المؤلفون: Frigo S., Raspolli Galletti A. M., Fulignati S., Licursi D., Bertin L., Martinez G. A., Pasini G.

المساهمون: Frigo S., Raspolli Galletti A.M., Fulignati S., Licursi D., Bertin L., Martinez G.A., Pasini G.

مصطلحات موضوعية: exhaust emission, hydrogenation, oxygenated bio-additive, rhenium catalyst, waste biomass

الوصف: The production of oxygenated bio-additives for traditional fuels represents a key challenge due to their depletion in the near-future and their positive contribution to the reduction in environmental pollution. The present study considers the synthesis of 1-hexanol/hexyl hexanoate mixtures, two oxygenated Diesel bio-additives produced through the hydrogenation of hexanoic acid, obtainable from the fermentation of a wide variety of waste biomasses. In our case, crude hexanoic acid was produced through the fermentation of grape pomace, an abundant Italian agrifood waste. Commercial 5 wt% Re/γ-Al2O3 was adopted for the catalytic hydrogenation of crude hexanoic acid, and the support acidity allowed the tuning of the reaction selectivity toward the formation of hexyl hexanoate, instead of 1-hexanol, reaching yields of 40 and 25 mol%, respectively. The effects of each bio-additive on Diesel engine performance and exhaust emissions (soot, nitrogen oxides, carbon monoxide, unburned hydrocarbons) were evaluated, highlighting noteworthy positive effects especially on the reduction in carbon monoxide and soot emissions, if compared with those of Diesel fuel alone. Similar promising performances were achieved by employing Diesel blend mixtures of 1-hexanol/hexyl hexanoate, mimicking typical compositions of the rhenium-catalyzed post-hydrogenation mixtures. Even in such cases, 1-hexanol/hexyl hexanoate mixtures can be blended with commercial Diesel fuel, up to high loadings currently not yet investigated (20 vol%), without altering the engine performances and, again, significantly lowering soot and carbon monoxide emissions by more than 40%. This work highlights the possibility of obtaining such oxygenated bio-additives starting from waste through to a fully sustainable process and proves their beneficial effects on the reduction in exhaust emissions with no changes in engine performance.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001082108700001; volume:16; issue:19; firstpage:1; lastpage:17; numberofpages:17; journal:ENERGIES; https://hdl.handle.net/11585/963084Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174059408; https://www.mdpi.com/1996-1073/16/19/6789Test

الإتاحة: https://doi.org/10.3390/en16196789Test
https://hdl.handle.net/11585/963084Test
https://www.mdpi.com/1996-1073/16/19/6789Test

المؤلفون: Bertani, L, Tricò, D, Barberio, B, Bretto, E, Ceccarelli, L, Calabrese, F, Pasta, A, Bertin, L, Fabiana, Z, Maniero, D, Frara, S, De Bernardi, A, Bodini, G, Ribaldone, D G, Costa, F, Savarino, E V

المساهمون: Bertani, L, Tricò, D, Barberio, B, Bretto, E, Ceccarelli, L, Calabrese, F, Pasta, A, Bertin, L, Fabiana, Z, Maniero, D, Frara, S, De Bernardi, A, Bodini, G, Ribaldone, D G, Costa, F, Savarino, E V

العلاقة: volume:18; issue:S1; firstpage:1753; lastpage:1753; numberofpages:1; journal:JOURNAL OF CROHN'S AND COLITIS; https://hdl.handle.net/11568/1220855Test

الإتاحة: https://doi.org/10.1093/ecco-jcc/jjad212.1095Test
https://hdl.handle.net/11568/1220855Test

المؤلفون: Bertani, L, Tricò, D, Barberio, B, Vernero, M, Bretto, E, Ceccarelli, L, Pardi, V, Calabrese, F, Pasta, A, Bertin, L, Fabiana, Z, Semprucci, G, Bodini, G, Ribaldone, D G, Savarino, E V, Costa, F

