. A stability study was also carried out in order to select the best storage conditions and to ensure product quality. After optimization of capillary electrophoresis conditions, injection of MIP NGs resulted in a single, sharp, and efficient peak. The mobility shift approach was applied to quantitatively estimate binding affinity, in this case resulting in an association constant of K ≈ 106 M–1. The optimized polymers further displayed a pronounced discrimination between the two sialylated sugars. The newly developed ACE protocol has the potential to become a very effective method for nonconstrained affinity screening of NG in solution, especially during the NG development phase and/or for a final accurate quantitation of the observed binding.

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66139Test

المؤلفون: Mumtaz, Tamseela, Iqbal, Muhammad Amir, Roohi, Nabila, Akhtar, Muhammad Waheed

المصدر: Pakistan Journal of Health Sciences; 2023: Volume 04 Issue 05 (May Issue); 160-165 ; 2790-9352 ; 2790-9344 ; 10.54393/pjhs.v4i05

مصطلحات موضوعية: Diagnostic marker, beta 2 microglobulin, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma, MICA 1, ELISA

الوصف: Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial fluid thus increasing the level of B2M in hematological malignancies. Objectives: To set forward B2M as potential biomarker for the detection and stage of malignant lymphoma. Methods: Serum of newly diagnosed Hodgkin’s and non-Hodgkin’s lymphoma patients presented to physician prior to any surgical or medicinal treatment were collected and evaluated through sandwich type of ELISA for the possible elevation of B2M. B2M concentrations in healthy individual’s serum (control group) were also detected. Mean values of B2M in all three groups were compared by applying one-way analysis of variance to determine the significant difference. Results: The serum of Hodgkin’s Lymphoma patients depicted 5 folds higher B2M concentration than the healthy subjects, while NHL showed more concentration of circulating B2M where it was 6-fold higher than healthy subjects. Moreover, the advanced stage of the disease with involvement of distant site or organ portrayed increase shedding of MICA 1 chain in circulating blood than localized or regional disease. Conclusions: Elevated serum B2M concentrations in blood surely a sign of neoplastic disease involving nucleated cell like lymphoma and its enhanced expression in distantly spreading disease proved it as a prognostic marker as well

وصف الملف: application/pdf

العلاقة: https://thejas.com.pk/index.php/pjhs/article/view/757/496Test; https://thejas.com.pk/index.php/pjhs/article/view/757Test

الإتاحة: https://doi.org/10.54393/pjhs.v4i05.757Test
https://doi.org/10.54393/pjhs.v4i05Test
https://thejas.com.pk/index.php/pjhs/article/view/757Test

المؤلفون: Foster, Meredith C, Levey, Andrew S, Inker, Lesley A, Shafi, Tariq, Fan, Li, Gudnason, Vilmundur, Katz, Ronit, Mitchell, Gary F, Okparavero, Aghogho, Palsson, Runolfur, Post, Wendy S, Shlipak, Michael G

المصدر: American Journal of Kidney Diseases. 70(3)

مصطلحات موضوعية: Clinical Research, Aging, Nutrition, Cardiovascular, Atherosclerosis, Prevention, Kidney Disease, Renal and urogenital, Age Factors, Aged, Aged, 80 and over, Biomarkers, Creatinine, Cross-Sectional Studies, Cystatin C, Female, Glomerular Filtration Rate, Humans, Intramolecular Oxidoreductases, Lipocalins, Male, Predictive Value of Tests, Renal Insufficiency, Chronic, Sex Factors, United States, beta 2-Microglobulin, Filtration markers, glomerular filtration rate, GFR estimation, elderly, creatinine, cystatin C, beta(2)-microglobulin, beta-trace protein, kidney function, biomarker, β(2)-microglobulin, Clinical Sciences, Public Health and Health Services, Urology & Nephrology

