المؤلفون: Nichols, H.B, House, M.G, Yarosh, R, Mitra, S, Goldberg, M, Bertrand, K.A, Eliassen, A.H, Giles, G.G, Jones, M.E, Milne, R.L, O’Brien, K.M, Palmer, J.R, Sandin, S, Willett, W.C, Yin, W, Sandler, D.P, Swerdlow, A.J, Schoemaker, M.J

المصدر: Breast Cancer Research and Treatment

مصطلحات موضوعية: Cohort, Epidemiology, Breast cancer

الوصف: Purpose: Women with preeclampsia are more likely to deliver preterm. Reports of inverse associations between preeclampsia and breast cancer risk, and positive associations between preterm birth and breast cancer risk are difficult to reconcile. We investigated the co-occurrence of preeclampsia/gestational hypertension with preterm birth and breast cancer risk using data from the Premenopausal Breast Cancer Collaborative Group. Methods: Across 6 cohorts, 3096 premenopausal breast cancers were diagnosed among 184,866 parous women. We estimated multivariable hazard ratios (HR) and 95% confidence intervals (CI) for premenopausal breast cancer risk using Cox proportional hazards regression. Results: Overall, preterm birth was not associated (HR 1.02, 95% CI 0.92, 1.14), and preeclampsia was inversely associated (HR 0.86, 95% CI 0.76, 0.99), with premenopausal breast cancer risk. In stratified analyses using data from 3 cohorts, preterm birth associations with breast cancer risk were modified by hypertensive conditions in first pregnancies (P-interaction = 0.09). Preterm birth was positively associated with premenopausal breast cancer in strata of women with preeclampsia or gestational hypertension (HR 1.52, 95% CI: 1.06, 2.18), but not among women with normotensive pregnancy (HR = 1.09, 95% CI: 0.93, 1.28). When stratified by preterm birth, the inverse association with preeclampsia was more apparent, but not statistically different (P-interaction = 0.2), among women who did not deliver preterm (HR = 0.82, 95% CI 0.68, 1.00) than those who did (HR = 1.07, 95% CI 0.73, 1.56). Conclusion: Findings support an overall inverse association of preeclampsia history with premenopausal breast cancer risk. Estimates for preterm birth and breast cancer may vary according to other conditions of pregnancy.

العلاقة: https://doi.org/10.17615/x13c-xp84Test; https://cdr.lib.unc.edu/downloads/z029pg53s?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/z029pg53sTest

الإتاحة: https://doi.org/10.17615/x13c-xp84Test
https://cdr.lib.unc.edu/downloads/z029pg53s?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/z029pg53sTest

المؤلفون: Webb, P.M., Na, R., Weiderpass, E., Adami, H.O., Anderson, K.E., Bertrand, K.A., Botteri, E., Brasky, T.M., Brinton, L.A., Chen, C., Doherty, J.A., Lu, L., McCann, S.E., Moysich, K.B., Olson, S., Petruzella, S., Palmer, J.R., Prizment, A.E., Schairer, C., Setiawan, V.W., Spurdle, A.B., Trabert, B., Wentzensen, N., Wilkens, L., Yang, H.P., Yu, H., Risch, H.A., Jordan, S.J.

المساهمون: National Health and Medical Research Council of Australia, Cancer Council Tasmania, National Cancer Institute/National Institutes of Health, National Institutes of Health, Swedish Research Council

المصدر: Annals of Oncology ; volume 30, issue 2, page 310-316 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mdy541Test
https://api.elsevier.com/content/article/PII:S0923753419310373?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753419310373?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/30/2/310/27970130/mdy541.pdfTest

المؤلفون: Crous-Bou, M., Du, M., Gunter, M.J., Setiawan, V.W., Schouten, L.J., Shu, X.O., Wentzensen, N., Bertrand, K.A., Cook, L.S., Friedenreich, C.M., Gapstur, S.M., Goodman, M.T., Ibiebele, T.I., La Vecchia, C., Levi, F., Liao, L.M., Negri, E., McCann, S.E., O'Connell, K., Palmer, J.R., Patel, A.V., Ponte, J., Reynolds, P., Sacerdote, C., Sinha, R., Spurdle, A.B., Trabert, B., van den Brandt, P.A., Webb, P.M., Petruzella, S., Olson, S.H., De Vivo, I.