المساهمون: Bertani, L, Tricò, D, Barberio, B, Vernero, M, Bretto, E, Ceccarelli, L, Pardi, V, Calabrese, F, Pasta, A, Bertin, L, Fabiana, Z, Semprucci, G, Bodini, G, Ribaldone, D G, Savarino, E V, Costa, F

العلاقة: volume:18; issue:S1; firstpage:1125; lastpage:1125; numberofpages:1; journal:JOURNAL OF CROHN'S AND COLITIS; https://hdl.handle.net/11568/1220789Test

الإتاحة: https://doi.org/10.1093/ecco-jcc/jjad212.0706Test
https://hdl.handle.net/11568/1220789Test

المؤلفون: Castex, E, Frapart, V, Bertin, L, Siauve, J, Forget, B

المصدر: Section 4: Clinical pharmacy services

الإتاحة: https://doi.org/10.1136/ejhpharm-2024-eahp.331Test

المؤلفون: Licursi, D, Galletti, AMR, Antonetti, C, Martinez, GA, Jones, E, Bertin, L, Di Fidio, N, Fulignati, S, Pasini, G, Frigo, S

المساهمون: Licursi, D, Galletti, AMR, Antonetti, C, Martinez, GA, Jones, E, Bertin, L, Di Fidio, N, Fulignati, S, Pasini, G, Frigo, S

مصطلحات موضوعية: grape pomace, carboxylic acid, rhenium catalyst, hydrogenation, diesel blendstock

الوصف: The transition from fossil resources to renewable ones represents a pressing need. The acidogenic fermentation of biomass-derived ethanol to carboxylic acids represents a novel and smart possibility, opening the way for the production of further value-added bio-products through cascade chemical approaches. In this work, the hydrogenation of commercial hexanoic acid to give 1-hexanol/hexyl hexanoate mixtures was preliminary studied in the presence of commercial rhenium catalysts (Re2O7 and 5 wt% Re/C), which resulted as mainly active and selective towards 1-hexanol. On the other hand, the use of niobium phosphate as the acid co-catalyst markedly shifted the selectivity towards hexyl hexanoate. Moreover, 5 wt% Re/C and physical mixtures of (5 wt% Re/C + niobium phosphate) were further tested for the hydrogenation of crude hexanoic acid obtained through fermentation of white grape pomace, confirming the promising performance of these catalytic systems and their recyclability. For the first time, the employment of 1-hexanol/hexyl hexanoate mixtures as a diesel blendstock was evaluated, highlighting a significant reduction of soot and CO emissions, without any significant change in the engine performance. The promising properties of these oxygenated additives are favorable for the partial replacement of traditional fossil fuels, in accordance with the short-term goals of EU countries.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000902206300001; volume:12; issue:12; firstpage:1; lastpage:16; numberofpages:16; journal:CATALYSTS; https://hdl.handle.net/11585/919014Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85144963474; https://www.mdpi.com/2073-4344/12/12/1550Test

الإتاحة: https://doi.org/10.3390/catal12121550Test
https://hdl.handle.net/11585/919014Test
https://www.mdpi.com/2073-4344/12/12/1550Test

المؤلفون: Samori' C., Martinez G. A., Bertin L., Pagliano G., Parodi A., Torri C., Galletti P.

المساهمون: Samori' C., Martinez G.A., Bertin L., Pagliano G., Parodi A., Torri C., Galletti P.

مصطلحات موضوعية: Chemical recycling, Crotonic acid, Cupriavidus necator, Polyhydroxybutyrate, Thermolysis