الوصف: BackgroundStudies in chronic kidney disease populations suggest that the non-glomerular filtration rate (GFR) determinants of serum levels of the low-molecular-weight protein filtration markers cystatin C, β2-microglobulin (B2M), and beta-trace protein (BTP) are less affected by age, sex, and ethnicity than those of creatinine.Study designCross-sectional study.Setting & participantsPredominantly elderly participants selected from the Age, Gene/Environment Susceptibility Kidney Study (AGES-Kidney; N=683; mean [SD] age, 79 [4] years; GFR, 62 [17]mL/min/1.73 m2) and from the Multi-Ethnic Study of Atherosclerosis Kidney Study (MESA-Kidney; N=273; mean [SD] age, 70.5 [9] years; GFR, 73 [19]mL/min/1.73 m2).PredictorsDemographic and clinical factors hypothesized to be associated with conditions affecting non-GFR determinants of the filtration markers.OutcomesMeasured GFRs and estimated GFRs (eGFRs) based on creatinine, cystatin C, B2M, and BTP levels (eGFRcr, eGFRcys, eGFRB2M, and eGFRBTP, respectively). Residual associations of factors with eGFR after accounting for measured GFR as the parameter of interest.ResultseGFRcys, eGFRB2M, and eGFRBTP had significantly less strong residual associations with age and sex than eGFRcr in both AGES-Kidney and MESA-Kidney and were not associated with ethnicity (black vs white) in MESA-Kidney. After adjusting for age, sex, and ethnicity, residual associations with most clinical factors were smaller than observed with age and sex. eGFRcys and eGFRB2M, but not eGFRBTP, had significant residual associations with C-reactive protein levels in both studies.LimitationsSmall sample size may limit power to detect associations. Participants may be healthier than the general population.ConclusionsSimilar to previous studies in chronic kidney disease, in community-dwelling elders, cystatin C, B2M, and BTP levels are less affected than creatinine level by age and sex and are not affected by ethnicity. Both cystatin C and B2M levels may be affected by inflammation. These findings are important for the development and use of GFR estimating equations based on low-molecular-weight serum proteins throughout the range in GFRs.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/84z989s3Test

المؤلفون: Paul Luchian Aldea, Andreea Liana Rachisan, Bogdan Ioan Stanciu, Andrei Picos, Alina Monica Picos, Dan Ioan Delean, Ramona Stroescu, Magdalena Iuliana Starcea, Cristina Maria Borzan, Florin Ioan Elec

المصدر: Frontiers in Pediatrics, Vol 10 (2022)

مصطلحات موضوعية: cystatin C, neutrophil gelatinase-related lipoprotein, kidney injury molecule 1, beta 2 microglobulin, biomarkers, graft function, Pediatrics, RJ1-570

الوصف: Kidney transplantation (KT) is currently the elective approach for patients with end-stage renal disease. Although it is a safe choice for these patients, the early complications can lead to graft dysfunction. One of the most redoubtable complications is delayed graft function (DGF), having no specific treatment. The effects of DGF on the graft survival are large enough to justify the formulation of specific biological protocols. Therefore, discovering biomarkers of acute impairment in renal transplanted patients is required. Creatinine is a poor marker to establish the kidney injury. Estimated glomerular filtration rate together with creatinine is ready to approximately measure the kidney function. Different serum and urine proteins are being studied as possible predictive biomarkers for delayed graft function. This review will concentrate on recent and existing research which provide insight concerning the contribution of some molecules for the estimation and evaluation of graft function after kidney transplantation. Further studies examining various aspects of DGF after KT are urgently needed to address a hitherto less-known clinical question.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fped.2022.869628/fullTest; https://doaj.org/toc/2296-2360Test

الوصول الحر: https://doaj.org/article/a6fdc85a70d74b9b8e760b604082d1dcTest

المؤلفون: Faravelli, Giulia, Mondani, Valentina, Mangione, P Patrizia, Raimondi, Sara, Marchese, Loredana, Lavatelli, Francesca, Stoppini, Monica, Corazza, Alessandra, Canetti, Diana, Verona, Guglielmo, Obici, Laura, Taylor, Graham W, Gillmore, Julian D, Giorgetti, Sofia, Bellotti, Vittorio

المصدر: Frontiers in Molecular Biosciences , 9 , Article 830006. (2022)