المساهمون: Epidemiology of Endometrial Cancer Consortium (E2C2)

المصدر: The American journal of clinical nutrition, vol. 116, no. 5, pp. 1219-1228

مصطلحات موضوعية: Female, Humans, Risk Factors, Endometrial Neoplasms/epidemiology, Endometrial Neoplasms/etiology, Endometrial Neoplasms/prevention & control, Logistic Models, Case-Control Studies, Data Collection, coffee consumption, endometrial cancer, epidemiology, pooled analysis

الوصف: Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating concentrations of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. Based on available meta-analyses, the World Cancer Research Fund (WCRF) concluded that consumption of coffee probably protects against EC. Our main aim was to examine the association between coffee consumption and EC risk by combining individual-level data in a pooled analysis. We also sought to evaluate potential effect modification by other risk factors for EC. We combined individual-level data from 19 epidemiologic studies (6 cohort, 13 case-control) of 12,159 EC cases and 27,479 controls from the Epidemiology of Endometrial Cancer Consortium (E2C2). Logistic regression was used to calculate ORs and their corresponding 95% CIs. All models were adjusted for potential confounders including age, race, BMI, smoking status, diabetes status, study design, and study site. Coffee drinkers had a lower risk of EC than non-coffee drinkers (multiadjusted OR: 0.87; 95% CI: 0.79, 0.95). There was a dose-response relation between higher coffee consumption and lower risk of EC: compared with non-coffee drinkers, the adjusted pooled ORs for those who drank 1, 2-3, and >4 cups/d were 0.90 (95% CI: 0.82, 1.00), 0.86 (95% CI: 0.78, 0.95), and 0.76 (95% CI: 0.66, 0.87), respectively (P-trend < 0.001). The inverse association between coffee consumption and EC risk was stronger in participants with BMI > 25 kg/m 2 . The results of the largest analysis to date pooling individual-level data further support the potentially beneficial health effects of coffee consumption in relation to EC, especially among females with higher BMI.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36041172; info:eu-repo/semantics/altIdentifier/eissn/1938-3207; https://serval.unil.ch/notice/serval:BIB_C7C7ACDB4916Test; urn:issn:0002-9165

الإتاحة: https://doi.org/10.1093/ajcn/nqac229Test
https://serval.unil.ch/notice/serval:BIB_C7C7ACDB4916Test