الوصف: The recycling of polyhydroxybutyrate (PHB) via depolymerization-polymerization is here proposed and assessed for the first time. Effective depolymerization of PHB to crotonic acid through a thermolytic distillation at mild conditions (170 °C and 150 mbar), and without the need of any catalyst, gives a crotonic acid-enriched condensate (94% yield and 98% selectivity towards trans-crotonic acid) that was used without any further purification as a substrate for producing renewed PHB with a culture of Cupriavidus necator. The yield of PHB (0.6 g PHB per g of crotonic acid), final PHB content (63%), and PHB-molecular weight (1.5 MDa) confirmed the technical feasibility of this tandem approach, with a 55% overall yield. A preliminary evaluation of the energy consumption of various depolymerization approaches indicated that the thermolytic distillation consumes 20–25% less energy than previously reported methods; the energy requirement for producing crotonic acid from PHBwaste with 50% moisture has a still acceptable energy demand (4 MJ/kgcrotonic acid), comparable to the energy required for obtaining fermentable sugars (4.4 MJ/kgsugar) to be used for feeding bacteria that accumulate PHB.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000767524900008; volume:178; firstpage:1; lastpage:7; numberofpages:7; journal:RESOURCES CONSERVATION AND RECYCLING; https://hdl.handle.net/11585/860077Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85120360209

الإتاحة: https://doi.org/10.1016/j.resconrec.2021.106082Test
https://hdl.handle.net/11585/860077Test

المؤلفون: Martinez G. A., Puccio S., Domingos J. M. B., Morselli E., Gioia C., Marchese P., Raspolli Galletti A. M., Celli A., Fava F., Bertin L.

المساهمون: Martinez, G. A., Puccio, S., Domingos, J. M. B., Morselli, E., Gioia, C., Marchese, P., Raspolli Galletti, A. M., Celli, A., Fava, F., Bertin, L.

مصطلحات موضوعية: Distillation, Extraction, Fermentation, Fuel additive, Hydrogenation, Chain elongation, Down-stream, Grape pomace, Hexanoic acid, Polyhydroxyhexanoate

الوصف: The management of grape pomace (GP), the main winery solid residue, is presently supported by government subsidies, promoting the energetically expensive recovery of ethanol by distillation. This work proposes and assesses a novel sustainable alternative GP valorisation strategy: chain elongation fermentation. Besides, the proof-of-concept of a multipurpose cascading scheme is presented based on experimental data for each step on the laboratory scale. The new cascading biorefinery scheme includes: (1) the ethanol upgrade into highly concentrated (ca. 900 g L−1) n-hexanoic acid (C6) by anaerobic acidogenic fermentation and a simple downstream; the exploitation of the obtained C6 as (2) a reagent for obtaining an ester-alcohol mixture as well as (3) a substrate for the production of medium chain length polyhydroxylalkanoates (mcl-PHAs), and (4) the complementary biomethanization of the solids leftovers from the acidogenic step. Specifically, the identified fermentation conditions (pH 7, 37 °C and P > Patm) allowed obtaining the highest C6 titer (22 g L−1) and productivity (6.2 g L−1 d−1) ever achieved from non pre-treated biowaste and without the need of either exogenus ethanol or methanization inhibitor or expensive in-line extraction methods. Such titer, allowed employing a cheap easy-direct C6 downstream leading to 54% C6 recovery (87% purity) at potentially competitive overall costs. Although a preliminary assessment showed that this partial valorisation could be economically sustainable in itself for GP-management, the exploitation of the highly concentrated GP-derived C6 was demonstrated for the first time. Heterogenous catalytic hydrogenation (180 °C and 115 bar), with pre-reduced commercial catalyst Re/C 5 wt%, allowed the conversion of the obtained C6 into a mixture of 1-hexanol and hexyl-hexanoate (molar yield of 75%), which represents a promising blendstock for both diesel and biodiesel fuels. On the other hand, a fed-batch culture system, carried out on a bench-top bioreactor, allowed obtaining 60% ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000768429400001; volume:24; issue:7; firstpage:2882; lastpage:2892; numberofpages:11; journal:GREEN CHEMISTRY; https://hdl.handle.net/11572/363047Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85127696974

الإتاحة: https://doi.org/10.1039/d2gc00044jTest
https://hdl.handle.net/11572/363047Test

المؤلفون: Bertani, L, Tricò, D, Barberio, B, Vernero, M, Bretto, E, Ceccarelli, L, Pardi, V, Calabrese, F, Pasta, A, Bertin, L, Fabiana, Z, Semprucci, G, Bodini, G, Ribaldone, D G, Savarino, E V, Costa, F