مصطلحات موضوعية: amyloidosis, transthyretin, beta 2-microglobulin, metamorphosis, amyloid, SYSTEMIC AMYLOIDOSIS, TRANSTHYRETIN AMYLOIDOSIS, D76N BETA(2)-MICROGLOBULIN, MOLECULAR-MECHANISMS, CARDIAC AMYLOIDOSIS, TRANSGENIC MICE, HUMAN-DISEASE, WILD-TYPE, MODEL, AGGREGATION

الوصف: The globular to fibrillar transition of proteins represents a key pathogenic event in the development of amyloid diseases. Although systemic amyloidoses share the common characteristic of amyloid deposition in the extracellular matrix, they are clinically heterogeneous as the affected organs may vary. The observation that precursors of amyloid fibrils derived from circulating globular plasma proteins led to huge efforts in trying to elucidate the structural events determining the protein metamorphosis from their globular to fibrillar state. Whereas the process of metamorphosis has inspired poets and writers from Ovid to Kafka, protein metamorphism is a more recent concept. It is an ideal metaphor in biochemistry for studying the protein folding paradigm and investigating determinants of folding dynamics. Although we have learned how to transform both normal and pathogenic globular proteins into fibrillar polymers in vitro, the events occurring in vivo, are far more complex and yet to be explained. A major gap still exists between in vivo and in vitro models of fibrillogenesis as the biological complexity of the disease in living organisms cannot be reproduced at the same extent in the test tube. Reviewing the major scientific attempts to monitor the amyloidogenic metamorphosis of globular proteins in systems of increasing complexity, from cell culture to human tissues, may help to bridge the gap between the experimental models and the actual pathological events in patients.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10144940/1/fmolb-09-830006.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10144940Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10144940/1/fmolb-09-830006.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10144940Test/

المؤلفون: Barlas C., Dağdelen M., Elverdi T., Salihoğlu A., Dinçbaş F.Ö.

مصطلحات موضوعية: bulky abdominal masses, Extramedullary myeloma, immunomodulatory drugs, pomalidomide, radiotherapy, alanine aminotransferase, albumin, alkaline phosphatase, aspartate aminotransferase, beta 2 microglobulin, bilirubin, bortezomib, calcium ion, carfilzomib, cisplatin, creatinine, cyclophosphamide, dexamethasone, doxorubicin, etoposide, gamma glutamyltransferase, hemoglobin, immunoglobulin lambda light chain, immunoglobulin light chain, lactate dehydrogenase, protein, thalidomide, unclassified drug, vincristine, zoledronic acid

الوصف: Extramedullary myeloma itself is a rare entity and treatment of recurrent e xtraosseous myeloma can be challenging during the prolonged disease course. We report a multiple myeloma (MM) patient with extramedullary bulky abdominal masses treated with palliative radiotherapy (RT) and concomitant pomalidomide. A 59-year-old woman diagnosed with MM presented with pancytopenia, widespread lytic bone lesions and intraperitoneal implants. The patient received multiple series of chemotherapy. Following autologous stem cell transplantation (ASCT), imaging studies displayed bulky abdominal masses. Due to the rapidly progressing symptoms, palliative RT 30 Gy in 15 fractions with concomitant pomalidomide was administered. Post-RT imagings showed near-complete regression. Extraosseous extramedullary MM has a poor prognosis and is an area of unme t clinical needs. Our report describes the treatment of a relapsed extramedullary myeloma case with RT and concomitant pomalidomide resulting in a near-complete response of disease inside the radiated area. To conclude, it was demonstrated that RT is an effective treatment modality to obtain symptom palliation and can be safely administered with an immunomodulatory drug. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.

وصف الملف: application/pdf

العلاقة: Eastern Journal of Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.5505/ejm.2022.02259Test; https://hdl.handle.net/20.500.12831/9493Test; 27; 330; 332; 2-s2.0-85130797714; 1124342

الإتاحة: https://doi.org/10.5505/ejm.2022.02259Test
https://doi.org/20.500.12831/9493Test
https://hdl.handle.net/20.500.12831/9493Test