المؤلفون: Berndt, S.I., Camp, N.J., Skibola, C.F., Vijai, J., Wang, Z., Gu, J., Nieters, A., Kelly, R.S., Smedby, K.E., Monnereau, A., Cozen, W., Cox, A., Wang, S.S., Lan, Q., Teras, L.R., Machado, M., Yeager, M., Brooks-Wilson, A.R., Hartge, P., Purdue, M.P., Birmann, B.M., Vajdic, C.M., Cocco, P., Zhang, Y., Giles, G.G., Zeleniuch-Jacquotte, A., Lawrence, C., Montalvan, R., Burdett, L., Hutchinson, A., Ye, Y., Call, T.G., Shanafelt, T.D., Novak, A.J., Kay, N.E., Liebow, M., Cunningham, J.M., Allmer, C., Hjalgrim, H., Adami, H.O., Melbye, M., Glimelius, B., Chang, E.T., Glenn, M., Curtin, K., Cannon-Albright, L.A., Diver, W.R., Link, B.K., Weiner, G.J., Conde, L., Bracci, P.M., Riby, J., Arnett, D.K., Zhi, D., Leach, J.M., Holly, E.A., Jackson, R.D., Tinker, L.F., Benavente, Y., Sala, N., Casabonne, D., Becker, N., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., McKay, J., Staines, A., Chaffee, K.G., Achenbach, S.J., Vachon, C.M., Goldin, L.R., Strom, S.S., Leis, J.F., Weinberg, J.B., Caporaso, N.E., Norman, A.D., De Roos, A.J., Morton, L.M., Severson, R.K., Riboli, E., Vineis, P., Kaaks, R., Masala, G., Weiderpass, E., Chirlaque, M.D., Vermeulen, R.C., Travis, R.C., Southey, M.C., Milne, R.L., Albanes, D., Virtamo, J., Weinstein, S., Clavel, J., Zheng, T., Holford, T.R., Villano, D.J., Maria, A., Spinelli, J.J., Gascoyne, R.D., Connors, J.M., Bertrand, K.A., Giovannucci, E., Kraft, P., Kricker, A., Turner, J., Ennas, M.G., Ferri, G.M., Miligi, L., Liang, L., Ma, B., Huang, J., Crouch, S., Park, J.H., Chatterjee, N., North, K.E., Snowden, J.A., Wright, J., Fraumeni, J.F., Offit, K., Wu, X., de Sanjose, S., Cerhan, J.R., Chanock, S.J., Rothman, N., Slager, S.L.

الوصف: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/96809/2/WRRO_96809.pdfTest; Berndt, S.I., Camp, N.J., Skibola, C.F. et al. (123 more authors) (2016) Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nature Communications, 7. 10933. ISSN 2041-1723

الإتاحة: https://doi.org/10.1038/ncomms10933Test
https://eprints.whiterose.ac.uk/96809Test/
https://eprints.whiterose.ac.uk/96809/2/WRRO_96809.pdfTest

المؤلفون: Farland, L.V., Tamimi, R.M., Bertrand, K.A., Eliassen, A., Chavarro, J.E., Grodstein, F., Missmer, S.A.

المصدر: Fertility and Sterility ; volume 106, issue 3, page e130 ; ISSN 0015-0282

مصطلحات موضوعية: Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.fertnstert.2016.07.387Test
https://api.elsevier.com/content/article/PII:S0015028216618009?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0015028216618009?httpAccept=text/plainTest

المؤلفون: Palmer, J.R, Zirpoli, G, Bertrand, K.A, Battaglia, T, Bernstein, L, Ambrosone, C.B, Bandera, E.V, Troester, M.A, Rosenberg, L, Pfeiffer, R.M, Trinquart, L

المصدر: Journal of Clinical Oncology, 39(34)

مصطلحات موضوعية: United States, Women's Health, breast biopsy, oral contraceptive agent, aged, population based case control study, Risk Assessment, case control study, Black person, Female, controlled study, cancer mortality, Case-Control Studies, prediction, middle aged, risk factor, mortality, adult, human, oral contraceptive use, Blacks, attributable risk, ovariectomy, Humans, Article, tumor biopsy, menarche, calibration, estrogen receptor, family history

الوصف: PURPOSE Breast cancer risk prediction models are used to identify high-risk women for early detection, targeted interventions, and enrollment into prevention trials. We sought to develop and evaluate a risk prediction model for breast cancer in US Black women, suitable for use in primary care settings. METHODS Breast cancer relative risks and attributable risks were estimated using data from Black women in three US population-based case-control studies (3,468 breast cancer cases; 3,578 controls age 30-69 years) and combined with SEER age- and race-specific incidence rates, with incorporation of competing mortality, to develop an absolute risk model. The model was validated in prospective data among 51,798 participants of the Black Women’s Health Study, including 1,515 who developed invasive breast cancer. A second risk prediction model was developed on the basis of estrogen receptor (ER)–specific relative risks and attributable risks. Model performance was assessed by calibration (expected/observed cases) and discriminatory accuracy (C-statistic). RESULTS The expected/observed ratio was 1.01 (95% CI, 0.95 to 1.07). Age-adjusted C-statistics were 0.58 (95% CI, 0.56 to 0.59) overall and 0.63 (95% CI, 0.58 to 0.68) among women younger than 40 years. These measures were almost identical in the model based on estrogen receptor–specific relative risks and attributable risks. CONCLUSION Discriminatory accuracy of the new model was similar to that of the most frequently used questionnaire-based breast cancer risk prediction models in White women, suggesting that effective risk stratification for Black women is now possible. This model may be especially valuable for risk stratification of young Black women, who are below the ages at which breast cancer screening is typically begun.