المصدر: Journal of Crohn's and Colitis ; volume 18, issue Supplement_1, page i1125-i1125 ; ISSN 1873-9946 1876-4479

مصطلحات موضوعية: Gastroenterology, General Medicine

الوصف: Background Ustekinumab (UST) is one of the most used biologic drugs for the treatment of Crohn’s Disease (CD) and Ulcerative Colitis (UC). However, not all patients achieve clinical remission and even less mucosal healing. There is currently scarce knowledge about the early markers of therapeutic response in this setting, with particular regard to mucosal healing. The aim of this multicenter study was to evaluate the role of fecal calprotectin (FC) as early predictor of mucosal healing. Methods We enrolled consecutive patients with CD or UC treated with UST for at least 48 weeks at four referral centers in the last 5 years. Therapeutic response was evaluated in terms of clinical remission (defined as a Partial Mayo Score <2 for patients with UC and as Harvey Bradshaw Index <5 for patients with CD, without concomitant corticosteroid therapy) and mucosal healing (defined as a Mayo Endoscopic Score <2 for UC and as the disappearance of ulcers for CD). We collected clinical and demographic data, as well as fecal calprotectin (FC) and C-Reactive Protein (CRP) levels at baseline and at week 24. Results Among 196 patients enrolled (73 [37.2%] women), 167 were affected by CD, whereas 29 by UC. Globally, 128 (65.3%) patients achieved clinical remission and 83 (42.3%) endoscopic remission at 48 weeks of treatment. There were no group differences in age, sex, BMI, baseline clinical and endoscopic indexes, or baseline CRP levels between patients achieving or not either clinical or endoscopic remission. Baseline calprotectin levels were lower in patients who achieved endoscopic remission (median [interquartile range] 391 [103, 1050] versus 825 [317, 1800] µg/mL,p=0.002). At week 24, lower calprotectin levels were observed in both the groups who achieved clinical (160 [50, 426] versus 439 [146, 1000] µg/mL,p<0.0001) and endoscopic remission (114 [43, 265] versus 392 [139, 912] µg/mL,p<0.0001) compared with non-responders. The effects of week-24 calprotectin levels on clinical ...

الإتاحة: https://doi.org/10.1093/ecco-jcc/jjad212.0706Test
https://academic.oup.com/ecco-jcc/article-pdf/18/Supplement_1/i1125/56349610/jjad212.0706.pdfTest

المؤلفون: Farkas, B, Borsos, M, Resál, T, Bacsur, P, Szepes, Z, Savarino, E V, Bertin, L, Limdi, J K, Sethi-Arora, K, Miheller, P, Vilmos, F, Castiglione, F, Bonacci, L, Lukas, M, Maharshak, N, Berman, G, Krznarić, Ž, Wetwittayakhlang, P, Lakatos, P L, Seidelin, J B, Attauabi, M, Michalopoulos, G, Ribaldone, D G, Kagramanova, A, Chashkova, E, Sarlós, P, Saibeni, S, Shitrit, A B G, Molnár, T, Farkas, K

المصدر: Journal of Crohn's and Colitis ; volume 18, issue Supplement_1, page i1837-i1838 ; ISSN 1873-9946 1876-4479