المؤلفون: Foster, Meredith C, Coresh, Josef, Hsu, Chi-yuan, Xie, Dawei, Levey, Andrew S, Nelson, Robert G, Eckfeldt, John H, Vasan, Ramachandran S, Kimmel, Paul L, Schelling, Jeffrey, Simonson, Michael, Sondheimer, James H, Anderson, Amanda Hyre, Akkina, Sanjeev, Feldman, Harold I, Kusek, John W, Ojo, Akinlolu O, Inker, Lesley A, Investigators, CKD Biomarker Consortium and the CRIC Study, Appel, Lawrence J, Go, Alan S, He, Jiang, Lash, James P, Rahman, Mahboob, Townsend, Raymond R

المصدر: American Journal of Kidney Diseases. 68(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Kidney Disease, Cardiovascular, Renal and urogenital, Good Health and Well Being, Biomarkers, Cardiovascular Diseases, Cohort Studies, Female, Humans, Intramolecular Oxidoreductases, Kidney Failure, Chronic, Lipocalins, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Renal Insufficiency, Chronic, beta 2-Microglobulin, Beta-trace protein, beta(2)-microglobulin, CKD Biomarkers Consortium, filtration markers, renal function, estimated glomerular filtration rate, chronic kidney disease, end-stage renal disease, mortality, cardiovascular events, Chronic Renal Insufficiency Cohort, CKD Biomarker Consortium and the CRIC Study Investigators, β(2)-microglobulin, Public Health and Health Services, Urology & Nephrology, Clinical sciences

الوصف: BackgroundSerum β-trace protein (BTP) and β2-microglobulin (B2M) are independently associated with end-stage renal disease (ESRD) and mortality in the general population and high-risk groups with diabetes or advanced chronic kidney disease (CKD). Less is known about their associations with outcomes and predictive ability in adults with moderate CKD.Study designProspective cohort study.Setting & participants3,613 adults from the CRIC (Chronic Renal Insufficiency Cohort) Study (45% women; mean age, 57.9 years; 41.0% non-Hispanic black; 51.9% with diabetes).PredictorsBTP and B2M levels with a reciprocal transformation to reflect their associations with filtration, creatinine-based estimated glomerular filtration rate (eGFRcr), measured GFR, and a 4-marker composite score combining BTP, B2M, creatinine, and cystatin C levels. Predictors were standardized as z scores for comparisons across filtration markers.OutcomesESRD, all-cause mortality, and new-onset cardiovascular disease.ResultsDuring a 6-year median follow-up, 755 (21%) participants developed ESRD, 653 died, and 292 developed new-onset cardiovascular disease. BTP, B2M, and the 4-marker composite score were independent predictors of ESRD and all-cause mortality, and B2M and the 4-marker composite score of cardiovascular events, after multivariable adjustment. These associations were stronger than those observed for eGFRcr (P vs eGFRcr≤0.02). The 4-marker composite score led to improvements in C statistic and 2.5-year risk reclassification beyond eGFRcr for all outcomes.LimitationsFiltration markers measured at one time point; measured GFR available in subset of cohort.ConclusionsBTP and B2M levels may contribute additional risk information beyond eGFRcr, and the use of multiple markers may improve risk prediction beyond this well-established marker of kidney function among persons with moderate CKD.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/27b5s1bnTest

المؤلفون: Thompson, Philip A, O'Brien, Susan M, Xiao, Lianchun, Wang, Xuemei, Burger, Jan A, Jain, Nitin, Ferrajoli, Alessandra, Estrov, Zeev, Keating, Michael J, Wierda, William G

المصدر: Cancer. 122(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Hematology, Clinical Research, Rare Diseases, Adenine, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Bendamustine Hydrochloride, Bone Marrow, Case-Control Studies, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 17, Cohort Studies, Cyclophosphamide, Disease-Free Survival, Female, Humans, Immunoglobulin Heavy Chains, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Neoplasm, Residual, Piperidines, Prognosis, Proportional Hazards Models, Pyrazoles, Pyrimidines, Retrospective Studies, Rituximab, Treatment Outcome, Vidarabine, ZAP-70 Protein-Tyrosine Kinase, beta 2-Microglobulin, beta(2)-microglobulin, BTK inhibitor, chemoimmunotherapy, chronic lymphocytic leukemia, ibrutinib, β2-microglobulin, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health