العلاقة: https://doi.org/10.17615/y51w-2p07Test; https://cdr.lib.unc.edu/downloads/g445cq61t?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/g445cq61tTest

الإتاحة: https://doi.org/10.17615/y51w-2p07Test
https://cdr.lib.unc.edu/downloads/g445cq61t?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/g445cq61tTest

المؤلفون: Bertrand, K.A, O'Brien, K.M, Wright, L.B, Palmer, J.R, Blot, W.J, Eliassen, A.H, Rosenberg, L, Sandin, S, Tobias, D, Weiderpass, E, Zheng, W, Swerdlow, A.J, Schoemaker, M.J, Nichols, H.B, Sandler, D.P

المصدر: International Journal of Epidemiology, 50(6)

مصطلحات موضوعية: Gestational diabetes mellitus, breast cancer, cohort, epidemiology

الوصف: Background: The history of gestational diabetes mellitus (GDM) has been associated with breast cancer risk in some studies, particularly in young women, but results of cohort studies are conflicting. Methods: We pooled data from 257 290 young (age <55 years) women from five cohorts. We used multivariable Cox proportional-hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between GDM history and risk of breast cancer, overall and by oestrogen receptor (ER) status, before age 55 years, adjusted for established breast cancer risk factors. Results: Five percent of women reported a history of GDM and 6842 women reported an incident breast-cancer diagnosis (median follow-up = 16 years; maximum = 24 years). Compared with parous women without GDM, women with a history of GDM were not at increased risk of young-onset breast cancer overall (HR = 0.90; 95% CI: 0.78, 1.03) or by ER status (HR = 0.96; 95% CI: 0.79, 1.16 for ER-positive; HR = 1.07; 95% CI: 0.78, 1.47 for ER-negative). Compared with nulliparous women, parous women with a history of GDM had a lower risk of breast cancer overall (HR = 0.79; 95% CI: 0.68, 0.91) and of ER-positive (HR = 0.82; 95% CI: 0.66, 1.02) but not ER-negative (HR = 1.09; 95% CI: 0.76, 1.54) invasive breast cancer. These results were consistent with the HRs comparing parous women without GDM to nulliparous women. Conclusions: Results of this analysis do not support the hypothesis that GDM is a risk factor for breast cancer in young women. Our findings suggest that the well-established protective effect of parity on risk of ER-positive breast cancer persists even for pregnancies complicated by GDM.

العلاقة: https://doi.org/10.17615/hgkw-et24Test; https://cdr.lib.unc.edu/downloads/tm70n614n?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/tm70n614nTest

الإتاحة: https://doi.org/10.17615/hgkw-et24Test
https://cdr.lib.unc.edu/downloads/tm70n614n?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/tm70n614nTest

المؤلفون: Bertrand, K.A, Bethea, T.N, Rosenberg, L, Bandera, E.V, Khoury, T, Troester, M.A, Ambrosone, C.B, Palmer, J.R

المصدر: Breast, 49

مصطلحات موضوعية: African American, Ductal carcinoma in situ, Risk factors, Breast cancer, Epidemiology