مصطلحات موضوعية: Gastroenterology, General Medicine

الوصف: Background The development of anti-TNFs has brought major advances in the treatment of ulcerative colitis (UC). Yet, a significant proportion of patients do not respond favorably to first-line anti-TNF therapy, which may require the use of second-, third-, or fourth-line biologics or small molecules. Treatment selection and sequencing, however, remains a major unmet need. Methods We conducted a multicenter, retrospective study including patients with moderate-to-severe UC who failed first-line anti-TNFs, and received sequential therapy with biologics or small-molecules. The effectiveness of sequential therapy, more specifically second-line agents was determined and compared by treatment persistence and colectomy-free survival up to 3 years post-initiation, and assessed using Kaplan-Meier analyses. Multivariate Cox regression analysis was performed to identify the predictive value of various factors for colectomy and persistence. Results 683 UC patients were included. The median follow-up time was 62 months (IQR: 36-98), during which 14.2% of patients required colectomy. The probability of colectomy-free survival was 97.5%, 93.9% and 92.3% at 1, 2, and 3 years. Persistence rates increased significantly with the number of therapy lines (P<.0001). The presence of deep ulcers at diagnosis (HR: 0.45; P=.009), prior cyclosporine use (CYA; HR: 0.41; P=.028), and low serum albumin at first-line therapy (HR: 0.92; P=.002) appeared to be predictive for colectomy. Following anti-TNF failure, significantly higher colectomy-free survival rates were observed over 3 years with ustekinumab (UST; P=.014; Figure 1a.), than with vedolizumab or tofacitinib. Second-line UST also showed superior persistence at 3, 6, 12, and 24 months (P=.049; Figure 1b.), but not at 36 months. Neither the risk of colectomy (P=.343), nor the rate of persistence with second-line therapy (P=.19) was influenced by the reason of first-line anti-TNF discontinuation. Prior CYA use (HR: 0.42; P=.047) negatively influenced persistence with ...

الإتاحة: https://doi.org/10.1093/ecco-jcc/jjad212.1146Test
https://academic.oup.com/ecco-jcc/article-pdf/18/Supplement_1/i1837/56349966/jjad212.1146.pdfTest

المؤلفون: Kaur G., Garcia-Gonzalez L., Elst K., Truzzi F., Bertin L., Kaushik A., Balakrishnan M., De Wever H.

المساهمون: Kaur G., Garcia-Gonzalez L., Elst K., Truzzi F., Bertin L., Kaushik A., Balakrishnan M., De Wever H.

مصطلحات موضوعية: Acidogenic fermentation, Carboxylate, Reactive extraction, Resource recovery, Waste stream, Wastewater biorefinery

الوصف: Biorefinery wastewaters can be fermented to produce carboxylates which are high-value platform chemicals. However, the major challenges in this fermentation are limited product yields and productivities faced due to product inhibition and difficulty in carboxylate separation and recovery from fermentation broths. To mitigate the above problems, process optimization via integrated fermentation-separation i.e. in-situ product recovery (ISPR) systems can be considered. As a first step towards development of such coupled carboxylate bioprocesses, this study aimed to provide a detailed analysis of extraction behaviour of a wide array of extractants and diluents for C2-C6 carboxylates in synthetic solutions and real effluent from acidogenic fermentation. Compared to physical extraction without extractant, a 75–85 % increase was achieved when using reactive extraction (RE) and the difference was more pronounced for short chain carboxylates, particularly at pH 4.5. Distribution coefficients and extraction efficiencies increased with increasing extractant concentration and reached an equilibrium at molar ratio of 1:2. Aliquat 336 and tri-octylphosphine oxide solved in methyloctanoate emerged as the best RE systems and yielded high extraction efficiencies of 11.5 and 29.5 (acetic acid) to almost 100 (caproic acid) respectively. Testing with real fermentation effluent demonstrated similar high extraction yields as observed on synthetic solutions. Potential toxicity of RE on acidogenic fermentation was also investigated which suggested the application of an external ISPR configuration for these coupled bioprocesses.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000542595600017; volume:160; firstpage:1; lastpage:12; numberofpages:12; journal:BIOCHEMICAL ENGINEERING JOURNAL; info:eu-repo/grantAgreement/EC/FP7/311933; http://hdl.handle.net/11585/775685Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85084797030; https://www-sciencedirect-com.ezproxy.unibo.it/science/article/pii/S1369703X20301959?via=ihubTest

الإتاحة: https://doi.org/10.1016/j.bej.2020.107641Test
http://hdl.handle.net/11585/775685Test
https://www-sciencedirect-com.ezproxy.unibo.it/science/article/pii/S1369703X20301959?via=ihubTest