الوصف: BackgroundA high pretreatment β2 -microglobulin (B2M) level is associated with inferior survival outcomes in patients with chronic lymphocytic leukemia. However, to the authors' knowledge, the prognostic and predictive significance of changes in B2M during treatment have not been reported to date.MethodsThe authors analyzed 83 patients treated with ibrutinib-based regimens (66 with recurrent/refractory disease) and 198 treatment-naive patients who were treated with combined fludarabine, cyclophosphamide, and rituximab (FCR) to characterize changes in B2M and their relationship with clinical outcomes.ResultsB2M rapidly decreased during treatment with ibrutinib; on multivariable analysis, patients who received FCR (odds ratio, 0.40; 95% confidence interval [95% CI], 0.18-0.90 [P = .027]) were less likely to have normalized B2M at 6 months than patients treated with ibrutinib. On univariable analysis, normalization of B2M was associated with superior progression-free survival (PFS) from the 6-month landmark in patients treated with ibrutinib-based regimens and FCR. On multivariable analysis, failure to achieve normalized B2M at 6 months of treatment was associated with inferior PFS (hazard ratio, 16.9; 95% CI, 1.3-220.0 [P = .031]) for patients treated with ibrutinib, after adjusting for the effects of baseline B2M, stage of disease, fludarabine-refractory disease, and del(17p). In contrast, in patients treated with FCR, negative minimal residual disease status in the bone marrow was the only variable found to be significantly associated with superior PFS (hazard ratio, 0.28; 95% CI, 0.12-0.67 [P = .004]).ConclusionsNormalization of B2M at 6 months in patients treated with ibrutinib was found to be a useful predictor of subsequent PFS and may assist in clinical decision-making.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5bn4w20cTest

المؤلفون: BüyükaÅŸik, Y., Alayvaz, Aslan, N., Sayinalp, N.

مصطلحات موضوعية: ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1, beta 2 microglobulin, lactate dehydrogenase, adult, aged, bone marrow, cancer patient, cancer prognosis, cancer staging, cancer survival, chronic lymphatic leukemia, Conference Paper, controlled study, female, fluorescence in situ hybridization, human, human tissue, International Prognostic Scoring System, major clinical study, male, overall survival, retrospective study, risk factor, treatment free survival, beta 2-microglobulin, chronic lymphocytic leukemia, prognosis, survival

الوصف: Chronic lymphocytic leukemia (CLL) is a disease with a highly variable clinical spectrum and prognosis, and is more common in the elderly population. The identification of high-risk patients according to prognostic factors and the application of new treatment regimens have improved survival in CLL. The purpose of our study was to examine the effects of important prognostic factors on survival in patients with CLL in our patient population. Treatment-free survival (TFS) and overall survival (OS) analyses were performed in patients diagnosed with CLL between January 2000 and June 2013 according to clinical characteristics at the time of diagnosis, bone marrow infiltration pattern, lactate dehydrogenase (LDH) and beta 2-Microglobulin levels, CD38 expression and fluorescent insitu hybridization (FISH) findings. Two hundred and forty-five patients were evaluated. Presence of initial B symptom, Rai stage>I, Binet stage B and C, diffuse infiltration of bone marrow by lymphocytes, LDH, and beta 2-Microglobulin levels above upper limit of normal (ULN), and CD38 positivity shortened both TFS and OS (p0.05). Also, age over 65 years, performance score of 2 and above, and del17p positivity shortened OS (p0.05) but did not make a statistically significant difference in TFS. In multivariate analysis, it was determined that advanced age was an independent poor prognostic factor affecting OS, and Rai stage was an independent risk factor affecting TFS (p0.05). When Rai stage was excluded, beta 2-Microglobulin and LDH were found to be negative prognostic risk factors affecting TFS independent of other factors. LDH level, which is not included in the international prognostic scoring system, was found to be a marker affecting TFS and OS in our study. © 2024 Ondokuz Mayis Universitesi. All rights reserved.

العلاقة: Journal of Experimental and Clinical Medicine (Turkey); DiÄŸer; https://hdl.handle.net/11499/57014Test; https://doi.org/10.52142/omujecm.41.1.21Test; 41; 125; 131; 2-s2.0-85189503624

الإتاحة: https://doi.org/10.52142/omujecm.41.1.21Test
https://hdl.handle.net/11499/57014Test