الوصف: Background: Compared to U.S. white women, African American women are more likely to die from ductal carcinoma in situ (DCIS). Elucidation of risk factors for DCIS in African American women may provide opportunities for risk reduction. Methods: We used data from three epidemiologic studies in the African American Breast Cancer Epidemiology and Risk Consortium to study risk factors for estrogen receptor (ER) positive DCIS (488 cases; 13,830 controls). Results were compared to associations observed for ER+ invasive breast cancer (n = 2,099). Results: First degree family history of breast cancer was associated with increased risk of ER+ DCIS [odds ratio (OR): 1.69, 95% confidence interval (CI): 1.31, 2.17]. Oral contraceptive use within the past 10 years (vs. never) was also associated with increased risk (OR: 1.43, 95%CI: 1.03, 1.97), as was late age at first birth (≥25 years vs. <20 years) (OR: 1.26, 95%CI: 0.96, 1.67). Risk was reduced in women with older age at menarche (≥15 years vs. <11 years) (OR: 0.62, 95%CI: 0.42, 0.93) and higher body mass index (BMI) in early adulthood (≥25 vs. <20 kg/m2 at age 18 or 21) (OR: 0.75, 95%CI: 0.55, 1.01). There was a positive association of recent BMI with risk in postmenopausal women only. In general, associations of risk factors for ER+ DCIS were similar in magnitude and direction to those for invasive ER+ breast cancer. Conclusions: Our findings suggest that most risk factors for invasive ER+ breast cancer are also associated with increased risk of ER+ DCIS among African American women.

العلاقة: https://doi.org/10.17615/j3a0-jc92Test; https://cdr.lib.unc.edu/downloads/8049gh23r?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/8049gh23rTest

الإتاحة: https://doi.org/10.17615/j3a0-jc92Test
https://cdr.lib.unc.edu/downloads/8049gh23r?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/8049gh23rTest

المؤلفون: Schoemaker, M.J, Nichols, H.B, Wright, L.B, Brook, M.N, Jones, M.E, O'Brien, K.M, Adami, H.-O, Baglietto, L, Bernstein, L, Bertrand, K.A, Boutron-Ruault, M.-C, Chen, Y, Connor, A.E, Dossus, L, Eliassen, A.H, Giles, G.G, Gram, I.T, Hankinson, S.E, Kaaks, R, Key, T.J, Kirsh, V.A, Kitahara, C.M, Larsson, S.C, Linet, M, Ma, H, Milne, R.L, Ozasa, K, Palmer, J.R, Riboli, E, Rohan, T.E, Sacerdote, C, Sadakane, A, Sund, M, Tamimi, R.M, Trichopoulou, A, Ursin, G, Visvanathan, K, Weiderpass, E, Willett, W.C, Wolk, A, Zeleniuch-Jacquotte, A, Sandler, D.P, Swerdlow, A.J

المصدر: International Journal of Cancer, 147(5)

مصطلحات موضوعية: cohort studies, breast neoplasms, body weight changes, risk factors, premenopause

الوصف: Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

العلاقة: https://doi.org/10.17615/0hza-ak90Test; https://cdr.lib.unc.edu/downloads/zw12zg95d?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/zw12zg95dTest

الإتاحة: https://doi.org/10.17615/0hza-ak90Test
https://cdr.lib.unc.edu/downloads/zw12zg95d?file=thumbnailTest
https://cdr.lib.unc.edu/downloads/zw12zg95dTest

المؤلفون: Liu, J.J., Bertrand, K.A., Karageorgi, S., Giovannucci, E., Hankinson, S.E., Rosner, B., Maxwell, L., Rodriguez, G., De Vivo, I.

المساهمون: National Institutes of Health, United States Army Medical Acquisition Activity, Nutritional Epidemiology of Cancer Education and Career Development Program

المصدر: Annals of Oncology ; volume 24, issue 3, page 687-692 ; ISSN 0923-7534

مصطلحات موضوعية: Oncology, Hematology

الإتاحة: https://doi.org/10.1093/annonc/mds509Test
https://api.elsevier.com/content/article/PII:S0923753419371352?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0923753419371352?httpAccept=text/plainTest
http://academic.oup.com/annonc/article-pdf/24/3/687/538402/mds509.pdfTest